标题
Transcriptional signature in microglia associated with Aβ plaque phagocytosis
作者
关键词
-
出版物
Nature Communications
Volume 12, Issue 1, Pages -
出版商
Springer Science and Business Media LLC
发表日期
2021-05-21
DOI
10.1038/s41467-021-23111-1
参考文献
相关参考文献
注意:仅列出部分参考文献,下载原文获取全部文献信息。- Molecular characterization of selectively vulnerable neurons in Alzheimer’s disease
- (2021) Kun Leng et al. NATURE NEUROSCIENCE
- Human and mouse single-nucleus transcriptomics reveal TREM2-dependent and TREM2-independent cellular responses in Alzheimer’s disease
- (2020) Yingyue Zhou et al. NATURE MEDICINE
- A CX3CR1 Reporter hESC Line Facilitates Integrative Analysis of In-Vitro-Derived Microglia and Improved Microglia Identity upon Neuron-Glia Co-culture
- (2020) Alexandra Grubman et al. Stem Cell Reports
- Proteome profiling in cerebrospinal fluid reveals novel biomarkers of Alzheimer's disease
- (2020) Jakob M Bader et al. Molecular Systems Biology
- A scalable SCENIC workflow for single-cell gene regulatory network analysis
- (2020) Bram Van de Sande et al. Nature Protocols
- Galectin-3, a novel endogenous TREM2 ligand, detrimentally regulates inflammatory response in Alzheimer’s disease
- (2019) Antonio Boza-Serrano et al. ACTA NEUROPATHOLOGICA
- Single-cell transcriptomic analysis of Alzheimer’s disease
- (2019) Hansruedi Mathys et al. NATURE
- A Breakdown in Metabolic Reprogramming Causes Microglia Dysfunction in Alzheimer's Disease
- (2019) Sung Hoon Baik et al. Cell Metabolism
- scds: computational annotation of doublets in single-cell RNA sequencing data
- (2019) Abha S Bais et al. BIOINFORMATICS
- A single-cell atlas of entorhinal cortex from individuals with Alzheimer’s disease reveals cell-type-specific gene expression regulation
- (2019) Alexandra Grubman et al. NATURE NEUROSCIENCE
- Unique molecular signature in mucolipidosis type IV microglia
- (2019) Antony Cougnoux et al. Journal of Neuroinflammation
- Orchestrating single-cell analysis with Bioconductor
- (2019) Robert A. Amezquita et al. NATURE METHODS
- A descriptive marker gene approach to single-cell pseudotime inference
- (2018) Kieran R Campbell et al. BIOINFORMATICS
- Slingshot: cell lineage and pseudotime inference for single-cell transcriptomics
- (2018) Kelly Street et al. BMC GENOMICS
- Disease-Associated Microglia: A Universal Immune Sensor of Neurodegeneration
- (2018) Aleksandra Deczkowska et al. CELL
- Re-evaluating microglia expression profiles using RiboTag and cell isolation strategies
- (2018) Zhana Haimon et al. NATURE IMMUNOLOGY
- Epigenetic regulation of brain region-specific microglia clearance activity
- (2018) Pinar Ayata et al. NATURE NEUROSCIENCE
- A transcriptomic atlas of aged human microglia
- (2018) Marta Olah et al. Nature Communications
- Brain Cell Type Specific Gene Expression and Co-expression Network Architectures
- (2018) Andrew T. McKenzie et al. Scientific Reports
- Diverse Brain Myeloid Expression Profiles Reveal Distinct Microglial Activation States and Aspects of Alzheimer’s Disease Not Evident in Mouse Models
- (2018) Brad A. Friedman et al. Cell Reports
- Microglial translational profiling reveals a convergent APOE pathway from aging, amyloid, and tau
- (2018) Silvia S. Kang et al. JOURNAL OF EXPERIMENTAL MEDICINE
- Innate immune memory in the brain shapes neurological disease hallmarks
- (2018) Ann-Christin Wendeln et al. NATURE
- M3Drop: dropout-based feature selection for scRNASeq
- (2018) Tallulah S Andrews et al. BIOINFORMATICS
- Development and validation of a simplified method to generate human microglia from pluripotent stem cells
- (2018) Amanda McQuade et al. Molecular Neurodegeneration
- CD47 Protects Synapses from Excess Microglia-Mediated Pruning during Development
- (2018) Emily K. Lehrman et al. NEURON
