Green Tea and Epigallocatechin Gallate (EGCG) for the Management of Nonalcoholic Fatty Liver Diseases (NAFLD): Insights into the Role of Oxidative Stress and Antioxidant Mechanism

Role of Oxidative Stress in the Pathogenesis of Non-Alcoholic Fatty Liver Disease: Implications for Prevention and Therapy

(2021) Johanna C. Arroyave-Ospina et al.   Antioxidants

Association Between Fibrosis Stage and Outcomes of Patients with Non-Alcoholic Fatty Liver Disease: a Systematic Review and Meta-Analysis

(2020) Rod S. Taylor et al.   GASTROENTEROLOGY

Effects of green tea or green tea catechin on liver enzymes in healthy individuals and people with nonalcoholic fatty liver disease: A systematic review and meta‐analysis of randomized clinical trials

(2020) Marzieh Mahmoodi et al.   PHYTOTHERAPY RESEARCH

The In Vivo Antioxidant and Hepatoprotective Actions of Selected Chinese Teas

(2020) Shi-Yu Cao et al.   Foods

Role of oxidative stress in the pathogenesis of nonalcoholic fatty liver disease

(2020) Ze Chen et al.   FREE RADICAL BIOLOGY AND MEDICINE

Prevalence and Risk Factors of Nonalcoholic Fatty Liver Disease and Advanced Fibrosis in General Population: the French Nationwide NASH-CO Study

(2020) Oumarou Nabi et al.   GASTROENTEROLOGY

Nonalcoholic Steatohepatitis

(2020) Adam C. Sheka et al.   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

Citrus. reticulata Blanco peel extract ameliorates hepatic steatosis, oxidative stress and inflammation in HF and MCD diet- induced NASH C57BL/6 J mice

(2020) Zunli Ke et al.   JOURNAL OF NUTRITIONAL BIOCHEMISTRY

Multiple Parallel Hits Hypothesis in NAFLD – Revisited After a Decade

(2020) Herbert Tilg et al.   HEPATOLOGY

Genistein Modulated Lipid Metabolism, Hepatic PPARγ, and Adiponectin Expression in Bilateral Ovariectomized Rats with Nonalcoholic Steatohepatitis (NASH)

(2020) Sudaporn Pummoung et al.   Antioxidants

Inflammation and Liver Cancer: Molecular Mechanisms and Therapeutic Targets

(2019) Yoon Yang et al.   SEMINARS IN LIVER DISEASE

Oxidative stress and adipokine levels were significantly correlated in diabetic patients with hyperglycemic crises

(2019) Juan Li et al.   Diabetology & Metabolic Syndrome

Coadministration of epigallocatechin-3-gallate (EGCG) and caffeine in low dose ameliorates obesity and nonalcoholic fatty liver disease in obese rats

(2019) Zhe Yang et al.   PHYTOTHERAPY RESEARCH

Oxidative Stress and Antioxidant Biomarkers in Clinical and Experimental Models of Non-Alcoholic Fatty Liver Disease

(2019) Ayokanmi Ore et al.   Medicina-Lithuania

Fibrosis and alcohol-related liver disease

(2019) Carolin Lackner et al.   JOURNAL OF HEPATOLOGY

Preventive Efficiency of Green Tea and Its Components on Non-alcoholic Fatty Liver Disease

(2019) Jie Zhou et al.   JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY

Hepatic IRF6 alleviates liver steatosis and metabolic disorder by transcriptionally suppressing PPARγ

(2019) Jingjing Tong et al.   HEPATOLOGY

Effects and mechanisms of tea for the prevention and management of cancers: An updated review

(2019) Xiao-Yu Xu et al.   CRITICAL REVIEWS IN FOOD SCIENCE AND NUTRITION

Lipidomic biomarkers and mechanisms of lipotoxicity in non-alcoholic fatty liver disease

(2019) Gianluca Svegliati-Baroni et al.   FREE RADICAL BIOLOGY AND MEDICINE

Recent Insight into the Role of Fibrosis in Nonalcoholic Steatohepatitis-Related Hepatocellular Carcinoma

(2019) Antonio Sircana et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Past, present and future perspectives in nonalcoholic fatty liver disease

(2019) Arun J. Sanyal   Nature Reviews Gastroenterology & Hepatology

Clinically Significant Fibrosis is Associated With Longitudinal Increases in Fibrosis-4 and NAFLD Fibrosis Scores

(2019) Preya Janubhai Patel et al.   Clinical Gastroenterology and Hepatology

Polyphenol-Rich Loquat Fruit Extract Prevents Fructose-Induced Nonalcoholic Fatty Liver Disease by Modulating Glycometabolism, Lipometabolism, Oxidative Stress, Inflammation, Intestinal Barrier, and Gut Microbiota in Mice

(2019) Wenfeng Li et al.   JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY

Simvastatin Reduces Hepatic Oxidative Stress and Endoplasmic Reticulum Stress in Nonalcoholic Steatohepatitis Experimental Model

(2019) Graziella Rodrigues et al.   Oxidative Medicine and Cellular Longevity

Ammonia scavenging prevents progression of fibrosis in experimental non‐alcoholic fatty liver disease

(2019) Francesco De Chiara et al.   HEPATOLOGY

Serum Nutritional Markers as Prognostic Factors for Hepatic and Extrahepatic Carcinogenesis in Japanese Patients with Nonalcoholic Fatty Liver Disease

(2019) Takanori Ito et al.   NUTRITION AND CANCER-AN INTERNATIONAL JOURNAL

Biochemical basis and metabolic interplay of redox regulation

(2019) Lixiao Zhang et al.   Redox Biology

Effects of (−) - epicatechin on the time course of the expression of perilipins in a diet-induced model of non-alcoholic steatohepatitis

(2019) Isabel Hidalgo et al.   JOURNAL OF NUTRITIONAL BIOCHEMISTRY

What’s new in NAFLD pathogenesis, biomarkers and treatment?

(2019) Christopher D. Byrne et al.   Nature Reviews Gastroenterology & Hepatology

Dietary plants, gut microbiota, and obesity: Effects and mechanisms

(2019) Shi-Yu Cao et al.   TRENDS IN FOOD SCIENCE & TECHNOLOGY

Effects of Tannase and Ultrasound Treatment on the Bioactive Compounds and Antioxidant Activity of Green Tea Extract

(2019) Xiao-Yu Xu et al.   Antioxidants

Effects of Food Processing on In Vivo Antioxidant and Hepatoprotective Properties of Green Tea Extracts

(2019) Xiao-Yu Xu et al.   Antioxidants

Health Functions and Related Molecular Mechanisms of Tea Components: An Update Review

(2019) Guo-Yi Tang et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Mitigation of nonalcoholic fatty liver disease in high-fat-fed mice by the combination of decaffeinated green tea extract and voluntary exercise

(2019) Weslie Y. Khoo et al.   JOURNAL OF NUTRITIONAL BIOCHEMISTRY

Green Tea Prevents NAFLD by Modulation of miR-34a and miR-194 Expression in a High-Fat Diet Mouse Model

(2019) L. F. Torres et al.   Oxidative Medicine and Cellular Longevity

Carbon monoxide releasing molecule-A1 improves nonalcoholic steatohepatitis via Nrf2 activation mediated improvement in oxidative stress and mitochondrial function

(2019) Kapil K. Upadhyay et al.   Redox Biology

How many deaths are caused by non-alcoholic fatty liver disease in the Asia-Pacific region?

