Molecular Repolarisation of Tumour-Associated Macrophages

Randomized phase III study of docetaxel plus bavituximab in previously treated advanced non-squamous non-small-cell lung cancer

(2018) D E Gerber et al.   ANNALS OF ONCOLOGY

Toll-like Receptor Agonist Conjugation: A Chemical Perspective

(2018) Bob J. Ignacio et al.   BIOCONJUGATE CHEMISTRY

Combined HDAC and Bromodomain Protein Inhibition Reprograms Tumor Cell Metabolism and Elicits Synthetic Lethality in Glioblastoma

(2018) Yiru Zhang et al.   CLINICAL CANCER RESEARCH

Metformin Inhibits Prostate Cancer Progression by Targeting Tumor-Associated Inflammatory Infiltration

(2018) Qiuli Liu et al.   CLINICAL CANCER RESEARCH

Repolarization of Tumor-Associated Macrophages in a Genetically Engineered Nonsmall Cell Lung Cancer Model by Intraperitoneal Administration of Hyaluronic Acid-Based Nanoparticles Encapsulating MicroRNA-125b

(2018) Neha N. Parayath et al.   NANO LETTERS

UC-1V150, a potent TLR7 agonist capable of activating macrophages and potentiating mAb-mediated target cell deletion

(2018) L. N. Dahal et al.   SCANDINAVIAN JOURNAL OF IMMUNOLOGY

Chloroquine modulates antitumor immune response by resetting tumor-associated macrophages toward M1 phenotype

(2018) Degao Chen et al.   Nature Communications

TLR-3 Stimulation Skews M2 Macrophages to M1 Through IFN-αβ Signaling and Restricts Tumor Progression

(2018) Aurobind Vidyarthi et al.   Frontiers in Immunology

TLR7/8-agonist-loaded nanoparticles promote the polarization of tumour-associated macrophages to enhance cancer immunotherapy

(2018) Christopher B. Rodell et al.   Nature Biomedical Engineering

Tumor hypoxia directed multimodal nanotherapy for overcoming drug resistance in renal cell carcinoma and reprogramming macrophages

(2018) Hashem O. Alsaab et al.   BIOMATERIALS

Prior exposure of pancreatic tumors to [sorafenib + vorinostat] enhances the efficacy of an anti-PD-1 antibody

(2018) Laurence Booth et al.   CANCER BIOLOGY & THERAPY

Efficacy of gefitinib‑celecoxib combination therapy in docetaxel‑resistant prostate cancer

(2018) Jian‑Zhong Lin et al.   ONCOLOGY REPORTS

Blocking immunoinhibitory receptor LILRB2 reprograms tumor-associated myeloid cells and promotes antitumor immunity

(2018) Hui-Ming Chen et al.   JOURNAL OF CLINICAL INVESTIGATION

Yeast-mediated mRNA delivery polarizes immuno-suppressive macrophages towards an immuno-stimulatory phenotype

(2017) Michelle Seif et al.   EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS

Chloroquine (CQ) exerts anti-breast cancer through modulating microenvironment and inducing apoptosis

(2017) Yanjun Zhang et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

HS-1793, a resveratrol analogue, downregulates the expression of hypoxia-induced HIF-1 and VEGF and inhibits tumor growth of human breast cancer cells in a nude mouse xenograft model

(2017) Dong Hwan Kim et al.   INTERNATIONAL JOURNAL OF ONCOLOGY

Discovery of Small Molecules as Multi-Toll-like Receptor Agonists with Proinflammatory and Anticancer Activities

(2017) Lei Zhang et al.   JOURNAL OF MEDICINAL CHEMISTRY

Synthetic Toll-Like Receptor 4 (TLR4) and TLR7 Ligands Work Additively via MyD88 To Induce Protective Antiviral Immunity in Mice

(2017) Peter H. Goff et al.   JOURNAL OF VIROLOGY

Colony-Stimulating Factor 1 Receptor Blockade Inhibits Tumor Growth by Altering the Polarization of Tumor-Associated Macrophages in Hepatocellular Carcinoma

(2017) Jian-Yang Ao et al.   MOLECULAR CANCER THERAPEUTICS

Reprogramming Tumor-Associated Macrophages To Reverse EGFRT790M Resistance by Dual-Targeting Codelivery of Gefitinib/Vorinostat

(2017) Huige Peng et al.   NANO LETTERS

Inhibition of colony stimulating factor-1 receptor abrogates microenvironment-mediated therapeutic resistance in gliomas

(2017) D Yan et al.   ONCOGENE

Metformin-treated cancer cells modulate macrophage polarization through AMPK-NF-κB signaling

(2017) Chi-Fu Chiang et al.   Oncotarget

Regulation of Human Macrophage M1–M2 Polarization Balance by Hypoxia and the Triggering Receptor Expressed on Myeloid Cells-1

(2017) Federica Raggi et al.   Frontiers in Immunology

Reprogramming of Tumor-Associated Macrophages with Anticancer Therapies: Radiotherapy versus Chemo- and Immunotherapies

(2017) Géraldine Genard et al.   Frontiers in Immunology

Chlorogenic acid inhibits glioblastoma growth through repolarizating macrophage from M2 to M1 phenotype

(2017) Nina Xue et al.   Scientific Reports

Antibody-Mediated Blockade of Phosphatidylserine Enhances the Antitumor Effect of Sorafenib in Hepatocellular Carcinomas Xenografts

(2016) Xiaoyun Cheng et al.   ANNALS OF SURGICAL ONCOLOGY

Targeted delivery of let-7b to reprogramme tumor-associated macrophages and tumor infiltrating dendritic cells for tumor rejection

(2016) Zhen Huang et al.   BIOMATERIALS

Evaluation of the potential therapeutic benefits of macrophage reprogramming in multiple myeloma

(2016) A. Gutierrez-Gonzalez et al.   BLOOD

Phosphatidylserine is a global immunosuppressive signal in efferocytosis, infectious disease and cancer

(2016) R B Birge et al.   CELL DEATH AND DIFFERENTIATION

Molecular Pathways: Deciphering Mechanisms of Resistance to Macrophage-Targeted Therapies

(2016) Daniela F. Quail et al.   CLINICAL CANCER RESEARCH

Phase Ib Trial of the Toll-like Receptor 8 Agonist, Motolimod (VTX-2337), Combined with Cetuximab in Patients with Recurrent or Metastatic SCCHN

(2016) Laura Q.M. Chow et al.   CLINICAL CANCER RESEARCH

A facile route to form self-carried redox-responsive vorinostat nanodrug for effective solid tumor therapy

(2016) Leiqiang Han et al.   International Journal of Nanomedicine

Manipulating the NF-κB pathway in macrophages using mannosylated, siRNA-delivering nanoparticles can induce immunostimulatory and tumor cytotoxic functions

(2016) Ryan Ortega et al.   International Journal of Nanomedicine

Ang-2/VEGF bispecific antibody reprograms macrophages and resident microglia to anti-tumor phenotype and prolongs glioblastoma survival

(2016) Jonas Kloepper et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Zoledronic acid impairs stromal reactivity by inhibiting M2-macrophages polarization and prostate cancer-associated fibroblasts

(2016) Giuseppina Comito et al.   Oncotarget

PA-MSHA in combination with EGFR tyrosine kinase inhibitor: A new strategy to overcome the drug resistance of non-small cell lung cancer cells

(2016) Xin-min Zhao et al.   Oncotarget

Pancreatic Cancer Cell Exosome-Mediated Macrophage Reprogramming and the Role of MicroRNAs 155 and 125b2 Transfection using Nanoparticle Delivery Systems

(2016) Mei-Ju Su et al.   Scientific Reports

STAT3 and STAT6 Signaling Pathways Synergize to Promote Cathepsin Secretion from Macrophages via IRE1α Activation

(2016) Dongyao Yan et al.   Cell Reports

Reprogramming Tumor-Associated Macrophages by Antibody Targeting Inhibits Cancer Progression and Metastasis

