Extracellular Vesicle Transmission of Chemoresistance to Ovarian Cancer Cells Is Associated with Hypoxia-Induced Expression of Glycolytic Pathway Proteins, and Prediction of Epithelial Ovarian Cancer Disease Recurrence

Exosome-mediated transfer of CD44 from high-metastatic ovarian cancer cells promotes migration and invasion of low-metastatic ovarian cancer cells

(2021) Xiameng Shen et al.   Journal of Ovarian Research

Tumour immune cell infiltration and survival after platinum-based chemotherapy in high-grade serous ovarian cancer subtypes: A gene expression-based computational study

(2020) Rong Liu et al.   EBioMedicine

The function and clinical application of extracellular vesicles in innate immune regulation

(2020) Xiaoxue Zhou et al.   Cellular & Molecular Immunology

Nonenzymatic function of Aldolase A downregulates miR-145 to promote the Oct4/DUSP4/TRAF4 axis and the acquisition of lung cancer stemness

(2020) Yu-Chan Chang et al.   Cell Death & Disease

Cancer cells with high-metastatic potential promote a glycolytic shift in activated fibroblasts

(2020) Akiko Kogure et al.   PLoS One

Enolase 1 regulates stem cell-like properties in gastric cancer cells by stimulating glycolysis

(2020) Ting Yang et al.   Cell Death & Disease

Chemotherapy induces dynamic immune responses in breast cancers that impact treatment outcome

(2020) Yeon Hee Park et al.   Nature Communications

Macrophages derived exosomes deliver miR-223 to epithelial ovarian cancer cells to elicit a chemoresistant phenotype

(2019) Xiaolan Zhu et al.   JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH

Extracellular vesicles-mediated intercellular communication: roles in the tumor microenvironment and anti-cancer drug resistance

(2019) Selma Maacha et al.   Molecular Cancer

Hypoxia‐induced secretion stimulates breast cancer stem cell regulatory signalling pathways

(2019) Hanna Jacobsson et al.   Molecular Oncology

Extracellular vesicle-packaged HIF-1α-stabilizing lncRNA from tumour-associated macrophages regulates aerobic glycolysis of breast cancer cells

(2019) Fei Chen et al.   NATURE CELL BIOLOGY

Ovarian cancer-derived exosomes promote tumour metastasis in vivo: an effect modulated by the invasiveness capacity of their originating cells

(2019) Mona Alharbi et al.   CLINICAL SCIENCE

When Place Matters: Shuttling of Enolase-1 Across Cellular Compartments

(2019) Miroslava Didiasova et al.   Frontiers in Cell and Developmental Biology

CircRNA-ENO1 promoted glycolysis and tumor progression in lung adenocarcinoma through upregulating its host gene ENO1

(2019) Jiayu Zhou et al.   Cell Death & Disease

Paclitaxel Sensitivity of Ovarian Cancer can be enhanced by knocking down Pairs of Kinases that regulate MAP4 Phosphorylation and Microtubule Stability

(2018) Hailing Yang et al.   CLINICAL CANCER RESEARCH

Hexokinase 2 confers resistance to cisplatin in ovarian cancer cells by enhancing cisplatin-induced autophagy

(2018) Xiao-Yan Zhang et al.   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY

Cancer-cell-secreted exosomal miR-105 promotes tumour growth through the MYC-dependent metabolic reprogramming of stromal cells

(2018) Wei Yan et al.   NATURE CELL BIOLOGY

Extracellular vesicles in cancer — implications for future improvements in cancer care

(2018) Rong Xu et al.   Nature Reviews Clinical Oncology

Hypoxia-induced exosomes contribute to a more aggressive and chemoresistant ovarian cancer phenotype: a novel mechanism linking STAT3/Rab proteins

(2018) Kalpana Deepa Priya Dorayappan et al.   ONCOGENE

Silencing of ENO1 by shRNA Inhibits the Proliferation of Gastric Cancer Cells

(2018) Hui Qiao et al.   TECHNOLOGY IN CANCER RESEARCH & TREATMENT

Defining the role of the tumor vasculature in antitumor immunity and immunotherapy

(2018) Marco B. Schaaf et al.   Cell Death & Disease

Exosomes Associated with Human Ovarian Tumors Harbor a Reversible Checkpoint of T-cell Responses

(2018) Gautam N. Shenoy et al.   Cancer Immunology Research

The hypoxic tumour microenvironment

(2018) Varvara Petrova et al.   Oncogenesis

Proteomic analysis of exosomes reveals an association between cell invasiveness and exosomal bioactivity on endothelial and mesenchymal cell migration in vitro

(2018) Shayna Sharma et al.   CLINICAL SCIENCE

The potential role of miRNAs and exosomes in chemotherapy in ovarian cancer

(2018) Mona Alharbi et al.   ENDOCRINE-RELATED CANCER

Sialic Acid–Dependent Inhibition of T Cells by Exosomal Ganglioside GD3 in Ovarian Tumor Microenvironments

(2018) Gautam N. Shenoy et al.   JOURNAL OF IMMUNOLOGY

Cancer-derived exosomal miR-25-3p promotes pre-metastatic niche formation by inducing vascular permeability and angiogenesis

(2018) Zhicheng Zeng et al.   Nature Communications

Phosphatidylserine Sensing by TAM Receptors Regulates AKT-Dependent Chemoresistance and PD-L1 Expression

(2017) Canan Kasikara et al.   MOLECULAR CANCER RESEARCH

Exosomes derived from hypoxic epithelial ovarian cancer deliver microRNA-940 to induce macrophage M2 polarization

(2017) Xin Chen et al.   ONCOLOGY REPORTS

Pyruvate kinase M2 is a poor prognostic marker of and a therapeutic target in ovarian cancer

(2017) Tai-Kuang Chao et al.   PLoS One

Enolase 1 stimulates glycolysis to promote chemoresistance in gastric cancer

(2017) Xiaoling Qian et al.   Oncotarget

Exosomes as mediators of platinum resistance in ovarian cancer

(2017) Jennifer Crow et al.   Oncotarget

The Glycolytic Switch in Tumors: How Many Players Are Involved?

