The exon-junction complex helicase eIF4A3 controls cell fate via coordinated regulation of ribosome biogenesis and translational output

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DNA-PKcs has KU-dependent function in rRNA processing and haematopoiesis

(2020) Zhengping Shao et al.   NATURE

DEqMS: A Method for Accurate Variance Estimation in Differential Protein Expression Analysis

(2020) Yafeng Zhu et al.   MOLECULAR & CELLULAR PROTEOMICS

Human RTEL1 associates with Poldip3 to facilitate responses to replication stress and R-loop resolution

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Phase-to-Phase With Nucleoli – Stress Responses, Protein Aggregation and Novel Roles of RNA

(2019) Leena Latonen   Frontiers in Cellular Neuroscience

First-in-Human RNA Polymerase I Transcription Inhibitor CX-5461 in Patients with Advanced Hematological Cancers: Results of a Phase I Dose Escalation Study

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GENT2: an updated gene expression database for normal and tumor tissues

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The antimalarial drug amodiaquine stabilizes p53 through ribosome biogenesis stress, independently of its autophagy-inhibitory activity

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Nonsense-mediated mRNA Decay and Cancer

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Extending the Compatibility of the SP3 Paramagnetic Bead Processing Approach for Proteomics

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Integrating single-cell transcriptomic data across different conditions, technologies, and species

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Proteome-wide identification of ubiquitin interactions using UbIA-MS

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EIF4A3-induced circular RNA MMP9 (circMMP9) acts as a sponge of miR-124 and promotes glioblastoma multiforme cell tumorigenesis

(2018) Renjie Wang et al.   Molecular Cancer

Exon Junction Complexes Suppress Spurious Splice Sites to Safeguard Transcriptome Integrity

(2018) Volker Boehm et al.   MOLECULAR CELL

STRING v11: protein–protein association networks with increased coverage, supporting functional discovery in genome-wide experimental datasets

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SIRT7 and the DEAD-box helicase DDX21 cooperate to resolve genomic R loops and safeguard genome stability

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EIF4A3 deficient human iPSCs and mouse models demonstrate neural crest defects that underlie Richieri-Costa-Pereira syndrome

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Discovery of Novel 1,4-Diacylpiperazines as Selective and Cell-Active eIF4A3 Inhibitors

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A subset of platinum-containing chemotherapeutic agents kills cells by inducing ribosome biogenesis stress

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Discovery of Novel 5-(Piperazine-1-carbonyl)pyridin-2(1H)-one Derivatives as Orally eIF4A3-Selective Inhibitors

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Eukaryotic ribosome assembly, transport and quality control

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Redefining the Translational Status of 80S Monosomes

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Exon Junction Complexes Show a Distributional Bias toward Alternatively Spliced mRNAs and against mRNAs Coding for Ribosomal Proteins

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Haploinsufficiency for Core Exon Junction Complex Components Disrupts Embryonic Neurogenesis and Causes p53-Mediated Microcephaly

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Dual Role of a SAS10/C1D Family Protein in Ribosomal RNA Gene Expression and Processing Is Essential for Reproduction in Arabidopsis thaliana

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hMYH and hMTH1 cooperate for survival in mismatch repair defective T-cell acute lymphoblastic leukemia

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The exon junction complex as a node of post-transcriptional networks

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A double-edged sword: R loops as threats to genome integrity and powerful regulators of gene expression

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iRegulon: From a Gene List to a Gene Regulatory Network Using Large Motif and Track Collections

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A Noncoding Expansion in EIF4A3 Causes Richieri-Costa-Pereira Syndrome, a Craniofacial Disorder Associated with Limb Defects

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TRIP12 and UBR5 Suppress Spreading of Chromatin Ubiquitylation at Damaged Chromosomes

(2012) Thorkell Gudjonsson et al.   CELL

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p53 is activated in response to disruption of the pre-mRNA splicing machinery

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Human eIF4AIII interacts with an eIF4G-like partner, NOM1, revealing an evolutionarily conserved function outside the exon junction complex

(2011) A. Alexandrov et al.   GENES & DEVELOPMENT

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A Critical Role for Noncoding 5S rRNA in Regulating Mdmx Stability

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