SIRT7: a sentinel of genome stability

SIRT 7 activates quiescent hair follicle stem cells to ensure hair growth in mice

(2020) Guo Li et al.   EMBO JOURNAL

SIRT7 Deacetylates STRAP to Regulate p53 Activity and Stability

(2020) Miao Yu et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

SIRT7 antagonizes human stem cell aging as a heterochromatin stabilizer

(2020) Shijia Bi et al.   Protein & Cell

An NAD+-Dependent Deacetylase SIRT7 Promotes HCC Development Through Deacetylation of USP39

(2020) Ling Dong et al.   iScience

A hairy tale: SIRT 7 safeguards skin stem cells during aging

(2020) Matthew Simon et al.   EMBO JOURNAL

SIRT7 Facilitates CENP-A Nucleosome Assembly and Suppresses Intestinal Tumorigenesis

(2020) Xiyang Liu et al.   iScience

A Click Chemistry Approach Reveals the Chromatin-Dependent Histone H3K36 Deacylase Nature of SIRT7

(2019) Wesley Wei Wang et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

SIRT7-mediated ATM deacetylation is essential for its deactivation and DNA damage repair

(2019) Ming Tang et al.   Science Advances

SIRT7 promotes chromosome synapsis during prophase I of female meiosis

(2019) Berta N. Vazquez et al.   CHROMOSOMA

SIRT7 regulates the nuclear export of NF-κB p65 by deacetylating Ran

(2019) Shihab U. Sobuz et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Glutarylation of Histone H4 Lysine 91 Regulates Chromatin Dynamics

(2019) Xiucong Bao et al.   MOLECULAR CELL

GLP-catalyzed H4K16me1 promotes 53BP1 recruitment to permit DNA damage repair and cell survival

(2019) Xiaopeng Lu et al.   NUCLEIC ACIDS RESEARCH

Cardiomyocyte Sirt (Sirtuin) 7 Ameliorates Stress-Induced Cardiac Hypertrophy by Interacting With and Deacetylating GATA4

(2019) Satoru Yamamura et al.   HYPERTENSION

Destabilization of linker histone H1.2 is essential for ATM activation and DNA damage repair

(2018) Zhiming Li et al.   CELL RESEARCH

The epigenetic regulator SIRT7 guards against mammalian cellular senescence induced by ribosomal DNA instability

(2018) Silvana Paredes et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

SIRT7 depletion inhibits cell proliferation, migration, and increases drug sensitivity by activating p38MAPK in breast cancer cells

(2018) Kun-Lin Chen et al.   JOURNAL OF CELLULAR PHYSIOLOGY

SIRT7 has a critical role in bone formation by regulating lysine acylation of SP7/Osterix

(2018) Masatoshi Fukuda et al.   Nature Communications

Arginine methylation of SIRT7 couples glucose sensing with mitochondria biogenesis

(2018) Wei‐Wei Yan et al.   EMBO REPORTS

Sirtuin 7–mediated deacetylation of WD repeat domain 77 (WDR77) suppresses cancer cell growth by reducing WDR77/PRMT5 transmethylase complex activity

(2018) Hao Qi et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

SIRT7-Dependent Deacetylation of Fibrillarin Controls Histone H2A Methylation and rRNA Synthesis during the Cell Cycle

(2018) Aishwarya Iyer-Bierhoff et al.   Cell Reports

SIRT7 and the DEAD-box helicase DDX21 cooperate to resolve genomic R loops and safeguard genome stability

(2017) Chenlin Song et al.   GENES & DEVELOPMENT

SIRT7-dependent deacetylation of CDK9 activates RNA polymerase II transcription

(2017) Maximilian F. Blank et al.   NUCLEIC ACIDS RESEARCH

Sirt7 promotes adipogenesis in the mouse by inhibiting autocatalytic activation of Sirt1

(2017) Jian Fang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Quantitative proteome-based systematic identification of SIRT7 substrates

(2017) Chaohua Zhang et al.   PROTEOMICS

SIRT7 antagonizes TGF-β signaling and inhibits breast cancer metastasis

(2017) Xiaolong Tang et al.   Nature Communications

Downregulation of SIRT7 by 5-fluorouracil induces radiosensitivity in human colorectal cancer

(2017) Ming Tang et al.   Theranostics

Regulation of Serine-Threonine Kinase Akt Activation by NAD + -Dependent Deacetylase SIRT7

(2017) Jia Yu et al.   Cell Reports

Sirtuins and DNA damage repair: SIRT7 comes to play

(2017) Berta N. Vazquez et al.   Nucleus

Sirtuins and DNA damage repair: SIRT7 comes to play

(2017) Berta N. Vazquez et al.   Nucleus

Biomarkers of Response and Resistance to DNA Repair Targeted Therapies

(2016) E. H. Stover et al.   CLINICAL CANCER RESEARCH

SIRT7 promotes genome integrity and modulates non‐homologous end joining DNA repair

