The histone methyltransferase SETD2 modulates oxidative stress to attenuate experimental colitis

Compartmentalized Response of IL-6/STAT3 Signaling in the Colonic Mucosa Mediates Colitis Development

(2019) Carolina Serrano et al.   JOURNAL OF IMMUNOLOGY

Myosin 1F Regulates M1-Polarization by Stimulating Intercellular Adhesion in Macrophages

(2019) Zayda L. Piedra-Quintero et al.   Frontiers in Immunology

Intestinal Mucosal Mast Cells: Key Modulators of Barrier Function and Homeostasis

(2019) Mercé Albert-Bayo et al.   Cells

SETD2 regulates the maternal epigenome, genomic imprinting and embryonic development

(2019) Qianhua Xu et al.   NATURE GENETICS

Tracing Oncogene Rearrangements in the Mutational History of Lung Adenocarcinoma

(2019) Jake June-Koo Lee et al.   CELL

The histone methyltransferase Setd2 is indispensable for V(D)J recombination

(2019) Zhongzhong Ji et al.   Nature Communications

Aronia Berry Supplementation Mitigates Inflammation in T Cell Transfer-Induced Colitis by Decreasing Oxidative Stress

(2019) Ruisong Pei et al.   Nutrients

BRG1 attenuates colonic inflammation and tumorigenesis through autophagy-dependent oxidative stress sequestration

(2019) Min Liu et al.   Nature Communications

Enteric Delivery of Regenerating Family Member 3 alpha Alters the Intestinal Microbiota and Controls Inflammation in Mice With Colitis

(2018) Marion Darnaud et al.   GASTROENTEROLOGY

The histone methyltransferase SETD2 is required for expression of acrosin-binding protein 1 and protamines and essential for spermiogenesis in mice

(2018) Xiaoli Zuo et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Structural Remodeling of the Human Colonic Mesenchyme in Inflammatory Bowel Disease

(2018) James Kinchen et al.   CELL

Epigenetics, DNA Organization, and Inflammatory Bowel Disease

(2018) Greeshma Ray et al.   INFLAMMATORY BOWEL DISEASES

H3K36 trimethylation mediated by SETD2 regulates the fate of bone marrow mesenchymal stem cells

(2018) Lijun Wang et al.   PLOS BIOLOGY

Intestinal Epithelial Sirtuin 1 Regulates Intestinal Inflammation During Aging in Mice by Altering the Intestinal Microbiota

(2017) Alicia S. Wellman et al.   GASTROENTEROLOGY

Intragenic DNA methylation prevents spurious transcription initiation

(2017) Francesco Neri et al.   NATURE

Pathomechanisms of Oxidative Stress in Inflammatory Bowel Disease and Potential Antioxidant Therapies

(2017) Tian Tian et al.   Oxidative Medicine and Cellular Longevity

Increased susceptibility of IDH2-deficient mice to dextran sodium sulfate-induced colitis

(2017) Hanvit Cha et al.   Redox Biology

Dual Chromatin and Cytoskeletal Remodeling by SETD2

(2016) In Young Park et al.   CELL

Genomic disruption of the histone methyltransferase SETD2 in chronic lymphocytic leukaemia

(2016) H Parker et al.   LEUKEMIA

The amino acid sensor GCN2 controls gut inflammation by inhibiting inflammasome activation

(2016) Rajesh Ravindran et al.   NATURE

Inhibiting WEE1 Selectively Kills Histone H3K36me3-Deficient Cancers by dNTP Starvation

(2015) Sophia X. Pfister et al.   CANCER CELL

Human Disease Modeling Reveals Integrated Transcriptional and Epigenetic Mechanisms of NOTCH1 Haploinsufficiency

(2015) Christina V. Theodoris et al.   CELL

Epithelial IL-18 Equilibrium Controls Barrier Function in Colitis

(2015) Roni Nowarski et al.   CELL

Uncovering effects of antibiotics on the host and microbiota using transkingdom gene networks

(2015) Andrey Morgun et al.   GUT

Selenoprotein P influences colitis-induced tumorigenesis by mediating stemness and oxidative damage

(2015) Caitlyn W. Barrett et al.   JOURNAL OF CLINICAL INVESTIGATION

SETD2 loss-of-function promotes renal cancer branched evolution through replication stress and impaired DNA repair

(2015) N Kanu et al.   ONCOGENE

Antioxidant therapy for treatment of inflammatory bowel disease: Does it work?

(2015) Fabiana Andréa Moura et al.   Redox Biology

Dual Function of p38α MAPK in Colon Cancer: Suppression of Colitis-Associated Tumor Initiation but Requirement for Cancer Cell Survival

(2014) Jalaj Gupta et al.   CANCER CELL

Role of the Microbiota in Immunity and Inflammation

(2014) Yasmine Belkaid et al.   CELL

NLRP6 Inflammasome Orchestrates the Colonic Host-Microbial Interface by Regulating Goblet Cell Mucus Secretion

(2014) Marta Wlodarska et al.   CELL

Mutations in epigenetic regulators including SETD2 are gained during relapse in paediatric acute lymphoblastic leukaemia

(2014) Brenton G. Mar et al.   Nature Communications

H3K36 Histone Methyltransferase Setd2 Is Required for Murine Embryonic Stem Cell Differentiation toward Endoderm

(2014) Yuanliang Zhang et al.   Cell Reports

Mutations in SETD2 and genes affecting histone H3K36 methylation target hemispheric high-grade gliomas

(2013) Adam M. Fontebasso et al.   ACTA NEUROPATHOLOGICA

The Histone Mark H3K36me3 Regulates Human DNA Mismatch Repair through Its Interaction with MutSα

(2013) Feng Li et al.   CELL

Histone deacetylase 3 coordinates commensal-bacteria-dependent intestinal homeostasis

(2013) Theresa Alenghat et al.   NATURE

A functional methylome map of ulcerative colitis

(2012) R. Hasler et al.   GENOME RESEARCH

Mucosal genome-wide methylation changes in inflammatory bowel disease

(2012) James Cooke et al.   INFLAMMATORY BOWEL DISEASES

Intestinal homeostasis and its breakdown in inflammatory bowel disease

(2011) Kevin J. Maloy et al.   NATURE

IL-17C regulates the innate immune function of epithelial cells in an autocrine manner

(2011) Vladimir Ramirez-Carrozzi et al.   NATURE IMMUNOLOGY

Paneth cells, antimicrobial peptides and maintenance of intestinal homeostasis

(2011) Charles L. Bevins et al.   NATURE REVIEWS MICROBIOLOGY

The intestinal epithelial barrier in the control of homeostasis and immunity

(2011) Maria Rescigno   TRENDS IN IMMUNOLOGY

Inflammatory Bowel Disease

(2010) Arthur Kaser et al.   Annual Review of Immunology

Immunity, Inflammation, and Cancer

(2010) Sergei I. Grivennikov et al.   CELL

Inflammation and Colon Cancer

(2010) Janoš Terzić et al.   GASTROENTEROLOGY

Role of oxidatively induced DNA lesions in human pathogenesis

(2010) Olga A. Sedelnikova et al.   MUTATION RESEARCH-REVIEWS IN MUTATION RESEARCH

Mechanisms of intestinal inflammation and development of associated cancers: Lessons learned from mouse models

(2010) Aya M. Westbrook et al.   MUTATION RESEARCH-REVIEWS IN MUTATION RESEARCH

Histone H3 lysine 36 methyltransferase Hypb/Setd2 is required for embryonic vascular remodeling

(2010) M. Hu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Cancer-related inflammation

(2008) Alberto Mantovani et al.   NATURE