Degrading proteins in animals: PROTACtion goes in vivo

In a recent paper published in Cell Discovery, Sun et al. report a novel chemical approach to rapidly and reversibly deplete endogenous proteins globally in both small and large animals via the PROTAC (PROteolysis TArgeting Chimera) approach. This strategy not only provides a powerful tool for protein function studies in vivo, but also highlights the potential of using PROTAC in future human cancer therapies.