(2019) Grace Lai-Hung Wong et al.   Lancet Gastroenterology & Hepatology

Epigallocatechin-3-Gallate-Rich Green Tea Extract Ameliorates Fatty Liver and Weight Gain in Mice Fed a High Fat Diet by Activating the Sirtuin 1 and AMP Activating Protein Kinase Pathway

(2018) Ui-Jin Bae et al.   AMERICAN JOURNAL OF CHINESE MEDICINE

NASH Leading Cause of Liver Transplant in Women: Updated Analysis of Indications For Liver Transplant and Ethnic and Gender Variances

(2018) Mazen Noureddin et al.   AMERICAN JOURNAL OF GASTROENTEROLOGY

Reactive Oxygen Species in Metabolic and Inflammatory Signaling

(2018) Steven J. Forrester et al.   CIRCULATION RESEARCH

Higher serum carotenoids associated with improvement of non-alcoholic fatty liver disease in adults: a prospective study

(2018) Mian-li Xiao et al.   EUROPEAN JOURNAL OF NUTRITION

Endoplasmic Reticulum stress signaling and the pathogenesis of Non-Alcoholic Fatty Liver Disease

(2018) Cynthia Lebeaupin et al.   JOURNAL OF HEPATOLOGY

Green tea extract protects against hepatic NFκB activation along the gut-liver axis in diet-induced obese mice with nonalcoholic steatohepatitis by reducing endotoxin and TLR4/MyD88 signaling

(2018) Jinhui Li et al.   JOURNAL OF NUTRITIONAL BIOCHEMISTRY

Green Tea Polyphenol EGCG Alleviates Metabolic Abnormality and Fatty Liver by Decreasing Bile Acid and Lipid Absorption in Mice

(2018) Jinbao Huang et al.   MOLECULAR NUTRITION & FOOD RESEARCH

Leptin and Leptin Resistance in the Pathogenesis of Obstructive Sleep Apnea: A Possible Link to Oxidative Stress and Cardiovascular Complications

(2018) Slava Berger et al.   Oxidative Medicine and Cellular Longevity

Role of Oxidative Stress in Pathophysiology of Nonalcoholic Fatty Liver Disease

(2018) Mario Masarone et al.   Oxidative Medicine and Cellular Longevity

Green tea as a safe alternative approach for nonalcoholic fatty liver treatment: A systematic review and meta-analysis of clinical trials

(2018) Fariborz Mansour-Ghanaei et al.   PHYTOTHERAPY RESEARCH

Role of gut microbiota and oxidative stress in the progression of non-alcoholic fatty liver disease to hepatocarcinoma: Current and innovative therapeutic approaches

(2018) Antonella Borrelli et al.   Redox Biology

Systematic review with meta-analysis: risk of hepatocellular carcinoma in non-alcoholic steatohepatitis without cirrhosis compared to other liver diseases

(2018) Jonathan G. Stine et al.   ALIMENTARY PHARMACOLOGY & THERAPEUTICS

Global Perspectives on Non-alcoholic Fatty Liver Disease and Non-alcoholic Steatohepatitis

(2018) Zobair Younossi et al.   HEPATOLOGY

The Major Green Tea Polyphenol, (-)-Epigallocatechin-3-Gallate, Inhibits Obesity, Metabolic Syndrome, and Fatty Liver Disease in High-Fat–Fed Mice

(2018) Mousumi Bose et al.   JOURNAL OF NUTRITION

Oxidative stress in chronic lung disease: From mitochondrial dysfunction to dysregulated redox signaling

(2018) Albert van der Vliet et al.   MOLECULAR ASPECTS OF MEDICINE

Obesity Drives STAT-1-Dependent NASH and STAT-3-Dependent HCC

(2018) Marcus Grohmann et al.   CELL

Epidemiology and Management of Hepatocellular Carcinoma

(2018) Laura Kulik et al.   GASTROENTEROLOGY

Relieving ER stress to target NASH-driven hepatocellular carcinoma

(2018) Saskia Reibe et al.   Nature Reviews Endocrinology

A spotlight on pathogenesis, interactions and novel therapeutic options in NAFLD

(2018) Ramy Younes et al.   Nature Reviews Gastroenterology & Hepatology

Redox-Mediated Regulatory Mechanisms of Endoplasmic Reticulum Homeostasis

(2018) Ryo Ushioda et al.   Cold Spring Harbor Perspectives in Biology

Green Tea in Non-Alcoholic Fatty Liver Disease: A Double Blind Randomized Clinical Trial

(2017) Seyed Mohammad Tabatabaee et al.   Hepatitis Monthly

Green tea extract treatment reduces NFκB activation in mice with diet-induced nonalcoholic steatohepatitis by lowering TNFR1 and TLR4 expression and ligand availability

(2017) Jinhui Li et al.   JOURNAL OF NUTRITIONAL BIOCHEMISTRY

Potential Biological Effects of (-)-Epigallocatechin-3-gallate on the Treatment of Nonalcoholic Fatty Liver Disease

(2017) Cheng Chen et al.   MOLECULAR NUTRITION & FOOD RESEARCH

Global burden of NAFLD and NASH: trends, predictions, risk factors and prevention

(2017) Zobair Younossi et al.   Nature Reviews Gastroenterology & Hepatology

Green tea polyphenols ameliorate non-alcoholic fatty liver disease through upregulating AMPK activation in high fat fed Zucker fatty rats

(2017) Yi Tan et al.   WORLD JOURNAL OF GASTROENTEROLOGY

Being right on Q: shaping eukaryotic evolution

(2016) D. Speijer   BIOCHEMICAL JOURNAL

Global epidemiology of nonalcoholic fatty liver disease-Meta-analytic assessment of prevalence, incidence, and outcomes

(2016) Zobair M. Younossi et al.   HEPATOLOGY

Green tea extract provides extensive Nrf2-independent protection against lipid accumulation and NFκB pro- inflammatory responses during nonalcoholic steatohepatitis in mice fed a high-fat diet

(2016) Jinhui Li et al.   MOLECULAR NUTRITION & FOOD RESEARCH

Insights into the Role and Interdependence of Oxidative Stress and Inflammation in Liver Diseases

(2016) Sha Li et al.   Oxidative Medicine and Cellular Longevity

ROS Generation in Peroxisomes and its Role in Cell Signaling

(2016) Luis A. del Río et al.   PLANT AND CELL PHYSIOLOGY

Redox homeostasis: The Golden Mean of healthy living

(2016) Fulvio Ursini et al.   Redox Biology

Green tea polyphenol epigallocatechin-3-gallate ameliorates insulin resistance in non-alcoholic fatty liver disease mice

(2015) Lu Gan et al.   ACTA PHARMACOLOGICA SINICA

Epigallocatechin gallate attenuated non-alcoholic steatohepatitis induced by methionine- and choline-deficient diet

(2015) Yi Ding et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Endoplasmic reticulum stress and Oxidative stress in the pathogenesis of Non-alcoholic fatty liver disease

(2015) N. U. Ashraf et al.   FREE RADICAL RESEARCH

The Role of Oxidative Stress and Antioxidants in Liver Diseases

(2015) Sha Li et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Dietary (−)-Epigallocatechin-3-gallate Supplementation Counteracts Aging-Associated Skeletal Muscle Insulin Resistance and Fatty Liver in Senescence-Accelerated Mouse

(2015) Hung-Wen Liu et al.   JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY

Green Tea Lowers Hepatic COX-2 and Prostaglandin E2 in Rats with Dietary Fat-Induced Nonalcoholic Steatohepatitis

(2015) Min-Yu Chung et al.   JOURNAL OF MEDICINAL FOOD

Decaffeinated green tea extract rich in epigallocatechin-3-gallate prevents fatty liver disease by increased activities of mitochondrial respiratory chain complexes in diet-induced obesity mice

(2015) Aline B. Santamarina et al.   JOURNAL OF NUTRITIONAL BIOCHEMISTRY

Green Tea Extract Rich in Epigallocatechin-3-Gallate Prevents Fatty Liver by AMPK Activation via LKB1 in Mice Fed a High-Fat Diet

(2015) Aline B. Santamarina et al.   PLoS One

ROS Function in Redox Signaling and Oxidative Stress

(2014) Michael Schieber et al.   CURRENT BIOLOGY

Hepatic Fibrosis and the Microenvironment: Fertile Soil for Hepatocellular Carcinoma Development

(2014) Michael C. Wallace et al.   GENE EXPRESSION

Are oxidative stress mechanisms the common denominator in the progression from hepatic steatosis towards non-alcoholic steatohepatitis (NASH)?

