Novel and potent inhibitors targeting DHODH are broad-spectrum antivirals against RNA viruses including newly-emerged coronavirus SARS-CoV-2

Remdesivir and chloroquine effectively inhibit the recently emerged novel coronavirus (2019-nCoV) in vitro

(2020) Manli Wang et al.   CELL RESEARCH

Clinical features of patients infected with 2019 novel coronavirus in Wuhan, China

(2020) Chaolin Huang et al.   LANCET

A new coronavirus associated with human respiratory disease in China

(2020) Fan Wu et al.   NATURE

A pneumonia outbreak associated with a new coronavirus of probable bat origin

(2020) Peng Zhou et al.   NATURE

RNA based mNGS approach identifies a novel human coronavirus from two individual pneumonia cases in 2019 Wuhan outbreak

(2020) Liangjun Chen et al.   Emerging Microbes & Infections

Expanding the activity spectrum of antiviral agents

(2019) Aleksandr Ianevski et al.   DRUG DISCOVERY TODAY

Discovery, Optimization, and Target Identification of Novel Potent Broad-Spectrum Antiviral Inhibitors

(2019) Yiqing Yang et al.   JOURNAL OF MEDICINAL CHEMISTRY

Suppression of pyrimidine biosynthesis by targeting DHODH enzyme robustly inhibits rotavirus replication

(2019) Sunrui Chen et al.   ANTIVIRAL RESEARCH

Broad-Spectrum Antiviral Agents: A Crucial Pandemic Tool

(2019) Amesh Adalja et al.   Expert Review of Anti-Infective Therapy

Antiviral effects of selected IMPDH and DHODH inhibitors against foot and mouth disease virus

(2019) Gong Mei-jiao et al.   BIOMEDICINE & PHARMACOTHERAPY

From “A”IV to “Z”IKV: Attacks from Emerging and Re-emerging Pathogens

(2018) George F. Gao   CELL

Inhibiting pyrimidine biosynthesis impairs Ebola virus replication through depletion of nucleoside pools and activation of innate immune responses

(2018) Priya Luthra et al.   ANTIVIRAL RESEARCH

Broad-spectrum inhibition of common respiratory RNA viruses by a pyrimidine synthesis inhibitor with involvement of the host antiviral response

(2017) Nam Nam Cheung et al.   JOURNAL OF GENERAL VIROLOGY

Zika virus preferentially replicates in the female reproductive tract after vaginal inoculation of rhesus macaques

(2017) Timothy Carroll et al.   PLoS Pathogens

Discovery of a Broad-Spectrum Antiviral Compound That Inhibits Pyrimidine Biosynthesis and Establishes a Type 1 Interferon-Independent Antiviral State

(2016) Dong-Hoon Chung et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Respiratory syncytial virus infection in macaques is not suppressed by intranasal sprays of pyrimidine biosynthesis inhibitors

(2016) Clément Grandin et al.   ANTIVIRAL RESEARCH

Higher incidence of Zika in adult women than adult men in Rio de Janeiro suggests a significant contribution of sexual transmission from men to women

(2016) Flavio Codeço Coelho et al.   INTERNATIONAL JOURNAL OF INFECTIOUS DISEASES

Structure-based design of potent human dihydroorotate dehydrogenase inhibitors as anticancer agents

(2016) Wenlin Song et al.   MedChemComm

A Mouse Model of Zika Virus Sexual Transmission and Vaginal Viral Replication

(2016) William Weihao Tang et al.   Cell Reports

Isolation and characterization of Zika virus imported to China using C6/36 mosquito cells

(2016) Chenglin Deng et al.   VIROLOGICA SINICA

The future of antivirals

(2015) Yannick Debing et al.   CURRENT OPINION IN INFECTIOUS DISEASES

Design, Synthesis, X-ray Crystallographic Analysis, and Biological Evaluation of Thiazole Derivatives as Potent and Selective Inhibitors of Human Dihydroorotate Dehydrogenase

(2015) Junsheng Zhu et al.   JOURNAL OF MEDICINAL CHEMISTRY

Rational Design of Benzylidenehydrazinyl-Substituted Thiazole Derivatives as Potent Inhibitors of Human Dihydroorotate Dehydrogenase with in Vivo Anti-arthritic Activity

(2015) Shiliang Li et al.   Scientific Reports

Sumoylation of Influenza A Virus Nucleoprotein Is Essential for Intracellular Trafficking and Virus Growth

(2014) Q. Han et al.   JOURNAL OF VIROLOGY

Assessment of drug candidates for broad-spectrum antiviral therapy targeting cellular pyrimidine biosynthesis

(2013) Manfred Marschall et al.   ANTIVIRAL RESEARCH

Hyperimmune IV Immunoglobulin Treatment

(2013) Ivan F.N. Hung et al.   CHEST

On Dihydroorotate Dehydrogenases and Their Inhibitors and Uses

(2013) Hélène Munier-Lehmann et al.   JOURNAL OF MEDICINAL CHEMISTRY

Advances in the development of nucleoside and nucleotide analogues for cancer and viral diseases

(2013) Lars Petter Jordheim et al.   NATURE REVIEWS DRUG DISCOVERY

Clinical Findings in 111 Cases of Influenza A (H7N9) Virus Infection

(2013) Hai-Nv Gao et al.   NEW ENGLAND JOURNAL OF MEDICINE

Discovery of Potent Broad Spectrum Antivirals Derived from Marine Actinobacteria

(2013) Avi Raveh et al.   PLoS One

SAR-Based Optimization of a 4-Quinoline Carboxylic Acid Analogue with Potent Antiviral Activity

(2013) Priyabrata Das et al.   ACS Medicinal Chemistry Letters

Inhibition of Pyrimidine Biosynthesis Pathway Suppresses Viral Growth through Innate Immunity

(2013) Marianne Lucas-Hourani et al.   PLoS Pathogens

Discovery of Diverse Human Dihydroorotate Dehydrogenase Inhibitors as Immunosuppressive Agents by Structure-Based Virtual Screening

(2012) Yanyan Diao et al.   JOURNAL OF MEDICINAL CHEMISTRY

REFMAC5 for the refinement of macromolecular crystal structures

(2011) Garib N. Murshudov et al.   ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY

Inhibition of Dengue Virus through Suppression of Host Pyrimidine Biosynthesis

(2011) Q.-Y. Wang et al.   JOURNAL OF VIROLOGY

Broad-spectrum antiviral that interferes with de novo pyrimidine biosynthesis

(2011) H.-H. Hoffmann et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Features and development ofCoot

(2010) P. Emsley et al.   ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY

Characterization of Dengue Virus Resistance to Brequinar in Cell Culture

(2010) M. Qing et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Minigenome-Based Reporter System Suitable for High-Throughput Screening of Compounds Able To Inhibit Ebolavirus Replication and/or Transcription

(2010) L. D. Jasenosky et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Cellular targets for influenza drugs

(2010) Ji-Young Min et al.   NATURE BIOTECHNOLOGY

GSK983: A novel compound with broad-spectrum antiviral activity

(2009) Robert Harvey et al.   ANTIVIRAL RESEARCH

Evaluation of the efficacy and safety of a statin/caffeine combination against H5N1, H3N2 and H1N1 virus infection in BALB/c mice

(2009) Zeyu Liu et al.   EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES