Article
Biochemistry & Molecular Biology
Yi-Chyan Chen, Li-Fang Yang, Ching-Long Lai, Shih-Jiun Yin
Summary: Alcohol sensitivity is influenced by genetic and sociocultural factors, with ALDH2*2 playing a major role in physiological negative responses related to acetaldehyde and providing genetic protection against alcoholism in East Asians.
Article
Urology & Nephrology
Daniel R. Greenberg, Hriday P. Bhambhvani, Satvir S. Basran, Brett P. Salazar, Luis Carl Rios, Sin-Jin Li, Che-Hong Chen, Daria Mochly-Rosen, Michael L. Eisenberg
Summary: This study found an association between alcohol intake and semen parameters among East Asian men carrying the ALDH2*2 allele. Alcohol consumption was associated with significantly lower total and progressive sperm motility in ALDH2*2 carriers. Furthermore, ALDH2 expression in spermatozoa was significantly lower in ALDH2*2 carriers.
JOURNAL OF UROLOGY
(2022)
Article
Pharmacology & Pharmacy
MengLin Chen, Min Chen, Danyi Lu, Yi Wang, Li Zhang, Zhigang Wang, Baojian Wu
Summary: The study focused on investigating the potential role of the Per2 gene in regulating the expression of hepatic CYP2B10, which is responsible for the metabolism and detoxification of many clinical drugs. The study showed that Per2 positively regulates the expression and activity of CYP2B10 in mouse liver by inhibiting its repressor REV-ERB alpha.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Multidisciplinary Sciences
Eric Simon, Maciej Motyka, Grietje H. Prins, Mei Li, Werner Rust, Stefan Kauschke, Coralie Viollet, Peter Olinga, Anouk Oldenburger
Summary: There is a need for predictive ex vivo models for NAFLD. This study profiles a new human and mouse PCLSs based assay for steatosis in NAFLD using RNASeq. Steatosis is induced by incremental supplementation of sugars, insulin, and fatty acids, and the gene expression regulation is analyzed across different nutrient conditions and time for both human and mouse liver organ derived PCLSs.
Review
Cell Biology
Che-Hong Chen, Benjamin R. Kraemer, Daria Mochly-Rosen
Summary: The ALDH2*2 variant is a genetic polymorphism that commonly leads to alcohol flushing reactions and is associated with the largest number of traits in humans. It affects nearly 8% of the world population, especially East Asians. Carriers of the ALDH2*2 variant present alterations in multiple blood biomarkers, clinical measurements, drug prescriptions, dietary habits, and lifestyle behaviors. They are also more susceptible to aldehyde-associated diseases. However, the interaction between alcohol and ALDH2-related pathology and the possible beneficial effects of ALDH2 deficiency are not well understood.
DISEASE MODELS & MECHANISMS
(2022)
Article
Medicine, General & Internal
Yijin Chen, Hongtao Liu, Zhikang Yu, Yang Yang, Qingyan Huang, Changqing Deng, Hui Rao, Heming Wu
Summary: In Hakka alcoholics from southern China, the ALDH2 gene rs671 *1/*2 genotype is a potential risk factor for developing alcoholic cirrhosis (ALC). The study found that the proportion of the G/G homozygous genotype was lower in ALC patients compared to other groups, while the G/A heterozygous genotype was higher in ALC patients. Additionally, low levels of neutrophil-to-lymphocyte ratio (NLR), lymphocyte-to-monocyte ratio (LMR), platelet-to-lymphocyte ratio (PLR), and the ALDH2 G/A genotype were significantly associated with an increased risk of ALC.
INTERNATIONAL JOURNAL OF GENERAL MEDICINE
(2022)
Review
Physiology
Soo K. Shin, Erin E. Kaiser, Franklin D. West
Summary: Pigs, as an animal model for simulating human alcohol use disorder, exhibit similar voluntary alcohol consumption and intoxication behaviors observed in humans, along with anatomical similarities in the brain and liver, making them a promising tool for studying the complex nature of AUD and its development in humans.
