Elimination of protein aggregates prevents premature senescence in human trisomy 21 fibroblasts
出版年份 2019 全文链接
标题
Elimination of protein aggregates prevents premature senescence in human trisomy 21 fibroblasts
作者
关键词
Fibroblasts, Down syndrome, Cultured fibroblasts, Gene expression, Induced pluripotent stem cells, Edwards syndrome, Mitochondria, Protein synthesis
出版物
PLoS One
Volume 14, Issue 7, Pages e0219592
出版商
Public Library of Science (PLoS)
发表日期
2019-07-30
DOI
10.1371/journal.pone.0219592
参考文献
相关参考文献
注意：仅列出部分参考文献，下载原文获取全部文献信息。- HDAC inhibitors: A new promising drug class in anti-aging research
- (2017) Elena G. Pasyukova et al. MECHANISMS OF AGEING AND DEVELOPMENT
- Normalizing single-cell RNA sequencing data: challenges and opportunities
- (2017) Catalina A Vallejos et al. NATURE METHODS
- Translational compensation of gene copy number alterations by aneuploidy in Drosophila melanogaster
- (2017) Zhenguo Zhang et al. NUCLEIC ACIDS RESEARCH
- A Pair of Maternal Chromosomes Derived from Meiotic Nondisjunction in Trisomy 21 Affects Nuclear Architecture and Transcriptional Regulation
- (2017) Sayaka Omori et al. Scientific Reports
- Microarray and whole-exome sequencing analysis of familial Behçet’s disease patients
- (2016) Daisuke Okuzaki et al. Scientific Reports
- Systematic Cellular Disease Models Reveal Synergistic Interaction of Trisomy 21 and GATA1 Mutations in Hematopoietic Abnormalities
- (2016) Kimihiko Banno et al. Cell Reports
- Constitutively active form of natriuretic peptide receptor 2 ameliorates experimental pulmonary arterial hypertension
- (2016) Nobutoshi Nawa et al. Molecular Therapy-Methods & Clinical Development
- Distinct stress conditions result in aggregation of proteins with similar properties
- (2016) Alan J. Weids et al. Scientific Reports
- Protein Oxidation in Aging: Does It Play a Role in Aging Progression?
- (2015) Sandra Reeg et al. ANTIOXIDANTS & REDOX SIGNALING
- Telomerase abrogates aneuploidy-induced telomere replication stress, senescence and cell depletion
- (2015) J. K. Meena et al. EMBO JOURNAL
- Aneuploid proliferation defects in yeast are not driven by copy number changes of a few dosage-sensitive genes
- (2015) Megan E. Bonney et al. GENES & DEVELOPMENT
- Targeting protein aggregation for the treatment of degenerative diseases
- (2015) Yvonne S. Eisele et al. NATURE REVIEWS DRUG DISCOVERY
- Short- and long-term effects of chromosome mis-segregation and aneuploidy
- (2015) Stefano Santaguida et al. NATURE REVIEWS MOLECULAR CELL BIOLOGY
- Intracellular Oxidant Activity, Antioxidant Enzyme Defense System, and Cell Senescence in Fibroblasts with Trisomy 21
- (2015) Víctor Rodríguez-Sureda et al. Oxidative Medicine and Cellular Longevity
- Aneuploidy: implications for protein homeostasis and disease
- (2014) A. B. Oromendia et al. Disease Models & Mechanisms
- Nucleosome loss leads to global transcriptional up-regulation and genomic instability during yeast aging
- (2014) Z. Hu et al. GENES & DEVELOPMENT
- The therapeutic potential of chemical chaperones in protein folding diseases
- (2014) Leonardo Cortez et al. Prion
- Quantitative proteomic analysis reveals posttranslational responses to aneuploidy in yeast
- (2014) Noah Dephoure et al. eLife
- Decreased cell proliferation and higher oxidative stress in fibroblasts from Down Syndrome fetuses. Preliminary study
- (2013) Amparo Gimeno et al. BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE
- Gene Copy-Number Alterations: A Cost-Benefit Analysis
- (2013) Yun-Chi Tang et al. CELL
- BET Bromodomains Mediate Transcriptional Pause Release in Heart Failure
- (2013) Priti Anand et al. CELL
