Mitochondrial aldehyde dehydrogenase 2 deficiency aggravates energy metabolism disturbance and diastolic dysfunction in diabetic mice

A novel protective mechanism for mitochondrial aldehyde dehydrogenase (ALDH2) in type i diabetes-induced cardiac dysfunction: Role of AMPK-regulated autophagy

(2015) Yuli Guo et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Acetaldehyde dehydrogenase 2 (ALDH2) deficiency exacerbates pressure overload-induced cardiac dysfunction by inhibiting Beclin-1 dependent autophagy pathway

(2015) Cheng Shen et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Diastolic dysfunction in the diabetic continuum: association with insulin resistance, metabolic syndrome and type 2 diabetes

(2015) Ricardo Fontes-Carvalho et al.   Cardiovascular Diabetology

Prospective association of fatty acids in the de novo lipogenesis pathway with risk of type 2 diabetes: the Cardiovascular Health Study

(2014) Wenjie Ma et al.   AMERICAN JOURNAL OF CLINICAL NUTRITION

Aldehyde dehydrogenase 2 activation in heart failure restores mitochondrial function and improves ventricular function and remodelling

(2014) Katia M.S. Gomes et al.   CARDIOVASCULAR RESEARCH

Matrix Revisited

(2014) Andrew N. Carley et al.   CIRCULATION RESEARCH

Heart Failure With Preserved Ejection Fraction

(2014) Francesco S. Loffredo et al.   CIRCULATION RESEARCH

Mitochondrial aldehyde dehydrogenase 2 accentuates aging-induced cardiac remodeling and contractile dysfunction: role of AMPK, Sirt1, and mitochondrial function

(2014) Yingmei Zhang et al.   FREE RADICAL BIOLOGY AND MEDICINE

AMP-activated protein kinase: a key regulator of energy balance with many roles in human disease

(2014) D. Grahame Hardie   JOURNAL OF INTERNAL MEDICINE

Aldehyde dehydrogenase 2 ameliorates doxorubicin-induced myocardial dysfunction through detoxification of 4-HNE and suppression of autophagy

(2014) Aijun Sun et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

Targeting Aldehyde Dehydrogenase 2: New Therapeutic Opportunities

(2014) Che-Hong Chen et al.   PHYSIOLOGICAL REVIEWS

Urine Bile Acids Relate to Glucose Control in Patients with Type 2 Diabetes Mellitus and a Body Mass Index Below 30 kg/m2

(2014) David R. Taylor et al.   PLoS One

AMPK activation—protean potential for boosting healthspan

(2013) Mark F. McCarty   AGE

Preserved endothelium-dependent dilatation of the coronary microvasculature at the early phase of diabetes mellitus despite the increased oxidative stress and depressed cardiac mechanical function ex vivo

(2013) Evangelia Mourmoura et al.   Cardiovascular Diabetology

Advanced glycation end products: role in pathology of diabetic cardiomyopathy

(2013) Vijaya Lakshmi Bodiga et al.   HEART FAILURE REVIEWS

Metabolic dysfunction in diabetic cardiomyopathy

(2013) Michael Isfort et al.   HEART FAILURE REVIEWS

Endogenous Prostaglandin D 2 and Its Metabolites Protect the Heart Against Ischemia–Reperfusion Injury by Activating Nrf2

(2013) Yoshinori Katsumata et al.   HYPERTENSION

LMBD1 Protein Serves as a Specific Adaptor for Insulin Receptor Internalization

(2013) Linda Tzu-Ling Tseng et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Metabonomic Profiling Revealed an Alteration in Purine Nucleotide Metabolism Associated with Cardiac Hypertrophy in Rats Treated with Thiazolidinediones

(2013) Yan Liu et al.   JOURNAL OF PROTEOME RESEARCH

Plasma Lipid Profiling Shows Similar Associations with Prediabetes and Type 2 Diabetes

(2013) Peter J. Meikle et al.   PLoS One

Effects of 4-hydroxynonenal on vascular endothelial and smooth muscle cell redox signaling and function in health and disease

(2013) Sarah J. Chapple et al.   Redox Biology

Mitochondrial aldehyde dehydrogenase (ALDH2) protects against streptozotocin-induced diabetic cardiomyopathy: role of GSK3β and mitochondrial function

(2012) Yingmei Zhang et al.   BMC Medicine

Effects of Catecholamine Stress on Diastolic Function and Myocardial Energetics in Obesity

(2012) Oliver J. Rider et al.   CIRCULATION

Metabolite Profiling Identifies Pathways Associated With Metabolic Risk in Humans

(2012) Susan Cheng et al.   CIRCULATION

Reversible Left Ventricular Diastolic Dysfunction on Doppler Tissue Imaging Predicts a More Favorable Prognosis in Chronic Heart Failure

(2012) Cheng-Hung Lee et al.   CIRCULATION JOURNAL

Ranolazine Improves Cardiac Diastolic Dysfunction Through Modulation of Myofilament Calcium Sensitivity

(2012) Joshua D. Lovelock et al.   CIRCULATION RESEARCH

Agonist-Induced Hypertrophy and Diastolic Dysfunction Are Associated With Selective Reduction in Glucose Oxidation

(2012) Jun Mori et al.   Circulation-Heart Failure

Diabetic cardiomyopathy

(2012) BR Goyal et al.   HUMAN & EXPERIMENTAL TOXICOLOGY

Diabetes Mellitus Worsens Diastolic Left Ventricular Dysfunction in Aortic Stenosis Through Altered Myocardial Structure and Cardiomyocyte Stiffness

(2011) Inês Falcão-Pires et al.   CIRCULATION

Mitochondria as a source and target of lipid peroxidation products in healthy and diseased heart

(2011) Ethan J Anderson et al.   CLINICAL AND EXPERIMENTAL PHARMACOLOGY AND PHYSIOLOGY

Phospholipid homeostasis regulates lipid metabolism and cardiac function through SREBP signaling in Drosophila

(2011) H.-Y. Lim et al.   GENES & DEVELOPMENT

Metabolic Regulation in Progression to Autoimmune Diabetes

(2011) Marko Sysi-Aho et al.   PLoS Computational Biology

Diabetes and the Risk of Heart Failure

(2011) Ravi Dhingra et al.   Heart Failure Clinics

Reduced in vivo high-energy phosphates precede Adriamycin-induced cardiac dysfunction

(2010) M. Y. Maslov et al.   AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY

Left ventricular function and energy homeostasis in patients with type 1 diabetes with and without microvascular complications

(2010) Gianluca Perseghin et al.   INTERNATIONAL JOURNAL OF CARDIOLOGY

Refined Geographic Distribution of the OrientalALDH2*504Lys(nee487Lys) Variant

(2009) Hui Li et al.   ANNALS OF HUMAN GENETICS