Structural and Functional Alterations in Mitochondria-Associated Membranes (MAMs) and in Mitochondria Activate Stress Response Mechanisms in an In Vitro Model of Alzheimer’s Disease

Role of PITRM1 in Mitochondrial Dysfunction and Neurodegeneration

(2021) Dario Brunetti et al.   Biomedicines

Mfn2 Ablation in the Adult Mouse Hippocampus and Cortex Causes Neuronal Death

(2020) Song Han et al.   Cells

Mitochondria dysfunction in the pathogenesis of Alzheimer’s disease: recent advances

(2020) Wenzhang Wang et al.   Molecular Neurodegeneration

Increased mitochondrial calcium levels associated with neuronal death in a mouse model of Alzheimer’s disease

(2020) Maria Calvo-Rodriguez et al.   Nature Communications

New BACE1 Chimeric Peptide Inhibitors Selectively Prevent AβPPβ Cleavage Decreasing Amyloid-β Production and Accumulation in Alzheimer’s Disease Models

(2020) Rosa Resende et al.   JOURNAL OF ALZHEIMERS DISEASE

Brain energy rescue: an emerging therapeutic concept for neurodegenerative disorders of ageing

(2020) Stephen C. Cunnane et al.   NATURE REVIEWS DRUG DISCOVERY

Calcium Modulation, Anti-Oxidant and Anti-Inflammatory Effect of Skin Allergens Targeting the Nrf2 Signaling Pathway in Alzheimer’s Disease Cellular Models

(2020) Ana Silva et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Mitochondrial Calcium Deregulation in the Mechanism of Beta-Amyloid and Tau Pathology

(2020) Noemi Esteras et al.   Cells

ER-mitochondria contact sites in neurodegeneration: genetic screening approaches to investigate novel disease mechanisms

(2020) Emma Louise Wilson et al.   CELL DEATH AND DIFFERENTIATION

Molecular Dysfunctions of Mitochondria-Associated Membranes (MAMs) in Alzheimer’s Disease

(2020) Fanny Eysert et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Non-canonical function of IRE1α determines mitochondria-associated endoplasmic reticulum composition to control calcium transfer and bioenergetics

(2019) Amado Carreras-Sureda et al.   NATURE CELL BIOLOGY

Metabolic implications of organelle–mitochondria communication

(2019) Isabel Gordaliza‐Alaguero et al.   EMBO REPORTS

The Effects of APOE4 on Mitochondrial Dynamics and Proteins in vivo

(2019) Shira Simonovitch et al.   JOURNAL OF ALZHEIMERS DISEASE

The functional universe of membrane contact sites

(2019) William A. Prinz et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Impaired mitochondrial calcium efflux contributes to disease progression in models of Alzheimer’s disease

(2019) Pooja Jadiya et al.   Nature Communications

Mitochondrial and endoplasmic reticulum calcium homeostasis and cell death

(2018) Saverio Marchi et al.   CELL CALCIUM

Plastic mitochondria-endoplasmic reticulum (ER) contacts use chaperones and tethers to mould their structure and signaling

(2018) Thomas Simmen et al.   CURRENT OPINION IN CELL BIOLOGY

Mitochondrial dynamics: overview of molecular mechanisms

(2018) Lisa Tilokani et al.   Essays in Biochemistry

Hippocampal mutant APP and amyloid beta-induced cognitive decline, dendritic spine loss, defective autophagy, mitophagy and mitochondrial abnormalities in a mouse model of Alzheimer’s disease

(2018) Maria Manczak et al.   HUMAN MOLECULAR GENETICS

Early Presymptomatic Changes in the Proteome of Mitochondria-Associated Membrane in the APP/PS1 Mouse Model of Alzheimer’s Disease

(2018) Katalin Völgyi et al.   MOLECULAR NEUROBIOLOGY

Mfn2 ablation causes an oxidative stress response and eventual neuronal death in the hippocampus and cortex

(2018) Sirui Jiang et al.   Molecular Neurodegeneration

Expression of nucleotide excision repair in Alzheimer’s disease is higher in brain tissue than in blood

(2018) Helge Leander B. Jensen et al.   NEUROSCIENCE LETTERS

VDAC1, mitochondrial dysfunction, and Alzheimer's disease

(2018) Varda Shoshan-Barmatz et al.   PHARMACOLOGICAL RESEARCH

Endoplasmic reticulum and mitochondria in diseases of motor and sensory neurons: a broken relationship?