(2016) Berta N Vazquez et al.   EMBO JOURNAL

Acetylation of PGK1 promotes liver cancer cell proliferation and tumorigenesis

(2016) Hongli Hu et al.   HEPATOLOGY

The interaction between acetylation and serine-574 phosphorylation regulates the apoptotic function of FOXO3

(2016) Z Li et al.   ONCOGENE

SIRT7-dependent deacetylation of the U3-55k protein controls pre-rRNA processing

(2016) Sifan Chen et al.   Nature Communications

SIRT7 is a histone desuccinylase that functionally links to chromatin compaction and genome stability

(2016) Lei Li et al.   Nature Communications

Sirtuin 7 promotes cellular survival following genomic stress by attenuation of DNA damage, SAPK activation and p53 response

(2015) Shashi Kiran et al.   EXPERIMENTAL CELL RESEARCH

Dicer interacts with SIRT7 and regulates H3K18 deacetylation in response to DNA damaging agents

(2015) Pei-Ying Zhang et al.   NUCLEIC ACIDS RESEARCH

A mitochondrial UPR-mediated metabolic checkpoint regulates hematopoietic stem cell aging

(2015) M. Mohrin et al.   SCIENCE

Stabilization of SIRT7 deacetylase by viral oncoprotein HBx leads to inhibition of growth restrictive RPS7 gene and facilitates cellular transformation

(2015) Vijaya Pandey et al.   Scientific Reports

A SIRT7-Dependent Acetylation Switch of GABPβ1 Controls Mitochondrial Function

(2014) Dongryeol Ryu et al.   Cell Metabolism

Overexpression of Sirt7 Exhibits Oncogenic Property and Serves as a Prognostic Factor in Colorectal Cancer

(2014) H. Yu et al.   CLINICAL CANCER RESEARCH

Comparative interactomes of SIRT6 and SIRT7: Implication of functional links to aging

(2014) Namgyu Lee et al.   PROTEOMICS

Repression of RNA Polymerase I upon Stress Is Caused by Inhibition of RNA-Dependent Deacetylation of PAF53 by SIRT7

(2013) Sifan Chen et al.   MOLECULAR CELL

SIRT6 Recruits SNF2H to DNA Break Sites, Preventing Genomic Instability through Chromatin Remodeling

(2013) Debra Toiber et al.   MOLECULAR CELL

SIRT6 regulates TNF-α secretion through hydrolysis of long-chain fatty acyl lysine

(2013) Hong Jiang et al.   NATURE

SIRT1 collaborates with ATM and HDAC1 to maintain genomic stability in neurons

(2013) Matthew M Dobbin et al.   NATURE NEUROSCIENCE

Double-strand break repair: 53BP1 comes into focus

(2013) Stephanie Panier et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

SIRT7 Represses Myc Activity to Suppress ER Stress and Prevent Fatty Liver Disease

(2013) Jiyung Shin et al.   Cell Reports

SIRT7 links H3K18 deacetylation to maintenance of oncogenic transformation

(2012) Matthew F. Barber et al.   NATURE

C. elegans SIRT6/7 Homolog SIR-2.4 Promotes DAF-16 Relocalization and Function during Stress

(2012) Wei-Chung Chiang et al.   PLoS Genetics

Hallmarks of Cancer: The Next Generation

(2011) Douglas Hanahan et al.   CELL

Dynamics of DNA damage response proteins at DNA breaks: a focus on protein modifications

(2011) S. E. Polo et al.   GENES & DEVELOPMENT

More than just a focus: The chromatin response to DNA damage and its role in genome integrity maintenance

(2011) Jiri Lukas et al.   NATURE CELL BIOLOGY

SIRT6 Promotes DNA Repair Under Stress by Activating PARP1

(2011) Z. Mao et al.   SCIENCE

Sirt5 Is a NAD-Dependent Protein Lysine Demalonylase and Desuccinylase

(2011) J. Du et al.   SCIENCE

Regulation of the DNA Damage Response to DSBs by Post-Translational Modifications

(2010) C. Oberle et al.   CURRENT GENOMICS

The DNA Damage Response: Making It Safe to Play with Knives

(2010) Alberto Ciccia et al.   MOLECULAR CELL

DNA Damage Response

(2010) G. Giglia-Mari et al.   Cold Spring Harbor Perspectives in Biology

Recent progress in the biology and physiology of sirtuins

(2009) Toren Finkel et al.   NATURE

The DNA-damage response in human biology and disease

(2009) Stephen P. Jackson et al.   NATURE

The emerging role of nuclear architecture in DNA repair and genome maintenance

(2009) Tom Misteli et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Sirt7 Increases Stress Resistance of Cardiomyocytes and Prevents Apoptosis and Inflammatory Cardiomyopathy in Mice

(2008) Olesya Vakhrusheva et al.   CIRCULATION RESEARCH