(2016) Anna-Maria Georgoudaki et al.   Cell Reports

Motolimod effectively drives immune activation in advanced cancer patients

(2016) Gregory N. Dietsch   OncoImmunology

CDDO-Me Redirects Activation of Breast Tumor Associated Macrophages

(2016) Michael S. Ball et al.   PLoS One

Bioconjugated Manganese Dioxide Nanoparticles Enhance Chemotherapy Response by Priming Tumor-Associated Macrophages toward M1-like Phenotype and Attenuating Tumor Hypoxia

(2015) Manli Song et al.   ACS Nano

An interferon-γ-delivery system based on chitosan/poly(γ-glutamic acid) polyelectrolyte complexes modulates macrophage-derived stimulation of cancer cell invasion in vitro

(2015) Ana P. Cardoso et al.   Acta Biomaterialia

Enhancement of the Immunostimulatory Activity of a TLR7 Ligand by Conjugation to Polysaccharides

(2015) Hiroyuki Shinchi et al.   BIOCONJUGATE CHEMISTRY

Synergistic antitumor responses by combined GITR activation and sunitinib in metastatic renal cell carcinoma

(2015) Nengwang Yu et al.   INTERNATIONAL JOURNAL OF CANCER

CDDO-Me inhibits tumor growth and prevents recurrence of pancreatic ductal adenocarcinoma

(2015) XIAOHUA GAO et al.   INTERNATIONAL JOURNAL OF ONCOLOGY

Dectin-1 Activation by a Natural Product β-Glucan Converts Immunosuppressive Macrophages into an M1-like Phenotype

(2015) Min Liu et al.   JOURNAL OF IMMUNOLOGY

Tumor necrosis factor–related apoptosis-inducing ligand induces the expression of proinflammatory cytokines in macrophages and re-educates tumor-associated macrophages to an antitumor phenotype

(2015) Jing Gao et al.   MOLECULAR BIOLOGY OF THE CELL

Dopamine induces growth inhibition and vascular normalization through reprogramming M2-polarized macrophages in rat C6 glioma

(2015) Tian Qin et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

The MSHA strain of Pseudomonas aeruginosa (PA-MSHA) inhibits gastric carcinoma progression by inducing M1 macrophage polarization

(2015) Changming Wang et al.   TUMOR BIOLOGY

Autophagy-induced RelB/p52 activation mediates tumour-associated macrophage repolarisation and suppression of hepatocellular carcinoma by natural compound baicalin

(2015) H-Y Tan et al.   Cell Death & Disease

Bruton Tyrosine Kinase-Dependent Immune Cell Cross-talk Drives Pancreas Cancer

(2015) A. J. Gunderson et al.   Cancer Discovery

Zoledronic acid prevents the tumor-promoting effects of mesenchymal stem cells via MCP-1 dependent recruitment of macrophages

(2015) Xiao-Hua Jia et al.   Oncotarget

Metformin prevents cancer metastasis by inhibiting M2-like polarization of tumor associated macrophages

(2015) Ling Ding et al.   Oncotarget

CD163+ tumor-associated macrophage is a prognostic biomarker and is associated with therapeutic effect on malignant pleural effusion of lung cancer patients

(2015) Li Yang et al.   Oncotarget

A phase I clinical trial of bavituximab and paclitaxel in patients with HER2 negative metastatic breast cancer

(2015) Pavani Chalasani et al.   Cancer Medicine

High and Low Molecular Weight Hyaluronic Acid Differentially Influence Macrophage Activation

(2015) Jamie E. Rayahin et al.   ACS Biomaterials-Science & Engineering

Much More than M1 and M2 Macrophages, There are also CD169+ and TCR+ Macrophages

(2015) Leslie Chávez-Galán et al.   Frontiers in Immunology

The combination of a novel immunomodulator with a regulatory T cell suppressing antibody (DTA-1) regress advanced stage B16F10 solid tumor by repolarizing tumor associated macrophagesin situ

(2015) Sayantan Banerjee et al.   OncoImmunology

Modulation of Innate Immune Responses via Covalently Linked TLR Agonists

(2015) Janine K. Tom et al.   ACS Central Science

High and Low Molecular Weight Hyaluronic Acid Differentially Influence Macrophage Activation

