标题
Targeting DNA damage response in cancer therapy
作者
关键词
-
出版物
CANCER SCIENCE
Volume 105, Issue 4, Pages 370-388
出版商
Wiley
发表日期
2014-01-31
DOI
10.1111/cas.12366
参考文献
相关参考文献
注意：仅列出部分参考文献，下载原文获取全部文献信息。- RBM3-Regulated Genes Promote DNA Integrity and Affect Clinical Outcome in Epithelial Ovarian Cancer
- (2014) Õsa Ehlén et al. Translational Oncology
- Histone deacetylase inhibitors as radiosensitisers: effects on DNA damage signalling and repair
- (2013) B Groselj et al. BRITISH JOURNAL OF CANCER
- Differential expression and prognostic value of ERCC1 and thymidylate synthase in resected gastric adenocarcinoma
- (2013) Malcolm H. Squires et al. CANCER
- A phase II study of the potent PARP inhibitor, Rucaparib (PF-01367338, AG014699), with temozolomide in patients with metastatic melanoma demonstrating evidence of chemopotentiation
- (2013) Ruth Plummer et al. CANCER CHEMOTHERAPY AND PHARMACOLOGY
- Genome-wide Profiling of Genetic Synthetic Lethality Identifies CDK12 as a Novel Determinant of PARP1/2 Inhibitor Sensitivity
- (2013) I. Bajrami et al. CANCER RESEARCH
- Curcumin suppresses multiple DNA damage response pathways and has potency as a sensitizer to PARP inhibitor
- (2013) Hideaki Ogiwara et al. CARCINOGENESIS
- The Different Roles of hRAD50 in Microsatellite Stable and Unstable Colorectal Cancers
- (2013) Jingfang Gao et al. DISEASE MARKERS
- A novel small molecule RAD51 inactivator overcomes imatinib-resistance in chronic myeloid leukaemia
- (2013) Jiewen Zhu et al. EMBO Molecular Medicine
- PARP expression in germ cell tumours
- (2013) Michal Mego et al. JOURNAL OF CLINICAL PATHOLOGY
- CHK1 levels correlate with sensitization to pemetrexed by CHK1 inhibitors in non-small cell lung cancer cells
- (2013) Svetlana Grabauskiene et al. LUNG CANCER
- Mammalian Base Excision Repair: the Forgotten Archangel
- (2013) Grigory L. Dianov et al. NUCLEIC ACIDS RESEARCH
- ATM signalling and cancer
- (2013) C A Cremona et al. ONCOGENE
- A high-throughput screen identifies PARP1/2 inhibitors as a potential therapy for ERCC1-deficient non-small cell lung cancer
- (2013) S Postel-Vinay et al. ONCOGENE
- 53BP1: pro choice in DNA repair
- (2013) Michal Zimmermann et al. TRENDS IN CELL BIOLOGY
- Small Molecules, Inhibitors of DNA-PK, Targeting DNA Repair, and Beyond
- (2013) David Davidson et al. Frontiers in Pharmacology
- The novel ATR inhibitor VE-821 increases sensitivity of pancreatic cancer cells to radiation and chemotherapy
- (2012) Remko Prevo et al. CANCER BIOLOGY & THERAPY
- An Inhibitor of Nonhomologous End-Joining Abrogates Double-Strand Break Repair and Impedes Cancer Progression
- (2012) Mrinal Srivastava et al. CELL
- Dynamic inhibition of ATM kinase provides a strategy for glioblastoma multiforme radiosensitization and growth control
- (2012) Sarah E. Golding et al. CELL CYCLE
- Regulation of DNA cross-link repair by the Fanconi anemia/BRCA pathway
- (2012) H. Kim et al. GENES & DEVELOPMENT
- Synthetic lethal targeting of DNA double-strand break repair deficient cells by human apurinic/apyrimidinic endonuclease inhibitors
- (2012) Rebeka Sultana et al. INTERNATIONAL JOURNAL OF CANCER
- DNA-PKcs Expression Predicts Response to Radiotherapy in Prostate Cancer
- (2012) Patrick Bouchaert et al. INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS
- CHK1 targets spleen tyrosine kinase (L) for proteolysis in hepatocellular carcinoma
- (2012) Jian Hong et al. JOURNAL OF CLINICAL INVESTIGATION
- Chemosensitization of Cancer Cells by KU-0060648, a Dual Inhibitor of DNA-PK and PI-3K
- (2012) J. M. Munck et al. MOLECULAR CANCER THERAPEUTICS
- Pancreatic cancer genomes reveal aberrations in axon guidance pathway genes
- (2012) Andrew V. Biankin et al. NATURE
- Comprehensive molecular portraits of human breast tumours
- (2012) Daniel C. Koboldt et al. NATURE
- The mutational landscape of lethal castration-resistant prostate cancer
- (2012) Catherine S. Grasso et al. NATURE
- Targeting abnormal DNA double-strand break repair in tyrosine kinase inhibitor-resistant chronic myeloid leukemias
- (2012) L A Tobin et al. ONCOGENE
- The growing complexity of HIF-1α’s role in tumorigenesis: DNA repair and beyond
- (2012) N Rohwer et al. ONCOGENE
- Suppressed miR-424 expression via upregulation of target gene Chk1 contributes to the progression of cervical cancer
- (2012) J Xu et al. ONCOGENE
- RAD52 inactivation is synthetically lethal with deficiencies in BRCA1 and PALB2 in addition to BRCA2 through RAD51-mediated homologous recombination
- (2012) B H Lok et al. ONCOGENE
- Nucleotide excision repair: new tricks with old bricks
- (2012) Irene Kamileri et al. TRENDS IN GENETICS
- Higher cytoplasmic and nuclear poly(ADP-ribose) polymerase expression in familial than in sporadic breast cancer
- (2012) Marie-Luise Klauke et al. VIRCHOWS ARCHIV
- Activation of the ATM-Snail pathway promotes breast cancer metastasis
- (2012) Mianen Sun et al. Journal of Molecular Cell Biology
- Loss of 53BP1 Causes PARP Inhibitor Resistance in Brca1 -Mutated Mouse Mammary Tumors
- (2012) Janneke E. Jaspers et al. Cancer Discovery
- Identification of Specific Inhibitors of Human RAD51 Recombinase Using High-Throughput Screening
- (2011) Fei Huang et al. ACS Chemical Biology
- Identification and evaluation of a potent novel ATR inhibitor, NU6027, in breast and ovarian cancer cell lines
- (2011) A Peasland et al. BRITISH JOURNAL OF CANCER
- Synaptonemal complex protein SYCP3 impairs mitotic recombination by interfering with BRCA2
- (2011) Noriko Hosoya et al. EMBO REPORTS
- Olaparib in patients with recurrent high-grade serous or poorly differentiated ovarian carcinoma or triple-negative breast cancer: a phase 2, multicentre, open-label, non-randomised study
- (2011) Karen A Gelmon et al. LANCET ONCOLOGY
- CDC25 Phosphatase Inhibitors: An Update
- (2011) A. Lavecchia et al. MINI-REVIEWS IN MEDICINAL CHEMISTRY
- Impact of PARP-1 and DNA-PK expression on survival in patients with glioblastoma multiforme
- (2011) Marju Kase et al. RADIOTHERAPY AND ONCOLOGY
- Anticancer therapy with checkpoint inhibitors: what, where and when?
- (2011) Michelle D. Garrett et al. TRENDS IN PHARMACOLOGICAL SCIENCES
- PARP Inhibitors in BRCA Gene-Mutated Ovarian Cancer and Beyond
- (2011) Susana Banerjee et al. Current Oncology Reports
- Human AP endonuclease 1 (APE1): From mechanistic insights to druggable target in cancer
- (2010) Rachel Abbotts et al. CANCER TREATMENT REVIEWS
- 53BP1 Inhibits Homologous Recombination in Brca1-Deficient Cells by Blocking Resection of DNA Breaks
- (2010) Samuel F. Bunting et al. CELL
- The Relationship of Platinum Resistance and ERCC1 Protein Expression in Epithelial Ovarian Cancer
- (2010) Karina Dahl Steffensen et al. INTERNATIONAL JOURNAL OF GYNECOLOGICAL CANCER
- Oral poly(ADP-ribose) polymerase inhibitor olaparib in patients with BRCA1 or BRCA2 mutations and recurrent ovarian cancer: a proof-of-concept trial
- (2010) M William Audeh et al. LANCET
- The DNA Damage Response: Making It Safe to Play with Knives
- (2010) Alberto Ciccia et al. MOLECULAR CELL
- 53BP1 loss rescues BRCA1 deficiency and is associated with triple-negative and BRCA-mutated breast cancers
- (2010) Peter Bouwman et al. NATURE STRUCTURAL & MOLECULAR BIOLOGY
- Rad52 inactivation is synthetically lethal with BRCA2 deficiency
- (2010) Z. Feng et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Mechanisms of double-strand break repair in somatic mammalian cells
- (2009) Andrea J. Hartlerode et al. BIOCHEMICAL JOURNAL
- p53 ubiquitination by Mdm2: A never ending tail?
