Hot Spot Analysis of YAP-TEAD Protein-Protein Interaction Using the Fragment Molecular Orbital Method and Its Application for Inhibitor Discovery
出版年份 2021 全文链接
标题
Hot Spot Analysis of YAP-TEAD Protein-Protein Interaction Using the Fragment Molecular Orbital Method and Its Application for Inhibitor Discovery
作者
关键词
-
出版物
Cancers
Volume 13, Issue 16, Pages 4246
出版商
MDPI AG
发表日期
2021-08-24
DOI
10.3390/cancers13164246
参考文献
相关参考文献
注意:仅列出部分参考文献,下载原文获取全部文献信息。- YAP/TAZ inhibition reduces metastatic potential of Ewing sarcoma cells
- (2021) Lisa Bierbaumer et al. Oncogenesis
- An Early Association between the α-Helix of the TEAD Binding Domain of YAP and TEAD Drives the Formation of the YAP:TEAD Complex
- (2020) Fedir Bokhovchuk et al. BIOCHEMISTRY
- Characterization of PD-L1 binding sites by a combined FMO/GRID-DRY approach
- (2020) Roberto Paciotti et al. JOURNAL OF COMPUTER-AIDED MOLECULAR DESIGN
- Targeting the Hippo pathway in cancer, fibrosis, wound healing and regenerative medicine
- (2020) Anwesha Dey et al. NATURE REVIEWS DRUG DISCOVERY
- Machine learning prediction of inter-fragment interaction energies between ligand and amino-acid residues on the fragment molecular orbital calculations for Janus kinase – inhibitor complex
- (2020) Shusuke Tokutomi et al. CHEMICAL PHYSICS LETTERS
- A novel method for analysis of the electrostatic complementarity of protein-protein interaction based on fragment molecular orbital method
- (2020) Takeshi Ishikawa CHEMICAL PHYSICS LETTERS
- Hot spot profiles of SARS-CoV-2 and human ACE2 receptor protein protein interaction obtained by density functional tight binding fragment molecular orbital method
- (2020) Hocheol Lim et al. Scientific Reports
- The Role of Photoactivated and Non-Photoactivated Verteporfin on Tumor
- (2020) Changran Wei et al. Frontiers in Pharmacology
- Protein-Protein Interaction Disruptors of the YAP/TAZ-TEAD Transcriptional Complex
- (2020) Ajaybabu V. Pobbati et al. MOLECULES
- DYSREGULATION OF THE HIPPO PATHWAY SIGNALING IN AGING AND CANCER
- (2019) Yiu To Yeung et al. PHARMACOLOGICAL RESEARCH
- Structure-based design of potent linear peptide inhibitors of the YAP-TEAD protein-protein interaction derived from the YAP omega-loop sequence
- (2019) Pascal Furet et al. BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
- A gain-of-functional screen identifies the Hippo pathway as a central mediator of receptor tyrosine kinases during tumorigenesis
- (2019) Taha Azad et al. ONCOGENE
- Investigation of protein-protein interactions and hot spot region between PD-1 and PD-L1 by fragment molecular orbital method
- (2019) Hocheol Lim et al. Scientific Reports
- Regulation of the Hippo pathway in cancer biology
- (2018) Sungho Moon et al. CELLULAR AND MOLECULAR LIFE SCIENCES
- Toward the Discovery of a Novel Class of YAP–TEAD Interaction Inhibitors by Virtual Screening Approach Targeting YAP–TEAD Protein–Protein Interface
- (2018) Floriane Gibault et al. Cancers
- The Hippo Pathway: Immunity and Cancer
- (2018) Zaid Taha et al. Cancers
- Targeting the Hippo Pathway and Cancer through the TEAD Family of Transcription Factors
- (2018) et al. Cancers
- Adaptation of the bound intrinsically disordered protein YAP to mutations at the YAP:TEAD interface
- (2018) Yannick Mesrouze et al. PROTEIN SCIENCE
- Targeting the Hippo Pathway for Breast Cancer Therapy
- (2018) Liqing Wu et al. Cancers
- Targeting Transcriptional Enhanced Associate Domains (TEADs)
- (2017) Floriane Gibault et al. JOURNAL OF MEDICINAL CHEMISTRY
- In silico structure-based approaches to discover protein-protein interaction-targeting drugs
- (2017) Woong-Hee Shin et al. METHODS
- Targeting YAP/TAZ-TEAD protein-protein interactions using fragment-based and computational modeling approaches
- (2017) Hung Yi Kristal Kaan et al. PLoS One
- Mammalian display screening of diverse cystine-dense peptides for difficult to drug targets
- (2017) Zachary R. Crook et al. Nature Communications
- Dissection of the interaction between the intrinsically disordered YAP protein and the transcription factor TEAD
- (2017) Yannick Mesrouze et al. eLife
- The roles of the Hippo pathway in cancer metastasis
- (2016) Helena J. Janse van Rensburg et al. CELLULAR SIGNALLING
- Mechanisms of Hippo pathway regulation
- (2016) Zhipeng Meng et al. GENES & DEVELOPMENT
