Article
Fisheries
Fei Shi, Zhijie Lu, Minxuan Yang, Feng Li, Fanbin Zhan, Lijuan Zhao, Yanan Li, Qingqing Li, Jiangtao Li, Jun Li, Li Lin, Zhendong Qin
Summary: The study showed that APS can modulate the intestinal microbiota and activate the immune response to protect grass carp from bacterial infection.
Article
Biochemistry & Molecular Biology
Jia Liu, Peijun Zhang, Bo Wang, Yuting Lu, Liang Li, Yuehong Li, Shaojun Liu
Summary: This experiment demonstrated that Astragalus polysaccharides (APS) had immunomodulatory effects on crucian carp, enhancing immune-related indicators and antiviral abilities. The results showed that APS could significantly improve the immune response and resistance against viral infection in crucian carp and EPC cells infected with SVCV.
COMPARATIVE BIOCHEMISTRY AND PHYSIOLOGY C-TOXICOLOGY & PHARMACOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Shengming Sun, Chao Bian, Na Zhou, Zhixin Shen, Ming Yu
Summary: Supplementation with different doses of Astragalus polysaccharides (APS) improved growth, innate immune response, and brain-gut axis in Macrobrachium rosenbergii. APS supplementation increased lipase and protease activities, reduced pathogenic intestinal bacteria, altered microbiota composition, increased fecal short chain fatty acid content, enhanced immunity, and improved disease resistance in prawns.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2023)
Article
Biochemistry & Molecular Biology
Bing Yang, Zhiwei Xiong, Meng Lin, Yanjun Yang, Yaping Chen, Jingqi Zeng, Xiaobin Jia, Liang Feng
Summary: This study found that polysaccharides, the main components of Astragalus, a traditional Chinese medicine, can regulate the gut microbiota associated with type 1 diabetes (T1D). It improves gut barrier function, gut microbiota composition, lowers blood glucose, and increases insulin levels. This effect may be related to the production of short-chain fatty acids and the modulation of inflammatory response.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2023)
Article
Food Science & Technology
Yiyun Zhang, Jinxing Wang, Qi Zhang, Liling Deng, Siyao Miao, Geng Zhong
Summary: According to a 1:1 ratio, konjac flour and mulberry leaf powder are combined to create a dietary fiber source (KMCP) that has been found to have anti-inflammatory properties. The exact effects and mechanisms of KMCP in treating allergic rhinitis are unknown. This study investigated the effects of KMCP on ovalbumin-induced allergic rhinitis and found a decrease in nasal rubbing, sneezing, eosinophil count, histamine levels, OVA-specific immunoglobulin E (OVA-sIgE) levels, and interleukin-4 (IL-4) levels, as well as inhibition of histopathological changes in the nasal mucosa. Additionally, KMCP treatment had a substantial impact on short-chain fatty acid metabolism in the cecum. Overall, this study suggests that KMCP can suppress the inflammatory response in allergic rhinitis and serve as a novel and side effect-free treatment option.
