Kynurenines increase MRS metabolites in basal ganglia and decrease resting-state connectivity in frontostriatal reward circuitry in depression

Role of Astrocytes in Major Neuropsychiatric Disorders

(2021) Xiaolu Zhang et al.   NEUROCHEMICAL RESEARCH

Aiding and Abetting Anhedonia: Impact of Inflammation on the Brain and Pharmacological Implications

(2021) Michael J. Lucido et al.   PHARMACOLOGICAL REVIEWS

Associations among peripheral and central kynurenine pathway metabolites and inflammation in depression

(2020) Ebrahim Haroon et al.   NEUROPSYCHOPHARMACOLOGY

Translocator Protein Distribution Volume Predicts Reduction of Symptoms During Open-Label Trial of Celecoxib in Major Depressive Disorder

(2020) Sophia Attwells et al.   BIOLOGICAL PSYCHIATRY

Kynurenine regulates NLRP2 inflammasome in astrocytes and its implications in depression

(2020) Qingyu Zhang et al.   BRAIN BEHAVIOR AND IMMUNITY

Dissecting diagnostic heterogeneity in depression by integrating neuroimaging and genetics

(2020) Amanda M. Buch et al.   NEUROPSYCHOPHARMACOLOGY

Can’t or Won’t? Immunometabolic Constraints on Dopaminergic Drive

(2019) Michael T. Treadway et al.   TRENDS IN COGNITIVE SCIENCES

Intrinsic Brain Network Biomarkers of Antidepressant Response: a Review

(2019) Katharine Dunlop et al.   Current Psychiatry Reports

Leucine competes with kynurenine for blood-to-brain transport and prevents lipopolysaccharide-induced depression-like behavior in mice

(2018) Adam K. Walker et al.   MOLECULAR PSYCHIATRY

What does plasma CRP tell us about peripheral and central inflammation in depression?

(2018) Jennifer C. Felger et al.   MOLECULAR PSYCHIATRY

Increased inflammation and brain glutamate define a subtype of depression with decreased regional homogeneity, impaired network integrity, and anhedonia

(2018) Ebrahim Haroon et al.   Translational Psychiatry

Glutamate Neurotransmission in Rodent Models of Traumatic Brain Injury

(2017) Christopher R. Dorsett et al.   JOURNAL OF NEUROTRAUMA

The brain and immune system prompt energy shortage in chronic inflammation and ageing

(2017) Rainer H. Straub   Nature Reviews Rheumatology

Conceptual convergence: increased inflammation is associated with increased basal ganglia glutamate in patients with major depression

(2016) E Haroon et al.   MOLECULAR PSYCHIATRY

Resting-state connectivity biomarkers define neurophysiological subtypes of depression

(2016) Andrew T Drysdale et al.   NATURE MEDICINE

Inflammation, Glutamate and Glia: A Trio of Trouble in Mood Disorders

(2016) Ebrahim Haroon et al.   NEUROPSYCHOPHARMACOLOGY

Assessing anhedonia in depression: Potentials and pitfalls

(2016) Sakina J. Rizvi et al.   NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS

Cluster failure: Why fMRI inferences for spatial extent have inflated false-positive rates

(2016) Anders Eklund et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Depression Phenotype, Inflammation, and the Brain

(2016) Rajeev Krishnadas et al.   PSYCHOSOMATIC MEDICINE

Neurotoxic kynurenine metabolism is increased in the dorsal hippocampus and drives distinct depressive behaviors during inflammation

(2016) J M Parrott et al.   Translational Psychiatry

Quantitative Magnetization Transfer Imaging as a Biomarker for Effects of Systemic Inflammation on the Brain

(2015) Neil A. Harrison et al.   BIOLOGICAL PSYCHIATRY

Age-related increases in basal ganglia glutamate are associated with TNF, reduced motivation and decreased psychomotor speed during IFN-alpha treatment: Preliminary findings

(2015) Ebrahim Haroon et al.   BRAIN BEHAVIOR AND IMMUNITY

A role for inflammatory metabolites as modulators of the glutamate N-methyl-d-aspartate receptor in depression and suicidality

(2015) Cecilie Bay-Richter et al.   BRAIN BEHAVIOR AND IMMUNITY

Inflammation is associated with decreased functional connectivity within corticostriatal reward circuitry in depression

(2015) J C Felger et al.   MOLECULAR PSYCHIATRY

Activation of the kynurenine pathway is associated with striatal volume in major depressive disorder

(2015) Jonathan Savitz et al.   PSYCHONEUROENDOCRINOLOGY

Prefrontal cortical regulation of brainwide circuit dynamics and reward-related behavior

(2015) E. A. Ferenczi et al.   SCIENCE

Large-Scale Network Dysfunction in Major Depressive Disorder

(2015) Roselinde H. Kaiser et al.   JAMA Psychiatry

Is there a role for glutamate-mediated excitotoxicity in inflammation-induced depression?