- Adaptive Downregulation of Mitochondrial Function in Down Syndrome
- (2013) Pablo Helguera et al. Cell Metabolism
- Aneuploid yeast strains exhibit defects in cell growth and passage through START
- (2013) Rebecca R. Thorburn et al. MOLECULAR BIOLOGY OF THE CELL
- New Insights into the Troubles of Aneuploidy
- (2012) Jake J. Siegel et al. Annual Review of Cell and Developmental Biology
- Revisiting Global Gene Expression Analysis
- (2012) Jakob Lovén et al. CELL
- Transcriptional Amplification in Tumor Cells with Elevated c-Myc
- (2012) Charles Y. Lin et al. CELL
- Aneuploidy causes proteotoxic stress in yeast
- (2012) A. B. Oromendia et al. GENES & DEVELOPMENT
- Transcriptional consequences of aneuploidy
- (2012) J. M. Sheltzer et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Antioxidants in Down syndrome
- (2011) Ira T. Lott BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE
- Down syndrome: searching for the genetic culprits
- (2011) E. Lana-Elola et al. Disease Models & Mechanisms
- Trisomy 21 and early brain development
- (2011) Tarik F. Haydar et al. TRENDS IN NEUROSCIENCES
- Updated national birth prevalence estimates for selected birth defects in the United States, 2004-2006
- (2010) Samantha E. Parker et al. BIRTH DEFECTS RESEARCH PART A-CLINICAL AND MOLECULAR TERATOLOGY
- Novel Cell- and Tissue-Based Assays for Detecting Misfolded and Aggregated Protein Accumulation Within Aggresomes and Inclusion Bodies
- (2010) Dee Shen et al. CELL BIOCHEMISTRY AND BIOPHYSICS
- The essence of senescence
- (2010) T. Kuilman et al. GENES & DEVELOPMENT
- Phenotypic Consequences of Aneuploidy in Arabidopsis thaliana
- (2010) I. M. Henry et al. GENETICS
- Phenylbutyrate rescues dendritic spine loss associated with memory deficits in a mouse model of Alzheimer disease
- (2010) Ana Ricobaraza et al. HIPPOCAMPUS
- Phenylbutyric Acid Rescues Endoplasmic Reticulum Stress-Induced Suppression of APP Proteolysis and Prevents Apoptosis in Neuronal Cells
- (2010) Jesse C. Wiley et al. PLoS One
- Widespread impairment of cell proliferation in the neonate Ts65Dn mouse, a model for Down syndrome
- (2009) A. Contestabile et al. CELL PROLIFERATION
- Healing and Hurting: Molecular Mechanisms, Functions, and Pathologies of Cellular Senescence
- (2009) Peter D. Adams MOLECULAR CELL
- Buffering of Segmental and Chromosomal Aneuploidies in Drosophila melanogaster
- (2009) Per Stenberg et al. PLoS Genetics
- Regulation of proteasome-mediated protein degradation during oxidative stress and aging
- (2008) Nicolle Breusing et al. BIOLOGICAL CHEMISTRY
- A Drug-Inducible System for Direct Reprogramming of Human Somatic Cells to Pluripotency
- (2008) Dirk Hockemeyer et al. Cell Stem Cell
- Free radicals and senescence
- (2008) Teng Lu et al. EXPERIMENTAL CELL RESEARCH
- Aneuploidy: Cells Losing Their Balance
- (2008) Eduardo M. Torres et al. GENETICS
- Protein Aggregates: an Aging Factor Involved in Cell Death
- (2008) E. Maisonneuve et al. JOURNAL OF BACTERIOLOGY
- Direct multiplexed measurement of gene expression with color-coded probe pairs
- (2008) Gary K Geiss et al. NATURE BIOTECHNOLOGY
- Generation of human-induced pluripotent stem cells
- (2008) In-Hyun Park et al. Nature Protocols
- Aneuploidy Affects Proliferation and Spontaneous Immortalization in Mammalian Cells
- (2008) B. R. Williams et al. SCIENCE
Add your recorded webinar
Do you already have a recorded webinar? Grow your audience and get more views by easily listing your recording on Peeref.
Upload NowBecome a Peeref-certified reviewer
The Peeref Institute provides free reviewer training that teaches the core competencies of the academic peer review process.
Get Started