(2018) Nathalie Bernard-Marissal et al.   Cell Death & Disease

Mitochondria-associated membranes in aging and senescence: structure, function, and dynamics

(2018) Justyna Janikiewicz et al.   Cell Death & Disease

A key role for MAM in mediating mitochondrial dysfunction in Alzheimer disease

(2018) Estela Area-Gomez et al.   Cell Death & Disease

Critical review: involvement of endoplasmic reticulum stress in the aetiology of Alzheimer's disease

(2018) Shoko Hashimoto et al.   Open Biology

Heat Shock Proteins in Alzheimer’s Disease: Role and Targeting

(2018) Claudia Campanella et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Mitochondrial permeability transition pore contributes to mitochondrial dysfunction in fibroblasts of patients with sporadic Alzheimer's disease

(2018) María José Pérez et al.   Redox Biology

Calcium, mitochondria and cell metabolism: A functional triangle in bioenergetics

(2018) Alice Rossi et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

On the Pathogenesis of Alzheimer's Disease: The MAM Hypothesis

(2017) Estela Area-Gomez et al.   FASEB JOURNAL

Emerging roles of ER stress in the etiology and pathogenesis of Alzheimer's disease

(2017) Yannis Gerakis et al.   FEBS Journal

Mitochondrial dysfunction in the APP/PSEN1 mouse model of Alzheimer’s disease and a novel protective role for ascorbate

(2017) Shilpy Dixit et al.   FREE RADICAL BIOLOGY AND MEDICINE

Endoplasmic reticulum-mitochondria tethering in neurodegenerative diseases

(2017) Yi Liu et al.   Translational Neurodegeneration

Alzheimer's Disease: From Mitochondrial Perturbations to Mitochondrial Medicine

(2016) Susana Cardoso et al.   BRAIN PATHOLOGY

The coming of age of the mitochondria–ER contact: a matter of thickness

(2016) M Giacomello et al.   CELL DEATH AND DIFFERENTIATION

Evidence for Mitochondrial UPR Gene Activation in Familial and Sporadic Alzheimer's Disease

(2016) John S. Beck et al.   Current Alzheimer Research

Mitochondria-associated ER membranes and Alzheimer disease

(2016) Estela Area-Gomez et al.   CURRENT OPINION IN GENETICS & DEVELOPMENT

Mitofusin-2 knockdown increases ER-mitochondria contact and decreases amyloid β-peptide production

(2016) Nuno Santos Leal et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

Defeating Alzheimer's disease and other dementias: a priority for European science and society

(2016) Bengt Winblad et al.   LANCET NEUROLOGY

Mitofusins, from Mitochondria to Metabolism

(2016) Emilie Schrepfer et al.   MOLECULAR CELL

Killing Me Softly: Connotations to Unfolded Protein Response and Oxidative Stress in Alzheimer’s Disease

(2016) Beata Pająk et al.   Oxidative Medicine and Cellular Longevity

Critical reappraisal confirms that Mitofusin 2 is an endoplasmic reticulum–mitochondria tether

(2016) Deborah Naon et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Mitochondria-Associated Membranes: Composition, Molecular Mechanisms, and Physiopathological Implications

(2015) Carlotta Giorgi et al.   ANTIOXIDANTS & REDOX SIGNALING

PCNA-interacting peptides reduce Akt phosphorylation and TLR-mediated cytokine secretion suggesting a role of PCNA in cellular signaling

(2015) Camilla Olaisen et al.   CELLULAR SIGNALLING

The Ins and Outs of Mitochondrial Calcium

(2015) T. Finkel et al.   CIRCULATION RESEARCH

Loss of mitofusin 2 links beta-amyloid-mediated mitochondrial fragmentation and Cdk5-induced oxidative stress in neuron cells

(2015) Junghyung Park et al.   JOURNAL OF NEUROCHEMISTRY

Mitofusin 2 ablation increases endoplasmic reticulum–mitochondria coupling

(2015) Riccardo Filadi et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

New functions of mitochondria associated membranes in cellular signaling

(2014) Alexander R. van Vliet et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Mitochondrial Dysfunction: Different Routes to Alzheimer’s Disease Therapy

(2014) Pasquale Picone et al.   Oxidative Medicine and Cellular Longevity

Activation of the endoplasmic reticulum stress response by the amyloid-beta 1–40 peptide in brain endothelial cells

(2013) Ana Catarina R.G. Fonseca et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Oxidative stress and mitochondrial dysfunction in Alzheimer's disease

(2013) Xinglong Wang et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Intracellular Accumulation of Toxic Turn Amyloid-β is Associated with Endoplasmic Reticulum Stress in Alzheimer’s Disease

(2013) Naoko Soejima et al.   Current Alzheimer Research

Mitochondrial Abnormalities in a Streptozotocin-Induced Rat Model of Sporadic Alzheimer's Disease

(2013) Sonia C. Correia et al.   Current Alzheimer Research

Mfn2 modulates the UPR and mitochondrial function via repression of PERK

(2013) Juan Pablo Muñoz et al.   EMBO JOURNAL

Bioenergetic flux, mitochondrial mass and mitochondrial morphology dynamics in AD and MCI cybrid cell lines

(2013) D. F. Silva et al.   HUMAN MOLECULAR GENETICS

Deconstructing Mitochondrial Dysfunction in Alzheimer Disease

(2013) Vega García-Escudero et al.   Oxidative Medicine and Cellular Longevity

Modulation of the endoplasmic reticulum-mitochondria interface in Alzheimer's disease and related models

