标题
BECLIN1: Protein Structure, Function and Regulation
作者
关键词
-
出版物
Cells
Volume 10, Issue 6, Pages 1522
出版商
MDPI AG
发表日期
2021-06-17
DOI
10.3390/cells10061522
参考文献
相关参考文献
注意:仅列出部分参考文献,下载原文获取全部文献信息。- Co-Chaperone Bag-1 Plays a Role in the Autophagy-Dependent Cell Survival through Beclin 1 Interaction
- (2021) Miray Turk et al. MOLECULES
- CUL3 (cullin 3)-mediated ubiquitination and degradation of BECN1 (beclin 1) inhibit autophagy and promote tumor progression
- (2021) Xuan Li et al. Autophagy
- Emerging roles of ATG proteins and membrane lipids in autophagosome formation
- (2020) Taki Nishimura et al. Cell Discovery
- Structural insights into BCL2 pro-survival protein interactions with the key autophagy regulator BECN1 following phosphorylation by STK4/MST1
- (2019) Erinna F. Lee et al. Autophagy
- Intestinal Epithelial Tight Junction Barrier regulation by Autophagy related protein ATG6/beclin 1
- (2019) Morgan Wong et al. AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY
- Calpain-dependent Beclin1 cleavage stimulates senescence-associated cell death in HT22 hippocampal cells under the oxidative stress conditions
- (2019) Huynh Quoc Nguyen et al. NEUROSCIENCE LETTERS
- Phosphorylation of Beclin-1 by BCR-ABL suppresses autophagy in chronic myeloid leukemia
- (2019) Chuanjiang Yu et al. HAEMATOLOGICA
- Targeting Autophagy in Cancer: Recent Advances and Future Directions
- (2019) Ravi K. Amaravadi et al. Cancer Discovery
- Structural pathway for allosteric activation of the autophagic PI 3-kinase complex I
- (2019) Lindsey N. Young et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Autophagy in cancer: moving from understanding mechanism to improving therapy responses in patients
- (2019) Jean M. Mulcahy Levy et al. CELL DEATH AND DIFFERENTIATION
- SKP2 attenuates autophagy through Beclin1-ubiquitination and its inhibition reduces MERS-Coronavirus infection
- (2019) Nils C. Gassen et al. Nature Communications
- ULK1 phosphorylates Ser30 of BECN1 in association with ATG14 to stimulate autophagy induction
- (2018) Ji-Man Park et al. Autophagy
- TRIM50 regulates Beclin 1 proautophagic activity
- (2018) Carmela Fusco et al. BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH
- Non-canonical activation of DAPK2 by AMPK constitutes a new pathway linking metabolic stress to autophagy
- (2018) Ruth Shiloh et al. Nature Communications
- AMPK-Mediated BECN1 Phosphorylation Promotes Ferroptosis by Directly Blocking System Xc– Activity
- (2018) Xinxin Song et al. CURRENT BIOLOGY
- Disruption of the beclin 1–BCL2 autophagy regulatory complex promotes longevity in mice
- (2018) Álvaro F. Fernández et al. NATURE
- The Roles of Autophagy in Cancer
- (2018) Chul Yun et al. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
- Bidirectional Control of Autophagy by BECN1 BARA Domain Dynamics
- (2018) Chunmei Chang et al. MOLECULAR CELL
- Proteolytic cleavage of Beclin 1 exacerbates neurodegeneration
- (2018) Gregor Bieri et al. Molecular Neurodegeneration
- Regulation of the Tumor-Suppressor BECLIN 1 by Distinct Ubiquitination Cascades
- (2017) Fahd Boutouja et al. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
- Vps34 Kinase Domain Dynamics Regulate the Autophagic PI 3-Kinase Complex
- (2017) Goran Stjepanovic et al. MOLECULAR CELL
- Phosphoglycerate Kinase 1 Phosphorylates Beclin1 to Induce Autophagy
- (2017) Xu Qian et al. MOLECULAR CELL
- Polyglutamine tracts regulate beclin 1-dependent autophagy
- (2017) Avraham Ashkenazi et al. NATURE
- CaMKII-mediated Beclin 1 phosphorylation regulates autophagy that promotes degradation of Id and neuroblastoma cell differentiation
- (2017) Xuan Li et al. Nature Communications
- Identification of novel small molecule Beclin 1 mimetics activating autophagy
- (2017) Jia Yu et al. Oncotarget
- A Becn1 mutation mediates hyperactive autophagic sequestration of amyloid oligomers and improved cognition in Alzheimer's disease
- (2017) Altea Rocchi et al. PLoS Genetics
