期刊
NATURE REVIEWS RHEUMATOLOGY
卷 13, 期 12, 页码 743-751出版社
NATURE PUBLISHING GROUP
DOI: 10.1038/nrrheum.2017.172
关键词
-
类别
资金
- Deutsche Forschungsgemeinschaft (DFG)
- German Federal Ministry of Education and Research
- State of Bavaria - University Hospital Regensburg
Sequelae frequently seen in patients with chronic inflammatory diseases, such as fatigue, depressed mood, sleep alterations, loss of appetite, muscle wasting, cachectic obesity, bone loss and hypertension, can be the result of energy shortages caused by an overactive immune system. These sequelae can also be found in patients with chronic inflammatory diseases that are in remission and in ageing individuals, despite the immune system being less active in these situations. This Perspectives article proposes a new way of understanding situations of chronic inflammation (such as rheumatic diseases) and ageing based on the principles of evolutionary medicine, energy regulation and neuroendocrine-immune crosstalk. A conceptual framework is provided to enable physicians and scientists to better understand the signs and symptoms of chronic inflammatory diseases and long-term disease consequences resulting from physical and mental inactivity.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据