(2013) L. Hedskog et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

ERO1α-dependent endoplasmic reticulum–mitochondrial calcium flux contributes to ER stress and mitochondrial permeabilization by procaspase-activating compound-1 (PAC-1)

(2013) M Seervi et al.   Cell Death & Disease

Endoplasmic reticulum stress occurs downstream of GluN2B subunit ofN-methyl-D-aspartate receptor in mature hippocampal cultures treated with amyloid-β oligomers

(2012) Rui O. Costa et al.   AGING CELL

Where the endoplasmic reticulum and the mitochondrion tie the knot: The mitochondria-associated membrane (MAM)

(2012) Arun Raturi et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Dopamine induces apoptosis in APPswe-expressing Neuro2A cells following Pepstatin-sensitive proteolysis of APP in acid compartments

(2012) Monica Cagnin et al.   BRAIN RESEARCH

PERK is required at the ER-mitochondrial contact sites to convey apoptosis after ROS-based ER stress

(2012) T Verfaillie et al.   CELL DEATH AND DIFFERENTIATION

Metabolic Alterations Induced by Sucrose Intake and Alzheimer’s Disease Promote Similar Brain Mitochondrial Abnormalities

(2012) Cristina Carvalho et al.   DIABETES

Swedish Alzheimer Mutation Induces Mitochondrial Dysfunction Mediated by HSP60 Mislocalization of Amyloid Precursor Protein (APP) and Beta-Amyloid

(2012) Ken Carlson Walls et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

MCUR1 is an essential component of mitochondrial Ca2+ uptake that regulates cellular metabolism

(2012) Karthik Mallilankaraman et al.   NATURE CELL BIOLOGY

Ero1α Regulates Ca2+ Fluxes at the Endoplasmic Reticulum–Mitochondria Interface (MAM)

(2011) Tiziana Anelli et al.   ANTIOXIDANTS & REDOX SIGNALING

Sigma-1Rs are upregulated via PERK/eIF2α/ATF4 pathway and execute protective function in ER stress

(2011) Teruhiko Mitsuda et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Calcium signaling around Mitochondria Associated Membranes (MAMs)

(2011) Simone Patergnani et al.   Cell Communication and Signaling

Impaired mitochondrial dynamics and abnormal interaction of amyloid beta with mitochondrial protein Drp1 in neurons from patients with Alzheimer's disease: implications for neuronal damage

(2011) Maria Manczak et al.   HUMAN MOLECULAR GENETICS

Amyloid β-induced ER stress is enhanced under mitochondrial dysfunction conditions

(2011) Rui O. Costa et al.   NEUROBIOLOGY OF AGING

A novel hypothesis for Alzheimer disease based on neuronal tetraploidy induced by p75NTR

(2010) Jose Maria Frade et al.   CELL CYCLE

Proliferating cell nuclear antigen acts as a cytoplasmic platform controlling human neutrophil survival

(2010) Véronique Witko-Sarsat et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Regulation of neuron mitochondrial biogenesis and relevance to brain health

(2009) Isaac G. Onyango et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Mitochondrial dysfunction is a trigger of Alzheimer's disease pathophysiology

(2009) Paula I. Moreira et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Role of ERO1-α–mediated stimulation of inositol 1,4,5-triphosphate receptor activity in endoplasmic reticulum stress–induced apoptosis

(2009) Gang Li et al.   JOURNAL OF CELL BIOLOGY

Mitochondrial accumulation of APP and Aβ: significance for Alzheimer disease pathogenesis

(2009) Pavel F. Pavlov et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

The role of abnormal mitochondrial dynamics in the pathogenesis of Alzheimer’s disease

(2009) Xinglong Wang et al.   JOURNAL OF NEUROCHEMISTRY

Brains With Medial Temporal Lobe Neurofibrillary Tangles But No Neuritic Amyloid Plaques Are a Diagnostic Dilemma But May Have Pathogenetic Aspects Distinct From Alzheimer Disease

(2009) Peter T. Nelson et al.   JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY

Isolation of mitochondria-associated membranes and mitochondria from animal tissues and cells

(2009) Mariusz R Wieckowski et al.   Nature Protocols

Aging Impairs the Unfolded Protein Response to Sleep Deprivation and Leads to Proapoptotic Signaling

(2008) N. Naidoo et al.   JOURNAL OF NEUROSCIENCE

Mitofusin 2 tethers endoplasmic reticulum to mitochondria

(2008) Olga Martins de Brito et al.   NATURE

Mitochondrial Ca2+ Overload Underlies Aβ Oligomers Neurotoxicity Providing an Unexpected Mechanism of Neuroprotection by NSAIDs

(2008) Sara Sanz-Blasco et al.   PLoS One

Amyloid-  overproduction causes abnormal mitochondrial dynamics via differential modulation of mitochondrial fission/fusion proteins

(2008) X. Wang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The amyloid  -peptide is imported into mitochondria via the TOM import machinery and localized to mitochondrial cristae

(2008) C. A. Hansson Petersen et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA