Article
Agricultural Engineering
M. Orive, M. Cebrian, J. Amayra, J. Zufia, C. Bald
Summary: An integrated valorisation scheme of olive pomace was developed in this study, including polyphenol extraction and continuous anaerobic digestion of dephenolised two-phase olive pomace. Economic feasibility assessment showed that this method is attractive, with a Net Present Value (NPV) of 1,493,234 and Internal Return Rate (IRR) of 12.8%.
BIOMASS & BIOENERGY
(2021)
Article
Biochemistry & Molecular Biology
Julen Diaz-Ramirez, Senda Basasoro, Kizkitza Gonzalez, Arantxa Eceiza, Alona Retegi, Nagore Gabilondo
Summary: This study successfully utilized grape pomace agricultural waste to prepare antioxidant Pickering emulsions. Rod-like bacterial cellulose nanocrystals with lengths up to 1.5 μm and widths of 5-30 nm were obtained through enzymatic hydrolysis. The polyphenolic extract obtained through ultrasound-assisted hydroalcoholic solvent extraction showed excellent antioxidant properties. The combination of nanocellulose and polyphenolic extract improved the colloidal stability and antioxidant activity of the emulsions.
Article
Plant Sciences
Yara Salem, Hiba N. Rajha, Lambertus A. M. van den Broek, Carl Safi, Arnoud Togtema, Maria Manconi, Maria Letizia Manca, Esperance Debs, Zeina Hobaika, Richard G. Maroun, Nicolas Louka
Summary: Grape seeds from Lebanese autochthonous grape varieties were subjected to multi-step biomass fractionation, resulting in the recovery of lipids, polyphenols, and proteins. The designed zero-waste approach has the potential to improve the valorization of grape seeds from these two Lebanese grape varieties.
Article
Food Science & Technology
Gean Charles Monteiro, Igor Otavio Minatel, Adilson Pimentel Junior, Hector Alonzo Gomez-Gomez, Joao Pedro Correa de Camargo, Marla Silvia Diamante, Leticia Silva Pereira Basilio, Marco Antonio Tecchio, Giuseppina Pace Pereira Lima
Summary: This study evaluated the phenolic compounds, antioxidant capacity, biogenic amines, and amino acids in flours obtained from grape pomace, finding valuable potential for new product development in flours from different cultivars or blends, with increased levels of phenolic compounds and antioxidant capacity in blends containing 'Niagara Rosada'. The flour production provides a better destination for industrial waste, as these flours can be used as additives or supplements in various industries to improve antioxidant and bioactive content in their products.
LWT-FOOD SCIENCE AND TECHNOLOGY
(2021)
Article
Nutrition & Dietetics
Filipa Campos, Andreia F. Peixoto, Pedro A. R. Fernandes, Manuel A. Coimbra, Nuno Mateus, Victor de Freitas, Iva Fernandes, Ana Fernandes
Summary: This study focuses on the recovery of polyphenols and polysaccharide-polyphenol conjugates from grape pomace for the management and prevention of type 2 diabetes mellitus.
Extracts obtained through pressurized hot water extraction showed higher total phenolic content and stronger antioxidant activity compared to extracts obtained through solid-liquid extraction.
Article
Engineering, Environmental
Menghan Wu, Xiaoqiang Gong, Xinning Liu, Weiming Tu, Peng Yu, Yina Zou, Hui Wang
Summary: Polyhydroxyalkanoates (PHAs), a biodegradable plastic, can be recovered from organic waste using mixed microbial cultures (MMCs) and offer environmental benefits compared to traditional plastics. This study conducted a 6-month pilot plant experiment using local food waste as the feedstock to analyze the technical feasibility and environmental impact of PHA production. The results showed promising PHA content and productivity, as well as potential environmental benefits when compared to petroleum-based plastics.
ENVIRONMENTAL SCIENCE & TECHNOLOGY
(2022)
Article
Microbiology
Carla Zannella, Annalisa Chianese, Giuseppe Annunziata, Annalisa Ambrosino, Anna De Filippis, Gian Carlo Tenore, Ettore Novellino, Mariano Stornaiuolo, Massimiliano Galdiero
Summary: Herpes simplex virus (HSV) is a common virus that causes oral or genital ulcers and can lead to severe complications. Current anti-HSV drugs have limitations, so there is a need for new antiviral compounds. This study tested a polyphenol-based nutraceutical formulation called Taurisolo(R), which showed potential in inhibiting the early stages of HSV-1 and HSV-2 infection. These findings suggest that Taurisolo(R) could be used as a topical treatment for preventing and healing herpes lesions.
Article
Biotechnology & Applied Microbiology
Xenie Kourilova, Iva Pernicova, Michaela Vidlakova, Roman Krejcirik, Katerina Mrazova, Kamila Hrubanova, Vladislav Krzyzanek, Jana Nebesarova, Stanislav Obruca
Summary: The thermophilic bacterium Tepidimonas taiwanensis LMG 22826 has been identified as a promising PHA producer, capable of efficiently synthesizing PHA and preferring glucose and fructose. This opens up the possibility of using various food wastes rich in these sugars for PHA production.
BIOENGINEERING-BASEL
(2021)
Article
Materials Science, Ceramics
Giacomo Riccucci, Martina Cazzola, Sara Ferraris, Virginia Alessandra Gobbo, Marta Miola, Antonella Bosso, Gissur Orlygsson, Chuen How Ng, Enrica Verne, Silvia Spriano
Summary: Polyphenols extracted from organic red grape pomace were used to functionalize bioactive glasses and hydroxyapatite. The functionalization was effective, maintained the antioxidant activity of polyphenols, and resulted in a continuous and persistent layer on both substrates with different release kinetics. The functionalized samples could be sterilized by gamma irradiation.
JOURNAL OF THE AMERICAN CERAMIC SOCIETY
(2022)
Article
Materials Science, Multidisciplinary
G. Riccucci, M. Cazzola, S. Ferraris, V. A. Gobbo, M. Guaita, S. Spriano
Summary: This study focuses on the effectiveness of a functionalization process using natural polyphenols on a Ti6Al4V alloy, exploring the grafting mechanism and redox/scavenging activity of the grafted biomolecules. Results show that the functionalized samples have a homogeneous distribution of polyphenols with micro-sized agglomerates, maintaining their redox chemical and radical scavenging ability. The release rate of polyphenols varies in different environments.
MATERIALS & DESIGN
(2021)
Article
Agricultural Engineering
Anga Hackula, Rajas Shinde, Daniel Hickey, Richard O'Shea, Jerry D. Murphy, David M. Wall
Summary: The valorization of whiskey by-products was compared in three anaerobic digestion systems, which produced similar methane yields. These systems could satisfy 44% of the thermal energy demand at a distillery, reducing the carbon footprint by displacing natural gas. Two-phase systems had higher methane content and unlocked opportunities for volatile fatty acid production. The extraction of butyric acid and caproic acid could generate approximately 6.76 million euros for a 50 million liter alcohol facility (0.14 euros per liter of whiskey). All three anaerobic digestion systems showed the potential to convert linear distillery production processes into circular repurpose and reuse production processes.
BIORESOURCE TECHNOLOGY
(2023)
Article
Energy & Fuels
Manuel Salgado-Ramos, Francesco Mariatti, Silvia Tabasso, Maria Prado Sanchez-Verdu, Andres Moreno, Giancarlo Cravotto
Summary: The goal of this work is to produce high value-added chemicals from the lignin fraction in grape stalks using non-conventional and sustainable methods. The researchers achieved delignification using NaOH and Natural Deep Eutectic Solvents (NaDESs) through microwave-assisted extraction (MAE). The obtained liquid fractions showed promising antioxidant activity. Further oxidation of the isolated lignin resulted in the production of valuable long chain fatty acids and bioaromatics.
CHEMICAL ENGINEERING AND PROCESSING-PROCESS INTENSIFICATION
(2022)
Article
Agricultural Engineering
Katiana Filippi, Nefeli Georgaka, Maria Alexandri, Harris Papapostolou, Apostolis Koutinas
Summary: A sustainable process for producing bio-based succinic acid from grape pomace and stalks has been proposed in this study, integrating efficient conversion with the extraction of value-added fractions.
INDUSTRIAL CROPS AND PRODUCTS
(2021)
Article
Chemistry, Applied
Yuridia Martinez-Meza, Jara Perez-Jimenez, Nuria E. Rocha-Guzman, Mario E. Rodriguez-Garcia, Maritza Alonzo-Macias, Rosalia Reynoso-Camacho
Summary: DIC treatment of grape pomace can increase the content of extractable polyphenols, while reducing the levels of anthocyanins and non-extractable proanthocyanidins. Additionally, some anthocyanins are transformed into phenolic acids and proanthocyanidins undergo depolymerization. The process also results in partial solubilization of insoluble dietary fiber.
Article
Food Science & Technology
Giuseppe Zeppa, Martina Tedesco, Marta Bertolino, Betul Cilek Tatar
Summary: Using grape pomace powders as coagulants to produce tofu led to differences in physicochemical characteristics and texture compared to traditional tofu, with variations in color depending on the grape pomace origin. The concentrations of polyphenols and radical scavenging activity levels were significantly higher in grape pomace tofu samples, leading to higher consumer acceptability with minimal differences among grape pomace varieties.
Article
Food Science & Technology
Mercedes Sotos-Prieto, Daniele Del Rio, Greg Drescher, Ramon Estruch, Chavanne Hanson, Timothy Harlan, Frank B. Hu, Maria Loi, James P. McClung, Angelo Mojica, Daniela Puglielli, Ken Toong, Fania Yangarber, Stefanos N. Kales
Summary: The traditional Mediterranean diet is recognized as the most evidence-based eating pattern for health and longevity, yet the popularity of fast, cheap, and processed foods has contributed to the obesity and diabetes epidemics. Expert consensus points to the Mediterranean diet as the easiest to follow among healthy eating patterns, but fewer American families cook at home and many food services lack healthy options compatible with this diet.
INTERNATIONAL JOURNAL OF FOOD SCIENCES AND NUTRITION
(2022)
Article
Nutrition & Dietetics
Pedro Mena, Claudia Favari, Animesh Acharjee, Saisakul Chernbumroong, Letizia Bresciani, Claudio Curti, Furio Brighenti, Christian Heiss, Ana Rodriguez-Mateos, Daniele Del Rio
Summary: This study aims to investigate the inter-individual variability in the metabolism of flavan-3-ol metabolites, defining different metabotypes through various data pre-treatment and clustering methods. The validation and robustness of urinary metabotypes in flavan-3-ol metabolism were confirmed, providing a step towards understanding the individual differences in this metabolism.
EUROPEAN JOURNAL OF NUTRITION
(2022)
Review
Neurosciences
Andrea Ticinesi, Leonardo Mancabelli, Luca Carnevali, Antonio Nouvenne, Tiziana Meschi, Daniele Del Rio, Marco Ventura, Andrea Sgoifo, Donato Angelino
Summary: Animal studies suggest that the composition and function of gut microbiota can play a role in the development and progression of Alzheimer's disease. However, there are limited human studies on this gut-brain axis, and diet as a determinant of gut microbiota composition has not been considered. Epidemiological studies show that a high intake of fruits and vegetables, such as in the Mediterranean diet, can modulate the progression of Alzheimer's disease. Therefore, nutritional interventions, particularly with polyphenols and fibers, are being explored as non-pharmacological strategies to slow down the progression of Alzheimer's disease.
JOURNAL OF ALZHEIMERS DISEASE
(2022)
Article
Food Science & Technology
Giuseppe Di Pede, Letizia Bresciani, Furio Brighenti, Michael N. Clifford, Alan Crozier, Daniele Del Rio, Pedro Mena
Summary: The study demonstrates that the flavan-3-ol structure significantly influences the colonic metabolism of native compounds, leading to different metabolites. Despite varying degrees of polymerization, the production of total PVL and PVA showed no significant differences during in vitro fecal incubation.