FOOD SCIENCE AND HUMAN WELLNESS
(2023)
Article
Biochemistry & Molecular Biology
Juyoung Hwang, Wei Zhang, Yadav Dhananjay, Eun-Koung An, Minseok Kwak, Sang Guan You, Peter Chang-Whan Lee, Jun-O Jin
Summary: Intranasal administration of Astragalus membranaceus polysaccharides (APS) activated mucosal immune cell populations and inhibited pulmonary metastatic melanoma in mice by stimulating NK cells and T cells in the mesenteric lymph nodes. The combination treatment of APS with anti-PD-L1 antibody showed a synergistic effect in inhibiting melanoma cell infiltration, with NK cells and CD8 T cells playing a critical role in mediating the anti-cancer immunity. These findings suggest that APS could serve as a topical mucosal adjuvant to enhance the anti-cancer effect of immune checkpoint inhibitors.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2021)
Article
Biochemistry & Molecular Biology
Yanan Li, Junping Zheng, Yao Wang, Huabing Yang, Lu Cao, Shuiyong Gan, Jun Ma, Hongtao Liu
Summary: This study investigates the role of gut microbiota in the immune-enhancing activity of Astragalus polysaccharides (APS) in mice. The results show that APS can ameliorate immunosuppression in mice and activate Toll-like receptor 4 (TLR4) and mitogen-activated protein kinase (MAPK) pathways. APS treatment also reverses gut microbiota dysbiosis in immunocompromised mice.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2023)
Article
Fisheries
Ramasamy Harikrishnan, Gunapathy Devi, Hien Van Doan, Wanaporn Tapingkae, Chellam Balasundaram, Jesu Arockiaraj, Einar Ringo
Summary: This study investigated the effects of Astragalus polysaccharides (APs) supplementation diets on the growth, haemato-biochemical parameters, metabolic-digestive enzymes, antioxidant activity, immune response, and cytokine gene expression in catla fish against Edwardsiella tarda. The results showed that the APs enriched diets improved the growth, haemato-biochemical parameters, antioxidant activity, immune response, and cytokine gene expression in catla fish.
FISH & SHELLFISH IMMUNOLOGY
(2022)
Article
Food Science & Technology
Yu-Jyun Wei, Rui-En Fang, Jing-Yi Ou, Chorng-Liang Pan, Chung-Hsiung Huang
Summary: Studies have shown the immune modulatory effects of Porphyra extract and derived polysaccharides, but little is known about the impact of Porphyra-derived oligosaccharides. This study found that Porphyra-derived polysaccharides and oligosaccharides can down-regulate antigen-specific immune responses and increase the IL-10/IL-4 ratio, suggesting their potential as functional foods for immunomodulation.
JOURNAL OF FUNCTIONAL FOODS
(2022)
Article
Biochemistry & Molecular Biology
Anastasia Mutovina, Kseniya Ayriyants, Eva Mezhlumyan, Yulia Ryabushkina, Ekaterina Litvinova, Natalia Bondar, Julia Khantakova, Vasiliy Reshetnikov
Summary: Inflammation plays a significant role in many diseases, and this study focused on investigating the inflammatory response in BTBR mice, a model of autism-like behavior. The results showed that BTBR mice had a stronger response to low-dose lipopolysaccharide and higher levels of activated microglia and astroglia in the brain compared to control mice.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Multidisciplinary Sciences
Cornelius C. Ssemakalu, Marta Ulaszewska, Sean Elias, Alexandra J. Spencer
Summary: This study investigated the potential of solar inactivated S. Typhimurium to induce an immune response in mice, showing that it can induce bactericidal antibodies and increase interferon-gamma secretion.
Article
Pharmacology & Pharmacy
Qianbo Song, Sau Wan Cheng, Dan Li, Huiyuan Cheng, Yuen Sze Lai, Quanbin Han, Hoi Yan Wu, Pang Chui Shaw, Zhong Zuo
Summary: This study investigated the role of gut microbiota in the hypoglycemic effect of Astragalus membranaceus polysaccharides (AMP) in db/db mice. Treatment with AMP significantly alleviated diabetic symptoms and restored gut microbiota community, leading to increased production of short chain fatty acids (SCFA) in feces. The relative abundance of two intestinal bacteria, Akkermansia and Faecalibaculum, were found to be positively correlated with the hypoglycemic effect of AMP and fecal SCFA production. Furthermore, AMP treatment stimulated the secretion of glucagon-like peptide-1 (GLP-1) and improved intestinal integrity. Mechanistic study revealed that the increased SCFA after AMP treatment could enhance the expression of G protein-coupled receptors 41/43 and tight junction proteins, resulting in the alleviation of diabetic symptoms in db/db mice.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Agriculture, Dairy & Animal Science
Q. Wang, X. F. Wang, T. Xing, J. L. Li, X. D. Zhu, L. Zhang, F. Gao
Summary: The combination of XOS and IAPS can enhance intestinal mucosal immunity and barrier function in broilers by increasing cytokine gene expression, IgA-producing cell production, and modulating cecal microbiota. Additionally, the combination effect of XOS and IAPS is superior to the individual effects of CTC, XOS, or IAPS in the current study.
