General Pyrrolidine Synthesis via Iridium-Catalyzed Reductive Azomethine Ylide Generation from Tertiary Amides and Lactams

Five-Step Total Synthesis of (±)-Aspidospermidine by a Lactam Strategy via an Azomethine Ylide

(2021) Seiya Katahara et al.   ORGANIC LETTERS

Understanding chemical reactivity using the activation strain model

(2020) Pascal Vermeeren et al.   Nature Protocols

Reverse Polarity Reductive Functionalization of Tertiary Amides via a Dual Iridium-Catalyzed Hydrosilylation and Single Electron Transfer Strategy

(2020) Tatiana Rogova et al.   ACS Catalysis

Proline derivatives incorporating hydrophobic long-chain derived from natural and synthetic fatty acids

(2019) Elisabet Selva et al.   TETRAHEDRON

Approach to Fully Substituted Cyclic Nitrones from N -Hydroxylactam Derivatives: Development and Application to the Total Synthesis of Cylindricine C

(2019) Shobu Hiraoka et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Switching Diastereoselectivity in Catalytic Enantioselective (3 + 2) Cycloadditions of Azomethine Ylides Promoted by Metal Salts and Privileged Segphos Derived Ligands

(2019) Guilherme S. Caleffi et al.   JOURNAL OF ORGANIC CHEMISTRY

Iridium-Catalyzed Aza-Spirocyclization of Indole-Tethered Amides: An Interrupted Pictet–Spengler Reaction

(2019) Pablo Gabriel et al.   ORGANIC LETTERS

Quaternary Carbon Center Forming [3 + 2] Cyclization Reaction by Adjusting the Substituents of Substrates

(2019) Xie-Chao Yang et al.   JOURNAL OF ORGANIC CHEMISTRY

Nucleophilic Substitution in Solution: Activation Strain Analysis of Weak and Strong Solvent Effects

(2018) Trevor A. Hamlin et al.   CHEMISTRY-A EUROPEAN JOURNAL

CuI-Catalyzed Asymmetric [3 + 2] Cycloaddition of Azomethine Ylides with Cyclobutenones

(2018) Javier Corpas et al.   ORGANIC LETTERS

1,3-Dipolar cycloadditions with azomethine ylide species generated from aminocyclopropanes

(2018) Andrzej Wolan et al.   TETRAHEDRON

Iridium-catalyzed reductive Ugi-type reactions of tertiary amides

(2018) Lan-Gui Xie et al.   Nature Communications

Cycloaddition/annulation strategies for the construction of multisubstituted pyrrolidines and their applications in natural product synthesis

(2018) Jundong Li et al.   Organic Chemistry Frontiers

Iridium-Catalyzed Reductive Nucleophilic Addition to Secondary Amides

(2018) Yoshito Takahashi et al.   ORGANIC LETTERS

Well-Designed Phosphine–Urea Ligand for Highly Diastereo- and Enantioselective 1,3-Dipolar Cycloaddition of Methacrylonitrile: A Combined Experimental and Theoretical Study

(2018) Yang Xiong et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Total Synthesis of (−)-Himalensine A

(2017) Heyao Shi et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Enantioselective Construction of the ABCDE Pentacyclic Core of the Strychnos Alkaloids

(2017) Adam D. Gammack Yamagata et al.   ORGANIC LETTERS

Sequential [1 + 4]- and [2 + 3]-Annulation of Prop-2-ynylsulfonium Salts: Access to Hexahydropyrrolo[3,2-b]indoles

(2017) Penghao Jia et al.   ORGANIC LETTERS

Tertiary amine synthesis via reductive coupling of amides with Grignard reagents

(2017) Lan-Gui Xie et al.   Chemical Science

Expeditious and Divergent Total Syntheses of Aspidosperma Alkaloids Exploiting Iridium(I)-Catalyzed Generation of Reactive Enamine Intermediates

(2016) Peng Wen Tan et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Asymmetric Brønsted Base Catalyzed and Directed [3+2] Cycloaddition of 2-Acyl Cycloheptatrienes with Azomethine Ylides

