Article
Immunology
Junhong Li, Shuxin Zhang, Siliang Chen, Yunbo Yuan, Mingrong Zuo, Tengfei Li, Zhihao Wang, Yanhui Liu
Summary: This study found a relationship between glioma and lipid metabolism and established a risk model based on lipid metabolism-related genes that can effectively predict prognosis in glioma patients. Additionally, the model can stratify patients into different groups with distinct immune characteristics, suggesting that immunotherapy may be beneficial for glioma patients with specific lipid metabolism profiles.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Neurosciences
Wenhua Fan, Di Wang, Guanzhang Li, Jianbao Xu, Changyuan Ren, Zhiyan Sun, Zhiliang Wang, Wenping Ma, Zheng Zhao, Zhaoshi Bao, Tao Jiang, Ying Zhang
Summary: This study aimed to construct a chemokine-based gene signature to evaluate the prognosis and therapeutic response in glioma. The chemokine gene signature was significantly associated with poorer survival and immune-relevant pathways. It also showed potential for predicting patients' response to immunotherapy.
CNS NEUROSCIENCE & THERAPEUTICS
(2022)
Article
Cell Biology
Yulian Zhang, Chuanpeng Zhang, Yanbo Yang, Guohui Wang, Zai Wang, Jiang Liu, Li Zhang, Yanbing Yu
Summary: In this study, a four-gene PRGs signature was constructed, which can effectively diagnose glioma and predict its prognosis. The signature is associated with the tumor microenvironment and immune cell infiltration in glioma.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2022)
Article
Cell Biology
Lin-Jian Wang, Yimeng Xue, Yongli Lou
Summary: This study found that increased TAMs in glioma may be an immune evasion mechanism. TAMs-related signature can be a valuable prognostic biomarker in glioma and provide new therapeutic targets.
Article
Oncology
Qinglong Guo, Xing Xiao, Jinsen Zhang
Summary: By exploring the immune and stromal components of the tumor microenvironment in gliomas, MYD88 was identified as a key gene with predictive prognostic value, particularly in dysregulating M2-type macrophages in glioma patients.
FRONTIERS IN ONCOLOGY
(2021)
Article
Oncology
Moxuan Zhang, Yanhao Cheng, Zhengchun Xue, Qiang Sun, Jian Zhang
Summary: This study established a risk model based on pyroptosis-related genes for predicting the survival risk of glioma patients. The risk score was found to be an independent factor predicting overall survival and was verified in a validation cohort. Analysis showed that high-risk glioma patients had significantly upregulated immune cell and pathway activities compared to low-risk patients.
Review
Oncology
Tianzhen Hua, Huanxiao Shi, Mengmei Zhu, Chao Chen, Yandong Su, Shengjia Wen, Xu Zhang, Juxiang Chen, Qilin Huang, Hongxiang Wang
Summary: This article provides an overview of the synaptic and functional integration between glioma and neurons, as well as the reciprocal effects of their interactions on neuronal pathophysiology. It also discusses current therapeutic approaches targeting critical factors involved in these interactions and proposes emerging technologies for gaining deeper insight into the mechanisms associated with neuron- and glioma-communicating networks. The importance of this article lies in its contribution to our understanding of the refractory disease and the development of potential therapeutic strategies.
INTERNATIONAL JOURNAL OF ONCOLOGY
(2022)
Article
Oncology
Zhihao Wang, Shuxin Zhang, Junhong Li, Yunbo Yuan, Siliang Chen, Mingrong Zuo, Wenhao Li, Wentao Feng, Mina Chen, Yanhui Liu
Summary: This study found that the expression of lactate metabolism genes in glioma patients is associated with prognosis and influences the activity of immune cells in the tumor microenvironment. This may serve as a potential biomarker for predicting the response of gliomas to immunotherapy.
FRONTIERS IN ONCOLOGY
(2022)
Article
Cell Biology
Zhimin Chen, Shenghua Zhuo, Guiying He, Jingzhi Tang, Weijie Hao, Wei-Qiang Gao, Kun Yang, Huiming Xu
Summary: Malignant gliomas exhibit strong immunosuppression and immune escape characteristics due to cancer-associated fibroblasts (CAFs) in the tumor microenvironment (TME). Regulation of CAFs and CAFs-related genes shows promise as effective immunotherapies for gliomas. A risk prediction model based on CAFs-related gene expression can serve as an independent prognostic indicator and predictor of patient response to immunotherapy.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Oncology
Guohui Wang, Huandi Zhou, Lei Tian, Tianfang Yan, Xuetao Han, Pengyu Chen, Haonan Li, Wenyan Wang, Zhiqing Xiao, Liubing Hou, Xiaoying Xue
Summary: This study identified a signature of 5 DNA damage repair genes in glioma, which could accurately predict prognosis by impacting the infiltration of immunosuppressive cells. The findings provide guidance for the treatment of glioma.