- BAX-BAK1-independent LC3B lipidation by BH3 mimetics is unrelated to BH3 mimetic activity and has only minimal effects on autophagic flux
- (2016) Boris Reljic et al. Autophagy
- The BECN1 N-terminal domain is intrinsically disordered
- (2016) Erinna F. Lee et al. Autophagy
- AMPK regulates autophagy by phosphorylating BECN1 at threonine 388
- (2016) Deyi Zhang et al. Autophagy
- Characterization of Atg38 and NRBF2, a fifth subunit of the autophagic Vps34/PIK3C3 complex
- (2016) Yohei Ohashi et al. Autophagy
- Conformational Flexibility Enables the Function of a BECN1 Region Essential for Starvation-Mediated Autophagy
- (2016) Yang Mei et al. BIOCHEMISTRY
- Characterisation of the conformational preference and dynamics of the intrinsically disordered N-terminal region of Beclin 1 by NMR spectroscopy
- (2016) Shenggen Yao et al. BIOCHIMICA ET BIOPHYSICA ACTA-PROTEINS AND PROTEOMICS
- USP19 modulates autophagy and antiviral immune responses by deubiquitinating Beclin‐1
- (2016) Shouheng Jin et al. EMBO JOURNAL
- USP14 regulates autophagy by suppressing K63 ubiquitination of Beclin 1
- (2016) Daichao Xu et al. GENES & DEVELOPMENT
- Regulation of Beclin 1 Protein Phosphorylation and Autophagy by Protein Phosphatase 2A (PP2A) and Death-associated Protein Kinase 3 (DAPK3)
- (2016) Nobuyuki Fujiwara et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Focal Adhesion Kinase-mediated Phosphorylation of Beclin1 Protein Suppresses Cardiomyocyte Autophagy and Initiates Hypertrophic Growth
- (2016) Zhaokang Cheng et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Dynamics and architecture of the NRBF2-containing phosphatidylinositol 3-kinase complex I of autophagy
- (2016) Lindsey N. Young et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- RNF216 contributes to proliferation and migration of colorectal cancer via suppressing BECN1-dependent autophagy
- (2016) Hui Wang et al. Oncotarget
- mTOR activates the VPS34-UVRAG complex to regulate autolysosomal tubulation and cell survival
- (2015) M. J. Munson et al. EMBO JOURNAL
- ATG14 promotes membrane tethering and fusion of autophagosomes to endolysosomes
- (2015) Jiajie Diao et al. NATURE
- Structure and flexibility of the endosomal Vps34 complex reveals the basis of its function on membranes
- (2015) K. Rostislavleva et al. SCIENCE
- Beclin orthologs: integrative hubs of cell signaling, membrane trafficking, and physiology
- (2015) Beth Levine et al. TRENDS IN CELL BIOLOGY
- The stress-responsive kinases MAPKAPK2/MAPKAPK3 activate starvation-induced autophagy through Beclin 1 phosphorylation
- (2015) Yongjie Wei et al. eLife
- Regulation of autophagy by E3 ubiquitin ligase RNF216 through BECN1 ubiquitination
- (2014) Congfeng Xu et al. Autophagy
- NRBF2 regulates macroautophagy as a component of Vps34 Complex I
- (2014) Yanyan Cao et al. BIOCHEMICAL JOURNAL
- Nrbf2 Protein Suppresses Autophagy by Modulating Atg14L Protein-containing Beclin 1-Vps34 Complex Architecture and Reducing Intracellular Phosphatidylinositol-3 Phosphate Levels
- (2014) Yu Zhong et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Mutational Landscape of the Essential Autophagy Gene BECN1 in Human Cancers
- (2014) Saurabh V. Laddha et al. MOLECULAR CANCER RESEARCH
- NRBF2 regulates autophagy and prevents liver injury by modulating Atg14L-linked phosphatidylinositol-3 kinase III activity
- (2014) Jiahong Lu et al. Nature Communications
- Beclin 1 Is Required for Neuron Viability and Regulates Endosome Pathways via the UVRAG-VPS34 Complex
- (2014) Nicole C. McKnight et al. PLoS Genetics
- Atg6/UVRAG/Vps34-Containing Lipid Kinase Complex Is Required for Receptor Downregulation through Endolysosomal Degradation and Epithelial Polarity duringDrosophilaWing Development
- (2014) Péter Lőrincz et al. Biomed Research International
- Architecture and dynamics of the autophagic phosphatidylinositol 3-kinase complex
- (2014) Sulochanadevi Baskaran et al. eLife
- Temporal analysis of recruitment of mammalian ATG proteins to the autophagosome formation site
- (2013) Ikuko Koyama-Honda et al. Autophagy
