Editorial Material
Biotechnology & Applied Microbiology
Hao Gao, Wankui Jiang, Wenming Zhang, Min Jiang, Fengxue Xin
Summary: Constructing stable microbial consortia is challenging, but can be addressed by creating spatial niches partitioning subpopulations.
TRENDS IN BIOTECHNOLOGY
(2023)
Editorial Material
Biotechnology & Applied Microbiology
Jian-Ming Liu, Christian Solem, Ting Lu, Peter Ruhdal Jensen
Summary: Lactic acid bacteria (LAB) are important members of synthetic microbial consortia due to their safety and diverse metabolic activities. Defined communities with LAB have the potential to reveal metabolic interactions, drive their assembly, and address sustainability challenges in food, environment, and health.
TRENDS IN BIOTECHNOLOGY
(2022)
Review
Agricultural Engineering
Hao Gao, Clarisse Manishimwe, Lu Yang, Hanxiao Wang, Yujia Jiang, Wankui Jiang, Wenming Zhang, Fengxue Xin, Min Jiang
Summary: Synthetic microbial consortia offer a versatile platform for biochemicals production, but their unmatched growing conditions, low stability, and low production efficiency hinder their further applications. This review comprehensively summarizes the progress of synthetic light-driven microbial consortia for chemicals production and discusses the potential of space efficient synthetic light-driven microbial consortia in hydrogel systems.
BIORESOURCE TECHNOLOGY
(2022)
Article
Ecology
Shuyao Li, Jing Xiao, Tianzheng Sun, Fangjian Yu, Kaihang Zhang, Yuantao Feng, Chenchao Xu, Baojun Wang, Lei Cheng
Summary: This study developed a microbial experimental system that allows for rapidly generating microbial consortia with programmable ecological interactions. By using engineered microbial consortia, the researchers showed different population dynamics under different initial inoculation conditions and controlled the transitions between exploitation, competition, and synergy by tuning the engineered modules. Mathematical models were derived to quantitatively capture the experimentally observed population dynamics of these synthetic microbial consortia.
METHODS IN ECOLOGY AND EVOLUTION
(2022)
Review
Biochemistry & Molecular Biology
Nicolas E. Grandel, Kiara Reyes Gamas, Matthew R. Bennett
Summary: Synthetic microbial systems are becoming more complex, but controlling their complexity remains difficult. Recent advances have improved our ability to control the structure of microbial systems, but integrating different parts into a unified system still poses challenges.
TRENDS IN MICROBIOLOGY
(2021)
Article
Biotechnology & Applied Microbiology
Yan Wang, Hengchang Li, Yu Liu, Mengyu Zhou, Mingzhu Ding, Yingjin Yuan
Summary: This study used systems biology analysis to construct a synthetic microbial consortium for high-efficiency production of 2-keto-Lgulonic acid. The results showed that the consortium had a symbiotic relationship, with the helper strain promoting the growth of the producing strain and increasing the production of 2-KLG. Additionally, the consortium exhibited reduced oxidative stress.
SYNTHETIC AND SYSTEMS BIOTECHNOLOGY
(2022)
Article
Food Science & Technology
Yanxia Wang, Lei Yang, Jianhong Xu, Fengxue Xin, Ling Jiang
Summary: This review mainly discusses the applications of synthetic microbial consortia in mycotoxin biodetoxification through degradation and adsorption, as well as in antagonism toward mycotoxin producers. Additionally, it provides challenges and future perspectives for the synthetic microbial consortia to mitigate mycotoxin contamination and fungal infection.
CURRENT OPINION IN FOOD SCIENCE
(2023)
Article
Agricultural Engineering
Qihang Su, Dunwu Dai, Youjun Liao, Hongbo Han, Jian Wu, Zhuqing Ren
Summary: This study successfully isolated and screened strains with the ability to degrade ammonia, hydrogen sulfide, and sulfur compounds, and then combined them to create synthetic microbial consortia for enhancing odor treatment in the BTF. The results showed that the BTF with synthetic microbial consortia significantly improved the removal rates of ammonia and hydrogen sulfide, as well as p-methyl mercaptan, methyl sulfide, and dimethyl disulfide.