(2016) Vibeke H. Lauridsen et al.   CHEMISTRY-A EUROPEAN JOURNAL

One-Pot Reductive 1,3-Dipolar Cycloaddition of Secondary Amides: A Two-Step Transformation of Primary Amides

(2016) Pei-Qiang Huang et al.   JOURNAL OF ORGANIC CHEMISTRY

An Iridium-Catalyzed Reductive Approach to Nitrones from N-Hydroxyamides

(2016) Seiya Katahara et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Progress in 1,3-dipolar cycloadditions in the recent decade: an update to strategic development towards the arsenal of organic synthesis

(2016) Maya Shankar Singh et al.   TETRAHEDRON

The Cyano Group as a Traceless Activation Group for the Intermolecular [3+2] Cycloaddition of Azomethine Ylides: A Five-Step Synthesis of (±)-Isoretronecanol

(2015) Jundong Li et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Recent Advances of Catalytic Asymmetric 1,3-Dipolar Cycloadditions

(2015) Takuya Hashimoto et al.   CHEMICAL REVIEWS

1,3-Dipolar cycloadditions of azomethine imines

(2015) Carmen Nájera et al.   ORGANIC & BIOMOLECULAR CHEMISTRY

Ligand-Controlled Diastereoselective 1,3-Dipolar Cycloadditions of Azomethine Ylides with Methacrylonitrile

(2015) Mary C. Walton et al.   ORGANIC LETTERS

Regio and diastereoselective multicomponent 1,3-dipolar cycloadditions between prolinate hydrochlorides, aldehydes and dipolarophiles for the direct synthesis of pyrrolizidines

(2015) Juan Mancebo-Aracil et al.   TETRAHEDRON

The activation strain model and molecular orbital theory

(2015) Lando P. Wolters et al.   Wiley Interdisciplinary Reviews-Computational Molecular Science

The activation strain model and molecular orbital theory: understanding and designing chemical reactions

(2014) Israel Fernández et al.   CHEMICAL SOCIETY REVIEWS

Iridium-Catalyzed Reductive Nitro-Mannich Cyclization

(2014) Alex W. Gregory et al.   CHEMISTRY-A EUROPEAN JOURNAL

Physical Meaning of Virtual Kohn–Sham Orbitals and Orbital Energies: An Ideal Basis for the Description of Molecular Excitations

(2014) R. van Meer et al.   Journal of Chemical Theory and Computation

Rings in Drugs

(2014) Richard D. Taylor et al.   JOURNAL OF MEDICINAL CHEMISTRY

Analysis of the Structural Diversity, Substitution Patterns, and Frequency of Nitrogen Heterocycles among U.S. FDA Approved Pharmaceuticals

(2014) Edon Vitaku et al.   JOURNAL OF MEDICINAL CHEMISTRY

Synthesis of Saturated N-Heterocycles

(2014) Cam-Van T. Vo et al.   JOURNAL OF ORGANIC CHEMISTRY

Two- and Three-dimensional Rings in Drugs

(2013) Matteo Aldeghi et al.   Chemical Biology & Drug Design

Recent advances in organocatalytic asymmetric synthesis of polysubstituted pyrrolidines

(2013) Man-Yi Han et al.   TETRAHEDRON LETTERS

Escape from Flatland 2: complexity and promiscuity

(2012) Frank Lovering   MedChemComm

The activation strain model of chemical reactivity

(2010) Willem-Jan van Zeist et al.   ORGANIC & BIOMOLECULAR CHEMISTRY

A Masked 1,3-Dipole Revealed from Aziridines

(2009) Philippe Dauban et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Escape from Flatland: Increasing Saturation as an Approach to Improving Clinical Success

(2009) Frank Lovering et al.   JOURNAL OF MEDICINAL CHEMISTRY

Theory of 1,3-Dipolar Cycloadditions: Distortion/Interaction and Frontier Molecular Orbital Models

(2008) Daniel H. Ess et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY