Oxidative stress and adipokine levels were significantly correlated in diabetic patients with hyperglycemic crises

BackgroundTo investigate the relationship between blood adipokine level and oxidative stress in diabetic patients with hyperglycemic crises before and after treatment.MethodsWe measured superoxide dismutase (SOD) activity, malondialdehyde (MDA) content, total antioxidant capacity (TAC), and levels of 8-iso-prostaglandin F2 (8-iso-PGF2), adiponectin, leptin, and resistin in 63 diabetic patients with hyperglycemic crises.ResultsPrior to treatment, patients with hyperglycemic crises had significantly lower serum SOD activity, TAC, and adiponectin and leptin levels, and higher serum levels of MDA, 8-iso-PGF2, and resistin compared with the healthy control individuals (all at P<0.05). After treatment, SOD, TAC, adiponectin, and leptin levels increased significantly, while MDA, 8-iso-PGF2, and resistin levels decreased significantly (all at P<0.05) in the patients.ConclusionsDiabetic patients with hyperglycemic crises have increased oxidative stress, which is associated with serum adipokine abnormalities; improved oxidative stress after treatment suggests that oxidative stress may serve as target and/or indicator for the treatment of hyperglycemic crises.