Exosomes derived from adipose-derived stem cells overexpressing glyoxalase-1 protect endothelial cells and enhance angiogenesis in type 2 diabetic mice with limb ischemia

The biology, function, and biomedical applications of exosomes

(2020) Raghu Kalluri et al.   SCIENCE

circINSR Promotes Proliferation and Reduces Apoptosis of Embryonic Myoblasts by Sponging miR-34a

(2020) Xuemei Shen et al.   Molecular Therapy-Nucleic Acids

Chondrocyte-Targeted MicroRNA Delivery by Engineered Exosomes toward a Cell-Free Osteoarthritis Therapy

(2020) Yujie Liang et al.   ACS Applied Materials & Interfaces

Exosomes derived from miR-155-5p–overexpressing synovial mesenchymal stem cells prevent osteoarthritis via enhancing proliferation and migration, attenuating apoptosis, and modulating extracellular matrix secretion in chondrocytes

(2020) Zhirong Wang et al.   CELL BIOLOGY AND TOXICOLOGY

Exosomal microRNAs derived from mesenchymal stem cells: cell-to-cell messages

(2020) Kasra Asgarpour et al.   Cell Communication and Signaling

NLRP3 inflammasome in endothelial dysfunction

(2020) Baochen Bai et al.   Cell Death & Disease

HIF-1α overexpression in mesenchymal stem cell-derived exosomes mediates cardioprotection in myocardial infarction by enhanced angiogenesis

(2020) Jiacheng Sun et al.   Stem Cell Research & Therapy

Hyperglycaemia and Ischaemia Impair Wound Healing via Toll-like Receptor 4 Pathway Activation in vitro and in an Experimental Murine Model

(2019) Mark J. Portou et al.   EUROPEAN JOURNAL OF VASCULAR AND ENDOVASCULAR SURGERY

Extracellular Vesicles From Adipose Stem Cells Prevent Muscle Damage and Inflammation in a Mouse Model of Hind Limb Ischemia

(2019) Federico Figliolini et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Extracellular vesicles as modulators of wound healing

(2018) Joana Cabral et al.   ADVANCED DRUG DELIVERY REVIEWS

Oxidative stress and reactive oxygen species in endothelial dysfunction associated with cardiovascular and metabolic diseases

(2018) Maria Angela Incalza et al.   VASCULAR PHARMACOLOGY

TRPC proteins contribute to development of diabetic retinopathy and regulate glyoxalase 1 activity and methylglyoxal accumulation

(2018) Robin Sachdeva et al.   Molecular Metabolism

Lower extremity arterial disease in patients with diabetes: a contemporary narrative review

(2018) Mathilde Nativel et al.   Cardiovascular Diabetology

Netrin-1 improves adipose-derived stem cell proliferation, migration, and treatment effect in type 2 diabetic mice with sciatic denervation

(2018) Xing Zhang et al.   Stem Cell Research & Therapy

Methylglyoxal and Advanced Glycation End Products in Patients with Diabetes – What We Know so Far and the Missing Links

(2017) Jan Groener et al.   EXPERIMENTAL AND CLINICAL ENDOCRINOLOGY & DIABETES

Diabetic foot ulcer severity predicts mortality among veterans with type 2 diabetes

(2017) Meghan B. Brennan et al.   JOURNAL OF DIABETES AND ITS COMPLICATIONS

Using data to tackle the burden of amputation in diabetes

(2017) William Jeffcoate et al.   LANCET

Therapeutic angiogenesis of adipose-derived stem cells for ischemic diseases

(2017) Lina Zhao et al.   Stem Cell Research & Therapy

Induced Pluripotent Stem Cell (iPSC)–Derived Extracellular Vesicles Are Safer and More Effective for Cardiac Repair Than iPSCs

(2017) Marta Adamiak et al.   CIRCULATION RESEARCH

Association of diabetic foot ulcer and death in a population-based cohort from the United Kingdom

(2016) J. W. Walsh et al.   DIABETIC MEDICINE

The financial burden of surgical and endovascular treatment of diabetic foot wounds

(2016) Maximilian O. Joret et al.   JOURNAL OF VASCULAR SURGERY

Localization of human adipose-derived stem cells and their effect in repair of diabetic foot ulcers in rats

(2016) Rongfeng Shi et al.   Stem Cell Research & Therapy

Glyoxalase-1 Overexpression Reverses Defective Proangiogenic Function of Diabetic Adipose-Derived Stem Cells in Streptozotocin-Induced Diabetic Mice Model of Critical Limb Ischemia

(2016) Zhiyou Peng et al.   Stem Cells Translational Medicine

Diabetic Mesenchymal Stem Cells Are Ineffective for Improving Limb Ischemia Due to Their Impaired Angiogenic Capability

(2015) Hyongbum Kim et al.   CELL TRANSPLANTATION

Lower Extremity Manifestations of Peripheral Artery Disease: The Pathophysiologic and Functional Implications of Leg Ischemia

(2015) M. M. McDermott   CIRCULATION RESEARCH

NLRP3 inflammasome: From a danger signal sensor to a regulatory node of oxidative stress and inflammatory diseases

(2015) Amna Abderrazak et al.   Redox Biology

New Strategies for Overcoming Limitations of Mesenchymal Stem Cell-Based Immune Modulation

(2015) Nayoun Kim et al.   International Journal of Stem Cells

Biosafety Challenges for Use of Lentiviral Vectors in Gene Therapy

(2014) Michael Rothe et al.   CURRENT GENE THERAPY

Disturbed angiogenic activity of adipose-derived stromal cells obtained from patients with coronary artery disease and diabetes mellitus type 2

(2014) Nina A Dzhoyashvili et al.   Journal of Translational Medicine

TRAIL negatively regulates VEGF-induced angiogenesis via caspase-8-mediated enzymatic and non-enzymatic functions

(2013) Hee-Jun Na et al.   ANGIOGENESIS

Glyoxalase-1 overexpression in bone marrow cells reverses defective neovascularization in STZ-induced diabetic mice

(2013) Branka Vulesevic et al.   CARDIOVASCULAR RESEARCH

Higher levels of advanced glycation endproducts in human carotid atherosclerotic plaques are associated with a rupture-prone phenotype

(2013) Nordin M.J. Hanssen et al.   EUROPEAN HEART JOURNAL

TXNIP shuttling: missing link between oxidative stress and inflammasome activation

(2013) Troy Lane et al.   Frontiers in Physiology

Delivery of siRNA to the mouse brain by systemic injection of targeted exosomes

(2011) Lydia Alvarez-Erviti et al.   NATURE BIOTECHNOLOGY

A role for mitochondria in NLRP3 inflammasome activation

(2010) Rongbin Zhou et al.   NATURE