Restoration of keratinocytic phenotypes in autonomous trisomy-rescued cells

Keratinocytes Derived from Patient-Specific Induced Pluripotent Stem Cells Recapitulate the Genetic Signature of Psoriasis Disease

(2020) Gowher Ali et al.   STEM CELLS AND DEVELOPMENT

Gorlin syndrome-induced pluripotent stem cells form medulloblastoma with loss of heterozygosity in PTCH1

(2020) Yu Ikemoto et al.   Aging-US

Autonomous trisomic rescue of Down syndrome cells

(2019) Momoko Inoue et al.   LABORATORY INVESTIGATION

Elimination of protein aggregates prevents premature senescence in human trisomy 21 fibroblasts

(2019) Nobutoshi Nawa et al.   PLoS One

Establishment of a Gorlin syndrome model from induced neural progenitor cells exhibiting constitutive GLI1 expression and high sensitivity to inhibition by smoothened (SMO)

(2019) Hajime Ikehara et al.   LABORATORY INVESTIGATION

Transcriptome analysis of genetically matched human induced pluripotent stem cells disomic or trisomic for chromosome 21

(2018) Patrick K. Gonzales et al.   PLoS One

Trisomy silencing by XIST normalizes Down syndrome cell pathogenesis demonstrated for hematopoietic defects in vitro

(2018) Jen-Chieh Chiang et al.   Nature Communications

Somatic mosaicism containing double mutations inPTCH1revealed by generation of induced pluripotent stem cells from nevoid basal cell carcinoma syndrome

(2017) Yu Ikemoto et al.   JOURNAL OF MEDICAL GENETICS

Fetal Therapy Model of Myelomeningocele with Three-Dimensional Skin Using Amniotic Fluid Cell-Derived Induced Pluripotent Stem Cells

(2017) Kazuhiro Kajiwara et al.   Stem Cell Reports

Low risk of solid tumors in persons with Down syndrome

(2016) Henrik Hasle et al.   GENETICS IN MEDICINE

Down syndrome and the complexity of genome dosage imbalance

(2016) Stylianos E. Antonarakis   NATURE REVIEWS GENETICS

Increased Skin Tumor Incidence and Keratinocyte Hyper-Proliferation in a Mouse Model of Down Syndrome

(2016) Annan Yang et al.   PLoS One

Efficiency of Human Epiphyseal Chondrocytes with Differential Replication Numbers for Cellular Therapy Products

(2016) Michiyo Nasu et al.   Biomed Research International

Immortalization of Primary Keratinocytes and Its Application to Skin Research

(2015) Moonju Choi et al.   Biomolecules & Therapeutics

Haematopoietic development and leukaemia in Down syndrome

(2014) Irene Roberts et al.   BRITISH JOURNAL OF HAEMATOLOGY

Stem and progenitor cell dysfunction in human trisomies

(2014) B. Liu et al.   EMBO REPORTS

Domains of genome-wide gene expression dysregulation in Down’s syndrome

(2014) Audrey Letourneau et al.   NATURE

Radiation Induces Diffusible Feeder Cell Factor(s) That Cooperate with ROCK Inhibitor to Conditionally Reprogram and Immortalize Epithelial Cells

(2013) Nancy Palechor-Ceron et al.   AMERICAN JOURNAL OF PATHOLOGY

Decreased cell proliferation and higher oxidative stress in fibroblasts from Down Syndrome fetuses. Preliminary study

(2013) Amparo Gimeno et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Modelling and rescuing neurodevelopmental defect of Down syndrome using induced pluripotent stem cells from monozygotic twins discordant for trisomy 21

(2013) Youssef Hibaoui et al.   EMBO Molecular Medicine

Usp16 contributes to somatic stem-cell defects in Down’s syndrome

(2013) Maddalena Adorno et al.   NATURE

Translating dosage compensation to trisomy 21

(2013) Jun Jiang et al.   NATURE

Deficits in human trisomy 21 iPSCs and neurons

(2013) J. P. Weick et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Concise Review: New Paradigms for Down Syndrome Research Using Induced Pluripotent Stem Cells: Tackling Complex Human Genetic Disease

(2013) James A. Briggs et al.   Stem Cells Translational Medicine

Trisomy Correction in Down Syndrome Induced Pluripotent Stem Cells

(2012) Li B. Li et al.   Cell Stem Cell

The E1 Protein of Human Papillomavirus Type 16 Is Dispensable for Maintenance Replication of the Viral Genome

(2012) N. Egawa et al.   JOURNAL OF VIROLOGY

Early-occurring proliferation defects in peripheral tissues of the Ts65Dn mouse model of Down syndrome are associated with patched1 over expression

(2012) Claudia Fuchs et al.   LABORATORY INVESTIGATION

Generation of disease-specific induced pluripotent stem cells from patients with different karyotypes of Down syndrome

(2012) Xiaoning Mou et al.   Stem Cell Research & Therapy

ROCK Inhibitor and Feeder Cells Induce the Conditional Reprogramming of Epithelial Cells

(2011) Xuefeng Liu et al.   AMERICAN JOURNAL OF PATHOLOGY

DNA Methylation Dynamics in Human Induced Pluripotent Stem Cells over Time

(2011) Koichiro Nishino et al.   PLoS Genetics

Human keratinocytes are efficiently immortalized by a Rho kinase inhibitor

(2010) Sandra Chapman et al.   JOURNAL OF CLINICAL INVESTIGATION