Diabetic Aldehyde Dehydrogenase 2 Mutant (ALDH2*2) Mice Are More Susceptible to Cardiac Ischemic‐Reperfusion Injury Due to 4‐Hydroxy‐2‐Nonenal Induced Coronary Endothelial Cell Damage

Aldehyde dehydrogenase 2 inhibition potentiates 4-hydroxy-2-nonenal induced decrease in angiogenesis of coronary endothelial cells

(2020) Bipradas Roy et al.   CELL BIOCHEMISTRY AND FUNCTION

4-hydroxy-2-nonenal decreases coronary endothelial cell migration: Potentiation by aldehyde dehydrogenase 2 inhibition

(2020) Bipradas Roy et al.   VASCULAR PHARMACOLOGY

Cardiospecific Overexpression of ATPGD1 (Carnosine Synthase) Increases Histidine Dipeptide Levels and Prevents Myocardial Ischemia Reperfusion Injury

(2020) Jingjing Zhao et al.   Journal of the American Heart Association

Heart Disease and Stroke Statistics—2018 Update: A Report From the American Heart Association

(2018) Emelia J. Benjamin et al.   CIRCULATION

Type-2 diabetic aldehyde dehydrogenase 2 mutant mice (ALDH 2*2) exhibiting heart failure with preserved ejection fraction phenotype can be determined by exercise stress echocardiography

(2018) Guodong Pan et al.   PLoS One

Genetic Polymorphisms of the Mitochondrial Aldehyde Dehydrogenase ALDH2 Gene in a Large Ethnic Hakka Population in Southern China

(2018) Zhixiong Zhong et al.   MEDICAL SCIENCE MONITOR

Mitochondrial aldehyde dehydrogenase 2 deficiency aggravates energy metabolism disturbance and diastolic dysfunction in diabetic mice

(2016) Cong Wang et al.   JOURNAL OF MOLECULAR MEDICINE-JMM

Cardiac Mitochondrial Respiratory Dysfunction and Tissue Damage in Chronic Hyperglycemia Correlate with Reduced Aldehyde Dehydrogenase-2 Activity

(2016) Vishal R. Mali et al.   PLoS One

ALDH2 Inhibition Potentiates High Glucose Stress-Induced Injury in Cultured Cardiomyocytes

(2016) Guodong Pan et al.   Journal of Diabetes Research

ALDH2(E487K) mutation increases protein turnover and promotes murine hepatocarcinogenesis

(2015) Shengfang Jin et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Protective Effect of Sevoflurane Postconditioning against Cardiac Ischemia/Reperfusion Injury via Ameliorating Mitochondrial Impairment, Oxidative Stress and Rescuing Autophagic Clearance

(2015) Peng Yu et al.   PLoS One

Aldehyde dehydrogenase 2 activation in heart failure restores mitochondrial function and improves ventricular function and remodelling

(2014) Katia M.S. Gomes et al.   CARDIOVASCULAR RESEARCH

Impairment of aldehyde dehydrogenase-2 by 4-hydroxy-2-nonenal adduct formation and cardiomyocyte hypertrophy in mice fed a high-fat diet and injected with low-dose streptozotocin

(2014) Vishal R Mali et al.   EXPERIMENTAL BIOLOGY AND MEDICINE

Aldehyde dehydrogenase-2 regulates nociception in rodent models of acute inflammatory pain

(2014) V. O. Zambelli et al.   Science Translational Medicine

CNGA3 is expressed in inner ear hair cells and binds to an intracellular C-terminus domain of EMILIN1

(2012) Dakshnamurthy Selvakumar et al.   BIOCHEMICAL JOURNAL

Mitochondrial aldehyde dehydrogenase (ALDH2) protects against streptozotocin-induced diabetic cardiomyopathy: role of GSK3β and mitochondrial function

(2012) Yingmei Zhang et al.   BMC Medicine

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(2011) Jiali Wang et al.   MOLECULAR MEDICINE

ALDH2 Activator Inhibits Increased Myocardial Infarction Injury by Nitroglycerin Tolerance

(2011) L. Sun et al.   Science Translational Medicine

Aldehyde Dehydrogenase Activation Prevents Reperfusion Arrhythmias by Inhibiting Local Renin Release From Cardiac Mast Cells

(2010) Kenichiro Koda et al.   CIRCULATION

Aldehyde dehydrogenase 2 (ALDH2) rescues myocardial ischaemia/reperfusion injury: role of autophagy paradox and toxic aldehyde

(2010) Heng Ma et al.   EUROPEAN HEART JOURNAL

PKCβII inhibition attenuates myocardial infarction induced heart failure and is associated with a reduction of fibrosis and pro-inflammatory responses

(2010) Suresh Selvaraj Palaniyandi et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

Alda-1 is an agonist and chemical chaperone for the common human aldehyde dehydrogenase 2 variant

(2010) Samantha Perez-Miller et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Roles of the lipid peroxidation product 4-hydroxynonenal in obesity, the metabolic syndrome, and associated vascular and neurodegenerative disorders

(2009) Mark P. Mattson   EXPERIMENTAL GERONTOLOGY

Origin and dispersal of atypical aldehyde dehydrogenase ALDH2⁎487Lys

(2009) Huai-Rong Luo et al.   GENE

4-Hydroxy-2-Nonenal Induces Mitochondrial Dysfunction and Aberrant Axonal Outgrowth in Adult Sensory Neurons that Mimics Features of Diabetic Neuropathy

(2009) Eli Akude et al.   NEUROTOXICITY RESEARCH

Myocardial ischaemia inhibits mitochondrial metabolism of 4-hydroxy-trans-2-nonenal

(2008) Bradford G. Hill et al.   BIOCHEMICAL JOURNAL

Aldose reductase decreases endoplasmic reticulum stress in ischemic hearts

(2008) Rachel J. Keith et al.   CHEMICO-BIOLOGICAL INTERACTIONS

Mast cells and ɛPKC: A role in cardiac remodeling in hypertension-induced heart failure

(2008) Suresh Selvaraj Palaniyandi et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

Activation of Aldehyde Dehydrogenase-2 Reduces Ischemic Damage to the Heart

(2008) Che-Hong Chen et al.   SCIENCE