- The fragment molecular orbital method combined with density-functional tight-binding and the polarizable continuum model
- (2016) Yoshio Nishimoto et al. PHYSICAL CHEMISTRY CHEMICAL PHYSICS
- Third-order density-functional tight-binding combined with the fragment molecular orbital method
- (2015) Yoshio Nishimoto et al. CHEMICAL PHYSICS LETTERS
- State-of-the-art strategies for targeting protein–protein interactions by small-molecule inhibitors
- (2015) Chunquan Sheng et al. CHEMICAL SOCIETY REVIEWS
- Targeting the Hippo Pathway for Anti-cancer Therapies
- (2015) Rui Gong et al. CURRENT MEDICINAL CHEMISTRY
- Targeting Hippo pathway by specific interruption of YAP-TEAD interaction using cyclic YAP-like peptides
- (2015) Zheng Zhou et al. FASEB JOURNAL
- The Fragment Molecular Orbital Method Reveals New Insight into the Chemical Nature of GPCR–Ligand Interactions
- (2015) Alexander Heifetz et al. Journal of Chemical Information and Modeling
- OPLS3: A Force Field Providing Broad Coverage of Drug-like Small Molecules and Proteins
- (2015) Edward Harder et al. Journal of Chemical Theory and Computation
- Tumor-selective proteotoxicity of verteporfin inhibits colon cancer progression independently of YAP1
- (2015) Huabing Zhang et al. Science Signaling
- Tumor-selective proteotoxicity of verteporfin inhibits colon cancer progression independently of YAP1
- (2015) Huabing Zhang et al. Science Signaling
- A Peptide Mimicking VGLL4 Function Acts as a YAP Antagonist Therapy against Gastric Cancer
- (2014) Shi Jiao et al. CANCER CELL
- Parameterization of DFTB3/3OB for Sulfur and Phosphorus for Chemical and Biological Applications
- (2014) Michael Gaus et al. Journal of Chemical Theory and Computation
- Identification, Mechanism of Action, and Antitumor Activity of a Small Molecule Inhibitor of Hippo, TGF- , and Wnt Signaling Pathways
- (2014) D. Basu et al. MOLECULAR CANCER THERAPEUTICS
- Electron-correlated fragment-molecular-orbital calculations for biomolecular and nano systems
- (2014) Shigenori Tanaka et al. PHYSICAL CHEMISTRY CHEMICAL PHYSICS
- The Biology of YAP/TAZ: Hippo Signaling and Beyond
- (2014) Stefano Piccolo et al. PHYSIOLOGICAL REVIEWS
- Structure-Based Design and Synthesis of Potent Cyclic Peptides Inhibiting the YAP–TEAD Protein–Protein Interaction
- (2014) Zhisen Zhang et al. ACS Medicinal Chemistry Letters
- Protein kinase A activates the Hippo pathway to modulate cell proliferation and differentiation
- (2013) F.-X. Yu et al. GENES & DEVELOPMENT
- Regulation of the Hippo-YAP Pathway by G-Protein-Coupled Receptor Signaling
- (2012) Fa-Xing Yu et al. CELL
- Features of protein–protein interactions that translate into potent inhibitors: topology, surface area and affinity
- (2012) Matthew C. Smith et al. EXPERT REVIEWS IN MOLECULAR MEDICINE
- Genetic and pharmacological disruption of the TEAD-YAP complex suppresses the oncogenic activity of YAP
- (2012) Y. Liu-Chittenden et al. GENES & DEVELOPMENT
- Exploring chemistry with the fragment molecular orbital method
- (2012) Dmitri G. Fedorov et al. PHYSICAL CHEMISTRY CHEMICAL PHYSICS
- The YAP and TAZ transcription co-activators: Key downstream effectors of the mammalian Hippo pathway
- (2012) Wanjin Hong et al. SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY
- Molecular mechanism of size control in development and human diseases
- (2011) Xiaolong Yang et al. CELL RESEARCH
- PROPKA3: Consistent Treatment of Internal and Surface Residues in Empirical pKaPredictions
- (2011) Mats H. M. Olsson et al. Journal of Chemical Theory and Computation
- Structural basis of YAP recognition by TEAD4 in the Hippo pathway
- (2010) L. Chen et al. GENES & DEVELOPMENT
- Structural insights into the YAP and TEAD complex
- (2010) Z. Li et al. GENES & DEVELOPMENT
- Structural and functional analysis of the YAP-binding domain of human TEAD2
- (2010) W. Tian et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
Publish scientific posters with Peeref
Peeref publishes scientific posters from all research disciplines. Our Diamond Open Access policy means free access to content and no publication fees for authors.
Learn MoreAdd your recorded webinar
Do you already have a recorded webinar? Grow your audience and get more views by easily listing your recording on Peeref.
Upload Now