Hybrid Quinolinyl Phosphonates as Heterocyclic Carboxylate Isosteres: Synthesis and Biological Evaluation against Topoisomerase 1B (TOP1B)

A patent review of topoisomerase I inhibitors (2016-present)

(2021) Asier Selas et al.   EXPERT OPINION ON THERAPEUTIC PATENTS

Synthesis of neocryptolepines and carbocycle-fused quinolines and evaluation of their anticancer and antiplasmodial activities

(2020) Bhornrawin Akkachairin et al.   BIOORGANIC CHEMISTRY

Modification of 7-piperazinylquinolone antibacterials to promising anticancer lead compounds: Synthesis and in vitro studies

(2019) Hamideh Ahadi et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

DNA Topoisomerases of Leishmania parasites; druggable targets for drug discovery

(2018) Rosa Mª Reguer et al.   CURRENT MEDICINAL CHEMISTRY

Substituted 1,5-naphthyridine derivatives as novel antileishmanial agents. Synthesis and biological evaluation

(2018) Ana Tejería et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Novel topoisomerase I inhibitors. Syntheses and biological evaluation of phosphorus substituted quinoline derivates with antiproliferative activity

(2018) Concepción Alonso et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Leishmaniasis

(2018) Sakib Burza et al.   LANCET

Antileishmanial activity of new hybrid tetrahydroquinoline and quinoline derivatives with phosphorus substituents

(2018) Ana Tejería et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

An overview of quinoline as a privileged scaffold in cancer drug discovery

(2017) Robert Musiol   Expert Opinion on Drug Discovery

Study of the Hetero-[4+2]-Cycloaddition Reaction of Aldimines and Alkynes. Synthesis of 1,5-Naphthyridine and Isoindolone Derivatives

(2017) Concepción Alonso et al.   JOURNAL OF ORGANIC CHEMISTRY

Antileishmanial effect of new indeno-1,5-naphthyridines, selective inhibitors of Leishmania infantum type IB DNA topoisomerase

(2016) Ana Tejería et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Synthesis and biological evaluation of indeno[1,5]naphthyridines as topoisomerase I (TopI) inhibitors with antiproliferative activity

(2016) Concepción Alonso et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

An overview of molecular hybrids in drug discovery

(2016) Gervais Bérubé   Expert Opinion on Drug Discovery

Synthesis and Biological Evaluation of 1,5-Naphthyridines as Topoisomerase I Inhibitors. A New Family of Antiproliferative Agents

(2015) Concepcion Alonso et al.   CURRENT TOPICS IN MEDICINAL CHEMISTRY

A review on anticancer potential of bioactive heterocycle quinoline

(2015) Obaid Afzal et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Infrared Fluorescent Imaging as a Potent Tool for In Vitro, Ex Vivo and In Vivo Models of Visceral Leishmaniasis

(2015) Estefanía Calvo-Álvarez et al.   PLoS Neglected Tropical Diseases

Targeting DNA damage response in cancer therapy

(2014) Noriko Hosoya et al.   CANCER SCIENCE

Trypanosomatids topoisomerase re-visited. New structural findings and role in drug discovery

(2014) Rafael Balaña-Fouce et al.   International Journal for Parasitology-Drugs and Drug Resistance

Advances in the development of hybrid anticancer drugs

(2013) Sébastien Fortin et al.   Expert Opinion on Drug Discovery

Interfacial inhibitors: targeting macromolecular complexes

(2011) Yves Pommier et al.   NATURE REVIEWS DRUG DISCOVERY

Structural studies of type I topoisomerases

(2008) N. M. Baker et al.   NUCLEIC ACIDS RESEARCH