The cGAS-STING pathway is a therapeutic target in a preclinical model of hepatocellular carcinoma

STING signaling remodels the tumor microenvironment by antagonizing myeloid-derived suppressor cell expansion

(2019) Chuan-xia Zhang et al.   CELL DEATH AND DIFFERENTIATION

Cancer statistics, 2018

(2018) Rebecca L. Siegel et al.   CA-A CANCER JOURNAL FOR CLINICIANS

Attenuation of cGAS‐STING signaling is mediated by a p62/SQSTM1‐dependent autophagy pathway activated by TBK1

(2018) Thaneas Prabakaran et al.   EMBO JOURNAL

The cGAS–cGAMP–STING pathway connects DNA damage to inflammation, senescence, and cancer

(2018) Tuo Li et al.   JOURNAL OF EXPERIMENTAL MEDICINE

PUMA amplifies necroptosis signaling by activating cytosolic DNA sensors

(2018) Dongshi Chen et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Downregulation of cytoplasmic DNases is implicated in cytoplasmic DNA accumulation and SASP in senescent cells

(2018) Akiko Takahashi et al.   Nature Communications

STING agonists enable antiviral cross-talk between human cells and confer protection against genital herpes in mice

(2018) Morten K. Skouboe et al.   PLoS Pathogens

Targeting Cytosolic Nucleic Acid-Sensing Pathways for Cancer Immunotherapies

(2018) Sandra Iurescia et al.   Frontiers in Immunology

Type 1 IFN and PD-L1 Coordinate Lymphatic Endothelial Cell Expansion and Contraction during an Inflammatory Immune Response

(2018) Erin D. Lucas et al.   JOURNAL OF IMMUNOLOGY

STING-mediated inflammation in Kupffer cells contributes to progression of nonalcoholic steatohepatitis

(2018) Yongsheng Yu et al.   JOURNAL OF CLINICAL INVESTIGATION

The Balancing Act between Cancer Immunity and Autoimmunity in Response to Immunotherapy

(2018) Arabella Young et al.   Cancer Immunology Research

Promising Targets for Cancer Immunotherapy: TLRs, RLRs, and STING-Mediated Innate Immune Pathways

(2017) Kai Li et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Cutting Edge: Activation of STING in T Cells Induces Type I IFN Responses and Cell Death

(2017) Bridget Larkin et al.   JOURNAL OF IMMUNOLOGY

cGAS is essential for the antitumor effect of immune checkpoint blockade

(2017) Hua Wang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Spontaneous regression of hepatocellular carcinoma: A mini-review

(2017) Akira Sakamaki et al.   WORLD JOURNAL OF GASTROENTEROLOGY

Signalling strength determines proapoptotic functions of STING

(2017) Muhammet F. Gulen et al.   Nature Communications

Autophagy, Inflammation, and Immunity: A Troika Governing Cancer and Its Treatment

(2016) Zhenyu Zhong et al.   CELL

Lack of immunological DNA sensing in hepatocytes facilitates hepatitis B virus infection

(2016) Martin K. Thomsen et al.   HEPATOLOGY

Mutations Associated with Acquired Resistance to PD-1 Blockade in Melanoma

(2016) Jesse M. Zaretsky et al.   NEW ENGLAND JOURNAL OF MEDICINE

Histopathology of hepatocellular carcinoma

(2016) Manuel Schlageter et al.   WORLD JOURNAL OF GASTROENTEROLOGY

Molecular Pathways: Targeting the Stimulator of Interferon Genes (STING) in the Immunotherapy of Cancer

(2015) L. Corrales et al.   CLINICAL CANCER RESEARCH

Activation and Regulation of DNA-Driven Immune Responses

(2015) Søren R. Paludan   MICROBIOLOGY AND MOLECULAR BIOLOGY REVIEWS

Diverse roles of STING-dependent signaling on the development of cancer

(2015) J Ahn et al.   ONCOGENE

DNA tumor virus oncogenes antagonize the cGAS-STING DNA-sensing pathway

(2015) L. Lau et al.   SCIENCE

Direct Activation of STING in the Tumor Microenvironment Leads to Potent and Systemic Tumor Regression and Immunity

(2015) Leticia Corrales et al.   Cell Reports

Cutting Edge: STING Mediates Protection against Colorectal Tumorigenesis by Governing the Magnitude of Intestinal Inflammation

(2014) Qifan Zhu et al.   JOURNAL OF IMMUNOLOGY

Interferons and Their Stimulated Genes in the Tumor Microenvironment

(2014) HyeonJoo Cheon et al.   SEMINARS IN ONCOLOGY

Inflammation-driven carcinogenesis is mediated through STING

(2014) Jeonghyun Ahn et al.   Nature Communications

Binding-Pocket and Lid-Region Substitutions Render Human STING Sensitive to the Species-Specific Drug DMXAA

(2014) Pu Gao et al.   Cell Reports

Hepatic RIG-I Predicts Survival and Interferon-α Therapeutic Response in Hepatocellular Carcinoma

(2013) Jin Hou et al.   CANCER CELL

Host Restriction Factor SAMHD1 Limits Human T Cell Leukemia Virus Type 1 Infection of Monocytes via STING-Mediated Apoptosis

(2013) Alexandre Sze et al.   Cell Host & Microbe

LOH in the HLA Class I Region at 6p21 Is Associated with Shorter Survival in Newly Diagnosed Adult Glioblastoma

(2013) J. T. Yeung et al.   CLINICAL CANCER RESEARCH

Mouse models for liver cancer

(2013) Latifa Bakiri et al.   Molecular Oncology

Pan-viral specificity of IFN-induced genes reveals new roles for cGAS in innate immunity

(2013) John W. Schoggins et al.   NATURE

The Innate Immune DNA Sensor cGAS Produces a Noncanonical Cyclic Dinucleotide that Activates Human STING

(2013) Elie J. Diner et al.   Cell Reports

Activation of Autophagy by α-Herpesviruses in Myeloid Cells Is Mediated by Cytoplasmic Viral DNA through a Mechanism Dependent on Stimulator of IFN Genes

(2011) Simon B. Rasmussen et al.   JOURNAL OF IMMUNOLOGY

T cell exhaustion

(2011) E John Wherry   NATURE IMMUNOLOGY

Imaging of liver cancer

(2009) Ben Ariff et al.   WORLD JOURNAL OF GASTROENTEROLOGY