期刊
NEUROBIOLOGY OF AGING
卷 32, 期 7, 页码 1161-1180出版社
ELSEVIER SCIENCE INC
DOI: 10.1016/j.neurobiolaging.2010.08.017
关键词
Epigenetics; DNA methylation; Histone acetylation; rDNA; miRNA; Genetics; Gene expression; Amyloid beta peptide; Inflammation; Oxidative stress; Cell cycle
资金
- NIA [AGO-7367-19, AG 036400]
- Arizona Alzheimer's Disease Consortium
Epigenetic modifications help orchestrate sweeping developmental, aging, and disease-causing changes in phenotype by altering transcriptional activity in multiple genes spanning multiple biologic pathways. Although previous epigenetic research has focused primarily on dividing cells, particularly in cancer, recent studies have shown rapid, dynamic, and persistent epigenetic modifications in neurons that have significant neuroendocrine, neurophysiologic, and neurodegenerative consequences. Here, we provide a review of the major mechanisms for epigenetic modification and how they are reportedly altered in aging and Alzheimer's disease (AD). Because of their reach across the genome, epigenetic mechanisms may provide a unique integrative framework for the pathologic diversity and complexity of AD. (C) 2011 Elsevier Inc. All rights reserved.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据