(2015) Jamie E. Rayahin et al.   ACS Biomaterials Science & Engineering

Consistent Inhibition of Cyclooxygenase Drives Macrophages towards the Inflammatory Phenotype

(2015) Yi Rang Na et al.   PLoS One

Extratumoral Macrophages Promote Tumor and Vascular Growth in an Orthotopic Rat Prostate Tumor Model

(2015) Sofia Halin et al.   NEOPLASIA

Targeted depletion of tumour-associated macrophages by an alendronate–glucomannan conjugate for cancer immunotherapy

(2014) Xiudan Zhan et al.   BIOMATERIALS

Emodin suppresses pulmonary metastasis of breast cancer accompanied with decreased macrophage recruitment and M2 polarization in the lungs

(2014) Xuemei Jia et al.   BREAST CANCER RESEARCH AND TREATMENT

CSF1/CSF1R Blockade Reprograms Tumor-Infiltrating Macrophages and Improves Response to T-cell Checkpoint Immunotherapy in Pancreatic Cancer Models

(2014) Y. Zhu et al.   CANCER RESEARCH

Tumor-Associated Macrophages: From Mechanisms to Therapy

(2014) Roy Noy et al.   IMMUNITY

Interferon gamma induced by resveratrol analog, HS-1793, reverses the properties of tumor associated macrophages

(2014) Soo Kyung Jeong et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

Euodenine A: A Small-Molecule Agonist of Human TLR4

(2014) Juliette E. Neve et al.   JOURNAL OF MEDICINAL CHEMISTRY

TREM-1 regulates macrophage polarization in ureteral obstruction

(2014) Tzu-Han Lo et al.   KIDNEY INTERNATIONAL

DMXAA Causes Tumor Site-Specific Vascular Disruption in Murine Non-Small Cell Lung Cancer, and like the Endogenous Non-Canonical Cyclic Dinucleotide STING Agonist, 2′3′-cGAMP, Induces M2 Macrophage Repolarization

(2014) Charlene M. Downey et al.   PLoS One

Molecular Mechanisms That Influence the Macrophage M1–M2 Polarization Balance

(2014) Nan Wang et al.   Frontiers in Immunology

Sorafenib perpetuates cellular anticancer effector functions by modulating the crosstalk between macrophages and natural killer cells

(2013) Martin Franz Sprinzl et al.   HEPATOLOGY

Improved Quenched Fluorescent Probe for Imaging of Cysteine Cathepsin Activity

(2013) Martijn Verdoes et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

CSF-1R inhibition alters macrophage polarization and blocks glioma progression

(2013) Stephanie M Pyonteck et al.   NATURE MEDICINE

Hydrazinocurcumin Encapsuled Nanoparticles “Re-Educate” Tumor-Associated Macrophages and Exhibit Anti-Tumor Effects on Breast Cancer Following STAT3 Suppression

(2013) Xiwen Zhang et al.   PLoS One

Cyclooxygenase-2 Inhibition Blocks M2 Macrophage Differentiation and Suppresses Metastasis in Murine Breast Cancer Model

(2013) Yi-Rang Na et al.   PLoS One

Self-Assembly of Poly-Adenine-Tailed CpG Oligonucleotide-Gold Nanoparticle Nanoconjugates with Immunostimulatory Activity

(2013) Nan Chen et al.   Small

Phosphatidylserine-Targeting Antibody Induces M1 Macrophage Polarization and Promotes Myeloid-Derived Suppressor Cell Differentiation

(2013) Y. Yin et al.   Cancer Immunology Research

Anti-tumor immune responses of tumor-associated macrophages via toll-like receptor 4 triggered by cationic polymers

(2012) Zhen Huang et al.   BIOMATERIALS

Differential Regulation of the Let-7 Family of MicroRNAs in CD4+ T Cells Alters IL-10 Expression

(2012) S. Swaminathan et al.   JOURNAL OF IMMUNOLOGY

Reprogramming of TAM toward proimmunogenic type through regulation of MAP kinases using a redox-active copper chelate