BIORESOURCE TECHNOLOGY
(2023)
Review
Biotechnology & Applied Microbiology
Francisco Massot, Nathalie Bernard, Lucas M. Martinez Alvarez, Maria M. Martorell, Walter P. Mac Cormack, Lucas A. M. Ruberto
Summary: Microbial associations play a significant role in biotechnological processes, particularly in bioremediation. However, there is a lack of consensus in the definition of these associations. This study aims to analyze the diversity of microbial consortia in the context of pollutant degradation and bioremediation, and proposes criteria for classification and definition.
APPLIED MICROBIOLOGY AND BIOTECHNOLOGY
(2022)
Article
Biotechnology & Applied Microbiology
Yanfang Wang, Theo Elzenga, Jan Dirk van Elsas
Summary: The study found that Coniochaeta sp. 2T2.1 played a key role in the degradation of wheat straw, with the two bacteria having additional roles. Temperature had minor effects on degradation, while pH and shaking speed were key determinants of organismal growth and wheat straw degradation levels.
APPLIED MICROBIOLOGY AND BIOTECHNOLOGY
(2021)
Article
Automation & Control Systems
Alex dos Reis de Souza, Denis Efimov, Andrey Polyakov, Jean-Luc Gouze, Eugenio Cinquemani
Summary: This article discusses the problem of state estimation of a microbial consortium. State estimators are proposed for each state component using available measurements of total biomass and a fluorescent reporter. The advantage of measuring the fluorescent reporter on the observer design is highlighted. Numerical experiment illustrates the methodology.
INTERNATIONAL JOURNAL OF ROBUST AND NONLINEAR CONTROL
(2023)
Review
Microbiology
Yu Liang, Anzhou Ma, Guoqiang Zhuang
Summary: In synthetic biology, engineering principles are used for system design, and one area of application is the development of synthetic microbial consortia. These systems involve co-cultivating multiple microorganisms under specific environmental conditions, with applications in various fields such as ecological restoration and theory. Synthetic microbial consortia are known for their high biological processing efficiencies due to the division of labor, reducing the metabolic burden on individual members. This review focuses on the environmental applications of synthetic microbial consortia, particularly the construction principles based on cross-feeding, and proposes methods for constructing these consortia based on traits and spatial structure from an ecological perspective to guide future research.
FRONTIERS IN MICROBIOLOGY
(2022)
Review
Biotechnology & Applied Microbiology
Zhibei Cao, Wenlong Yan, Mingzhu Ding, Yingjin Yuan
Summary: This review discusses the strategies and recent advances in using microbial consortia to degrade complex compounds, including plastics, petroleum, antibiotics, azo dyes, and pollutants in sewage. It is shown that microbial consortia have advantages over isolated bacteria as they are more adaptable and stable, and can provide a suitable catalytic environment for each enzyme. The development of synthetic biology and gene-editing tools allows the design of artificial microbial consortia systems that are more efficient, stable, and robust.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2022)
Editorial Material
Chemistry, Multidisciplinary
Bo Wang, Zhuojun Dai
Summary: Microbial consortia consisting of phototrophs and heterotrophs have gained attention for their potential in sustainable biotechnology. The Ni Lab has developed a highly compatible autotrophic-heterotrophic symbiotic system comprising Synechococcus elongatus and Vibrio natriegens, which together enable carbon-negative biosynthesis by channeling CO2 into valuable chemicals.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2023)
Article
Chemistry, Multidisciplinary
Bingjie Dang, Keqin Liu, Xulei Wu, Zhen Yang, Liying Xu, Yuchao Yang, Ru Huang
Summary: The recent advances in optic neuromorphic devices have enabled the development of energy-efficient artificial-vision systems. These devices are widely used due to their ability to capture, store, and process visual information. However, existing optic neuromorphic devices have limitations such as nonlinear weight updates, cross-talk issues, and silicon process incompatibility. This study introduces a highly linear, light-tunable, cross-talk-free, and silicon-compatible optic memristor for the implementation of an optic artificial neural network (OANN). The experimental results show that the OANN achieves an accuracy of 99.3% after ten training epochs, demonstrating the effectiveness of the proposed optic memristor as a hardware solution for efficient optic neuromorphic and edge computing.
