标题
Light-Controllable PROTACs for Temporospatial Control of Protein Degradation
作者
关键词
-
出版物
Frontiers in Cell and Developmental Biology
Volume 9, Issue -, Pages -
出版商
Frontiers Media SA
发表日期
2021-07-19
DOI
10.3389/fcell.2021.678077
参考文献
相关参考文献
注意:仅列出部分参考文献,下载原文获取全部文献信息。- Antibody-Mediated Delivery of Chimeric BRD4 Degraders. Part 1: Exploration of Antibody Linker, Payload Loading, and Payload Molecular Properties
- (2021) Peter S. Dragovich et al. JOURNAL OF MEDICINAL CHEMISTRY
- Antibody-Mediated Delivery of Chimeric BRD4 Degraders. Part 2: Improvement of In Vitro Antiproliferation Activity and In Vivo Antitumor Efficacy
- (2021) Peter S. Dragovich et al. JOURNAL OF MEDICINAL CHEMISTRY
- Discovery of a first-in-class CDK2 selective degrader for AML differentiation therapy
- (2021) Liguo Wang et al. Nature Chemical Biology
- Cancer Selective Target Degradation by Folate-Caged PROTACs
- (2021) Jing Liu et al. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
- Targeted protein degraders crowd into the clinic
- (2021) Asher Mullard NATURE REVIEWS DRUG DISCOVERY
- Selective inhibition of Ph-positive ALL cell growth through kinase-dependent and independent effects by CDK6-specific PROTACs
- (2020) Marco De Dominici et al. BLOOD
- Proteolysis‐targeting chimeras in drug development: A safety perspective
- (2020) Kevin Moreau et al. BRITISH JOURNAL OF PHARMACOLOGY
- Development of a Brigatinib degrader (SIAIS117) as a potential treatment for ALK positive cancer resistance
- (2020) Ning Sun et al. EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
- Discovery of potent epidermal growth factor receptor (EGFR) degraders by proteolysis targeting chimera (PROTAC)
- (2020) Hao Zhang et al. EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
- Discovery of Potent and Selective Epidermal Growth Factor Receptor (EGFR) Bifunctional Small-Molecule Degraders
- (2020) Meng Cheng et al. JOURNAL OF MEDICINAL CHEMISTRY
- Optical Control of Small Molecule-Induced Protein Degradation
- (2020) Yuta Naro et al. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
- Light-induced control of protein destruction by opto-PROTAC
- (2020) Jing Liu et al. Science Advances
- PHOTACs enable optical control of protein degradation
- (2020) Martin Reynders et al. Science Advances
- Antibody–PROTAC Conjugates Enable HER2-Dependent Targeted Protein Degradation of BRD4
- (2020) Marı́a Maneiro et al. ACS Chemical Biology
- Development of CDK2 and CDK5 Dual Degrader TMX‐2172
- (2020) Nathanael Schiander Gray et al. ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
- Discovery of PROTAC BCL-XL degraders as potent anticancer agents with low on-target platelet toxicity
- (2020) Xuan Zhang et al. EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
- Design and synthesis of selective degraders of EGFRL858R/T790M mutant
- (2020) Xin Zhang et al. EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
- First-in-human phase I study of ARV-110, an androgen receptor (AR) PROTAC degrader in patients (pts) with metastatic castrate-resistant prostate cancer (mCRPC) following enzalutamide (ENZ) and/or abiraterone (ABI).
- (2020) Daniel Peter Petrylak et al. JOURNAL OF CLINICAL ONCOLOGY
- Discovery of Selective Small Molecule Degraders of BRAF-V600E
- (2020) Xiao-Ran Han et al. JOURNAL OF MEDICINAL CHEMISTRY
- Azo-PROTAC: Novel Light-Controlled Small-Molecule Tool for Protein Knockdown
- (2020) Yu-Hui Jin et al. JOURNAL OF MEDICINAL CHEMISTRY
- Degradation versus Inhibition: Development of Proteolysis-Targeting Chimeras for Overcoming Statin-Induced Compensatory Upregulation of 3-Hydroxy-3-methylglutaryl Coenzyme A Reductase
- (2020) Mei-Xin Li et al. JOURNAL OF MEDICINAL CHEMISTRY
- Discovery of SHP2-D26 as a First, Potent, and Effective PROTAC Degrader of SHP2 Protein
- (2020) Mingliang Wang et al. JOURNAL OF MEDICINAL CHEMISTRY
- Exploiting the folate receptor α in oncology
- (2020) Mariana Scaranti et al. Nature Reviews Clinical Oncology
- Crystal structure of the SALL4–pomalidomide–cereblon–DDB1 complex
- (2020) Mary E. Matyskiela et al. NATURE STRUCTURAL & MOLECULAR BIOLOGY
- Development of Selective Histone Deacetylase 6 (HDAC6) Degraders Recruiting Von Hippel–Lindau (VHL) E3 Ubiquitin Ligase
- (2020) Ka Yang et al. ACS Medicinal Chemistry Letters
- Using proteolysis-targeting chimera technology to reduce navitoclax platelet toxicity and improve its senolytic activity
- (2020) Yonghan He et al. Nature Communications
- FAK-targeting PROTAC as a chemical tool for the investigation of non-enzymatic FAK function in mice
- (2020) Hongying Gao et al. Protein & Cell
- Mutant‐Selective Allosteric EGFR Degraders are Effective Against a Broad Range of Drug‐Resistant Mutations
- (2020) Jaebong Jang et al. ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
- Targeted Degradation of Oncogenic KRASG12C by VHL-Recruiting PROTACs
- (2020) Michael J. Bond et al. ACS Central Science
- ARID2 is a pomalidomide-dependent CRL4CRBN substrate in multiple myeloma cells
- (2020) Junichi Yamamoto et al. Nature Chemical Biology
- PROTAC-mediated degradation reveals a non-catalytic function of AURORA-A kinase
- (2020) Bikash Adhikari et al. Nature Chemical Biology
- Discovery of ERD-308 as a Highly Potent Proteolysis Targeting Chimera (PROTAC) Degrader of Estrogen Receptor (ER)
- (2019) Jiantao Hu et al. JOURNAL OF MEDICINAL CHEMISTRY
- Discovery of ARD-69 as a Highly Potent Proteolysis Targeting Chimera (PROTAC) Degrader of Androgen Receptor (AR) for the Treatment of Prostate Cancer
- (2019) Xin Han et al. JOURNAL OF MEDICINAL CHEMISTRY
- Differential PROTAC substrate specificity dictated by orientation of recruited E3 ligase
- (2019) Blake E. Smith et al. Nature Communications
- Developing potent PROTACs tools for selective degradation of HDAC6 protein
- (2019) Zixuan An et al. Protein & Cell
- Degradation of Bruton’s tyrosine kinase mutants by PROTACs for potential treatment of ibrutinib-resistant non-Hodgkin lymphomas
- (2019) Yonghui Sun et al. LEUKEMIA
- Degrading proteins in animals: “PROTAC”tion goes in vivo
- (2019) Jianping Guo et al. CELL RESEARCH
- Selective Degradation of CDK6 by a Palbociclib Based PROTAC
- (2019) Sandeep Rana et al. BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
- Development of Dual and Selective Degraders of Cyclin-Dependent Kinases 4 and 6
- (2019) Baishan Jiang et al. ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
- PROTAC-Mediated Degradation of Bruton’s Tyrosine Kinase Is Inhibited by Covalent Binding
- (2019) Christopher P. Tinworth et al. ACS Chemical Biology
- Targeting Nuclear Receptors with PROTAC degraders
- (2019) John J. Flanagan et al. MOLECULAR AND CELLULAR ENDOCRINOLOGY
- Identification of New Small-Molecule Inducers of Estrogen-related Receptor α (ERRα) Degradation
- (2019) Lijie Peng et al. ACS Medicinal Chemistry Letters
- Phage display screening of therapeutic peptide for cancer targeting and therapy
- (2019) Phei Er Saw et al. Protein & Cell
- Pomalidomide hybrids act as proteolysis targeting chimeras: Synthesis, anticancer activity and B-Raf degradation
- (2019) Hong Chen et al. BIOORGANIC CHEMISTRY
- Targeting BCR-ABL1 in Chronic Myeloid Leukemia by PROTAC-mediated Targeted Protein Degradation
- (2019) George M Burslem et al. CANCER RESEARCH
- Targeted protein degradation: elements of PROTAC design
- (2019) Stacey-Lynn Paiva et al. CURRENT OPINION IN CHEMICAL BIOLOGY
- Development of Multifunctional Histone Deacetylase 6 Degraders with Potent Antimyeloma Activity
- (2019) Hao Wu et al. JOURNAL OF MEDICINAL CHEMISTRY
- BAF complex vulnerabilities in cancer demonstrated via structure-based PROTAC design
- (2019) William Farnaby et al. Nature Chemical Biology
- Targeting IRAK4 for Degradation with PROTACs
- (2019) Joao Nunes et al. ACS Medicinal Chemistry Letters
- Design and Characterization of SGK3-PROTAC1, an Isoform Specific SGK3 Kinase PROTAC Degrader
- (2019) Hannah Tovell et al. ACS Chemical Biology
- Development of photolabile protecting groups and their application to the optochemical control of cell signaling
- (2019) Anirban Bardhan et al. CURRENT OPINION IN STRUCTURAL BIOLOGY
- Potent and Preferential Degradation of CDK6 via Proteolysis Targeting Chimera Degraders
- (2019) Shang Su et al. JOURNAL OF MEDICINAL CHEMISTRY
- Proteolysis Targeting Chimeras for the Selective Degradation of Mcl-1/Bcl-2 Derived from Nonselective Target Binding Ligands
- (2019) Ziqian Wang et al. JOURNAL OF MEDICINAL CHEMISTRY
- PROTAC-Mediated Degradation of Estrogen Receptor in the Treatment of Cancer
- (2019) Robert B. Kargbo ACS Medicinal Chemistry Letters
- Reversible Spatiotemporal Control of Induced Protein Degradation by Bistable PhotoPROTACs
- (2019) Patrick Pfaff et al. ACS Central Science
- A Potent and Selective Small-Molecule Degrader of STAT3 Achieves Complete Tumor Regression In Vivo
- (2019) Longchuan Bai et al. CANCER CELL
- Antibody Conjugation of a Chimeric BET Degrader Enables in vivo Activity
- (2019) Thomas H. Pillow et al. ChemMedChem
- Discovery of SIAIS178 as an Effective BCR-ABL Degrader by Recruiting Von Hippel–Lindau (VHL) E3 Ubiquitin Ligase
- (2019) Quanju Zhao et al. JOURNAL OF MEDICINAL CHEMISTRY
- Discovery of a First-in-Class Mitogen-Activated Protein Kinase Kinase 1/2 Degrader
- (2019) Jieli Wei et al. JOURNAL OF MEDICINAL CHEMISTRY
- Light-Induced Protein Degradation with Photocaged PROTACs
- (2019) Gang Xue et al. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
- p63 is a cereblon substrate involved in thalidomide teratogenicity
- (2019) Tomoko Asatsuma-Okumura et al. Nature Chemical Biology
- Uncoupling of PARP1 trapping and inhibition using selective PARP1 degradation
- (2019) Shuai Wang et al. Nature Chemical Biology
- Targeted protein degradation: expanding the toolbox
- (2019) Matthieu Schapira et al. NATURE REVIEWS DRUG DISCOVERY
- ELM—the eukaryotic linear motif resource in 2020
- (2019) Manjeet Kumar et al. NUCLEIC ACIDS RESEARCH
- Cellular quality control by the ubiquitin-proteasome system and autophagy
- (2019) Christian Pohl et al. SCIENCE
- A novel strategy to block mitotic progression for targeted therapy
- (2019) Junlong (Jack) Chi et al. EBioMedicine
- Antibody-mediated delivery of chimeric protein degraders which target estrogen receptor alpha (ERα)
- (2019) Peter S. Dragovich et al. BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
- Development of selective mono or dual PROTAC degrader probe of CDK isoforms
- (2019) Fei Zhou et al. EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
- Design, Synthesis, and Biological Evaluation of MEK PROTACs
- (2019) Stefan Vollmer et al. JOURNAL OF MEDICINAL CHEMISTRY
- Structure-Based Discovery of SD-36 as a Potent, Selective, and Efficacious PROTAC Degrader of STAT3 Protein
- (2019) Haibin Zhou et al. JOURNAL OF MEDICINAL CHEMISTRY
- A selective BCL-XL PROTAC degrader achieves safe and potent antitumor activity
- (2019) Sajid Khan et al. NATURE MEDICINE
- Development of the first small molecule histone deacetylase 6 (HDAC6) degraders
- (2018) Ka Yang et al. BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