- (2009) Amanda S. Coutts et al. DNA REPAIR
- Epigenetic inactivation of checkpoint kinase 2 gene in non-small cell lung cancer and its relationship with clinicopathological features
- (2009) Dong Sun Kim et al. LUNG CANCER
- CHK1 inhibition as a strategy for targeting fanconi anemia (FA) DNA repair pathway deficient tumors
- (2009) Clark C Chen et al. Molecular Cancer
- Inhibition of Poly(ADP-Ribose) Polymerase in Tumors fromBRCAMutation Carriers
- (2009) Peter C. Fong et al. NEW ENGLAND JOURNAL OF MEDICINE
- DNA Damage, Aging, and Cancer
- (2009) Jan H.J. Hoeijmakers NEW ENGLAND JOURNAL OF MEDICINE
- Inhibition of ATR protein kinase activity by schisandrin B in DNA damage response
- (2009) H. Nishida et al. NUCLEIC ACIDS RESEARCH
- Specific synthetic lethal killing of RAD54B-deficient human colorectal cancer cells by FEN1 silencing
- (2009) K. J. McManus et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Up-regulation of WRN and DNA ligase III in chronic myeloid leukemia: consequences for the repair of DNA double-strand breaks
- (2008) A. Sallmyr et al. BLOOD
- Secondary BRCA1 Mutations in BRCA1-Mutated Ovarian Carcinomas with Platinum Resistance
- (2008) E. M. Swisher et al. CANCER RESEARCH
- Phase I Study of the Poly(ADP-Ribose) Polymerase Inhibitor, AG014699, in Combination with Temozolomide in Patients with Advanced Solid Tumors
- (2008) R. Plummer et al. CLINICAL CANCER RESEARCH
- A Synthetic Lethal Therapeutic Approach: Poly(ADP) Ribose Polymerase Inhibitors for the Treatment of Cancers Deficient in DNA Double-Strand Break Repair
- (2008) Alan Ashworth JOURNAL OF CLINICAL ONCOLOGY
- DNA mismatch repair: Molecular mechanism, cancer, and ageing
- (2008) Peggy Hsieh et al. MECHANISMS OF AGEING AND DEVELOPMENT
- Aberrations of the MRE11-RAD50-NBS1 DNA damage sensor complex in human breast cancer: MRE11 as a candidate familial cancer-predisposing gene
- (2008) Jirina Bartkova et al. Molecular Oncology
- The importance of making ends meet: Mutations in genes and altered expression of proteins of the MRN complex and cancer
- (2008) A DZIKIEWICZKRAWCZYK MUTATION RESEARCH-REVIEWS IN MUTATION RESEARCH
- Secondary mutations as a mechanism of cisplatin resistance in BRCA2-mutated cancers
- (2008) Wataru Sakai et al. NATURE
- Resistance to therapy caused by intragenic deletion in BRCA2
- (2008) Stacey L. Edwards et al. NATURE
- High sensitivity of BRCA1-deficient mammary tumors to the PARP inhibitor AZD2281 alone and in combination with platinum drugs
- (2008) S. Rottenberg et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
Find Funding. Review Successful Grants.
Explore over 25,000 new funding opportunities and over 6,000,000 successful grants.
ExploreDiscover Peeref hubs
Discuss science. Find collaborators. Network.
Join a conversation