FRONTIERS IN PHYSIOLOGY
(2021)
Article
Endocrinology & Metabolism
Shiyun Jin, Qi Cao, Fanghan Yang, Hongying Zhu, Su Xu, Qi Chen, Ziyi Wang, Yuhong Lin, Resat Cinar, Robert J. Pawlosky, Ye Zhang, Wei Xiong, Bin Gao, George F. Koob, David M. Lovinger, Li Zhang
Summary: The study demonstrates that astrocytic ALDH2 metabolizes ethanol in the brain, affecting the behavioral effects of alcohol. It shows that astrocytic ALDH2 controls the production and behavioral effects of alcohol metabolites in different brain regions.
Article
Biochemistry & Molecular Biology
Wiramon Rungratanawanich, Yuhong Lin, Xin Wang, Toshihiro Kawamoto, Saravana Babu Chidambaram, Byoung-Joon Song
Summary: This study found that mice lacking ALDH2 are more susceptible to binge alcohol-induced liver injury, possibly due to increased oxidative stress, increased gut permeability, and endotoxemia. This suggests that ALDH2 plays a protective role in alcohol-related gut and liver injury.
Article
Medicine, Research & Experimental
Min Wei, Ting Li, Houkang Cao, Haiyan He, Chaoyue Yang, Yifan Yin, Huijie Lu, Petr Novak, Kefeng Zhang, Ya Gao
Summary: This study found that Scoparone (SCO) has significant hepatoprotective effects on liver injury induced by alcohol and high-fat diet (HFD) in mice. By regulating alcohol metabolism and lipid metabolism pathways, SCO can inhibit lipid accumulation, improve alcohol metabolism, reduce oxidative stress, and inhibit inflammatory response.
BIOMEDICINE & PHARMACOTHERAPY
(2022)
Article
Biology
Chih-Yao Hu, Chung-Lieh Hung, Yen-Chang Huang, Po-Han Huang, Da-Yo Tseng, Yi-Hsuan Lin, Fang-Ju Sun, Fu-Jen Kao, Hung- Yeh, Yen-Yu Liu
Summary: The study found that using the HSV model analysis with APT resulted in better sensitivity and equal specificity compared to visual inspection, showing that the HSV model could help in predicting ALDH2 genetic polymorphisms.
COMPUTERS IN BIOLOGY AND MEDICINE
(2022)
Article
Biochemistry & Molecular Biology
Abraham S. Meijnikman, Mark Davids, Hilde Herrema, Omrum Aydin, Valentina Tremaroli, Melany Rios-Morales, Han Levels, Sjoerd Bruin, Maurits de Brauw, Joanne Verheij, Marleen Kemper, Adriaan G. Holleboom, Maarten E. Tushuizen, Thue W. Schwartz, Jens Nielsen, Dees Brandjes, Eveline Dirinck, Jonas Weyler, An Verrijken, Christophe E. M. De Block, Luisa Vonghia, Sven Francque, Ulrich Beuers, Victor E. A. Gerdes, Fredrik Backhed, Albert K. Groen, Max Nieuwdorp
Summary: This study found that microbial ethanol might contribute to pathogenesis in some patients with nonalcoholic fatty liver disease. The research suggests that microbial ethanol could be considered in the pathogenesis of this highly prevalent liver disease.
Review
Biochemistry & Molecular Biology
Jeongeun Hyun, Jinsol Han, Chanbin Lee, Myunghee Yoon, Youngmi Jung
Summary: Alcoholic liver disease (ALD) is a chronic liver disease caused by chronic or binge alcohol consumption, leading to liver damage and inflammatory reactions. However, the lack of animal models that fully mimic human ALD has posed challenges for the development of novel treatments.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Biochemistry & Molecular Biology
Raquel G. Bardallo, Rui Teixeira da Silva, Teresa Carbonell, Emma Folch-Puy, Carlos Palmeira, Joan Rosello-Catafau, Jacques Pirenne, Rene Adam, Arnau Panisello-Rosello
Summary: This study investigates the effects of PEG35 in different liver preservation solutions, showing that PEG35 promotes the activity of mitochondrial enzyme ALDH2 and, when combined with glutathione, prevents the formation of toxic aldehyde adducts, reducing damage in a fatty liver rat model.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Biochemistry & Molecular Biology
Valeria Scalcon, Alessandra Folda, Maria Giovanna Lupo, Federica Tonolo, Naixuan Pei, Ilaria Battisti, Nicola Ferri, Giorgio Arrigoni, Alberto Bindoli, Arne Holmgren, Lucia Coppo, Maria Pia Rigobello
Summary: This study reveals the specific role of mitochondrial Grx2 in the regulation of cell metabolism and highlights an unknown association between Grx2 and metabolic dysfunction-associated fatty liver disease (MAFLD).
Article
Chemistry, Organic
Tiejun Yan, Fengguang Wu, Canbin Ouyang, Xin Wang, Guangjiong Qin, Guojie Zhao
Summary: This paper reports the synthesis and characterization of novel chromophores based on chlorogenic acid. The new chromophores showed good thermal stability and nonlinear optical properties, as well as significant improvement in water solubility. They are promising candidates for practical use in applications such as molecule probes, SHG imaging, and photodynamic/photothermal therapy.
POLYCYCLIC AROMATIC COMPOUNDS
(2022)
Article
Chemistry, Multidisciplinary
Hongfei Cheng, Nailiang Yang, Xiaozhi Liu, Yilv Guo, Bin Liu, Jianhui Yang, Ye Chen, Bo Chen, Zhanxi Fan, Qipeng Lu, Shijun Yuan, Jinlan Wang, Lin Gu, Hua Zhang
Summary: Phase engineering of nanomaterials is an effective strategy to tune their physicochemical properties for various applications. In this study, four novel magnetic nanostructures were synthesized based on quasi-epitaxial growth using 4H-Au nanoribbons as templates. These nanostructures exhibit unique magnetic behaviors at room temperature, paving the way for exploring phase-dependent properties in nanomaterials.
ADVANCED MATERIALS
(2021)
Article
Chemistry, Multidisciplinary
Jingjie Ge, Peiqun Yin, Ye Chen, Hongfei Cheng, Jiawei Liu, Bo Chen, Chaoliang Tan, Peng-Fei Yin, Hong-Xing Zheng, Qiang-Qiang Li, Shuangming Chen, Wenjie Xu, Xiaoqian Wang, Geng Wu, Rongbo Sun, Xiang-Huan Shan, Xun Hong, Hua Zhang
Summary: This study presents a novel method for synthesizing ultrathin amorphous/crystalline Rh and Rh-based bimetallic alloy nanosheets using a wet-chemical approach, demonstrating their enhanced catalytic activity for indole synthesis. The obtained amorphous/crystalline RhCu alloy nanosheets exhibit exceptionally high selectivity (>99.9%) and conversion efficiency (100%) towards indole, highlighting the importance of phase engineering and metal alloying in the rational design of heterogeneous catalysts for fine chemical synthesis.
ADVANCED MATERIALS
(2021)
Article
Chemistry, Multidisciplinary
Ade Kismarahardja, Zhanxin Wang, Dongwei Li, Lihua Wang, Libo Fu, Yujie Chen, Zhanxi Fan, Ye Chen, Xiaodong Han, Hua Zhang, Xiaozhou Liao
Summary: The deformation mechanism of gold nanoribbons with unconventional hexagonal structures is investigated using atomic-resolution in situ tensile-straining transmission electron microscopy. The results reveal that plastic deformation involves three stages and includes both full and partial dislocation activities.
Article
Chemistry, Multidisciplinary
Liangjun Chen, Minchu Huang, Bo Chen, Chengtao Gong, Nanjun Li, Hongfei Cheng, Ye Chen, Yongwu Peng, Guodong Xu
Summary: Two-dimensional covalent organic framework nanosheets are attracting research attention due to their unique properties with great potential in energy-related applications. They provide high transport pathways for charge carriers through two typical synthetic methods. Future research will face challenges and opportunities.
CHINESE CHEMICAL LETTERS
(2022)
Article
Chemistry, Multidisciplinary
Yangbo Ma, Jinli Yu, Mingzi Sun, Bo Chen, Xichen Zhou, Chenliang Ye, Zhiqiang Guan, Weihua Guo, Gang Wang, Shiyao Lu, Dongsheng Xia, Yunhao Wang, Zhen He, Long Zheng, Qinbai Yun, Liqiang Wang, Jingwen Zhou, Pengyi Lu, Jinwen Yin, Yifei Zhao, Zhongbin Luo, Li Zhai, Lingwen Liao, Zonglong Zhu, Ruquan Ye, Ye Chen, Yang Lu, Shibo Xi, Bolong Huang, Chun-Sing Lee, Zhanxi Fan
Summary: This study reports the synthesis of highly selective Ag-Cu Janus nanostructures for the electrocatalytic reduction of CO2 to multicarbon products. The Ag-Cu Janus nanostructures demonstrated superior selectivity and performance compared to Cu nanocubes. The study provides an effective strategy for designing advanced catalysts for the extensive application of CO2RR.
ADVANCED MATERIALS
(2022)
Article
Nanoscience & Nanotechnology
Peng Yang, Jiajia Zha, Guoyun Gao, Long Zheng, Haoxin Huang, Yunpeng Xia, Songcen Xu, Tengfei Xiong, Zhuomin Zhang, Zhengbao Yang, Ye Chen, Dong-Keun Ki, Juin J. Liou, Wugang Liao, Chaoliang Tan
Summary: The lack of stable p-type van der Waals (vdW) semiconductors has been a major barrier for the development of low-dimensional materials in the industry. In this study, high-quality Te nanobelts were grown on atomically flat hexagonal boron nitride (h-BN) substrate, enabling the fabrication of high-performance p-type field-effect transistors (FETs). The Te-based FET showed an ultrahigh hole mobility at room temperature, which holds great potential for future high-performance p-type 2D FETs and metal-oxide-semiconductor (p-MOS) inverters.
NANO-MICRO LETTERS
(2022)
Article
Chemistry, Multidisciplinary
Wenbin Wang, Junlei Qi, Li Zhai, Chen Ma, Chengxuan Ke, Wei Zhai, Zongxiao Wu, Kai Bao, Yao Yao, Siyuan Li, Bo Chen, D. V. Maheswar Repaka, Xiao Zhang, Ruquan Ye, Zhuangchai Lai, Guangfu Luo, Ye Chen, Qiyuan He
Summary: The emerging nonlayered 2D materials (NL2DMs) have sparked interest due to their unique properties and enhanced performance. In this study, nonlayered molybdenum phosphide (MoP) with well-defined 2D morphology was synthesized and showed promising performance in the electrocatalytic hydrogen evolution reaction (HER). This work provides a new synthetic strategy for high-quality nonlayered materials with well-defined 2D morphology.