Article
Food Science & Technology
Jingxuan Zhou, Nanhai Zhang, Liang Zhao, Wei Wu, Liebing Zhang, Feng Zhou, Jingming Li
Summary: Astragalus saponins (AS) and astragalus polysaccharides (AP) from astragalus plant demonstrate ameliorative effects on hepatic injury induced by alcohol in mice, reducing lipid accumulation in serum and liver, and modulating oxidative stress, inflammatory response, and gut flora disorder. AS shows more efficient effect than AP, with dose proportionality in the results.
Article
Pharmacology & Pharmacy
Lingna Xie, Kaiye Yang, Yiheng Liang, Zhenyuan Zhu, Zhengqiang Yuan, Zhiyun Du
Summary: Tremella fuciformis polysaccharides (TFPS) have therapeutic effects on atopic dermatitis (AD), with oral administration showing better efficacy than topical application. TFPS treatment increases the proportion of regulatory T cells and modulates the composition of gut microbiota.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Integrative & Complementary Medicine
Siying Dong, Zixuan Zhao, Wenle Li, Yuyang Cai, Ziling Zhang, Minghua Bai, Ji Wang
Summary: This study aims to provide a standard and unified translation method for terms of traditional Chinese medicine (TCM) constitution through the Delphi expert consultation strategy. Following a 3-round Delphi survey, the translation criteria of most terms were unified, but there were still a few terms that did not reach a consensus.
EVIDENCE-BASED COMPLEMENTARY AND ALTERNATIVE MEDICINE
(2022)
Article
Biochemical Research Methods
Liang Hong, Zihui Ye, Cheng Wang, Ji Wang, Qi Wang, Shaoping Li, Jing Zhao
Summary: The volatile compound set of the traditional Chinese medicine "anti-epidemic sachet (FYXN)" was constructed using gas chromatography-mass spectrometry (GC-MS), and the active compounds and antiviral mechanism were analyzed. Network pharmacology was used to validate the pharmacological effects of key compounds and pathways.
JOURNAL OF CHROMATOGRAPHY A
(2023)
Article
Multidisciplinary Sciences
Haihong Zhao, Yuhan Zong, Wenle Li, Yaqi Wang, Weibo Zhao, Xianghe Meng, Fan Yang, Jingwei Kong, Xiaoshan Zhao, Ji Wang
Summary: This study investigated the overall constitution distribution in Chinese infants and analyzed the characteristics of gut microbiota and urine metabolites in infants with damp-heat constitution. The findings contribute to a better understanding of constitution classification in infants.
Article
Chemistry, Medicinal
Mingsheng Lyu, Jingbo Qin, Shuaiyang Huang, Dongmei Shao, Guirui Huang, Fan Yang, Xuefeng Gong, Shiyu Zhang, Zhijie Zhang, Ji Wang, Hongsheng Cui
Summary: Through network pharmacology study and experimental validation, it was found that Tuo-Min-Ding-Chuan Decoction has significant anti-inflammatory effects on allergic asthma, and its mechanism may be related to the NOD-like receptor pathway and Toll-like receptor pathway.
DRUG DESIGN DEVELOPMENT AND THERAPY
(2023)
Article
Multidisciplinary Sciences
Haihong Zhao, Qiqi Ren, Huai-yu Wang, Yuhan Zong, Weibo Zhao, Yaqi Wang, Miao Qu, Ji Wang
Summary: This study aimed to evaluate the characteristics of gut microbiota and urinary metabolites in infants with Yin-deficiency constitution (YINDC), find biomarkers to identify YINDC, and enhance our understanding of infant constitution classification. The results showed significant differences in the diversity and composition of gut microbiota and urinary metabolites between YINDC and other constitution types. Additionally, a combined marker comprising two genera had the potential to efficiently identify YINDC.