(2014) Zoon Tariq et al.   LIVER INTERNATIONAL

Effects of green tea catechins on nonalcoholic steatohepatitis (NASH) patients

(2014) Yoshitaka Fukuzawa et al.   Journal of Functional Foods

Non-alcoholic steatohepatitis and preneoplastic lesions develop in the liver of obese and hypertensive rats: Suppressing effects of EGCG on the development of liver lesions

(2013) Takahiro Kochi et al.   CANCER LETTERS

Epigallocatechin gallate attenuates fibrosis, oxidative stress, and inflammation in non-alcoholic fatty liver disease rat model through TGF/SMAD, PI3 K/Akt/FoxO1, and NF-kappa B pathways

(2013) Jia Xiao et al.   EUROPEAN JOURNAL OF NUTRITION

Free radical biology for medicine: learning from nonalcoholic fatty liver disease

(2013) Gaetano Serviddio et al.   FREE RADICAL BIOLOGY AND MEDICINE

Mitochondrial adaptations and dysfunctions in nonalcoholic fatty liver disease

(2013) Karima Begriche et al.   HEPATOLOGY

Green tea with high-density catechins improves liver function and fat infiltration in non-alcoholic fatty liver disease (NAFLD) patients: A double-blind placebo-controlled study

(2013) RYUICHIRO SAKATA et al.   INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE

Multiple Hits, Including Oxidative Stress, as Pathogenesis and Treatment Target in Non-Alcoholic Steatohepatitis (NASH)

(2013) Akinobu Takaki et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Hepatocellular carcinoma patients with increased oxidative stress levels are prone to recurrence after curative treatment: a prospective case series study using the d-ROM test

(2013) Yusuke Suzuki et al.   JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY

Tumor microenviroment and hepatocellular carcinoma metastasis

(2013) Hongyang Wang et al.   JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY

The relationship between oxidative stress and nonalcoholic fatty liver disease: Its effects on the development of nonalcoholic steatohepatitis

(2013) Fatma Ucar et al.   REDOX REPORT

Roles of adiponectin and oxidative stress in obesity-associated metabolic and cardiovascular diseases

(2013) Morihiro Matsuda et al.   REVIEWS IN ENDOCRINE & METABOLIC DISORDERS

(-)-Epigallocatechin-3-gallate suppresses hepatic preneoplastic lesions developed in a novel rat model of non-alcoholic steatohepatitis

(2013) Takafumi Sumi et al.   SpringerPlus

Mitochondria as a Source of Reactive Oxygen and Nitrogen Species: From Molecular Mechanisms to Human Health

(2012) Tiago R. Figueira et al.   ANTIOXIDANTS & REDOX SIGNALING

Immunological functions of leptin and adiponectin

(2012) Fortunata Carbone et al.   BIOCHIMIE

Nonalcoholic steatohepatitis versus steatosis: Adipose tissue insulin resistance and dysfunctional response to fat ingestion predict liver injury and altered glucose and lipoprotein metabolism

(2012) Giovanni Musso et al.   HEPATOLOGY

Natural killer cells in liver disease

(2012) Zhigang Tian et al.   HEPATOLOGY

Therapeutic potential of green tea in nonalcoholic fatty liver disease

(2012) Christopher Masterjohn et al.   NUTRITION REVIEWS

Excessive Hepatic Mitochondrial TCA Cycle and Gluconeogenesis in Humans with Nonalcoholic Fatty Liver Disease