- PROTAC-induced BTK degradation as a novel therapy for mutated BTK C481S induced ibrutinib-resistant B-cell malignancies
- (2018) Yonghui Sun et al. CELL RESEARCH
- Proteolysis Targeting Chimeras (PROTACs) of Anaplastic Lymphoma Kinase (ALK)
- (2018) Chengwei Zhang et al. EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
- Phthalimide conjugations for the degradation of oncogenic PI3K
- (2018) Wenlu Li et al. EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
- Chemically Induced Degradation of Anaplastic Lymphoma Kinase (ALK)
- (2018) Chelsea E. Powell et al. JOURNAL OF MEDICINAL CHEMISTRY
- 3-Fluoro-4-hydroxyprolines: Synthesis, Conformational Analysis, and Stereoselective Recognition by the VHL E3 Ubiquitin Ligase for Targeted Protein Degradation
- (2018) Andrea Testa et al. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
- Functional TRIM24 degrader via conjugation of ineffectual bromodomain and VHL ligands
- (2018) Lara N. Gechijian et al. Nature Chemical Biology
- Rapid Aqueous Photouncaging by Red Light
- (2018) Xiaodi Wang et al. ORGANIC LETTERS
- Delineating the role of cooperativity in the design of potent PROTACs for BTK
- (2018) Adelajda Zorba et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Modulating PCAF/GCN5 Immune Cell Function through a PROTAC Approach
- (2018) Zuni I. Bassi et al. ACS Chemical Biology
- Induced protein degradation of anaplastic lymphoma kinase (ALK) by proteolysis targeting chimera (PROTAC)
- (2018) Chung Hyo Kang et al. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
- Discovery of Wogonin-based PROTACs against CDK9 and capable of achieving antitumor activity
- (2018) Jinlei Bian et al. BIOORGANIC CHEMISTRY
- Thalidomide promotes degradation of SALL4, a transcription factor implicated in Duane Radial Ray syndrome
- (2018) Katherine A Donovan et al. eLife
- Development of a Novel B-Cell Lymphoma 6 (BCL6) PROTAC To Provide Insight into Small Molecule Targeting of BCL6
- (2018) William McCoull et al. ACS Chemical Biology
- MDM2-Recruiting PROTAC Offers Superior, Synergistic Antiproliferative Activity via Simultaneous Degradation of BRD4 and Stabilization of p53
- (2018) John Hines et al. CANCER RESEARCH
- Iterative Design and Optimization of Initially Inactive Proteolysis Targeting Chimeras (PROTACs) Identify VZ185 as a Potent, Fast, and Selective von Hippel–Lindau (VHL) Based Dual Degrader Probe of BRD9 and BRD7
- (2018) Vittoria Zoppi et al. JOURNAL OF MEDICINAL CHEMISTRY
- Targeted Degradation of MDM2 as a New Approach to Improve the Efficacy of MDM2-p53 Inhibitors
- (2018) Ryan P. Wurz et al. JOURNAL OF MEDICINAL CHEMISTRY
- Discovery of MD-224 as a First-in-Class, Highly Potent, and Efficacious Proteolysis Targeting Chimera Murine Double Minute 2 Degrader Capable of Achieving Complete and Durable Tumor Regression
- (2018) Yangbing Li et al. JOURNAL OF MEDICINAL CHEMISTRY
- Addressing Kinase-Independent Functions of Fak via PROTAC-Mediated Degradation
- (2018) Philipp M. Cromm et al. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
- Near IR Photochemistry for Biology: Exploiting the Optical Window of Tissue
- (2018) Alexander Alabugin PHOTOCHEMISTRY AND PHOTOBIOLOGY
- Defining the human C2H2 zinc finger degrome targeted by thalidomide analogs through CRBN
- (2018) Quinlan L. Sievers et al. SCIENCE
- Different Degradation Mechanisms of Inhibitor of Apoptosis Proteins (IAPs) by the Specific and Nongenetic IAP-Dependent Protein Eraser (SNIPER)
- (2018) Nobumichi Ohoka et al. CHEMICAL & PHARMACEUTICAL BULLETIN
- In VivoKnockdown of Pathogenic Proteins via Specific and Nongenetic Inhibitor of Apoptosis Protein (IAP)-dependent Protein Erasers (SNIPERs)
- (2017) Nobumichi Ohoka et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Development of Protein Degradation Inducers of Androgen Receptor by Conjugation of Androgen Receptor Ligands and Inhibitor of Apoptosis Protein Ligands
- (2017) Norihito Shibata et al. JOURNAL OF MEDICINAL CHEMISTRY
- Protac-Induced Protein Degradation in Drug Discovery: Breaking the Rules or Just Making New Ones?
- (2017) Ian Churcher JOURNAL OF MEDICINAL CHEMISTRY
- Chemically Induced Degradation of Sirtuin 2 (Sirt2) by a Proteolysis Targeting Chimera (PROTAC) Based on Sirtuin Rearranging Ligands (SirReals)
- (2017) Matthias Schiedel et al. JOURNAL OF MEDICINAL CHEMISTRY
- Discovery of a Small-Molecule Degrader of Bromodomain and Extra-Terminal (BET) Proteins with Picomolar Cellular Potencies and Capable of Achieving Tumor Regression
- (2017) Bing Zhou et al. JOURNAL OF MEDICINAL CHEMISTRY
- BET protein proteolysis targeting chimera (PROTAC) exerts potent lethal activity against mantle cell lymphoma cells
- (2017) B Sun et al. LEUKEMIA
- BET Bromodomain Proteins Function as Master Transcription Elongation Factors Independent of CDK9 Recruitment
- (2017) Georg E. Winter et al. MOLECULAR CELL
- Targeted protein degradation by PROTACs
- (2017) Taavi K. Neklesa et al. PHARMACOLOGY & THERAPEUTICS
- Degrons in cancer
- (2017) Bálint Mészáros et al. Science Signaling
- Targeting the Allosteric Site of Oncoprotein BCR-ABL as an Alternative Strategy for Effective Target Protein Degradation
- (2017) Kenichiro Shimokawa et al. ACS Medicinal Chemistry Letters
- Degrons in cancer
- (2017) Bálint Mészáros et al. Science Signaling
- New strategy for renal fibrosis: Targeting Smad3 proteins for ubiquitination and degradation
- (2016) Xin Wang et al. BIOCHEMICAL PHARMACOLOGY
- Development of BCR-ABL degradation inducers via the conjugation of an imatinib derivative and a cIAP1 ligand
- (2016) Yosuke Demizu et al. BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
- Photocontrol of NO, H2S, and HNO Release in Biological Systems by Using Specific Caged Compounds
- (2016) Hidehiko Nakagawa CHEMICAL & PHARMACEUTICAL BULLETIN
- LCL161 increases paclitaxel-induced apoptosis by degrading cIAP1 and cIAP2 in NSCLC
- (2016) Chengcheng Yang et al. JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH
- Targeted Degradation of Proteins Localized in Subcellular Compartments by Hybrid Small Molecules
- (2016) Keiichiro Okuhira et al. MOLECULAR PHARMACOLOGY
- A novel cereblon modulator recruits GSPT1 to the CRL4CRBN ubiquitin ligase
- (2016) Mary E. Matyskiela et al. NATURE
- Structural basis of lenalidomide-induced CK1α degradation by the CRL4CRBN ubiquitin ligase
- (2016) Georg Petzold et al. NATURE
- PROTAC-induced BET protein degradation as a therapy for castration-resistant prostate cancer
- (2016) Kanak Raina et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Selective Small Molecule Induced Degradation of the BET Bromodomain Protein BRD4
- (2015) Michael Zengerle et al. ACS Chemical Biology
- Modular PROTAC Design for the Degradation of Oncogenic BCR-ABL
- (2015) Ashton C. Lai et al. ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
- Hijacking the E3 Ubiquitin Ligase Cereblon to Efficiently Target BRD4
- (2015) Jing Lu et al. CHEMISTRY & BIOLOGY
- Lenalidomide induces ubiquitination and degradation of CK1α in del(5q) MDS
- (2015) Jan Krönke et al. NATURE
- Phthalimide conjugation as a strategy for in vivo target protein degradation
- (2015) G. E. Winter et al. SCIENCE
- Structure-Guided Design and Optimization of Small Molecules Targeting the Protein–Protein Interaction between the von Hippel–Lindau (VHL) E3 Ubiquitin Ligase and the Hypoxia Inducible Factor (HIF) Alpha Subunit with in Vitro Nanomolar Affinities
- (2014) Carles Galdeano et al. JOURNAL OF MEDICINAL CHEMISTRY
- Structure of the DDB1–CRBN E3 ubiquitin ligase in complex with thalidomide
