Tumor vessel co-option probed by single-cell analysis

An Integrated Gene Expression Landscape Profiling Approach to Identify Lung Tumor Endothelial Cell Heterogeneity and Angiogenic Candidates

(2020) Jermaine Goveia et al.   CANCER CELL

Single-Cell Transcriptome Atlas of Murine Endothelial Cells

(2020) Joanna Kalucka et al.   CELL

CellPhoneDB: inferring cell–cell communication from combined expression of multi-subunit ligand–receptor complexes

(2020) Mirjana Efremova et al.   Nature Protocols

Single-Cell RNA Sequencing Maps Endothelial Metabolic Plasticity in Pathological Angiogenesis

(2020) Katerina Rohlenova et al.   Cell Metabolism

BIOMEX: an interactive workflow for (single cell) omics data interpretation and visualization

(2020) Federico Taverna et al.   NUCLEIC ACIDS RESEARCH

A pan-cancer blueprint of the heterogeneous tumor microenvironment revealed by single-cell profiling

(2020) Junbin Qian et al.   CELL RESEARCH

Combination of anti-angiogenic therapy and immune checkpoint blockade normalizes vascular-immune crosstalk to potentiate cancer immunity

(2020) Won Suk Lee et al.   EXPERIMENTAL AND MOLECULAR MEDICINE

CD248: A therapeutic target in cancer and fibrotic diseases

(2019) Beverly A. Teicher   Oncotarget

Vessel co-option in cancer

(2019) Elizabeth A. Kuczynski et al.   Nature Reviews Clinical Oncology

Regulation of Blood and Lymphatic Vessels by Immune Cells in Tumors and Metastasis

(2019) Massimiliano Mazzone et al.   Annual Review of Physiology

Dissecting intratumoral myeloid cell plasticity by single cell RNA‐seq

(2019) Qianqian Song et al.   Cancer Medicine

Intra- and Inter-cellular Rewiring of the Human Colon during Ulcerative Colitis

(2019) Christopher S. Smillie et al.   CELL

Current best practices in single‐cell RNA‐seq analysis: a tutorial

(2019) Malte D Luecken et al.   Molecular Systems Biology

Pericytes and Neurovascular Function in the Healthy and Diseased Brain

(2019) Lachlan S. Brown et al.   Frontiers in Cellular Neuroscience

Podoplanin-Expressing Macrophages Promote Lymphangiogenesis and Lymphoinvasion in Breast Cancer

(2019) Paweł Bieniasz-Krzywiec et al.   Cell Metabolism

CXCL16 positively correlated with M2-macrophage infiltration, enhanced angiogenesis, and poor prognosis in thyroid cancer

(2019) Min Joo Kim et al.   Scientific Reports

The Role of Matrix Gla Protein (MGP) in Vascular Calcification

(2019) Geir Bjørklund et al.   CURRENT MEDICINAL CHEMISTRY

A Glial Signature and Wnt7 Signaling Regulate Glioma-Vascular Interactions and Tumor Microenvironment

(2018) Amelie Griveau et al.   CANCER CELL

Podoplanin: An emerging cancer biomarker and therapeutic target

(2018) Harini Krishnan et al.   CANCER SCIENCE

Single-Cell Map of Diverse Immune Phenotypes in the Breast Tumor Microenvironment

(2018) Elham Azizi et al.   CELL

Vascular targeting of LIGHT normalizes blood vessels in primary brain cancer and induces intratumoural high endothelial venules

(2018) Bo He et al.   JOURNAL OF PATHOLOGY

Cysteine cathepsins in extracellular matrix remodeling: Extracellular matrix degradation and beyond

(2018) Matej Vizovišek et al.   MATRIX BIOLOGY

Batch effects in single-cell RNA-sequencing data are corrected by matching mutual nearest neighbors

(2018) Laleh Haghverdi et al.   NATURE BIOTECHNOLOGY

M1-like macrophages change tumor blood vessels and microenvironment in murine melanoma

(2018) Magdalena Jarosz-Biej et al.   PLoS One

Single-Cell Deconvolution of Fibroblast Heterogeneity in Mouse Pulmonary Fibrosis

(2018) Ting Xie et al.   Cell Reports

Nanocomplex-based TP53 gene therapy promotes anti-tumor immunity through TP53- and STING-dependent mechanisms

(2018) Ellen C. Moore et al.   OncoImmunology

A molecular atlas of cell types and zonation in the brain vasculature

(2018) Michael Vanlandewijck et al.   NATURE

Isolation and differential transcriptome of vascular smooth muscle cells and mid-capillary pericytes from the rat brain

(2018) Stéphanie Chasseigneaux et al.   Scientific Reports

AEBP1 promotes epithelial-mesenchymal transition of gastric cancer cells by activating the NF-κB pathway and predicts poor outcome of the patients

(2018) Jun-yan Liu et al.   Scientific Reports

Single-cell RNA sequencing of mouse brain and lung vascular and vessel-associated cell types

(2018) Liqun He et al.   Scientific Data

The role of the unfolded protein response in cancer progression: From oncogenesis to chemoresistance

(2018) Emma Madden et al.   BIOLOGY OF THE CELL

M2 Macrophage-Derived Exosomes Promote Cell Migration and Invasion in Colon Cancer

(2018) Jingqin Lan et al.   CANCER RESEARCH

Lung Single-Cell Signaling Interaction Map Reveals Basophil Role in Macrophage Imprinting

(2018) Merav Cohen et al.   CELL

Molecular Repolarisation of Tumour-Associated Macrophages

(2018) Floris van Dalen et al.   MOLECULES

Single-cell transcriptomics of 20 mouse organs creates a Tabula Muris

(2018) et al.   NATURE

HSPA5 Gene encoding Hsp70 chaperone BiP in the endoplasmic reticulum

(2017) Jie Wang et al.   GENE

Macrophages as Key Drivers of Cancer Progression and Metastasis

(2017) Sebastian R. Nielsen et al.   MEDIATORS OF INFLAMMATION

Single-cell sequencing reveals dissociation-induced gene expression in tissue subpopulations

(2017) Susanne C van den Brink et al.   NATURE METHODS

EGFR-mediated macrophage activation promotes colitis-associated tumorigenesis

(2017) D M Hardbower et al.   ONCOGENE

Pericytes, an overlooked player in vascular pathobiology

(2017) David Ferland-McCollough et al.   PHARMACOLOGY & THERAPEUTICS

Dual angiopoietin-2 and VEGFA inhibition elicits antitumor immunity that is enhanced by PD-1 checkpoint blockade

(2017) Martina Schmittnaegel et al.   Science Translational Medicine

Combined antiangiogenic and anti–PD-L1 therapy stimulates tumor immunity through HEV formation

(2017) Elizabeth Allen et al.   Science Translational Medicine

Interferon Receptor Signaling Pathways Regulating PD-L1 and PD-L2 Expression

(2017) Angel Garcia-Diaz et al.   Cell Reports

Classification of M1/M2-polarized human macrophages by label-free hyperspectral reflectance confocal microscopy and multivariate analysis

(2017) Francesca R. Bertani et al.   Scientific Reports

Inhibition of the Glycolytic Activator PFKFB3 in Endothelium Induces Tumor Vessel Normalization, Impairs Metastasis, and Improves Chemotherapy

(2016) Anna Rita Cantelmo et al.   CANCER CELL

The impact of hypoxia on tumor-associated macrophages

(2016) Anne-Theres Henze et al.   JOURNAL OF CLINICAL INVESTIGATION

Vessel co-option is common in human lung metastases and mediates resistance to anti-angiogenic therapy in preclinical lung metastasis models

(2016) Victoria L Bridgeman et al.   JOURNAL OF PATHOLOGY

Co-option of Liver Vessels and Not Sprouting Angiogenesis Drives Acquired Sorafenib Resistance in Hepatocellular Carcinoma

(2016) Elizabeth A. Kuczynski et al.   JNCI-Journal of the National Cancer Institute

Vessel co-option mediates resistance to anti-angiogenic therapy in liver metastases

(2016) Sophia Frentzas et al.   NATURE MEDICINE

Atezolizumab in combination with bevacizumab enhances antigen-specific T-cell migration in metastatic renal cell carcinoma

(2016) Jeffrey J. Wallin et al.   Nature Communications

Co-option of Liver Vessels and Not Sprouting Angiogenesis Drives Acquired Sorafenib Resistance in Hepatocellular Carcinoma

(2016) Elizabeth A. Kuczynski et al.   JNCI-Journal of the National Cancer Institute

Osteopontin—A Master Regulator of Epithelial-Mesenchymal Transition

(2016) Anai Kothari et al.   Journal of Clinical Medicine

Vascular-targeted TNFα improves tumor blood vessel function and enhances antitumor immunity and chemotherapy in colorectal cancer

(2015) Lan Lu et al.   JOURNAL OF CONTROLLED RELEASE

Spatial reconstruction of single-cell gene expression data

(2015) Rahul Satija et al.   NATURE BIOTECHNOLOGY

limma powers differential expression analyses for RNA-sequencing and microarray studies

(2015) Matthew E. Ritchie et al.   NUCLEIC ACIDS RESEARCH

Glioma-Associated Microglia/Macrophages Display an Expression Profile Different from M1 and M2 Polarization and Highly Express Gpnmb and Spp1

(2015) Frank Szulzewsky et al.   PLoS One

Tissue-based map of the human proteome

(2015) M. Uhlen et al.   SCIENCE

Real-Time Imaging Reveals Local, Transient Vascular Permeability, and Tumor Cell Intravasation Stimulated by TIE2hi Macrophage-Derived VEGFA

(2015) A. S. Harney et al.   Cancer Discovery

Combined deficiency of Notch1 and Notch3 causes pericyte dysfunction, models CADASIL and results in arteriovenous malformations

(2015) Natalie M. Kofler et al.   Scientific Reports

The tumor vessel targeting agent NGR-TNF controls the different stages of the tumorigenic process in transgenic mice by distinct mechanisms

(2015) Simona Porcellini et al.   OncoImmunology

Anti-angiogenic therapy for cancer: current progress, unresolved questions and future directions

(2014) Naveen S. Vasudev et al.   ANGIOGENESIS

Endothelial CD276 (B7-H3) expression is increased in human malignancies and distinguishes between normal and tumour-derived circulating endothelial cells

(2014) J Kraan et al.   BRITISH JOURNAL OF CANCER

CSF1/CSF1R Blockade Reprograms Tumor-Infiltrating Macrophages and Improves Response to T-cell Checkpoint Immunotherapy in Pancreatic Cancer Models

(2014) Y. Zhu et al.   CANCER RESEARCH

Serpins Promote Cancer Cell Survival and Vascular Co-Option in Brain Metastasis

(2014) Manuel Valiente et al.   CELL

Esm1 Modulates Endothelial Tip Cell Behavior and Vascular Permeability by Enhancing VEGF Bioavailability

(2014) Susana F. Rocha et al.   CIRCULATION RESEARCH

PD-L1 is a novel direct target of HIF-1α, and its blockade under hypoxia enhanced MDSC-mediated T cell activation

(2014) Muhammad Zaeem Noman et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Pericyte Dynamics during Angiogenesis: New Insights from New Identities

(2014) Peter C. Stapor et al.   JOURNAL OF VASCULAR RESEARCH

Glioblastoma: A Pathogenic Crosstalk between Tumor Cells and Pericytes

(2014) Elisabetta M. Caspani et al.   PLoS One

Complement, C1q, and C1q-Related Molecules Regulate Macrophage Polarization

(2014) Suzanne S. Bohlson et al.   Frontiers in Immunology

GSVA: gene set variation analysis for microarray and RNA-Seq data

(2013) Sonja Hänzelmann et al.   BMC BIOINFORMATICS

CSF-1R inhibition alters macrophage polarization and blocks glioma progression

(2013) Stephanie M Pyonteck et al.   NATURE MEDICINE

An interleukin-17–mediated paracrine network promotes tumor resistance to anti-angiogenic therapy

(2013) Alicia S Chung et al.   NATURE MEDICINE

Neutrophil-mediated tumour angiogenesis: Subversion of immune responses to promote tumour growth

(2013) Simon Tazzyman et al.   SEMINARS IN CANCER BIOLOGY

SPARC Is a Key Regulator of Proliferation, Apoptosis and Invasion in Human Ovarian Cancer

(2012) Jie Chen et al.   PLoS One

HRG Inhibits Tumor Growth and Metastasis by Inducing Macrophage Polarization and Vessel Normalization through Downregulation of PlGF