(2014) Robert Dantzer et al.   JOURNAL OF NEURAL TRANSMISSION

Glutamate as a neurotransmitter in the healthy brain

(2014) Y. Zhou et al.   JOURNAL OF NEURAL TRANSMISSION

IFN-Alpha-Induced Cortical and Subcortical Glutamate Changes Assessed by Magnetic Resonance Spectroscopy

(2014) Ebrahim Haroon et al.   NEUROPSYCHOPHARMACOLOGY

Regulation of Extrasynaptic Glutamate Levels as a Pathophysiological Mechanism in Disorders of Motivation and Addiction

(2014) Robert E McCullumsmith et al.   NEUROPSYCHOPHARMACOLOGY

Dysphoria and Anhedonia as Risk Factors for Disability or Death in Older Persons: Implications for the Assessment of Geriatric Depression

(2013) Kenneth E. Covinsky et al.   AMERICAN JOURNAL OF GERIATRIC PSYCHIATRY

Anhedonia and Reward-Circuit Connectivity Distinguish Nonresponders from Responders to Dorsomedial Prefrontal Repetitive Transcranial Magnetic Stimulation in Major Depression

(2013) Jonathan Downar et al.   BIOLOGICAL PSYCHIATRY

Connecting inflammation with glutamate agonism in suicidality

(2013) Sophie Erhardt et al.   NEUROPSYCHOPHARMACOLOGY

NMDA Receptor Blockade by Ketamine Abrogates Lipopolysaccharide-Induced Depressive-Like Behavior in C57BL/6J Mice

(2013) Adam K Walker et al.   NEUROPSYCHOPHARMACOLOGY

Synaptic Potentiation Is Critical for Rapid Antidepressant Response to Ketamine in Treatment-Resistant Major Depression

(2012) Brian R. Cornwell et al.   BIOLOGICAL PSYCHIATRY

Quinolinic acid, the inescapable neurotoxin

(2012) Gilles J. Guillemin   FEBS Journal

Kynurenines in the mammalian brain: when physiology meets pathology

(2012) Robert Schwarcz et al.   NATURE REVIEWS NEUROSCIENCE

Astrocytic Hypertrophy in Anterior Cingulate White Matter of Depressed Suicides

(2011) Susana G Torres-Platas et al.   NEUROPSYCHOPHARMACOLOGY

Inflammation-Induced Anhedonia: Endotoxin Reduces Ventral Striatum Responses to Reward

(2010) Naomi I. Eisenberger et al.   BIOLOGICAL PSYCHIATRY

Visualization of glutamate as a volume transmitter

(2010) Yohei Okubo et al.   JOURNAL OF PHYSIOLOGY-LONDON

Synaptic versus extrasynaptic NMDA receptor signalling: implications for neurodegenerative disorders

(2010) Giles E. Hardingham et al.   NATURE REVIEWS NEUROSCIENCE

Default mode network abnormalities in bipolar disorder and schizophrenia

(2010) Dost Öngür et al.   PSYCHIATRY RESEARCH-NEUROIMAGING

Inflammation-associated depression: From serotonin to kynurenine

(2010) Robert Dantzer et al.   PSYCHONEUROENDOCRINOLOGY

Inflammation Causes Mood Changes Through Alterations in Subgenual Cingulate Activity and Mesolimbic Connectivity

(2009) Neil A. Harrison et al.   BIOLOGICAL PSYCHIATRY

Induction of IDO by Bacille Calmette-Guerin Is Responsible for Development of Murine Depressive-Like Behavior

(2009) J. C. O'Connor et al.   JOURNAL OF IMMUNOLOGY

Interferon-  and Tumor Necrosis Factor-  Mediate the Upregulation of Indoleamine 2,3-Dioxygenase and the Induction of Depressive-Like Behavior in Mice in Response to Bacillus Calmette-Guerin

(2009) J. C. O'Connor et al.   JOURNAL OF NEUROSCIENCE

CSF concentrations of brain tryptophan and kynurenines during immune stimulation with IFN-α: relationship to CNS immune responses and depression

(2009) C L Raison et al.   MOLECULAR PSYCHIATRY

The oscillating brain: Complex and reliable

(2009) Xi-Nian Zuo et al.   NEUROIMAGE

Amplitude of low-frequency oscillations in schizophrenia: A resting state fMRI study

(2009) Matthew J. Hoptman et al.   SCHIZOPHRENIA RESEARCH

From inflammation to sickness and depression: when the immune system subjugates the brain

(2007) Robert Dantzer et al.   NATURE REVIEWS NEUROSCIENCE

Detection and scaling of task-induced fMRI-BOLD response using resting state fluctuations

(2007) Sridhar S. Kannurpatti et al.   NEUROIMAGE