- (2014) Eric S. Fischer et al. NATURE
- Cancer cell death induced by novel small molecules degrading the TACC3 protein via the ubiquitin–proteasome pathway
- (2014) N Ohoka et al. Cell Death & Disease
- Inducible In Vivo Silencing of Brd4 Identifies Potential Toxicities of Sustained BET Protein Inhibition
- (2014) Jessica E. Bolden et al. Cell Reports
- Development of hybrid small molecules that induce degradation of estrogen receptor-alpha and necrotic cell death in breast cancer cells
- (2013) Keiichiro Okuhira et al. CANCER SCIENCE
- Genetically engineered mouse models for functional studies of SKP1-CUL1-F-box-protein (SCF) E3 ubiquitin ligases
- (2013) Weihua Zhou et al. CELL RESEARCH
- Posttranslational protein knockdown coupled to receptor tyrosine kinase activation with phosphoPROTACs
- (2013) J. Hines et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Lenalidomide Causes Selective Degradation of IKZF1 and IKZF3 in Multiple Myeloma Cells
- (2013) J. Kronke et al. SCIENCE
- The Myeloma Drug Lenalidomide Promotes the Cereblon-Dependent Destruction of Ikaros Proteins
- (2013) G. Lu et al. SCIENCE
- Small-Molecule Inhibitors of the Interaction between the E3 Ligase VHL and HIF1α
- (2012) Dennis L. Buckley et al. ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
- The Ubiquitin Code
- (2012) David Komander et al. Annual Review of Biochemistry
- Photoremovable Protecting Groups in Chemistry and Biology: Reaction Mechanisms and Efficacy
- (2012) Petr Klán et al. CHEMICAL REVIEWS
- Targeting the von Hippel–Lindau E3 Ubiquitin Ligase Using Small Molecules To Disrupt the VHL/HIF-1α Interaction
- (2012) Dennis L. Buckley et al. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
- Photodynamic therapy of cancer: An update
- (2011) Patrizia Agostinis et al. CA-A CANCER JOURNAL FOR CLINICIANS
- Oxidatively Generated Damage to DNA by UVA Radiation in Cells and Human Skin
- (2011) Jean Cadet et al. JOURNAL OF INVESTIGATIVE DERMATOLOGY
- Protacs for Treatment of Cancer
- (2010) Kathleen M Sakamoto PEDIATRIC RESEARCH
- Identification of a Primary Target of Thalidomide Teratogenicity
- (2010) T. Ito et al. SCIENCE
- Photodynamic therapy for prostate cancer—a review of current status and future promise
- (2009) Caroline M Moore et al. Nature clinical practice. Urology
- Targeted intracellular protein degradation induced by a small molecule: En route to chemical proteomics
- (2008) Ashley R. Schneekloth et al. BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
- Demonstration of direct binding of cIAP1 degradation-promoting bestatin analogs to BIR3 domain: Synthesis and application of fluorescent bestatin ester analogs
- (2008) Shinichi Sato et al. BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
- The HECT Family of E3 Ubiquitin Ligases: Multiple Players in Cancer Development
- (2008) Francesca Bernassola et al. CANCER CELL
- Small Molecules Destabilize cIAP1 by Activating Auto-ubiquitylation
- (2008) Keiko Sekine et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Targeting steroid hormone receptors for ubiquitination and degradation in breast and prostate cancer
- (2008) A Rodriguez-Gonzalez et al. ONCOGENE
Discover Peeref hubs
Discuss science. Find collaborators. Network.
Join a conversationAsk a Question. Answer a Question.
Quickly pose questions to the entire community. Debate answers and get clarity on the most important issues facing researchers.
Get Started