- Quantitative proteomic profiling of cerebrospinal fluid to identify candidate biomarkers for Alzheimer's disease
- (2018) Gajanan Sathe et al. Proteomics Clinical Applications
- The TREM2-APOE Pathway Drives the Transcriptional Phenotype of Dysfunctional Microglia in Neurodegenerative Diseases
- (2017) Susanne Krasemann et al. IMMUNITY
- Α-synuclein induces microglial cell migration through stimulating HIF-1α accumulation
- (2017) Hongfei Qiao et al. JOURNAL OF NEUROSCIENCE RESEARCH
- Integrative single-cell analysis of transcriptional and epigenetic states in the human adult brain
- (2017) Blue B Lake et al. NATURE BIOTECHNOLOGY
- Reference component analysis of single-cell transcriptomes elucidates cellular heterogeneity in human colorectal tumors
- (2017) Huipeng Li et al. NATURE GENETICS
- SCENIC: single-cell regulatory network inference and clustering
- (2017) Sara Aibar et al. NATURE METHODS
- SC3: consensus clustering of single-cell RNA-seq data
- (2017) Vladimir Yu Kiselev et al. NATURE METHODS
- Transcriptomic analysis of purified human cortical microglia reveals age-associated changes
- (2017) Thais F Galatro et al. NATURE NEUROSCIENCE
- iPSC-Derived Human Microglia-like Cells to Study Neurological Diseases
- (2017) Edsel M. Abud et al. NEURON
- TDP-43 Depletion in Microglia Promotes Amyloid Clearance but Also Induces Synapse Loss
- (2017) Rosa C. Paolicelli et al. NEURON
- Local Cues Establish and Maintain Region-Specific Phenotypes of Basal Ganglia Microglia
- (2017) Lindsay M. De Biase et al. NEURON
- Diverse Requirements for Microglial Survival, Specification, and Function Revealed by Defined-Medium Cultures
- (2017) Christopher J. Bohlen et al. NEURON
- An environment-dependent transcriptional network specifies human microglia identity
- (2017) David Gosselin et al. SCIENCE
- Massively parallel digital transcriptional profiling of single cells
- (2017) Grace X. Y. Zheng et al. Nature Communications
- Temporal Tracking of Microglia Activation in Neurodegeneration at Single-Cell Resolution
- (2017) Hansruedi Mathys et al. Cell Reports
- Transcriptional profiling of CD11c-positive microglia accumulating around amyloid plaques in a mouse model for Alzheimer's disease
- (2016) Willem Kamphuis et al. BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE
- Je, a versatile suite to handle multiplexed NGS libraries with unique molecular identifiers
- (2016) Charles Girardot et al. BMC BIOINFORMATICS
- Pharmacological targeting of CSF1R inhibits microglial proliferation and prevents the progression of Alzheimer’s-like pathology
- (2016) Adrian Olmos-Alonso et al. BRAIN
- TREM2-mediated early microglial response limits diffusion and toxicity of amyloid plaques
- (2016) Yaming Wang et al. JOURNAL OF EXPERIMENTAL MEDICINE
- Multitasking Microglia and Alzheimer’s Disease: Diversity, Tools and Therapeutic Targets
- (2016) Alexandra Grubman et al. JOURNAL OF MOLECULAR NEUROSCIENCE
- Disease Progression-Dependent Effects of TREM2 Deficiency in a Mouse Model of Alzheimer's Disease
- (2016) Taylor R. Jay et al. JOURNAL OF NEUROSCIENCE
- A predictive computational framework for direct reprogramming between human cell types
- (2016) Owen J L Rackham et al. NATURE GENETICS
- Microglial brain region−dependent diversity and selective regional sensitivities to aging
- (2016) Kathleen Grabert et al. NATURE NEUROSCIENCE
- TREM2 Haplodeficiency in Mice and Humans Impairs the Microglia Barrier Function Leading to Decreased Amyloid Compaction and Severe Axonal Dystrophy
- (2016) Peng Yuan et al. NEURON
- TREM2 Binds to Apolipoproteins, Including APOE and CLU/APOJ, and Thereby Facilitates Uptake of Amyloid-Beta by Microglia
- (2016) Felix L. Yeh et al. NEURON
- g:Profiler—a web server for functional interpretation of gene lists (2016 update)
- (2016) Jüri Reimand et al. NUCLEIC ACIDS RESEARCH