(2011) Nishanth E. Sunny et al.   Cell Metabolism

Role of oxidative stress in the pathogenesis of nonalcoholic steatohepatitis

(2011) Anabela P. Rolo et al.   FREE RADICAL BIOLOGY AND MEDICINE

Autophagy-deficient mice develop multiple liver tumors

(2011) A. Takamura et al.   GENES & DEVELOPMENT

Suppression of innate immunity (natural killer cell/interferon-γ) in the advanced stages of liver fibrosis in mice

(2011) Won-Il Jeong et al.   HEPATOLOGY

Green Tea Extract Suppresses NFκB Activation and Inflammatory Responses in Diet-Induced Obese Rats with Nonalcoholic Steatohepatitis

(2011) Hea Jin Park et al.   JOURNAL OF NUTRITION

Green tea extract protects against nonalcoholic steatohepatitis in ob/ob mice by decreasing oxidative and nitrative stress responses induced by proinflammatory enzymes

(2011) Min-Yu Chung et al.   JOURNAL OF NUTRITIONAL BIOCHEMISTRY

Molecular Hydrogen Improves Obesity and Diabetes by Inducing Hepatic FGF21 and Stimulating Energy Metabolism in db/db Mice

(2011) Naomi Kamimura et al.   Obesity

Increased expression of cytochrome P450 2E1 in nonalcoholic fatty liver disease: Mechanisms and pathophysiological role

(2011) J. Aubert et al.   Clinics and Research in Hepatology and Gastroenterology

Evolution of inflammation in nonalcoholic fatty liver disease: The multiple parallel hits hypothesis

(2010) Herbert Tilg et al.   HEPATOLOGY

Regulation of synthesis and oxidation of fatty acids by adiponectin receptors (AdipoR1/R2) and insulin receptor substrate isoforms (IRS-1/-2) of the liver in a nonalcoholic steatohepatitis animal model

(2010) Tokio Matsunami et al.   METABOLISM-CLINICAL AND EXPERIMENTAL

Serum total adiponectin in nonalcoholic fatty liver disease: a systematic review and meta-analysis

(2010) Stergios A. Polyzos et al.   METABOLISM-CLINICAL AND EXPERIMENTAL

Pioglitazone, Vitamin E, or Placebo for Nonalcoholic Steatohepatitis

(2010) Arun J. Sanyal et al.   NEW ENGLAND JOURNAL OF MEDICINE

Tissue-, substrate-, and site-specific characteristics of mitochondrial reactive oxygen species generation

(2009) Erich B. Tahara et al.   FREE RADICAL BIOLOGY AND MEDICINE

Epigallocatechin-3-gallate improves nonalcoholic steatohepatitis model mice expressing nuclear sterol regulatory element binding protein-1c in adipose tissue

(2009) Ueno   INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE

Beneficial Effects of Fermented Green Tea Extract in a Rat Model of Non-alcoholic Steatohepatitis

(2009) Kazuo Nakamoto et al.   JOURNAL OF CLINICAL BIOCHEMISTRY AND NUTRITION

Serum adipokine levels predictive of liver injury in non-alcoholic fatty liver disease

(2009) Maud Lemoine et al.   LIVER INTERNATIONAL

Carbohydrate responsive element binding protein and lipid homeostasis

(2008) Pierre-Damien Denechaud et al.   CURRENT OPINION IN LIPIDOLOGY

Liver stem cells and hepatocellular carcinoma

(2008) Lopa Mishra et al.   HEPATOLOGY

Risk of severe liver disease in nonalcoholic fatty liver disease with normal aminotransferase levels: A role for insulin resistance and diabetes

(2008) Anna Ludovica Fracanzani et al.   HEPATOLOGY

NAD+/NADH and NADP+/NADPH in Cellular Functions and Cell Death: Regulation and Biological Consequences

(2007) Weihai Ying   ANTIOXIDANTS & REDOX SIGNALING

Epigallocatechin gallate attenuates experimental non-alcoholic steatohepatitis induced by high fat diet

(2007) Nalan Kuzu et al.   JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY