Acid-base transporters and pH dynamics in human breast carcinomas predict proliferative activity, metastasis, and survival

Pyrazine ring-based Na+/H+ exchanger (NHE) inhibitors potently inhibit cancer cell growth in 3D culture, independent of NHE1

(2020) Michala G. Rolver et al.   Scientific Reports

Targeting the Acidic Tumor Microenvironment: Unexpected Pro-Neoplastic Effects of Oral NaHCO3 Therapy in Murine Breast Tissue

(2020) Ninna C. S. Voss et al.   Cancers

Protective Role of IRBIT on Sodium Bicarbonate Cotransporter-n1 for Migratory Cancer Cells

(2020) Soyoung Hwang et al.   Pharmaceutics

Incidence Trends of Breast Cancer Molecular Subtypes by Age and Race/Ethnicity in the US From 2010 to 2016

(2020) Teofilia Acheampong et al.   JAMA Network Open

Mutation–selection balance and compensatory mechanisms in tumour evolution

(2020) Erez Persi et al.   NATURE REVIEWS GENETICS

Na+,HCO3− cotransporter NBCn1 accelerates breast carcinogenesis

(2019) Ebbe Boedtkjer   CANCER AND METASTASIS REVIEWS

Extracellular Acidosis Modulates the Expression of Epithelial-Mesenchymal Transition (EMT) Markers and Adhesion of Epithelial and Tumor Cells

(2019) Anne Riemann et al.   NEOPLASIA

Invasive lobular breast cancer: A review of pathogenesis, diagnosis, management, and future directions of early stage disease

(2019) Mathew Thomas et al.   SEMINARS IN ONCOLOGY

Assessment of Long-term Distant Recurrence-Free Survival Associated With Tamoxifen Therapy in Postmenopausal Patients With Luminal A or Luminal B Breast Cancer

(2019) Nancy Y. Yu et al.   JAMA Oncology

The Acidic Tumor Microenvironment as a Driver of Cancer

(2019) Ebbe Boedtkjer et al.   Annual Review of Physiology

Tumor Microenvironment: A Metabolic Player that Shapes the Immune Response

(2019) Shamir Cassim et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Roles of pH in control of cell proliferation

(2018) M. Flinck et al.   Acta Physiologica

Na+,HCO3–-cotransporter NBCn1 (Slc4a7) accelerates ErbB2-induced breast cancer development and tumor growth in mice

(2018) Soojung Lee et al.   ONCOGENE

Trafficking, localization and degradation of the Na+,HCO3− co-transporter NBCn1 in kidney and breast epithelial cells

(2018) Christina Wilkens Olesen et al.   Scientific Reports

Hypoxia and cellular metabolism in tumour pathophysiology

(2017) Scott K. Parks et al.   JOURNAL OF PHYSIOLOGY-LONDON

Na + /H + exchanger-mediated hydrogen ion extrusion as a carcinogenic signal in triple-negative breast cancer etiopathogenesis and prospects for its inhibition in therapeutics

(2017) Schammim Ray Amith et al.   SEMINARS IN CANCER BIOLOGY

Roles of pH and the Na + /H + exchanger NHE1 in cancer: From cell biology and animal models to an emerging translational perspective?

(2017) Christian Stock et al.   SEMINARS IN CANCER BIOLOGY

Predictors of Surgical Margin Following Breast-Conserving Surgery: A Large Population-Based Cohort Study

(2016) Carolien H. M. van Deurzen   ANNALS OF SURGICAL ONCOLOGY

Monocarboxylate transporters in the brain and in cancer

(2016) Jhudit Pérez-Escuredo et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Molecular Subtypes of Breast Cancer: Long-term Incidence Trends and Prognostic Differences

(2016) M. Valla et al.   CANCER EPIDEMIOLOGY BIOMARKERS & PREVENTION

Na+, HCO3−-cotransporter NBCn1 increases pHigradients, filopodia, and migration of smooth muscle cells and promotes arterial remodelling

(2016) Ebbe Boedtkjer et al.   CARDIOVASCULAR RESEARCH

The Function of V-ATPases in Cancer

(2016) Laura Stransky et al.   PHYSIOLOGICAL REVIEWS

Tailoring therapies—improving the management of early breast cancer: St Gallen International Expert Consensus on the Primary Therapy of Early Breast Cancer 2015