- EGFR-Mediated Beclin 1 Phosphorylation in Autophagy Suppression, Tumor Progression, and Tumor Chemoresistance
- (2013) Yongjie Wei et al. CELL
- Differential Regulation of Distinct Vps34 Complexes by AMPK in Nutrient Stress and Autophagy
- (2013) Joungmok Kim et al. CELL
- Atg6 is required for multiple vesicle trafficking pathways and hematopoiesis in Drosophila
- (2013) B. V. Shravage et al. DEVELOPMENT
- WASH inhibits autophagy through suppression of Beclin 1 ubiquitination
- (2013) Pengyan Xia et al. EMBO JOURNAL
- Interaction between Her2 and Beclin-1 Proteins Underlies a New Mechanism of Reciprocal Regulation
- (2013) Jie Han et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Role of Membrane Association and Atg14-Dependent Phosphorylation in Beclin-1-Mediated Autophagy
- (2013) A. I. Fogel et al. MOLECULAR AND CELLULAR BIOLOGY
- Autophagosomes form at ER–mitochondria contact sites
- (2013) Maho Hamasaki et al. NATURE
- Identification of a candidate therapeutic autophagy-inducing peptide
- (2013) Sanae Shoji-Kawata et al. NATURE
- ULK1 induces autophagy by phosphorylating Beclin-1 and activating VPS34 lipid kinase
- (2013) Ryan C. Russell et al. NATURE CELL BIOLOGY
- Mst1 inhibits autophagy by promoting the interaction between Beclin1 and Bcl-2
- (2013) Yasuhiro Maejima et al. NATURE MEDICINE
- Identification of ROCK1 kinase as a critical regulator of Beclin1-mediated autophagy during metabolic stress
- (2013) Aditi U. Gurkar et al. Nature Communications
- The VMP1-Beclin 1 interaction regulates autophagy induction
- (2013) Maria I. Molejon et al. Scientific Reports
- The anti-apoptotic Bcl-B protein inhibits BECN1-dependent autophagic cell death
- (2012) Guillaume Robert et al. Autophagy
- Crystal structure and biochemical analyses reveal Beclin 1 as a novel membrane binding protein
- (2012) Weijiao Huang et al. CELL RESEARCH
- Structure of the Novel C-terminal Domain of Vacuolar Protein Sorting 30/Autophagy-related Protein 6 and Its Specific Role in Autophagy
- (2012) Nobuo N. Noda et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Beclin-1-interacting autophagy protein Atg14L targets the SNARE-associated protein Snapin to coordinate endocytic trafficking
- (2012) H. J. Kim et al. JOURNAL OF CELL SCIENCE
- Akt-Mediated Regulation of Autophagy and Tumorigenesis Through Beclin 1 Phosphorylation
- (2012) R. C. Wang et al. SCIENCE
- Imperfect interface of Beclin1 coiled-coil domain regulates homodimer and heterodimer formation with Atg14L and UVRAG
- (2012) Xiaohua Li et al. Nature Communications
- Regulation of the Autophagic Bcl-2/Beclin 1 Interaction
- (2012) Jean-Paul Decuypere et al. Cells
- Reticulon 3 attenuates the clearance of cytosolic prion aggregates via inhibiting autophagy
- (2011) Rui Chen et al. Autophagy
- The Atg6/Vps30/Beclin 1 ortholog BEC-1 mediates endocytic retrograde transport in addition to autophagy inC. elegans
- (2011) Alexander Ruck et al. Autophagy
- Nedd4-dependent lysine-11-linked polyubiquitination of the tumour suppressor Beclin 1
- (2011) Harald W. Platta et al. BIOCHEMICAL JOURNAL
- Following Cytochrome c Release, Autophagy Is Inhibited during Chemotherapy-Induced Apoptosis by Caspase 8-Mediated Cleavage of Beclin 1
- (2011) H. Li et al. CANCER RESEARCH
- Beclin1 Controls the Levels of p53 by Regulating the Deubiquitination Activity of USP10 and USP13
- (2011) Junli Liu et al. CELL
- Mitochondrial BCL-2 inhibits AMBRA1-induced autophagy
- (2011) Flavie Strappazzon et al. EMBO JOURNAL
- Autophagosome targeting and membrane curvature sensing by Barkor/Atg14(L)
- (2011) W. Fan et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Beclin-1 Targeting for Viral Immune Escape
- (2011) Christian Münz Viruses-Basel
- A phosphatidylinositol 3-kinase class III sub-complex containing VPS15, VPS34, Beclin 1, UVRAG and BIF-1 regulates cytokinesis and degradative endocytic traffic
- (2010) Sigrid B. Thoresen et al. EXPERIMENTAL CELL RESEARCH
- The RUN Domain of Rubicon Is Important for hVps34 Binding, Lipid Kinase Inhibition, and Autophagy Suppression
