期刊
CELLULAR AND MOLECULAR LIFE SCIENCES
卷 74, 期 8, 页码 1475-1483出版社
SPRINGER BASEL AG
DOI: 10.1007/s00018-016-2410-z
关键词
VPS10P domain receptors; Protein sorting; Retromer; GGA; Alzheimer's disease; Obesity
资金
- European Research Council (BeyOND) [335692]
- Helmholtz Association (iCEMED, International Research Groups)
- Berlin Institute of Health (Collaborative Research Group) [11220008]
- European Research Council (ERC) [335692] Funding Source: European Research Council (ERC)
Sorting-related receptor with A-type repeats (SORLA) is an intracellular sorting receptor that directs cargo proteins, such as kinases, phosphatases, and signaling receptors, to their correct location within the cell. The activity of SORLA assures proper function of cells and tissues, and receptor dysfunction is the underlying cause of common human malignancies, including Alzheimer's disease, atherosclerosis, and obesity. Here, we discuss the molecular mechanisms that govern sorting of SORLA and its cargo in multiple cell types, and why genetic defects in this receptor results in devastating diseases.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据