The Effects of APOE4 on Mitochondrial Dynamics and Proteins in vivo

Apolipoprotein E4 inhibits autophagy gene products through direct, specific binding to CLEAR motifs

(2018) Paul A. Parcon et al.   Alzheimers & Dementia

Hippocampal mutant APP and amyloid beta-induced cognitive decline, dendritic spine loss, defective autophagy, mitophagy and mitochondrial abnormalities in a mouse model of Alzheimer’s disease

(2018) Maria Manczak et al.   HUMAN MOLECULAR GENETICS

The Interplay Between Apolipoprotein E4 and the Autophagic–Endocytic–Lysosomal Axis

(2018) E. Schmukler et al.   MOLECULAR NEUROBIOLOGY

The Isoform-Specific Pathological Effects of ApoE4 in vivo are Prevented by a Fish Oil (DHA) Diet and are Modified by Cholesterol

(2018) Zehavit Kariv-Inbal et al.   JOURNAL OF ALZHEIMERS DISEASE

Mitochondrial dynamics changes with age in an APPsw/PS1dE9 mouse model of Alzheimer’s disease

(2017) Lin-Lin Xu et al.   NEUROREPORT

Mitochondrial Heterogeneity: Evaluating Mitochondrial Subpopulation Dynamics in Stem Cells

(2017) D. C. Woods   Stem Cells International

Platelet cytochrome oxidase and citrate synthase activities in APOE ε4 carrier and non-carrier Alzheimer's disease patients

(2017) Heather M. Wilkins et al.   Redox Biology

Following Activation of the Amyloid Cascade, Apolipoprotein E4 Drives the in vivo Oligomerization of Amyloid-β Resulting in Neurodegeneration

(2017) Haim Belinson et al.   JOURNAL OF ALZHEIMERS DISEASE

Autophagy flux in CA1 neurons of Alzheimer hippocampus: Increased induction overburdens failing lysosomes to propel neuritic dystrophy

(2016) Matteo Bordi et al.   Autophagy

Impaired Autophagy in APOE4 Astrocytes

(2016) Shira Simonovitch et al.   JOURNAL OF ALZHEIMERS DISEASE

Altered Energy Metabolism Pathways in the Posterior Cingulate in Young Adult Apolipoprotein E ɛ4 Carriers

(2016) Michelle Perkins et al.   JOURNAL OF ALZHEIMERS DISEASE

Reversal of ApoE4-Driven Brain Pathology by Vascular Endothelial Growth Factor Treatment

(2016) Shiran Salomon-Zimri et al.   JOURNAL OF ALZHEIMERS DISEASE

Plasticity in mitochondrial cristae density allows metabolic capacity modulation in human skeletal muscle

(2016) Joachim Nielsen et al.   JOURNAL OF PHYSIOLOGY-LONDON

APOE genotype and stress response - a mini review

(2016) Janina Dose et al.   Lipids in Health and Disease

Deciphering the Molecular Signals of PINK1/Parkin Mitophagy

(2016) Thanh N. Nguyen et al.   TRENDS IN CELL BIOLOGY

Human wild-type full-length tau accumulation disrupts mitochondrial dynamics and the functions via increasing mitofusins

(2016) Xia-Chun Li et al.   Scientific Reports

Parkin-mediated mitophagy in mutant hAPP neurons and Alzheimer's disease patient brains

(2015) Xuan Ye et al.   HUMAN MOLECULAR GENETICS

APOE ε4: The most prevalent yet understudied risk factor for Alzheimer's disease

(2014) Daniel M. Michaelson   Alzheimers & Dementia

Oxidative Stress and Metabolic Syndrome: Cause or Consequence of Alzheimer's Disease?

(2014) Diana Luque-Contreras et al.   Oxidative Medicine and Cellular Longevity

Tyrosine kinase inhibition increases functional parkin-Beclin-1 interaction and enhances amyloid clearance and cognitive performance

(2013) Irina Lonskaya et al.   EMBO Molecular Medicine

Parkin overexpression ameliorates hippocampal long-term potentiation and  -amyloid load in an Alzheimer's disease mouse model

(2013) X. Hong et al.   HUMAN MOLECULAR GENETICS

ApoE4 induces Aβ42, tau, and neuronal pathology in the hippocampus of young targeted replacement apoE4 mice

(2013) Ori Liraz et al.   Molecular Neurodegeneration

Accumulation of autophagic adaptor protein, p62/sequestosome 1, in the brains of Alzheimer�s disease

(2013) Tanji Kunikazu et al.   Frontiers in Immunology

Mitochondria and Mitophagy

(2012) Dieter A. Kubli et al.   CIRCULATION RESEARCH

The Effects of Apolipoproteins E3 and E4 on the Transforming Growth Factor-ß System in Targeted Replacement Mice

(2012) Adi Haas et al.   Neurodegenerative Diseases

Analysis of blood-based gene expression signature in first-episode psychosis

(2012) Jimmy Lee et al.   PSYCHIATRY RESEARCH

Mitochondrial dynamics in neurodegeneration

(2012) Kie Itoh et al.   TRENDS IN CELL BIOLOGY

Impaired mitochondrial dynamics and abnormal interaction of amyloid beta with mitochondrial protein Drp1 in neurons from patients with Alzheimer's disease: implications for neuronal damage

(2011) Maria Manczak et al.   HUMAN MOLECULAR GENETICS

Proteomic Analysis of Mitochondria in APOE Transgenic Mice and in Response to an Ischemic Challenge

(2011) Rachel James et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

Mitochondrial DNA deletions cause the biochemical defect observed in Alzheimer's disease

(2011) Kim J. Krishnan et al.   NEUROBIOLOGY OF AGING

Emerging role of p62/sequestosome-1 in the pathogenesis of Alzheimer's disease

(2011) Antero Salminen et al.   PROGRESS IN NEUROBIOLOGY

Mitochondrial Dysfunction: Common Final Pathway in Brain Aging and Alzheimer’s Disease—Therapeutic Aspects

(2010) Walter E. Müller et al.   MOLECULAR NEUROBIOLOGY

Inhibition of mTOR by Rapamycin Abolishes Cognitive Deficits and Reduces Amyloid-β Levels in a Mouse Model of Alzheimer's Disease

(2010) Patricia Spilman et al.   PLoS One

ApoE4-dependent Aβ-mediated neurodegeneration is associated with inflammatory activation in the hippocampus but not the septum

(2009) Haim Belinson et al.   JOURNAL OF NEURAL TRANSMISSION

Impaired Balance of Mitochondrial Fission and Fusion in Alzheimer's Disease

(2009) X. Wang et al.   JOURNAL OF NEUROSCIENCE

Apolipoprotein E and its receptors in Alzheimer's disease: pathways, pathogenesis and therapy

(2009) Guojun Bu   NATURE REVIEWS NEUROSCIENCE

The Role of Apolipoprotein E in Alzheimer's Disease

(2009) Jungsu Kim et al.   NEURON

Activation of the Amyloid Cascade in Apolipoprotein E4 Transgenic Mice Induces Lysosomal Activation and Neurodegeneration Resulting in Marked Cognitive Deficits

(2008) H. Belinson et al.   JOURNAL OF NEUROSCIENCE