Examining the potential clinical value of curcumin in the prevention and diagnosis of Alzheimer’s disease

1α,25-dihydroxyvitamin D3 Interacts with Curcuminoids to Stimulate Amyloid-β Clearance by Macrophages of Alzheimer's Disease Patients

(2017) Ava Masoumi et al.   JOURNAL OF ALZHEIMERS DISEASE

Accumulated Amyloid-β Peptide and Hyperphosphorylated Tau Protein: Relationship and Links in Alzheimer's Disease

(2017) Han-Chang Huang et al.   JOURNAL OF ALZHEIMERS DISEASE

Mitochondria-Targeted Antioxidants Protect Against Amyloid-β Toxicity in Alzheimer's Disease Neurons

(2017) Maria Manczak et al.   JOURNAL OF ALZHEIMERS DISEASE

Ocular Biomarkers for Early Detection of Alzheimer's Disease

(2017) Shaun Frost et al.   JOURNAL OF ALZHEIMERS DISEASE

Curcumin/Melatonin Hybrid 5-(4-Hydroxy-phenyl)-3-oxo-pentanoic Acid [2-(5-Methoxy-1H-indol-3-yl)-ethyl]-amide Ameliorates AD-Like Pathology in the APP/PS1 Mouse Model

(2015) Gorka Gerenu et al.   ACS Chemical Neuroscience

Curcumin-conjugated magnetic nanoparticles for detecting amyloid plaques in Alzheimer's disease mice using magnetic resonance imaging (MRI)

(2015) Kwok Kin Cheng et al.   BIOMATERIALS

Inhibitory Activity of Curcumin Derivatives Towards Metal-Free and Metal-Induced Amyloid-β Aggregation

(2015) Akiko Kochi et al.   Current Alzheimer Research

Activation of the Wnt/β-catenin pathway represses the transcription of the β-amyloid precursor protein cleaving enzyme (BACE1) via binding of T-cell factor-4 to BACE1 promoter

(2015) Callum Parr et al.   FASEB JOURNAL

Curcumin Targeted, Polymalic Acid-Based MRI Contrast Agent for the Detection of Aβ Plaques in Alzheimer's Disease

(2015) Rameshwar Patil et al.   MACROMOLECULAR BIOSCIENCE

Curcumin derivative with the substitution at C-4 position, but not curcumin, is effective against amyloid pathology in APP/PS1 mice

(2015) Daijiro Yanagisawa et al.   NEUROBIOLOGY OF AGING

Curcumin inhibits Aβ-induced microglial inflammatory responses in vitro: Involvement of ERK1/2 and p38 signaling pathways

(2015) Xiaolei Shi et al.   NEUROSCIENCE LETTERS

Product Development Studies on Sonocrystallized Curcumin for the Treatment of Gastric Cancer

(2015) Mohammad Khan et al.   Pharmaceutics

Aβ dimers differ from monomers in structural propensity, aggregation paths and population of synaptotoxic assemblies

(2014) Tiernan T. O’Malley et al.   BIOCHEMICAL JOURNAL

Capping of Aβ42 Oligomers by Small Molecule Inhibitors

(2014) Ziao Fu et al.   BIOCHEMISTRY

Effects of curcuminoids identified in rhizomes of Curcuma longa on BACE-1 inhibitory and behavioral activity and lifespan of Alzheimer’s disease Drosophila models

(2014) Xue Wang et al.   BMC Complementary and Alternative Medicine

Curcumin Suppresses Proliferation of Colon Cancer Cells by Targeting CDK2

(2014) T.-G. Lim et al.   Cancer Prevention Research

CNB-001, a novel pyrazole derivative mitigates motor impairments associated with neurodegeneration via suppression of neuroinflammatory and apoptotic response in experimental Parkinson’s disease mice

(2014) Richard L. Jayaraj et al.   CHEMICO-BIOLOGICAL INTERACTIONS

Curcumin for the treatment of major depression: A randomised, double-blind, placebo controlled study

(2014) Adrian L. Lopresti et al.   JOURNAL OF AFFECTIVE DISORDERS

Curcumin Alters the Salt Bridge-containing Turn Region in Amyloid β(1–42) Aggregates

(2014) Venus Singh Mithu et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Hyperhomocysteinemia and Neurologic Disorders: a Review

(2014) Ramin Ansari et al.   Journal of Clinical Neurology

Epigenetic nutraceutical diets in Alzheimer’s disease

(2014) S. Davinelli et al.   Journal of Nutrition Health & Aging

Investigation of the effects of solid lipid curcumin on cognition and mood in a healthy older population

(2014) Katherine HM Cox et al.   JOURNAL OF PSYCHOPHARMACOLOGY

Alzheimer's disease and epigenetic diet

(2014) Zeynep Sezgin et al.   NEUROCHEMISTRY INTERNATIONAL

Telomerase: A Target for Therapeutic Effects of Curcumin and a Curcumin Derivative in Aβ1-42 Insult In Vitro

(2014) Zijian Xiao et al.   PLoS One

Recent Developments in Delivery, Bioavailability, Absorption and Metabolism of Curcumin: the Golden Pigment from Golden Spice

(2014) Sahdeo Prasad et al.   Cancer Research and Treatment

Wnt signaling: Role in LTP, neural networks and memory

(2013) Carolina A. Oliva et al.   AGEING RESEARCH REVIEWS

Curcumin, a component of turmeric: From farm to pharmacy

(2013) Subash C. Gupta et al.   BIOFACTORS

Curcumin improves spatial memory and decreases oxidative damage in aged female rats

(2013) Muaz Belviranlı et al.   BIOGERONTOLOGY

Nature: A Substantial Source of Auspicious Substances with Acetylcholinesterase Inhibitory Action

(2013) Ilkay Orhan   Current Neuropharmacology

Neuroprotective effect of curcumin on okadaic acid induced memory impairment in mice

(2013) N. Rajasekar et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

The Effect of Curcumin on Breast Cancer Cells

(2013) Dongwu Liu et al.   Journal of Breast Cancer

Curcumin Ameliorates the Permeability of the Blood–Brain Barrier During Hypoxia by Upregulating Heme Oxygenase-1 Expression in Brain Microvascular Endothelial Cells

(2013) Yan-feng Wang et al.   JOURNAL OF MOLECULAR NEUROSCIENCE

Modulation of 5-Lipoxygenase in Proteotoxicity and Alzheimer's Disease

(2013) E. Valera et al.   JOURNAL OF NEUROSCIENCE

Amyloid β deposition, neurodegeneration, and cognitive decline in sporadic Alzheimer's disease: a prospective cohort study

(2013) Victor L Villemagne et al.   LANCET NEUROLOGY

Curcumin as a regulator of epigenetic events

(2013) Marie-Hélène Teiten et al.   MOLECULAR NUTRITION & FOOD RESEARCH

The pattern of atrophy in familial Alzheimer disease: Volumetric MRI results from the DIAN study

(2013) D. M. Cash et al.   NEUROLOGY

Alterations of Serum Levels of BDNF-Related miRNAs in Patients with Depression

(2013) You-Jie Li et al.   PLoS One

Effect of Curcumin on the metal ion induced fibrillization of Amyloid-β peptide

(2013) Rona Banerjee   SPECTROCHIMICA ACTA PART A-MOLECULAR AND BIOMOLECULAR SPECTROSCOPY

Highly Stabilized Curcumin Nanoparticles Tested in an In Vitro Blood–Brain Barrier Model and in Alzheimer’s Disease Tg2576 Mice

(2012) Kwok Kin Cheng et al.   AAPS Journal

Benefits of combined cholinesterase inhibitor and memantine treatment in moderate–severe Alzheimer's disease

(2012) Serge Gauthier et al.   Alzheimers & Dementia

pH-dependence of the specific binding of Cu(II) and Zn(II) ions to the amyloid-β peptide

(2012) Leila Ghalebani et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Probing ion channel activity of human islet amyloid polypeptide (amylin)

(2012) Jun Zhao et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES

Anticoagulant activities of curcumin and its derivative

(2012) Dong-Chan Kim et al.   BMB Reports

A Bioinorganic View of Alzheimer’s Disease: When Misplaced Metal Ions (Re)direct the Electrons to the Wrong Target

(2012) Peter Faller et al.   CHEMISTRY-A EUROPEAN JOURNAL

BACE1 in Alzheimer's disease

(2012) M. Sathya et al.   CLINICA CHIMICA ACTA

The Targets of Curcumin

(2012) Hongyu Zhou et al.   CURRENT DRUG TARGETS

The Secreted Wnt Antagonist Dickkopf-1 Is Required for Amyloid  -Mediated Synaptic Loss

(2012) S. A. Purro et al.   JOURNAL OF NEUROSCIENCE

Curcumin inhibits cholesterol uptake in Caco-2 cells by down-regulation of NPC1L1 expression

(2012) Dan Feng et al.   Lipids in Health and Disease

From BACE1 Inhibitor to Multifunctionality of Tryptoline and Tryptamine Triazole Derivatives for Alzheimer’s Disease

(2012) Jutamas Jiaranaikulwanitch et al.   MOLECULES

Nanotechnology for neurodegenerative disorders

(2012) Francesca Re et al.   Nanomedicine-Nanotechnology Biology and Medicine

Protective Effects of Curcumin on Amyloid-β-Induced Neuronal Oxidative Damage

(2012) Han-Chang Huang et al.   NEUROCHEMICAL RESEARCH

Accelerated cortical atrophy in cognitively normal elderly with high  -amyloid deposition

(2012) G. Chetelat et al.   NEUROLOGY

Reactivation of RASSF1A in Breast Cancer Cells by Curcumin

(2012) Liping Du et al.   NUTRITION AND CANCER-AN INTERNATIONAL JOURNAL

Diverse effects of a low dose supplement of lipidated curcumin in healthy middle aged people

(2012) Robert A DiSilvestro et al.   Nutrition Journal

Curcumin Enhances Neurogenesis and Cognition in Aged Rats: Implications for Transcriptional Interactions Related to Growth and Synaptic Plasticity

(2012) Suzhen Dong et al.   PLoS One

Curcumin Promotes A-beta Fibrillation and Reduces Neurotoxicity in Transgenic Drosophila

(2012) Ina Caesar et al.   PLoS One

Oral curcumin for Alzheimer's disease: tolerability and efficacy in a 24-week randomized, double blind, placebo-controlled study

(2012) John M Ringman et al.   Alzheimers Research & Therapy

The diagnosis of dementia due to Alzheimer’s disease: Recommendations from the National Institute on Aging-Alzheimer’s Association workgroups on diagnostic guidelines for Alzheimer's disease

(2011) Guy M. McKhann et al.   Alzheimers & Dementia

Abnormal mitochondrial dynamics and synaptic degeneration as early events in Alzheimer's disease: Implications to mitochondria-targeted antioxidant therapeutics

(2011) P. Hemachandra Reddy et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Independent contribution of temporal β-amyloid deposition to memory decline in the pre-dementia phase of Alzheimer’s disease

(2011) Gaël Chételat et al.   BRAIN

Epigenetic Mechanisms in Alzheimer's Disease

(2011) M. Daniilidou et al.   CURRENT MEDICINAL CHEMISTRY

Curcumin activates Wnt/β-catenin signaling pathway through inhibiting the activity of GSK-3β in APPswe transfected SY5Y cells

(2011) Xiong Zhang et al.   EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES

Challenges associated with curcumin therapy in Alzheimer disease

(2011) Abdenour Belkacemi et al.   EXPERT REVIEWS IN MOLECULAR MEDICINE

Epigenetic changes induced by curcumin and other natural compounds

(2011) Simone Reuter et al.   Genes and Nutrition

Curcumin and its nano-formulation: The kinetics of tissue distribution and blood–brain barrier penetration

(2011) Yin-Meng Tsai et al.   INTERNATIONAL JOURNAL OF PHARMACEUTICS

Synthesis of labeled curcumin derivatives as tools for in vitro blood brain barrier trafficking studies

(2011) Cristiano Zona et al.   JOURNAL OF LABELLED COMPOUNDS & RADIOPHARMACEUTICALS

Binding of Curcumin to Senile Plaques and Cerebral Amyloid Angiopathy in the Aged Brain of Various Animals and to Neurofibrillary Tangles in Alzheimer's Brain

(2011) Mayu MUTSUGA et al.   JOURNAL OF VETERINARY MEDICAL SCIENCE

Curcumin: An Anti-Inflammatory Molecule from a Curry Spice on the Path to Cancer Treatment

(2011) Purusotam Basnet et al.   MOLECULES

Epigenetic mechanisms in Alzheimer's disease: progress but much to do

(2011) Robert Balazs et al.   NEUROBIOLOGY OF AGING

Epigenetic mechanisms in Alzheimer's disease

(2011) Diego Mastroeni et al.   NEUROBIOLOGY OF AGING

The Aβ oligomer hypothesis for synapse failure and memory loss in Alzheimer’s disease

(2011) Sergio T. Ferreira et al.   NEUROBIOLOGY OF LEARNING AND MEMORY

Higher Incidence of Mild Cognitive Impairment in Familial Hypercholesterolemia

(2010) Daniel Zambón et al.   AMERICAN JOURNAL OF MEDICINE

Curcumin analogues exhibit enhanced growth suppressive activity in human pancreatic cancer cells

(2010) Lauren Friedman et al.   ANTI-CANCER DRUGS

Injectable Sustained Release Microparticles of Curcumin: A New Concept for Cancer Chemoprevention

(2010) Komal Shahani et al.   CANCER RESEARCH

Dendritic Function of Tau Mediates Amyloid-β Toxicity in Alzheimer's Disease Mouse Models

(2010) Lars M. Ittner et al.   CELL

REVIEW: Curcumin and Alzheimer's Disease

(2010) Tsuyoshi Hamaguchi et al.   CNS Neuroscience & Therapeutics

Curcumin Decreases Amyloid-β Peptide Levels by Attenuating the Maturation of Amyloid-β Precursor Protein

(2010) Can Zhang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Curcumin Exerts Neuroprotective Effects Against Homocysteine Intracerebroventricular Injection-Induced Cognitive Impairment and Oxidative Stress in Rat Brain

(2010) Amin Ataie et al.   JOURNAL OF MEDICINAL FOOD

Curcumin Labeling of Neuronal Fibrillar Tau Inclusions in Human Brain Samples

(2010) Nina Mohorko et al.   JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY

Role of curcumin in the prevention of cholinergic mediated cortical dysfunctions in streptozotocin-induced diabetic rats

(2010) T. Peeyush Kumar et al.   MOLECULAR AND CELLULAR ENDOCRINOLOGY

Curcuminoids enhance memory in an amyloid-infused rat model of Alzheimer's disease

(2010) T. Ahmed et al.   NEUROSCIENCE

The inhibitory effects of different curcuminoids on β-amyloid protein, β-amyloid precursor protein and β-site amyloid precursor protein cleaving enzyme 1 in swAPP HEK293 cells

(2010) Hongying Liu et al.   NEUROSCIENCE LETTERS

Hypocholesterolemic effects of curcumin via up-regulation of cholesterol 7a-hydroxylase in rats fed a high fat diet

(2010) Minji Kim et al.   Nutrition Research and Practice

Epigenetic regulation in the pathophysiology of Alzheimer's disease

(2010) Leonidas Chouliaras et al.   PROGRESS IN NEUROBIOLOGY

The effect of curcumin (turmeric) onAlzheimer′s disease: An overview

(2009) Shrikant Mishra et al.   Annals of Indian Academy of Neurology

RETRACTED: Design of curcumin-loaded PLGA nanoparticles formulation with enhanced cellular uptake, and increased bioactivity in vitro and superior bioavailability in vivo

(2009) Preetha Anand et al.   BIOCHEMICAL PHARMACOLOGY

The structure and function of Alzheimer’s gamma secretase enzyme complex

(2009) Sudarsan Krishnaswamy et al.   CRITICAL REVIEWS IN CLINICAL LABORATORY SCIENCES

Curcumin has Bright Prospects for the Treatment of Inflammatory Bowel Disease

(2009) Hiroyuki Hanai et al.   CURRENT PHARMACEUTICAL DESIGN

Nanoparticle encapsulation improves oral bioavailability of curcumin by at least 9-fold when compared to curcumin administered with piperine as absorption enhancer

(2009) J. Shaikh et al.   EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES

A pilot cross-over study to evaluate human oral bioavailability of BCM-95®CG (BiocurcumaxTM), a novel bioenhanced preparation of curcumin

(2009) B Antony et al.   INDIAN JOURNAL OF PHARMACEUTICAL SCIENCES

Six-Month Randomized, Placebo-Controlled, Double-Blind, Pilot Clinical Trial of Curcumin in Patients With Alzheimer Disease

(2009) Larry Baum et al.   JOURNAL OF CLINICAL PSYCHOPHARMACOLOGY

Workshop 5

(2009)   JOURNAL OF NEUROCHEMISTRY

 -Amyloid Oligomers Induce Phosphorylation of Tau and Inactivation of Insulin Receptor Substrate via c-Jun N-Terminal Kinase Signaling: Suppression by Omega-3 Fatty Acids and Curcumin

(2009) Q.-L. Ma et al.   JOURNAL OF NEUROSCIENCE

Epigallocatechin-3-gallate and curcumin suppress amyloid beta-induced beta-site APP cleaving enzyme-1 upregulation

(2009) Yoshiari Shimmyo et al.   NEUROREPORT

Consumption of Grape Seed Extract Prevents Amyloid-β Deposition and Attenuates Inflammation in Brain of an Alzheimer’s Disease Mouse

(2009) Yan-Jiang Wang et al.   NEUROTOXICITY RESEARCH

Curcumin protected PC12 cells against beta-amyloid-induced toxicity through the inhibition of oxidative damage and tau hyperphosphorylation

(2008) So-Young Park et al.   FOOD AND CHEMICAL TOXICOLOGY

Curcumin Blocks the Activation of Androgen and Interlukin-6 on Prostate-Specific Antigen Expression in Human Prostatic Carcinoma Cells

(2008) K.-H. Tsui et al.   JOURNAL OF ANDROLOGY

Curcumin Stimulates Proliferation of Embryonic Neural Progenitor Cells and Neurogenesis in the Adult Hippocampus

(2008) So Jung Kim et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Increased 5-Lipoxygenase Immunoreactivity in the Hippocampus of Patients With Alzheimer's Disease

(2008) Milos D. Ikonomovic et al.   JOURNAL OF HISTOCHEMISTRY & CYTOCHEMISTRY

A broadly neuroprotective derivative of curcumin

(2008) Yuanbin Liu et al.   JOURNAL OF NEUROCHEMISTRY

Curcumin Structure-Function, Bioavailability, and Efficacy in Models of Neuroinflammation and Alzheimer's Disease

(2008) A. N. Begum et al.   JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS

Oral curcumin in the treatment of moderate to severe psoriasis vulgaris: A prospective clinical trial

(2008) Shanu Kohli Kurd et al.   JOURNAL OF THE AMERICAN ACADEMY OF DERMATOLOGY

Immunization in Alzheimer's disease: naïve hope or realistic clinical potential?

(2008) J K Foster et al.   MOLECULAR PSYCHIATRY

Clearance mechanisms of Alzheimer's amyloid-β peptide: implications for therapeutic design and diagnostic tests

(2008) K A Bates et al.   MOLECULAR PSYCHIATRY

A pyrazole derivative of curcumin enhances memory

(2008) Pamela Maher et al.   NEUROBIOLOGY OF AGING

Exposure to metal ions regulates mRNA levels of APP and BACE1 in PC12 cells: Blockage by curcumin

(2008) Raozhou Lin et al.   NEUROSCIENCE LETTERS

Inhibitory effect of curcuminoids on acetylcholinesterase activity and attenuation of scopolamine-induced amnesia may explain medicinal use of turmeric in Alzheimer's disease

(2008) Touqeer Ahmed et al.   PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR

Curcumin as “Curecumin”: From kitchen to clinic

(2007) Ajay Goel et al.   BIOCHEMICAL PHARMACOLOGY