ADVANCED MATERIALS
(2022)
Article
Chemistry, Multidisciplinary
Liangkun Pan, Long Zheng, Ye Chen, Zhihai Ke, Ying-Yeung Yeung
Summary: A mechanochemical method using hypervalent iodine reagents has been developed for the functionalization of olefins, enabling the synthesis of 1,3-dioxygenated compounds. Under similar reaction conditions with the addition of molecular iodine, 1,4-iodoalcohols can also be synthesized. These valuable products are difficult to achieve using traditional solution-phase methods. Mechanistic study suggests that the hypervalent iodine reagent may dimerize at the solid state and trigger the 1,3- and 1,4-difunctionalization reactions in an intermolecular cascade manner.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2022)
Article
Oncology
Kathy Han, Anthony Fyles, Tina Shek, Jennifer Croke, Neesha Dhani, David D'Souza, Ting-Yim Lee, Naz Chaudary, Jeffrey Bruce, Melania Pintilie, Rob Cairns, Douglass Vines, Sara Pakbaz, David Jaffray, Ur Metser, Marjan Rouzbahman, Michael Milosevic, Marianne Koritzinsky
Summary: This study found that metformin can reduce tumor hypoxia in cervical cancer and improve the tumor's response to radiation therapy. After using metformin, the hypoxic volume decreased and the disease-free survival rate of the patients increased.
CLINICAL CANCER RESEARCH
(2022)
Correction
Oncology
Sameer Agnihotri, Brian Golbourn, Xi Huang, Marc Remke, Susan Younger, Rob A. Cairns, Alan Chalil, Christian A. Smith, Stacey-Lynn Krumholtz, Danielle Mackenzie, Patricia Rakopoulos, Vijay Ramaswamy, Michael S. Taccone, Paul S. Mischel, Gregory N. Fuller, Cynthia Hawkins, William Stanford, Michael D. Taylor, Gelareh Zadeh, James T. Rutka
Article
Nanoscience & Nanotechnology
Yunpeng Xia, Jiajia Zha, Haoxin Huang, Huide Wang, Peng Yang, Long Zheng, Zhuomin Zhang, Zhengbao Yang, Ye Chen, Hau Ping Chan, Johnny C. C. Ho, Chaoliang Tan
Summary: This study explores the effect of different crystal phases of MoTe2 as the charge-trapping layer in 2D van der Waals heterostructure-based flash memory devices. It is found that the device based on MoS2/h-BN/1T'-MoTe2 exhibits better performance than the device based on MoS2/h-BN/2H-MoTe2, including a larger memory window, faster switching speed, and higher extinction ratio. This research demonstrates that the crystal phase of 2D TMDs has a significant impact on the performance of nonvolatile flash memory devices based on 2D vdW heterostructures.
ACS APPLIED MATERIALS & INTERFACES
(2023)
Review
Electrochemistry
Yanjie Zhai, Peng Han, Qinbai Yun, Yiyao Ge, Xiao Zhang, Ye Chen, Hua Zhang
Summary: Phase engineering is an important strategy to regulate the catalytic performance of metal nanocatalysts for the electrochemical CO2 reduction reaction (CO2RR), enabling efficient and selective CO2RR. Significant achievements have been made in developing metal nanocatalysts with conventional and unconventional crystal phases.
Review
Chemistry, Multidisciplinary
Chen Ma, Long Zheng, Gang Wang, Jun Guo, Liuxiao Li, Qiyuan He, Ye Chen, Hua Zhang
Summary: Metal-organic frameworks (MOFs) have unique structural features such as tunable pore structure and enormous surface area, attracting extensive research interests. Phase engineering of nanomaterials (PEN) provides an effective strategy to tune the functional properties of MOFs. Controlling the crystal phase of MOFs is essential for improving their performances in various applications and recent advances have been made in this area.
Review
Chemistry, Physical
Gang Wang, Chen Ma, Long Zheng, Ye Chen
Summary: This review provides a comprehensive overview of the morphology- and crystal phase-controlled synthesis of gold nanomaterials using the [Au(i)-oleylamine] complex as the intermediate. Various proposed formation mechanisms of different morphologies and crystal phases are discussed, highlighting the uniqueness of the [Au(i)-oleylamine] interaction. Additionally, the applications of oleylamine-capped gold nanomaterials in catalysis and electronic devices are introduced, with perspectives on the challenges and opportunities in this direction.
JOURNAL OF MATERIALS CHEMISTRY A
(2021)