ADVANCED MATERIALS
(2023)
Article
Biochemical Research Methods
Janna Tenenbaum-Katan, Arbel Artzy-Schnirman, Rami Fishler, Netanel Korin, Josue Sznitman
Article
Multidisciplinary Sciences
Mark Epshtein, Netanel Korin
SCIENTIFIC REPORTS
(2018)
Editorial Material
Biochemical Research Methods
Netanel Korin, Josue Sznitman
Article
Cell Biology
Anne-Laure Papa, Amanda Jiang, Netanel Korin, Michelle B. Chen, Erin T. Langan, Anna Waterhouse, Emma Nash, Jildaz Caroff, Amanda Graveline, Andyna Vernet, Akiko Mammoto, Tadanori Mammoto, Abhishek Jain, Roger D. Kamm, Matthew J. Gounis, Donald E. Ingber
SCIENCE TRANSLATIONAL MEDICINE
(2019)
Article
Biochemistry & Molecular Biology
Yathreb Asaad, Mark Epshtein, Andrew Yee, Netanel Korin
Article
Chemistry, Analytical
Danielle Nemcovsky Amar, Mark Epshtein, Netanel Korin
Article
Multidisciplinary Sciences
Mark Epshtein, Netanel Korin
JOURNAL OF THE ROYAL SOCIETY INTERFACE
(2020)
Article
Biotechnology & Applied Microbiology
Mark Epshtein, Moran Levi, Afif M. Kraitem, Hikaia Zidan, Robert M. King, Meinrad Gawaz, Matthew J. Gounis, Netanel Korin
Summary: Localized delivery of diagnostic/therapeutic agents to cerebral aneurysms and brain arterial lesions through targeted particulate carriers shows potential for a new treatment paradigm. By leveraging the endogenous biophysical properties of brain aneurysms and utilizing flow guided targeting with functionalized microparticles, the study demonstrates enhanced localization at high-risk aneurysms both in vitro and in vivo. This biophysical strategy may offer novel treatment opportunities for cerebral aneurysms.
BIOENGINEERING & TRANSLATIONAL MEDICINE
(2022)
Article
Biochemistry & Molecular Biology
Ramsha Aamir, Cameron Fyffe, Netanel Korin, Daniel A. Lawrence, Enming J. Su, Mathumai Kanapathipillai
Summary: This study reports a novel nanoformulation of plasmin based on heparin and arginine, which shows increased stability and efficacy. In vitro studies demonstrate significant plasmin stability and efficient fibrinolytic activity with the nanoformulation. The research indicates the potential of using plasmin nanoparticles in ischemic stroke therapy.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Biochemistry & Molecular Biology
Jeremy A. Nestele, Anne-Katrin Rohlfing, Valerie Dicenta, Alexander Bild, Daniela Eissler, Frederic Emschermann, Marcel Kremser, Konstantin Krutzke, Tilman E. Schaeffer, Oliver Borst, Moran Levi, Netanel Korin, Meinrad Paul Gawaz
Summary: Nanoparticles provide a novel approach for targeted antithrombotic therapy, delivering drugs to specific sites with low side effects. In this study, nanoparticles combined with established proteins successfully inhibited platelet aggregation and thrombus formation, indicating a promising therapeutic strategy for antithrombotic treatment.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Biotechnology & Applied Microbiology
Hila Zukerman, Maria Khoury, Yosi Shammay, Josue Sznitman, Noah Lotan, Netanel Korin
BIOENGINEERING & TRANSLATIONAL MEDICINE
(2020)
Article
Engineering, Biomedical
Anne-Laure Papa, Netanel Korin, Mathumai Kanapathipillai, Akiko Mammoto, Tadanori Mammoto, Amanda Jiang, Robert Mannix, Oktay Uzun, Christopher Johnson, Deen Bhatta, Garry Cuneo, Donald E. Ingber
Article
Biochemical Research Methods
Hagit Stauber, Dan Waisman, Netanel Korin, Josue Sznitman