FRONTIERS IN ONCOLOGY
(2021)
Article
Oncology
Lin-jian Wang, Peipei Lv, Yongli Lou
Summary: This study analyzed TAF infiltration in glioma and found that high levels of TAF infiltration were associated with poorer prognosis. Gene enrichment analysis revealed that differentially expressed genes in glioma were significantly enriched in ECM remodeling-related signaling. By analyzing co-expression modules and candidate hub genes, a high-efficacy prediction signature was constructed, correlating with TAF infiltration abundance and serving as an independent risk factor for glioma.
FRONTIERS IN ONCOLOGY
(2022)
Review
Oncology
Lennart Barthel, Martin Hadamitzky, Philipp Dammann, Manfred Schedlowski, Ulrich Sure, Basant Kumar Thakur, Susann Hetze
Summary: Gliomas exhibit significant molecular heterogeneity, with the tumor microenvironment playing a crucial role in their development and therapy resistance. Active communication between glioma cells and surrounding healthy cells, as well as the immune environment, contributes to the cancerogenic processes and the establishment of therapy resistance.
CANCER AND METASTASIS REVIEWS
(2022)
Article
Medicine, Research & Experimental
Ting Zhao, Jianming Zeng, Yujie Xu, Zhongping Su, Yulong Chong, Tao Ling, Haozhe Xu, Hui Shi, Minggao Zhu, Qi Mo, Xiaoying Huang, Yingchang Li, Xiaoren Zhang, Hongbin Ni, Qiang You
Summary: This study reveals that CHI3L1 is overexpressed in glioma and plays a crucial role in tumor progression. It enhances the NF-kappa B signaling pathway and interacts with ACTN4 and NFKB1. Additionally, CHI3L1 reprograms the tumor microenvironment and contributes to M2 macrophage polarization. It is also positively correlated with the expression of immune checkpoints and remodels the TME to an immunosuppressive phenotype.
Article
Genetics & Heredity
Zhe Zhang, Xiaoli Shen, Zilong Tan, Yuran Mei, Tianzhu Lu, Yulong Ji, Sida Cheng, Yu Xu, Zekun Wang, Xinxian Liu, Wei He, Zhen Chen, Shuhui Chen, Qiaoli Lv
Summary: In this study, a risk scoring model was constructed using interferon gamma (IFN-gamma) related genes, which were found to be independent prognostic factors for predicting overall survival in glioma patients. This model is closely associated with immune cell infiltration and immune checkpoint molecule expression.
FRONTIERS IN GENETICS
(2023)
Article
Genetics & Heredity
Tianhao Hu, Yutao Wang, Xiaoliang Wang, Run Wang, Yifu Song, Li Zhang, Sheng Han
Summary: In this study, a comprehensive analysis of angiogenesis-related genes (ARGs) in glioma was conducted, resulting in the establishment of a 14-gene risk signature that independently predicted the clinical outcomes of patients and was associated with the tumor immune microenvironment.
FRONTIERS IN GENETICS
(2022)
Article
Oncology
Yuki Ohkawa, Anna Wade, Olle R. Lindberg, Katharine Y. Chen, Vy M. Tran, Spencer J. Brown, Anupam Kumar, Mausam Kalita, C. David James, Joanna J. Phillips
Summary: Heparan sulfate plays a crucial role in promoting receptor tyrosine kinase signaling in glioblastoma, contributing to tumor growth and invasion. Cells deficient in heparan sulfate show decreased proliferation and activation of multiple RTKs, leading to impaired tumor establishment and growth in vivo. Furthermore, heparan sulfate regulates the ligand-receptor interaction of platelet-derived growth factor receptor alpha, affecting sensitivity to targeted RTK inhibition in human GBM tumorspheres and murine GBM models.
MOLECULAR CANCER RESEARCH
(2021)
Review
Neurosciences
Jun Nagai, Xinzhu Yu, Thomas Papouin, Eunji Cheong, Marc R. Freeman, Kelly R. Monk, Michael H. Hastings, Philip G. Haydon, David Rowitch, Shai Shaham, Baljit S. Khakh
Summary: Astrocytes play crucial roles in the nervous system, regulating neural circuits to affect various behavioral outcomes. Recent studies have uncovered diverse mechanisms of astrocytes and their association with certain human diseases. Including astrocytes in neural circuit research offers new perspectives for understanding behavior, its regulation, and manifestations related to diseases.
Letter
Medicine, General & Internal
D. H. Rowitch, S. O'Rahilly, G. C. S. Smith
QJM-AN INTERNATIONAL JOURNAL OF MEDICINE
(2021)
Editorial Material
Medicine, General & Internal
D. H. Rowitch, S. O'Rahilly, G. C. S. Smith
QJM-AN INTERNATIONAL JOURNAL OF MEDICINE
(2021)
Review
Oncology
Olivia Le Saux, Helene Vanacker, Fatma Guermazi, Melodie Carbonnaux, Clemence Romeo, Louis Larrouquere, Olivier Tredan, Isabelle Ray-Coquard
Summary: This review discusses the therapy targeting ovarian cancers' difficulty in repairing DNA and highly vascularized tumors, highlighting the advantages of combining anti-angiogenic agents with PARP inhibitors. Data from laboratory and clinical studies support the efficacy of this combination treatment, showing synergistic activity and a good safety and cost-effective profile.
Article
Oncology
Elisabetta Stanzani, Leire Pedrosa, Guillaume Bourmeau, Oceane Anezo, Aleix Noguera-Castells, Anna Esteve-Codina, Lorena Passoni, Michela Matteoli, Nuria de la Iglesia, Giorgio Seano, Fina Martinez-Soler, Avelina Tortosa
Summary: The study reveals the crucial role of integrin a6 in controlling stemness and radiotherapy resistance in different molecular subtypes of glioblastoma stem-like cells. Inhibition of integrin a6 can potentially limit malignant characteristics and tumor relapse in both GSCs subtypes, highlighting its importance in improving patient outcomes.
Editorial Material
Multidisciplinary Sciences
Arturo Alvarez-Buylla, Arantxa Cebrian-Silla, Shawn F. Sorrells, Marcos Assis Nascimento, Mercedes F. Paredes, Jose Manuel Garcia-Verdugo, Zhengang Yang, Eric J. Huang
Summary: This study lacks evidence to support the link between proliferating cells and neurogenesis, the role of multipolar nestin(+) astrocytes as progenitors, and the identity of mature-looking doublecortin+ neurons as adult-born. The histology-marker expression observed differs from species with well-documented adult hippocampal neurogenesis.
Editorial Material
Cell Biology
Mary Clare Beytagh, William A. Weiss
Summary: EGFR plays a tumour-suppressive role in EGFR-amplified glioblastoma, regulated by ligand abundance. Increased EGFR ligand suppresses invasion by upregulating BIN3 and inhibiting activation of Rho GTPases.
NATURE CELL BIOLOGY
(2022)
Review
Oncology
Megan L. Tigue, Matthew A. Loberg, Jeremy A. Goettel, William A. Weiss, Ethan Lee, Vivian L. Weiss
Summary: Tumor-associated macrophages (TAM) have a significant impact on tumor growth and immune responses, with TAM infiltration being linked to poor prognosis in various cancers. TAMs can be categorized as pro-inflammatory, M1-like, or anti-inflammatory, M2-like. Recent evidence suggests that Wnt signaling plays a crucial role in promoting an immunosuppressive, M2-like phenotype in TAMs, facilitating cancer cell proliferation, invasion, and metastasis. Targeting TAM polarization and their protumorigenic functions through Wnt signaling inhibitors could potentially be an effective treatment strategy in cancers with a high presence of macrophages in the microenvironment.