(2017) Li Yu et al.   Journal of Cancer

Inhibition of Pyruvate Kinase M2 Markedly Reduces Chemoresistance of Advanced Bladder Cancer to Cisplatin

(2017) Xing Wang et al.   Scientific Reports

ALDOA functions as an oncogene in the highly metastatic pancreatic cancer

(2016) Shunrong Ji et al.   CANCER LETTERS

Hypoxia‐inducible factors: coupling glucose metabolism and redox regulation with induction of the breast cancer stem cell phenotype

(2016) Gregg L Semenza   EMBO JOURNAL

Assessing the genetic architecture of epithelial ovarian cancer histological subtypes

(2016) Gabriel Cuellar-Partida et al.   HUMAN GENETICS

Fructose-bisphosphate aldolase A is a key regulator of hypoxic adaptation in colorectal cancer cells and involved in treatment resistance and poor prognosis

(2016) Kenji Kawai et al.   INTERNATIONAL JOURNAL OF ONCOLOGY

Hypoxic control of metastasis

(2016) E. B. Rankin et al.   SCIENCE

Pyruvate kinase M2 overexpression and poor prognosis in solid tumors of digestive system: evidence from 16 cohort studies

(2016) Jiayuan Wu et al.   OncoTargets and Therapy

Exosomal transfer of stroma-derived miR21 confers paclitaxel resistance in ovarian cancer cells through targeting APAF1

(2016) Chi Lam Au Yeung et al.   Nature Communications

Tumor microenvironment derived exosomes pleiotropically modulate cancer cell metabolism

(2016) Hongyun Zhao et al.   eLife

Pyruvate kinase isoenzyme M2 is a therapeutic target of gemcitabine-resistant pancreatic cancer cells

(2015) Dong Joon Kim et al.   EXPERIMENTAL CELL RESEARCH

Breast-cancer-secreted miR-122 reprograms glucose metabolism in premetastatic niche to promote metastasis

(2015) Miranda Y. Fong et al.   NATURE CELL BIOLOGY

Review of aerobic glycolysis and its key enzymes - new targets for lung cancer therapy

(2015) Xue-bing Li et al.   Thoracic Cancer

Extracellular Vesicles Present in Human Ovarian Tumor Microenvironments Induce a Phosphatidylserine-Dependent Arrest in the T-cell Signaling Cascade

(2015) R. J. Kelleher et al.   Cancer Immunology Research

Fibroblast-Derived Exosomes Contribute to Chemoresistance through Priming Cancer Stem Cells in Colorectal Cancer

(2015) Yibing Hu et al.   PLoS One

Defining normoxia, physoxia and hypoxia in tumours—implications for treatment response

(2014) S R McKeown   BRITISH JOURNAL OF RADIOLOGY

Ovarian cancer cell invasiveness is associated with discordant exosomal sequestration of Let-7 miRNA and miR-200

(2014) Miharu Kobayashi et al.   Journal of Translational Medicine

Fructose-Bisphosphate Aldolase A Is a Potential Metastasis-Associated Marker of Lung Squamous Cell Carcinoma and Promotes Lung Cell Tumorigenesis and Migration

(2014) Sha Du et al.   PLoS One

Hexokinase 2 Is Required for Tumor Initiation and Maintenance and Its Systemic Deletion Is Therapeutic in Mouse Models of Cancer

(2013) Krushna C. Patra et al.   CANCER CELL

Acidic extracellular microenvironment and cancer

(2013) Yasumasa Kato et al.   Cancer Cell International

Tumor-derived exosomes are enriched in ΔNp73, which promotes oncogenic potential in acceptor cells and correlates with patient survival

(2013) Beatriz Soldevilla et al.   HUMAN MOLECULAR GENETICS

Hypoxic enhancement of exosome release by breast cancer cells

(2012) Hamish W King et al.   BMC CANCER

Selective extracellular vesicle-mediated export of an overlapping set of microRNAs from multiple cell types

(2012) Jasenka Guduric-Fuchs et al.   BMC GENOMICS

Molecular Identification of GD3 as a Suppressor of the Innate Immune Response in Ovarian Cancer

(2012) T. J. Webb et al.   CANCER RESEARCH

The Warburg effect in 2012

(2011) Jean-Pierre Bayley et al.   CURRENT OPINION IN ONCOLOGY

Hexokinase 2 is a key mediator of aerobic glycolysis and promotes tumor growth in human glioblastoma multiforme

(2011) Amparo Wolf et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Pyruvate kinase type M2: A key regulator of the metabolic budget system in tumor cells

(2010) Sybille Mazurek   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY

Targeted Proteomic Analysis of Glycolysis in Cancer Cells

(2010) J. Patrick Murphy et al.   JOURNAL OF PROTEOME RESEARCH

Chemotherapy, chemoresistance and the changing treatment landscape for NSCLC

(2010) Alex Chang   LUNG CANCER