MOLECULAR NUTRITION & FOOD RESEARCH
(2022)
Review
Nutrition & Dietetics
Francesco Visioli, Franca Marangoni, Vincenzo Fogliano, Daniele Del Rio, J. Alfredo Martinez, Gunter Kuhnle, Judith Buttriss, Hugo Da Costa Ribeiro, Dennis Bier, Andrea Poli
Summary: The NOVA classification is questioned for its lack of clear definition for key terms and unclear theoretical grounds. It conflicts with the traditional evaluation of foods based on composition and portion size. The biological plausibility of the NOVA system is considered lacking, and further examination and elaboration are needed to support the claim that ultra-processed foods are intrinsically unhealthy.
NUTRITION RESEARCH REVIEWS
(2022)
Article
Chemistry, Applied
Alvaro Cruz-Carrion, Luca Calani, Ma. Josefina Ruiz de Azua, Pedro Mena, Daniele Del Rio, Manuel Suarez, Anna Arola-Arnal
Summary: This study investigated the effect of tomato's growing location on the (poly)phenol profile and in vivo absorption and metabolism upon consumption. The results showed that local and non-local tomatoes had different concentrations of native (poly)phenols, which may be due to diverse cultivation origins. Rat serum analysis revealed different serum concentrations of (poly)phenolic metabolites after tomato feeding, suggesting that the absorption mainly occurred in the upper gastrointestinal tract.
Article
Nutrition & Dietetics
Cindy Romain, Letizia Bresciani, Jananee Muralidharan, Pedro Mena, Linda H. Chung, Pedro E. Alcaraz, Daniele Del Rio, Julien Cases
Summary: Dietary (poly)phenol intake from fruits and vegetables can protect against non-communicable diseases. This study validates the concept of a (poly)phenolic supplement that provides sustained exposure to various (poly)phenolic metabolites and reduces inter-individual variation.
Article
Plant Sciences
Luca Calani, Letizia Bresciani, Margherita Rodolfi, Daniele Del Rio, Raffaella Petruccelli, Cecilia Faraloni, Tommaso Ganino
Summary: The (poly)phenols composition of fig peel from twelve different cultivars in Tuscany was analyzed, and a rich content of (poly)phenolic compounds was found with significant variation among the cultivars. Rutin and 5-caffeoylquinic acid were the main compounds in greenish fig peel, while cyanidin-3-O-rutinoside was the main component in dark-violet fig peel.
Article
Food Science & Technology
A. Natolino, L. Tat, A. Gallo, T. Roman, E. Celotti
Summary: The precipitation of tartaric salts in white wines can be prevented by adding potassium polyaspartate (KPA), which can limit the precipitation of tartaric salts by linking the potassium cation. The present study found that KPA addition had positive effects on the quality of white wines, reducing unstable proteins and preserving the aroma concentration without adverse effects. KPA could be considered a multifunctional product against tartaric and protein instability of white wines, while maintaining their aroma profile.
FOOD RESEARCH INTERNATIONAL
(2023)
Article
Engineering, Chemical
Valeria D'Ambrosio, Gonzalo Martinez, Emma Jones, Lorenzo Bertin, Carlo Pastore
Summary: A novel route was investigated to obtain ethyl hexanoate-rich streams from grape pomace, an agro by-product generated from the winery industry. Highly concentrated hexanoic acid (87 wt%) was efficiently produced through chain elongation fermentation, easily separated and reacted with ethanol using AlCl3 center dot 6H(2)O as a catalyst. This promising green and sustainable approach could produce ethyl esters of volatile fatty acids from agro by-products.
SEPARATION AND PURIFICATION TECHNOLOGY
(2023)
Review
Biotechnology & Applied Microbiology
Stefano Buiatti, Lara Tat, Andrea Natolino, Paolo Passaghe
Summary: The research on the biodiversity of yeast strains in brewing technology is important for their fermentative activity and metabolic capacities. Yeast metabolism plays a crucial role in enhancing the aroma of beers through biotransformations with specific aromatic compounds, mainly terpenes, derived from hops. Utilizing these biotransformations to increase aroma while reducing the use of hops promotes sustainability in the brewing process by minimizing raw material costs and environmental impact.
FERMENTATION-BASEL
(2023)
Article
Energy & Fuels
Stefano Frigo, Anna Maria Raspolli Galletti, Sara Fulignati, Domenico Licursi, Lorenzo Bertin, Gonzalo Agustin Martinez, Gianluca Pasini
Summary: This study investigates the production of oxygenated bio-additives from waste biomass and their effects on diesel engine performance and exhaust emissions. The results show that the bio-additives have significant positive effects on reducing carbon monoxide and soot emissions, and can be blended with commercial diesel fuel without altering engine performance.
Review
Nutrition & Dietetics
Antonio Costa-Perez, Vanesa Nunez-Gomez, Nieves Baenas, Giuseppe Di Pede, Mariem Achour, Claudine Manach, Pedro Mena, Daniele Del Rio, Cristina Garcia-Viguera, Diego A. Moreno, Raul Dominguez-Perles
Summary: This systematic review summarizes the findings of human studies on the metabolism and bioavailability of glucosinolates (GSL) and isothiocyanates (ITC), providing a comprehensive analysis for future research and consultation on this less studied area of GSL for food and health.
Article
Biochemistry & Molecular Biology
Jananee Muralidharan, Cindy Romain, Letizia Bresciani, Pedro Mena, Donato Angelino, Daniele Del Rio, Linda H. Chung, Pedro E. Alcaraz, Julien Cases
Summary: This study evaluated the nutrikinetics and bioavailability of a flavanone-rich product, Sinetrol (R) Xpur, in overweight and obese individuals. The results showed that while urinary excretion of metabolites decreased significantly over 16 weeks, there was no significant decrease in circulating metabolites. This suggests that chronic intake may not offer the same bioavailability as acute intake.
Article
Biochemistry & Molecular Biology
Alicia Moreno-Ortega, Giuseppe Di Pede, Pedro Mena, Luca Calani, Daniele Del Rio, Jose Manuel Moreno-Rojas, Gema Pereira-Caro
Summary: The health benefits of onion intake are mainly attributed to the presence of phenolic and organosulfur compounds. This study investigated the stability of these compounds in fresh and black onion during in vitro colonic fermentation. Fresh onion showed an increase in phenolic content and stable organosulfur compound content, while black onion exhibited decreases in both phenolic and organosulfur compound content. The compounds detected after colonic fermentation could be related to the health benefits of consuming fresh and black onion.
Article
Chemistry, Multidisciplinary
Xuemei Liu, Chaonan Cui, Shuoshuo Wei, Jinyu Han, Xinli Zhu, Qingfeng Ge, Hua Wang
Summary: This study presents a new strategy for designing efficient photocatalysts that can convert CO2 into hydrocarbons by utilizing synergistic catalytic sites. The findings provide a solution for the selective photocatalytic reduction of CO2 to CH4.
Article
Chemistry, Multidisciplinary
Chengxian Hu, Dan Wang, Lu Wang, Ying Fu, Zhengyin Du
Summary: A novel one-pot, three-component reaction conducted under electrochemical conditions was studied. The reaction involved 2-aminothiophenols, aldehydes, and malononitrile, using TBABF4 as an electrolyte and CuI as a catalyst. The proposed reaction mechanism suggested that CuI served as an electron relay. This method offers simplified operation, high atom economy, and mild reaction conditions.
Article
Chemistry, Multidisciplinary
Zhi Yang, Yu Chen, Linxi Wan, Yuxiao Li, Dan Chen, Jianlin Tao, Pei Tang, Fen-Er Chen
Summary: A highly enantioselective method for the complete hydrogenation of pyrimidinium salts using Ir/(S,S)-f-Binaphane complex as the catalyst was developed. This method provides easy access to fully saturated chiral hexahydropyrimidines, which are prevalent in many bioactive molecules. The reactions exhibit high yields and enantioselectivities under mild reaction conditions without additives. Successful application of this methodology in a continuous flow fashion further extends its practical utility.
Article
Chemistry, Multidisciplinary
Tina Jeoh, Jennifer Danger Nill, Wujun Zhao, Sankar Raju Narayanasamy, Liang Chen, Hoi-Ying N. Holman
Summary: In this study, the enzymatic hydrolysis of cellulose was investigated using real-time infrared spectromicroscopy. The spatial heterogeneity of cellulose was found to impact the hydrolysis kinetics. Hydration affected cellulose ordering, and Cel7A preferentially removed less extensively hydrogen bonded cellulose.