(2012) P. Chakraborty et al.   JOURNAL OF LEUKOCYTE BIOLOGY

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(2012) Salvatore Coniglio et al.   MOLECULAR MEDICINE

Vascular normalizing doses of antiangiogenic treatment reprogram the immunosuppressive tumor microenvironment and enhance immunotherapy

(2012) Y. Huang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

HRG Inhibits Tumor Growth and Metastasis by Inducing Macrophage Polarization and Vessel Normalization through Downregulation of PlGF

(2011) Charlotte Rolny et al.   CANCER CELL

COX-2 inhibition alters the phenotype of tumor-associated macrophages from M2 to M1 in ApcMin/+ mouse polyps

(2011) Y. Nakanishi et al.   CARCINOGENESIS

Tumor-Associated Macrophages Promote Angiogenesis and Melanoma Growth via Adrenomedullin in a Paracrine and Autocrine Manner

(2011) P. Chen et al.   CLINICAL CANCER RESEARCH

Mononuclear phagocyte heterogeneity in cancer: Different subsets and activation states reaching out at the tumor site

(2011) Damya Laoui et al.   IMMUNOBIOLOGY

CCL2 recruits inflammatory monocytes to facilitate breast-tumour metastasis

(2011) Bin-Zhi Qian et al.   NATURE

Macrophage Diversity Enhances Tumor Progression and Metastasis

(2010) Bin-Zhi Qian et al.   CELL

Macrophages, innate immunity and cancer: balance, tolerance, and diversity

(2010) Alberto Mantovani et al.   CURRENT OPINION IN IMMUNOLOGY

IL-4 induces cathepsin protease activity in tumor-associated macrophages to promote cancer growth and invasion

(2010) V. Gocheva et al.   GENES & DEVELOPMENT

Anti-tumour synergy of cytotoxic chemotherapy and anti-CD40 plus CpG-ODN immunotherapy through repolarization of tumour-associated macrophages

(2010) Ilia N. Buhtoiarov et al.   IMMUNOLOGY

Macrophage plasticity and interaction with lymphocyte subsets: cancer as a paradigm

(2010) Subhra K Biswas et al.   NATURE IMMUNOLOGY

Granulocyte Macrophage Colony-Stimulating Factor Inhibits Breast Cancer Growth and Metastasis by Invoking an Anti-Angiogenic Program in Tumor-Educated Macrophages

(2009) T. D. Eubank et al.   CANCER RESEARCH

Macrophages within NSCLC tumour islets are predominantly of a cytotoxic M1 phenotype associated with extended survival

(2009) C. M. Ohri et al.   EUROPEAN RESPIRATORY JOURNAL

Tumor-associated macrophages and the related myeloid-derived suppressor cells as a paradigm of the diversity of macrophage activation

(2009) Alberto Mantovani et al.   HUMAN IMMUNOLOGY

Zoledronic acid repolarizes tumour-associated macrophages and inhibits mammary carcinogenesis by targeting the mevalonate pathway

(2009) Marta Coscia et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

M-CSF inhibition selectively targets pathological angiogenesis and lymphangiogenesis

(2009) Yoshiaki Kubota et al.   JOURNAL OF EXPERIMENTAL MEDICINE

A Distinct Macrophage Population Mediates Metastatic Breast Cancer Cell Extravasation, Establishment and Growth

(2009) Binzhi Qian et al.   PLoS One

A Novel Copper Chelate Modulates Tumor Associated Macrophages to Promote Anti-Tumor Response of T Cells

(2009) Shilpak Chatterjee et al.   PLoS One

Tolerance and M2 (alternative) macrophage polarization are related processes orchestrated by p50 nuclear factor  B

(2009) C. Porta et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Endocannabinoid 2-Arachidonoylglycerol Protects Neurons by Limiting COX-2 Elevation

(2008) Jian Zhang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

DNA damage induced by chronic inflammation contributes to colon carcinogenesis in mice

(2008) Lisiane B. Meira et al.   JOURNAL OF CLINICAL INVESTIGATION

“Re-educating” tumor-associated macrophages by targeting NF-κB

(2008) Thorsten Hagemann et al.   JOURNAL OF EXPERIMENTAL MEDICINE