(2011) Charlotte Rolny et al.   CANCER CELL

Lipocalin 2 in cancer: When good immunity goes bad

(2011) Jeffrey J. Rodvold et al.   CANCER LETTERS

Glioblastoma Recurrence after Cediranib Therapy in Patients: Lack of "Rebound" Revascularization as Mode of Escape

(2011) E. di Tomaso et al.   CANCER RESEARCH

Basic and Therapeutic Aspects of Angiogenesis

(2011) Michael Potente et al.   CELL

Pericytes: Developmental, Physiological, and Pathological Perspectives, Problems, and Promises

(2011) Annika Armulik et al.   DEVELOPMENTAL CELL

The role of pericytes in angiogenesis

(2011) Domenico Ribatti et al.   INTERNATIONAL JOURNAL OF DEVELOPMENTAL BIOLOGY

Combinational Therapy of Interferon-α and Chemotherapy Normalizes Tumor Vasculature by Regulating Pericytes Including the Novel Marker RGS5 in Melanoma

(2011) Pian Liu et al.   JOURNAL OF IMMUNOTHERAPY

Molecular mechanisms and clinical applications of angiogenesis

(2011) Peter Carmeliet et al.   NATURE

Central nervous system pericytes in health and disease

(2011) Ethan A Winkler et al.   NATURE NEUROSCIENCE

Molecular control of endothelial cell behaviour during blood vessel morphogenesis

(2011) Shane P. Herbert et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Tumor invasion after treatment of glioblastoma with bevacizumab: radiographic and pathologic correlation in humans and mice

(2011) J. F. de Groot et al.   NEURO-ONCOLOGY

Molecular mechanisms regulating macrophage response to hypoxia

(2011) Michal A. Rahat   Frontiers in Immunology

Macrophage Expression of Hypoxia-Inducible Factor-1  Suppresses T-Cell Function and Promotes Tumor Progression

(2010) A. L. Doedens et al.   CANCER RESEARCH

Further Pharmacological and Genetic Evidence for the Efficacy of PlGF Inhibition in Cancer and Eye Disease

(2010) Sara Van de Veire et al.   CELL

Differential activation and antagonistic function of HIF-  isoforms in macrophages are essential for NO homeostasis

(2010) N. Takeda et al.   GENES & DEVELOPMENT

TGF-beta driven lung fibrosis is macrophage dependent and blocked by Serum amyloid P

(2010) Lynne A. Murray et al.   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY

Tumor-Conditioned Macrophages Secrete Migration-Stimulating Factor: A New Marker for M2-Polarization, Influencing Tumor Cell Motility

(2010) G. Solinas et al.   JOURNAL OF IMMUNOLOGY

Macrophage plasticity and interaction with lymphocyte subsets: cancer as a paradigm

(2010) Subhra K Biswas et al.   NATURE IMMUNOLOGY

Inositol-requiring enzyme 1  is a key regulator of angiogenesis and invasion in malignant glioma

(2010) G. Auf et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Endothelial-Mural Cell Signaling in Vascular Development and Angiogenesis

(2009) Konstantin Gaengel et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

GOrilla: a tool for discovery and visualization of enriched GO terms in ranked gene lists

(2009) Eran Eden et al.   BMC BIOINFORMATICS

Accelerated Metastasis after Short-Term Treatment with a Potent Inhibitor of Tumor Angiogenesis

(2009) John M.L. Ebos et al.   CANCER CELL

Antiangiogenic Therapy Elicits Malignant Progression of Tumors to Increased Local Invasion and Distant Metastasis

(2009) Marta Pàez-Ribes et al.   CANCER CELL

Mediators of Glioblastoma Resistance and Invasion during Antivascular Endothelial Growth Factor Therapy

(2009) A. K. Lucio-Eterovic et al.   CLINICAL CANCER RESEARCH

G-CSF-initiated myeloid cell mobilization and angiogenesis mediate tumor refractoriness to anti-VEGF therapy in mouse models

(2009) F. Shojaei et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Regulated association of misfolded endoplasmic reticulum lumenal proteins with P58/DNAJc3

(2008) Kseniya Petrova et al.   EMBO JOURNAL

Role of platelet-derived growth factors in physiology and medicine

(2008) J. Andrae et al.   GENES & DEVELOPMENT

Endosialin (CD248) is a marker of tumor-associated pericytes in high-grade glioma

(2008) Nicole Simonavicius et al.   MODERN PATHOLOGY