- IL-33 ameliorates Alzheimer’s disease-like pathology and cognitive decline
- (2016) Amy K. Y. Fu et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Complement and microglia mediate early synapse loss in Alzheimer mouse models
- (2016) S. Hong et al. SCIENCE
- destiny: diffusion maps for large-scale single-cell data in R
- (2015) Philipp Angerer et al. BIOINFORMATICS
- TREM2 Lipid Sensing Sustains the Microglial Response in an Alzheimer’s Disease Model
- (2015) Yaming Wang et al. CELL
- TREM2 deficiency eliminates TREM2+inflammatory macrophages and ameliorates pathology in Alzheimer’s disease mouse models
- (2015) Taylor R. Jay et al. JOURNAL OF EXPERIMENTAL MEDICINE
- Computational assignment of cell-cycle stage from single-cell transcriptome data
- (2015) Antonio Scialdone et al. METHODS
- Conserved epigenomic signals in mice and humans reveal immune basis of Alzheimer’s disease
- (2015) Elizabeta Gjoneska et al. NATURE
- Spatial reconstruction of single-cell gene expression data
- (2015) Rahul Satija et al. NATURE BIOTECHNOLOGY
- Orchestrating high-throughput genomic analysis with Bioconductor
- (2015) Wolfgang Huber et al. NATURE METHODS
- limma powers differential expression analyses for RNA-sequencing and microarray studies
- (2015) Matthew E. Ritchie et al. NUCLEIC ACIDS RESEARCH
- Cell types in the mouse cortex and hippocampus revealed by single-cell RNA-seq
- (2015) A. Zeisel et al. SCIENCE
- Scanning ultrasound removes amyloid-β and restores memory in an Alzheimer’s disease mouse model
- (2015) Gerhard Leinenga et al. Science Translational Medicine
- Forebrain microglia from wild-type but not adult 5xFAD mice prevent amyloid-β plaque formation in organotypic hippocampal slice cultures
- (2015) Sabine Hellwig et al. Scientific Reports
- FastRFunctions for Robust Correlations and Hierarchical Clustering
- (2015) Peter Langfelder et al. Journal of Statistical Software
- DOSE: an R/Bioconductor package for disease ontology semantic and enrichment analysis
- (2014) Guangchuang Yu et al. BIOINFORMATICS
- Trimmomatic: a flexible trimmer for Illumina sequence data
- (2014) Anthony M. Bolger et al. BIOINFORMATICS
- Apolipoprotein E isoforms and lipoprotein metabolism
- (2014) Michael C. Phillips IUBMB LIFE
- mTOR Signaling Inhibition Modulates Macrophage/Microglia-Mediated Neuroinflammation and Secondary Injury via Regulatory T Cells after Focal Ischemia
- (2014) L. Xie et al. JOURNAL OF IMMUNOLOGY
- featureCounts: an efficient general purpose program for assigning sequence reads to genomic features
- (2013) Y. Liao et al. BIOINFORMATICS
- Causal analysis approaches in Ingenuity Pathway Analysis
- (2013) Andreas Krämer et al. BIOINFORMATICS
- Integrated Systems Approach Identifies Genetic Nodes and Networks in Late-Onset Alzheimer’s Disease
- (2013) Bin Zhang et al. CELL
- Amyloid β deposition, neurodegeneration, and cognitive decline in sporadic Alzheimer's disease: a prospective cohort study
- (2013) Victor L Villemagne et al. LANCET NEUROLOGY
- viSNE enables visualization of high dimensional single-cell data and reveals phenotypic heterogeneity of leukemia
- (2013) El-ad David Amir et al. NATURE BIOTECHNOLOGY
- The microglial sensome revealed by direct RNA sequencing
- (2013) Suzanne E Hickman et al. NATURE NEUROSCIENCE
- BMP9 ameliorates amyloidosis and the cholinergic defect in a mouse model of Alzheimer's disease
- (2013) R. M. Burke et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- A Neurodegeneration-Specific Gene-Expression Signature of Acutely Isolated Microglia from an Amyotrophic Lateral Sclerosis Mouse Model
- (2013) Isaac M. Chiu et al. Cell Reports
- STAR: ultrafast universal RNA-seq aligner
- (2012) Alexander Dobin et al. BIOINFORMATICS
- Low-density Lipoprotein Receptor Represents an Apolipoprotein E-independent Pathway of Aβ Uptake and Degradation by Astrocytes
- (2012) Jacob M. Basak et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Targeted Data Extraction of the MS/MS Spectra Generated by Data-independent Acquisition: A New Concept for Consistent and Accurate Proteome Analysis
- (2012) Ludovic C. Gillet et al. MOLECULAR & CELLULAR PROTEOMICS
- NLRP3 is activated in Alzheimer’s disease and contributes to pathology in APP/PS1 mice
- (2012) Michael T. Heneka et al. NATURE
- Immune self-reactivity triggered by drug-modified HLA-peptide repertoire
- (2012) Patricia T. Illing et al. NATURE
- TREM2 Variants in Alzheimer's Disease
- (2012) Rita Guerreiro et al. NEW ENGLAND JOURNAL OF MEDICINE
- clusterProfiler: an R Package for Comparing Biological Themes Among Gene Clusters
- (2012) Guangchuang Yu et al. OMICS-A JOURNAL OF INTEGRATIVE BIOLOGY
- Using iRT, a normalized retention time for more targeted measurement of peptides
- (2012) Claudia Escher et al. PROTEOMICS
- MyD88 Deficiency Ameliorates β-Amyloidosis in an Animal Model of Alzheimer's Disease
- (2011) Jeong-Eun Lim et al. AMERICAN JOURNAL OF PATHOLOGY
- Quality control and preprocessing of metagenomic datasets
- (2011) R. Schmieder et al. BIOINFORMATICS
- VennDiagram: a package for the generation of highly-customizable Venn and Euler diagrams in R
- (2011) Hanbo Chen et al. BMC BIOINFORMATICS
- CX3CR1 Protein Signaling Modulates Microglial Activation and Protects against Plaque-independent Cognitive Deficits in a Mouse Model of Alzheimer Disease
- (2011) Seo-Hyun Cho et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- MyD88-adaptor protein acts as a preventive mechanism for memory deficits in a mouse model of Alzheimer's disease
- (2011) Jean-Philippe Michaud et al. Molecular Neurodegeneration
- Common variants at MS4A4/MS4A6E, CD2AP, CD33 and EPHA1 are associated with late-onset Alzheimer's disease
- (2011) Adam C Naj et al. NATURE GENETICS
- Common variants at ABCA7, MS4A6A/MS4A4E, EPHA1, CD33 and CD2AP are associated with Alzheimer's disease
- (2011) Paul Hollingworth et al. NATURE GENETICS
- Synaptic Pruning by Microglia Is Necessary for Normal Brain Development
- (2011) R. C. Paolicelli et al. SCIENCE
- Skyline: an open source document editor for creating and analyzing targeted proteomics experiments
- (2010) Brendan MacLean et al. BIOINFORMATICS
- CX3CR1 in Microglia Regulates Brain Amyloid Deposition through Selective Protofibrillar Amyloid- Phagocytosis
- (2010) Z. Liu et al. JOURNAL OF NEUROSCIENCE
- Microglial Cx3cr1 knockout prevents neuron loss in a mouse model of Alzheimer's disease
- (2010) Martin Fuhrmann et al. NATURE NEUROSCIENCE
- Enrichment Map: A Network-Based Method for Gene-Set Enrichment Visualization and Interpretation
- (2010) Daniele Merico et al. PLoS One
- edgeR: a Bioconductor package for differential expression analysis of digital gene expression data
- (2009) M. D. Robinson et al. BIOINFORMATICS
- Oligomeric amyloid associates with postsynaptic densities and correlates with excitatory synapse loss near senile plaques
- (2009) R. M. Koffie et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Post-mortem correlates of in vivo PiB-PET amyloid imaging in a typical case of Alzheimer's disease
- (2008) Milos D. Ikonomovic et al. BRAIN
- The NALP3 inflammasome is involved in the innate immune response to amyloid-β
- (2008) Annett Halle et al. NATURE IMMUNOLOGY
Publish scientific posters with Peeref
Peeref publishes scientific posters from all research disciplines. Our Diamond Open Access policy means free access to content and no publication fees for authors.
Learn MoreCreate your own webinar
Interested in hosting your own webinar? Check the schedule and propose your idea to the Peeref Content Team.
Create Now