期刊
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
卷 58, 期 13, 页码 4381-4385出版社
WILEY-V C H VERLAG GMBH
DOI: 10.1002/anie.201901049
关键词
amides; nitrones; nucleophilic addition; synthetic methods; total synthesis
资金
- MEXT [18K05127]
- JGC-S Scholarship Foundation
- Tobe Maki foundation
- Grants-in-Aid for Scientific Research [18K05127] Funding Source: KAKEN
An approach to cyclic nitrones from N-hydroxylactam derivatives is documented. The nucleophilic addition of an organolithium reagent to an N-OSEM [SEM=2-(trimethylsilyl)ethoxymethyl] lactam forms a five-membered chelated intermediate, which undergoes both elimination and deprotection to give a fully substituted nitrone in a one-pot process. When combined with the N-oxidation of easily available chiral lactams, this method becomes especially useful for the quick synthesis of chiral nitrones in enantio-pure form, enabling the concise total synthesis of cylindricineC.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据