Article
Chemistry, Multidisciplinary
Tiphaine Richard, Walid Abdallah, Xavier Trivelli, Mathieu Sauthier, Clement Dumont
Summary: An effective method of grafting functionalities onto lignin based on glycerol carbonate has been developed using an efficient nickel-catalysed telomerisation reaction. This method allows lignin to have new reactive functions and reduces the glass transition temperatures of modified lignins, thereby expanding the application range of lignin-based resins.
Article
Chemistry, Multidisciplinary
Jing Qi, Xiyan Wang, Gan Wang, Srinivas Reddy Dubbaka, Patrick ONeill, Hwee Ting Ang, Jie Wu
Summary: This study presents a green and environmentally friendly approach for the synthesis of imides using electrocatalytic oxidation with H2O as the oxygen source. The method eliminates the need for toxic or expensive oxidants and achieves high yields under mild reaction conditions. It shows broad substrate compatibility and potential for industrial applications.
Article
Chemistry, Multidisciplinary
Babasaheb Sopan Gore, Lin-Wei Pan, Jun-Hao Lin, Yi-Chi Luo, Jeh-Jeng Wang
Summary: Here, we report a visible light-promoted intramolecular radical cascade reaction for the construction of fluorenol and naphthalene-fused cyclopropyl carbaldehyde derivatives. This method offers mild reaction conditions, a broad substrate scope, excellent step efficiency, and scalability, without the need for external chemical oxidants. The novelty of this protocol was demonstrated by synthesizing chrysene analogs and performing late-stage functionalizations.
Article
Chemistry, Multidisciplinary
Juho Antti Sirvio, Idamaria Romakkaniemi, Juha Ahola, Svitlana Filonenko, Juha P. Heiskanen, Ari Ammala
Summary: This article discusses the method of using supramolecular interaction between an aromatic hydrogen bond donor and lignin to achieve rapid delignification of softwood at low temperatures.
Article
Chemistry, Multidisciplinary
Yunyan Meng, Chunxiang Pan, Na Liu, Hongjiang Li, Zixiu Liu, Yao Deng, Zixiang Wei, Jianbin Xu, Baomin Fan
Summary: A novel visible light-driven synthesis method for 2,3-diamines has been developed, which has mild conditions, avoids the use of metal reagents, and can synthesize diamines and diols in one pot.
Article
Chemistry, Multidisciplinary
Mingqing Huang, Haiyang Huang, Mengyao You, Xinxin Zhang, Longgen Sun, Chao Chen, Zhichao Mei, Ruchun Yang, Qiang Xiao
Summary: A direct air-oxidized strategy for the synthesis of benzo[b]phosphole oxides was developed in this study. Arylphosphine oxides were transformed into phosphinoyl radicals, which were further combined with various alkynes to achieve the desired products. DFT calculations revealed the mechanism of phosphinoyl radical formation.
Article
Chemistry, Multidisciplinary
Anwei Wang, Jiayin Huang, Chunsheng Zhao, Yu Fan, Junfeng Qian, Qun Chen, Mingyang He, Weiyou Zhou
Summary: This study demonstrates an innovative strategy for the aerobic oxidation of C(sp(3))-H bonds using gamma-valerolactone. By optimizing the reaction conditions and utilizing specific catalysts, efficient oxidation of C(sp(3))-H bonds is achieved with good chemoselectivity in certain cases.
Article
Chemistry, Multidisciplinary
Shun Li, Likai Tong, Zhijian Peng, Bo Zhang, Xiuli Fu
Summary: Sulfide compounds show promise as electrocatalysts for water splitting, but their performance is limited by factors such as limited active sites and hindered substance transport. This study successfully prepared a high-entropy sulfide (ZnCoMnFeAlMg)(9)S-8, which reduced grain size and increased specific surface area, enabling the realization of a dual-functional catalyst with multiple catalytic sites. High entropy also modulated the electronic properties of sulfides, reducing the potential energy barrier for hydrolysis. This research introduces a new approach for functionalizing high entropy nanomaterials and improves the performance of water splitting catalysts.