Article
Medicine, Research & Experimental
Joris Guyon, Ignacio Fernandez-Moncada, Claire M. Larrieu, Cyrielle L. Bouchez, Antonio C. Pagano Zottola, Johanna Galvis, Tiffanie Chouleur, Audrey Burban, Kevin Joseph, Vidhya M. Ravi, Heidi Espedal, Gro Vatne Rosland, Boutaina Daher, Aurelien Barre, Benjamin Dartigues, Slim Karkar, Justine Rudewicz, Irati Romero-Garmendia, Barbara Klink, Konrad Gruetzmann, Marie-Alix Derieppe, Thibaut Molinie, Nina Obad, Celine Leon, Giorgio Seano, Hrvoje Miletic, Dieter Henrik Heiland, Giovanni Marsicano, Macha Nikolski, Rolf Bjerkvig, Andreas Bikfalvi, Thomas Daubon
Summary: Lactate plays a crucial role in the metabolism of glioblastoma, and the inhibition of both LDHA and LDHB sensitizes the tumor to therapy, improving survival rates in mice.
EMBO MOLECULAR MEDICINE
(2022)
Article
Multidisciplinary Sciences
Ziyang Zhang, Qiwen Fan, Xujun Luo, Kevin Lou, William A. Weiss, Kevan M. Shokat
Summary: This study presents a strategy to achieve brain-specific treatment of central nervous system diseases by combining brain-permeable and brain-impermeable drugs. The design of cell-permeable FKBP12-dependent kinase inhibitors enables brain-restricted inhibition of specific kinase targets.
Article
Oncology
Eshini Panditharatna, Joana G. Marques, Tingjian Wang, Maria C. Trissal, Ilon Liu, Li Jiang, Alexander Beck, Andrew Groves, Neekesh Dharia, Deyao Li, Samantha E. Hoffman, Guillaume Kugener, McKenzie L. Shaw, Hafsa M. Mire, Olivia A. Hack, Joshua M. Dempster, Caleb Lareau, Lingling Dai, Logan H. Sigua, Michael A. Quezada, Ann-Catherine J. Stanton, Meghan Wyatt, Zohra Kalani, Amy Goodale, Francisca Vazquez, Federica Piccioni, John G. Doench, David E. Root, Jamie N. Anastas, Kristen L. Jones, Amy Saur Conway, Sylwia Stopka, Michael S. Regan, Yu Liang, Hyuk-Soo Seo, Kijun Song, Puspalata Bashyal, William P. Jerome, Nathan D. Mathewson, Sirano Dhe-Paganon, Mario L. Suva, Angel M. Carcaboso, Cinzia Lavarino, Jaume Mora, Quang-De Nguyen, Keith L. Ligon, Yang Shi, Sameer Agnihotri, Nathalie Y. R. Agar, Kimberly Stegmaier, Charles D. Stiles, Michelle Monje, Todd R. Golub, Jun Qi, Mariella G. Filbin
Summary: This article introduces a new treatment strategy for H3K27M gliomas by inhibiting the BAF complex, which promotes differentiation and improves survival in patients.
Article
Multidisciplinary Sciences
Lai Man Natalie Wu, Feng Zhang, Rohit Rao, Mike Adam, Kai Pollard, Sara Szabo, Xuezhao Liu, Katie A. Belcher, Zaili Luo, Sean Ogurek, Colleen Reilly, Xin Zhou, Li Zhang, Joshua Rubin, Long-Sheng Chang, Mei Xin, Jiyang Yu, Mario Suva, Christine A. Pratilas, Steven Potter, Q. Richard Lu
Summary: Malignant peripheral nerve sheath tumor (MPNST) is a highly aggressive soft tissue sarcoma derived from benign neurofibroma (NF). A novel nestin-negative malignant stem-like subpopulation has been identified in MPNST, which is common to both mouse and human MPNSTs and correlates with clinical severity. Unique regulatory networks and druggable targets have been identified in MPNST, and targeting key epithelial-mesenchymal transition and stemness regulators can impede MPNST growth. These studies reveal the underlying principles of tumor cell-state evolution during NF-to-MPNST transformation and highlight a previously unrecognized mesenchymal stem-like subpopulation in MPNST disease progression.
Editorial Material
Oncology
Mary Clare Beytagh, William A. Weiss
Summary: Epigenetic reprogramming plays a role in tumorigenesis in pediatric H3K27M glioma by altering the functions of chromatin remodeling complexes. BRG1 is identified as a novel dependency in this type of tumor and its recruitment to regulatory elements drives tumor progression.
Meeting Abstract
Oncology
Eumorphia Konstantakou, Elizabeth Perez, Alex Barbera, Nicholas Haradhvala, Marcello Stanzione, Fred Barker, Brian Nahed, Anat Stemmer-Rachamimov, Nick Dyson, Gad Getz, Mario Suva, Othon Iliopoulos