(2015) A. S. Coates et al.   ANNALS OF ONCOLOGY

Disrupting Na+,HCO3–-cotransporter NBCn1 (Slc4a7) delays murine breast cancer development

(2015) S Lee et al.   ONCOGENE

Synthesis of N-cyano-substituted sulfilimine and sulfoximine derivatives of S0859 and their biological evaluation as sodium bicarbonate co-transport inhibitors

(2015) Anne-Dorothee Steinkamp et al.   MedChemComm

Acidic extracellular pH promotes epithelial mesenchymal transition in Lewis lung carcinoma model

(2014) Atsuko Suzuki et al.   Cancer Cell International

Na+,HCO3 −-cotransport is functionally upregulated during human breast carcinogenesis and required for the inverted pH gradient across the plasma membrane

(2014) Soojung Lee et al.   PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY

Splice Cassette II of Na+,HCO3−Cotransporter NBCn1 (slc4a7) Interacts with Calcineurin A

(2013) Andreas A. Danielsen et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Gram-Scale Solution-Phase Synthesis of Selective Sodium Bicarbonate Co-transport Inhibitor S0859: in vitro Efficacy Studies in Breast Cancer Cells

(2012) Ann M. Larsen et al.   ChemMedChem

NHE-1: A Promising Target for Novel Anti-cancer Therapeutics

(2012) Ser Yue Loo et al.   CURRENT PHARMACEUTICAL DESIGN

Physiology, Pharmacology and Pathophysiology of the pH Regulatory Transport Proteins NHE1 and NBCn1: Similarities, Differences, and Implications for Cancer Therapy

(2012) E. Boedtkjer et al.   CURRENT PHARMACEUTICAL DESIGN

Contribution of Na+,HCO3−-cotransport to cellular pH control in human breast cancer: A role for the breast cancer susceptibility locus NBCn1 (SLC4A7)

(2012) Ebbe Boedtkjer et al.   INTERNATIONAL JOURNAL OF CANCER

Intracellular pH in the Resistance Vasculature: Regulation and Functional Implications

(2012) Ebbe Boedtkjer et al.   JOURNAL OF VASCULAR RESEARCH

Role of Ion Channels and Transporters in Cell Migration

(2012) Albrecht Schwab et al.   PHYSIOLOGICAL REVIEWS

Acid–base transporters modulate cell migration, growth and proliferation: Implications for structure development and remodeling of resistance arteries?

(2012) Ebbe Boedtkjer et al.   TRENDS IN CARDIOVASCULAR MEDICINE

The Na+/H+ exchanger NHE1, but not the Na+, cotransporter NBCn1, regulates motility of MCF7 breast cancer cells expressing constitutively active ErbB2

(2011) Gitte Lauritzen et al.   CANCER LETTERS

Dual Role of CO2/HCO3−Buffer in the Regulation of Intracellular pH of Three-dimensional Tumor Growths

(2011) Alzbeta Hulikova et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

NBCn1 and NHE1 expression and activity in ΔNErbB2 receptor-expressing MCF-7 breast cancer cells: Contributions to pHi regulation and chemotherapy resistance

(2010) G. Lauritzen et al.   EXPERIMENTAL CELL RESEARCH

Supervised Risk Predictor of Breast Cancer Based on Intrinsic Subtypes

(2009) Joel S. Parker et al.   JOURNAL OF CLINICAL ONCOLOGY

Insulin inhibits Na+/H+ exchange in vascular smooth muscle and endothelial cells in situ: involvement of H2O2 and tyrosine phosphatase SHP-2

(2008) Ebbe Boedtkjer et al.   AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY

Sodium-Hydrogen Exchange Inhibition by Cariporide to Reduce the Risk of Ischemic Cardiac Events in Patients Undergoing Coronary Artery Bypass Grafting: Results of the EXPEDITION Study

(2008) Robert M. Mentzer et al.   ANNALS OF THORACIC SURGERY

The Humoral Immune System Has a Key Prognostic Impact in Node-Negative Breast Cancer

(2008) M. Schmidt et al.   CANCER RESEARCH