- (2010) Qiming Sun et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- The dynamic interaction of AMBRA1 with the dynein motor complex regulates mammalian autophagy
- (2010) Sabrina Di Bartolomeo et al. JOURNAL OF CELL BIOLOGY
- Endogenous HMGB1 regulates autophagy
- (2010) Daolin Tang et al. JOURNAL OF CELL BIOLOGY
- Beclin 1 self-association is independent of autophagy induction by amino acid deprivation and rapamycin treatment
- (2010) Shelly Adi-Harel et al. JOURNAL OF CELLULAR BIOCHEMISTRY
- Rubicon controls endosome maturation as a Rab7 effector
- (2010) Q. Sun et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- TRAF6 and A20 Regulate Lysine 63-Linked Ubiquitination of Beclin-1 to Control TLR4-Induced Autophagy
- (2010) C. S. Shi et al. Science Signaling
- Caspase-mediated cleavage of Beclin-1 inactivates Beclin-1-induced autophagy and enhances apoptosis by promoting the release of proapoptotic factors from mitochondria
- (2010) E Wirawan et al. Cell Death & Disease
- Beclin 1 cleavage by caspase-3 inactivates autophagy and promotes apoptosis
- (2010) Yushan Zhu et al. Protein & Cell
- High-Resolution Structural Characterization of a Helical α/β-Peptide Foldamer Bound to the Anti-Apoptotic Protein Bcl-xL
- (2009) Erinna F. Lee et al. ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
- Phosphorylation of Beclin 1 by DAP-kinase promotes autophagy by weakening its interactions with Bcl-2 and Bcl-XL
- (2009) Einat Zalckvar et al. Autophagy
- The inositol 1,4,5-trisphosphate receptor regulates autophagy through its interaction with Beclin 1
- (2009) J M Vicencio et al. CELL DEATH AND DIFFERENTIATION
- Apoptosis blocks Beclin 1-dependent autophagosome synthesis: an effect rescued by Bcl-xL
- (2009) S Luo et al. CELL DEATH AND DIFFERENTIATION
- Antagonism of Beclin 1-dependent autophagy by BCL-2 at the endoplasmic reticulum requires NAF-1
- (2009) Natasha C Chang et al. EMBO JOURNAL
- Distinct regulation of autophagic activity by Atg14L and Rubicon associated with Beclin 1–phosphatidylinositol-3-kinase complex
- (2009) Yun Zhong et al. NATURE CELL BIOLOGY
- Two Beclin 1-binding proteins, Atg14L and Rubicon, reciprocally regulate autophagy at different stages
- (2009) Kohichi Matsunaga et al. NATURE CELL BIOLOGY
- Bcl-2 complexed with Beclin-1 maintains full anti-apoptotic function
- (2009) I A Ciechomska et al. ONCOGENE
- Caspase-mediated cleavage of ATG6/Beclin-1 links apoptosis to autophagy in HeLa cells
- (2008) Dong-Hyung Cho et al. CANCER LETTERS
- ARF Induces Autophagy by Virtue of Interaction with Bcl-xl
- (2008) Julia Pimkina et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Bcl-xLand UVRAG Cause a Monomer-Dimer Switch in Beclin1
- (2008) Christian G. Noble et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- The autophagy-related protein beclin 1 shows reduced expression in early Alzheimer disease and regulates amyloid β accumulation in mice
- (2008) Fiona Pickford et al. JOURNAL OF CLINICAL INVESTIGATION
- Beclin 1 Forms Two Distinct Phosphatidylinositol 3-Kinase Complexes with Mammalian Atg14 and UVRAG
- (2008) Eisuke Itakura et al. MOLECULAR BIOLOGY OF THE CELL
- JNK1-Mediated Phosphorylation of Bcl-2 Regulates Starvation-Induced Autophagy
- (2008) Yongjie Wei et al. MOLECULAR CELL
- Beclin1-binding UVRAG targets the class C Vps complex to coordinate autophagosome maturation and endocytic trafficking
- (2008) Chengyu Liang et al. NATURE CELL BIOLOGY
- Identification of Barkor as a mammalian autophagy-specific factor for Beclin 1 and class III phosphatidylinositol 3-kinase
- (2008) Q. Sun et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
Publish scientific posters with Peeref
Peeref publishes scientific posters from all research disciplines. Our Diamond Open Access policy means free access to content and no publication fees for authors.
Learn MoreFind the ideal target journal for your manuscript
Explore over 38,000 international journals covering a vast array of academic fields.
Search