Article
Engineering, Biomedical
Xin Liu, Xinhuan Wang, Liming Zhang, Lulu Sun, Heran Wang, Hao Zhao, Zhengtao Zhang, Wenli Liu, Yiming Huang, Shen Ji, Jingjinqiu Zhang, Kai Li, Biaobiao Song, Chun Li, Hui Zhang, Song Li, Shu Wang, Xiongfei Zheng, Qi Gu
Summary: This study presents a methodology for fabricating soft vascularized tissue at centimeter scale using multimaterial bioprinting with a customized multistage-temperature-control printer. The printed constructs can support 3D capillary networks to mimic mature and functional liver tissue, and also enable direct surgical anastomosis of blood vessels with the printed pressure-bearing layer. This versatile platform allows for optimal cellularization in engineered tissues through the replication of vasculature networks.
ADVANCED HEALTHCARE MATERIALS
(2021)
Review
Chemistry, Multidisciplinary
Annan Chen, Wanying Wang, Zhengyi Mao, Yunhu He, Shiting Chen, Guo Liu, Jin Su, Pei Feng, Yusheng Shi, Chunze Yan, Jian Lu
Summary: Additive manufacturing (AM) has significant advantages in the fabrication of tissue engineering implants. However, many tissue constructs have anisotropic heterogeneous structures, which pose challenges for conventional AM processes. Multimaterial 3D and 4D bioprinting offer a promising solution for constructing multifunctional implants with heterogeneous structures that can better mimic the host microenvironment.
ADVANCED MATERIALS
(2023)
Article
Nanoscience & Nanotechnology
Shabir Hassan, Eduardo Gomez-Reyes, Eduardo Enciso-Martinez, Kun Shi, Jorge Gonzalez Campos, Oscar Yael Perez Soria, Eder Luna-Ceron, Myung Chul Lee, Isaac Garcia-Reyes, Joshua Steakelum, Haziq Jeelani, Luis Enrique Garcia-Rivera, Minsung Cho, Stephanie Sanchez Cortes, Tom Kamperman, Haihang Wang, Jeroen Leijten, Lance Fiondella, Su Ryon Shin
Summary: A combinational multimaterial and embedded bioprinting approach is used to develop implantable constructs that can maintain their structure in vivo. Self-healing and biodegradable colloidal gels are introduced as support baths to improve printing fidelity and provide suitable microenvironments for cell growth and infiltration.
ACS APPLIED MATERIALS & INTERFACES
(2022)
Article
Chemistry, Applied
Payam Baei, Hamed Daemi, Fatemeh Aramesh, Hossein Baharvand, Mohamadreza Baghaban Eslaminejad
Summary: The purpose of cartilage tissue engineering is to create artificial constructs that mimic native tissue in terms of biological functions and mechanical features, with the aim of improving tissue regeneration. Polysaccharides, due to their structural similarity to the cartilage extracellular matrix (ECM), have attracted attention for developing biomimetic materials. The mechanical properties of constructs and the addition of bioactive molecules play crucial roles in cartilage tissue regeneration. This article discusses polysaccharide-based constructs for cartilage regeneration, with a focus on newly developed biomimetic materials, tuning the mechanical properties of constructs, designing carriers loaded with chondroinductive agents, and the development of appropriate bioinks for bioprinting.
CARBOHYDRATE POLYMERS
(2023)
Article
Chemistry, Multidisciplinary
Alberto Pardo, Syeda Mahwish Bakht, Manuel Gomez-Florit, Ramon Rial, Rosa F. Monteiro, Simao P. B. Teixeira, Pablo Taboada, Rui L. Reis, Rui M. A. Domingues, Manuela E. Gomes
Summary: Combining the concepts of magnetically- and matrix-assisted 3D bioprinting, a new strategy has been developed to fabricate anisotropic high-resolution magnetic composites with remote stimulation capabilities, opening up new possibilities for tissue engineering applications.
ADVANCED FUNCTIONAL MATERIALS
(2022)
Article
Chemistry, Multidisciplinary
Tiziana Fischetti, Giorgia Borciani, Sofia Avnet, Katia Rubini, Nicola Baldini, Gabriela Graziani, Elisa Boanini
Summary: Reproducing a model of the bone microenvironment in vitro is currently needed. In vitro three-dimensional (3D) bone models, obtained through 3D bioprinting using hydroxyapatite nanoparticles, have advantages of high-throughput screening, low costs, and high reproducibility. These models can benefit preclinical in vitro screening, drug discovery, and pathophysiology studies. The use of hydroxyapatite nanoparticles derived from bone mineral as a component in the 3D bioprinting allows for control of scaffold characteristics and cell behavior. The findings show that the nanoparticles can be embedded in the inks without compromising cell viability, and different particle characteristics can significantly affect the behavior of the bioprinted constructs.
Article
Chemistry, Multidisciplinary
Bram G. Soliman, Alessia Longoni, Mian Wang, Wanlu Li, Paulina N. Bernal, Alessandro Cianciosi, Gabriella C. J. Lindberg, Jos Malda, Juergen Groll, Tomasz Jungst, Riccardo Levato, Jelena Rnjak-Kovacina, Tim B. F. Woodfield, Yu Shrike Zhang, Khoon S. Lim
Summary: Sacrificial printing involves using 3D-printed sacrificial ink to create open-channels in hydrogel constructs. Traditional sacrificial inks lack the ability to mimic tissue development dynamics. To overcome this, a new class of sacrificial inks was developed with tailorable and programmable delayed dissolution profiles. These inks showed compatibility with various biofabrication technologies and allowed precise control over the introduction of architectural features into cell-laden hydrogel constructs.
ADVANCED FUNCTIONAL MATERIALS
(2023)
Article
Engineering, Biomedical
Heran Wang, Kai Guo, Liming Zhang, Huixuan Zhu, Shijie Li, Song Li, Feiyang Gao, Xin Liu, Qi Gu, Lianqing Liu, Xiongfei Zheng
Summary: Bioprinting is a promising technology for tissue manufacturing, focusing on precise assembly of multiple materials. The valve-based consecutive bioprinting (VCB) method presented in this study offers greater mechanical strength and printing efficiency compared to the extrusion-based multi-printhead bioprinting (MPB) method. The VCB method allows for seamless switching of materials at the interface, leading to the fabrication of heterogeneous tissues with complex multimaterial interfaces.
Article
Engineering, Multidisciplinary
Zhenjiang Ma, Hongtao He, Changxu Deng, Ya Ren, Dezhi Lu, Wentao Li, Xin Sun, Wenhao Wang, Yuxin Zhang, Yuanjing Xu, Xiaojun Zhou, Liang Zhou, Jingsheng Lin, Tao Li, Tao Wu, Jinwu Wang
Summary: This study successfully fabricated scaffolds with immunomodulatory properties using 3D bioprinting, optimizing the hydrogel's performance and printing feasibility to promote angiogenesis and tissue regeneration. The combination of bioink and cross-linking procedure regulated the immune microenvironment, aiding in forming a confluent endothelium and providing a potentially efficient strategy for developing complex vascularized tissues.
COMPOSITES PART B-ENGINEERING
(2022)
Article
Chemistry, Multidisciplinary
Malin Becker, Melvin Gurian, Maik Schot, Jeroen Leijten
Summary: Embedded 3D bioprinting using low-viscosity ink 3D (LoV3D) bioprinting based on aqueous two-phase stabilization allows for the fabrication of living constructs at high speeds with high viability. The liquid/liquid interfaces of LoV3D bioprinting offer unique advantages for fusing structures, creating vasculature, and modifying surfaces. The low interfacial tension of LoV3D bioprinting allows for nozzle-independent control over filament diameter, enabling the printing of a wide range of diameters down to the width of a single cell.
Article
Nanoscience & Nanotechnology
Yongcong Fang, Mengke Ji, Bingyan Wu, Xinxin Xu, Ge Wang, Yanmei Zhang, Yingkai Xia, Zhe Li, Ting Zhang, Wei Sun, Zhuo Xiong
Summary: The study developed a GAP bioink for engineering highly vascularized bone tissues using prevascularized mesenchymal spheroids. The prevascularized spheroids formed an interconnected vascular network through angiogenic sprouting after printing. The results showed that prevascularized spheroids were more conducive to osteogenesis and angiogenesis.
ACS APPLIED MATERIALS & INTERFACES
(2023)
Article
Engineering, Biomedical
Hyeongjin Lee, Carlos Kengla, Han Su Kim, Ickhee Kim, Jae-Gu Cho, Eric Renteria, Kyungsup Shin, Anthony Atala, James J. Yoo, Sang Jin Lee
Summary: Medical imaging and 3D bioprinting can be used to create patient-specific bone scaffolds with complex shapes and controlled inner architectures. This study investigates the effectiveness of a biomimetic approach to scaffold design and demonstrates that the biomimetic scaffold with a dense external layer improves bone regeneration compared to the control scaffold. Histological examination confirms the superior bone regeneration in the biomimetic scaffolds and suggests that patient-specific anatomy can be accurately translated into a 3D bioprinting strategy, leading to clinically relevant constructs.
ADVANCED HEALTHCARE MATERIALS
(2023)
Review
Chemistry, Multidisciplinary
Alessandra Dellaquila, Chau Le Bao, Didier Letourneur, Teresa Simon-Yarza
Summary: The study discusses the importance of vascularization techniques in tissue engineering and the current research progress. By using different strategies and materials, more biologically relevant and organ-specific 3D models can be established, which are expected to be used for regenerative medicine and drug development in the future.
Article
Engineering, Biomedical
Zhou Jian, Tian Zhuang, Tian Qinyu, Peng Liqing, Li Kun, Luo Xujiang, Wang Diaodiao, Yang Zhen, Jiang Shuangpeng, Sui Xiang, Huang Jingxiang, Liu Shuyun, Hao Libo, Tang Peifu, Yao Qi, Guo Quany
Summary: By optimizing the preparation of meniscus-derived bioink and utilizing a custom 3D bioprinting system, a biomimetic meniscal scaffold with optimal features in terms of morphology and components was successfully created. Comprehensive evaluations were conducted on cell viability, mechanics, biodegradation, and tissue formation to ensure the scaffold's feasibility and functionality for application in tissue engineering.
BIOACTIVE MATERIALS
(2021)
Review
Engineering, Biomedical
Yang Wu, Ming Li, Hao Su, Huaying Chen, Yonggang Zhu
Summary: This review discusses the major considerations, challenges, and potential strategies for bone bioprinting, and summarizes the latest progress in this field. It uncovers the immense potential of bioprinting in re-establishing the 3D dynamic microenvironment of the native bone, and can assist researchers in reconstructing clinically relevant bone tissues with appropriate mechanical properties and precisely regulated biological behaviors.
INTERNATIONAL JOURNAL OF BIOPRINTING
(2023)
Review
Engineering, Biomedical
Fahimeh Shahabipour, Sandro Satta, Mahboobeh Mahmoodi, Argus Sun, Natan Roberto de Barros, Song Li, Tzung Hsiai, Nureddin Ashammakhi
Summary: Amidst the COVID-19 pandemic, more resources have been directed towards investigating therapeutics and vaccines for the virus. Current investigations mostly use 2D cell culture and animal models, but these methods fail to replicate multicellular interactions and the 3D microenvironment. Organ-on-a-chip devices offer a promising solution for modeling viral infections in human tissues, enabling high-throughput screening of antiviral therapeutics. This review provides an overview of the strengths and challenges of in vitro organ-on-a-chip-based modeling of viral infection.
Article
Multidisciplinary Sciences
Ani Baghdasaryan, Feifei Wang, Fuqiang Ren, Zhuoran Ma, Jiachen Li, Xueting Zhou, Lilit Grigoryan, Chun Xu, Hongjie Dai
Summary: Functionalized gold molecular clusters show promise as lymphographic tracers for NIR-II fluorescence imaging of draining lymph nodes in cancer models, with high safety and biocompatibility.
NATURE COMMUNICATIONS
(2022)
Article
Chemistry, Applied
Parvin Ahmaditabar, Mahboobeh Mahmoodi, Ramezan Ali Taheri, Azadeh Asefnejad
Summary: The study aimed to design a liposome drug delivery system for controlled release of tissue plasminogen activator (tPA) and delivery of the drug system into the thrombus using Nd:YAG laser. The results showed that Lip/PSCS-tPA had a higher release rate, improved thrombolysis, and better cardiac function compared to tPA alone. Thus, the combination of Lip/ PSCS-tPA and laser thrombolysis can be introduced as an appropriate technique for accelerating thrombolysis.
CARBOHYDRATE POLYMERS
(2023)
Article
Engineering, Chemical
Pan Zhu, Yujing Ma, Jun Li, Yang Jin, Haitao Cai, Chun Xu, Minggang Huang, Ming Chen
Summary: Artificial photosynthesis is a feasible solution for the synthesis of hydrogen peroxide (H2O2), which is both a clean fuel and an environmentally friendly oxidant. In this study, a hydrophobic silver-based coordination polymer, PhC2Ag, was used to achieve the photocatalytic generation of H2O2 in a benzyl alcohol (BA)/water two-phase system. It was found that a low-pH aqueous solution and decreasing the volume of the aqueous phase were beneficial for H2O2 synthesis.
INDUSTRIAL & ENGINEERING CHEMISTRY RESEARCH
(2023)
Article
Biochemistry & Molecular Biology
Fatemeh Mirjalili, Mahboobeh Mahmoodi
Summary: In this study, platelet-rich fibrin-chitosan (CH-PRF) nanoparticles were loaded into gelatin-chitosan hydrogel (Gel-CH/CH-PRF) to create a hydrogel dressing for wound healing. The Gel-CH/CH-PRF hydrogel exhibited excellent swelling behavior, good porosity, high absorption of wound exudates, and proper vapor permeability rate. It also demonstrated sustained release of proteins and strong antimicrobial activity. In vivo experiments showed that the Gel-CH/CH-PRF hydrogel promoted wound closure, increased epidermis thickness, and enhanced the formation of new granulation tissue. These findings highlight the potential of Gel-CH/CH-PRF hydrogel as an effective wound dressing.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2023)
Article
Materials Science, Multidisciplinary
Minggang Huang, Xiangli Jiang, Chun Xu, Shuo Zhao, Shan Zhang, Guochun Li
Summary: The performance of lithium-sulfur batteries can be significantly improved by using CoMoO4 nanorods of different sizes as functional coating materials. Smaller-sized CoMoO4-24 nanorods can increase the contact area and reactive sites with the electrolyte, promote electrolyte penetration, and achieve rapid transformation of lithium polysulfides, resulting in higher electrochemical performance.
MATERIALS CHEMISTRY AND PHYSICS
(2023)
Article
Engineering, Chemical
Pan Zhu, Yujing Ma, Jun Li, Yang Jin, Haitao Cai, Chun Xu, Minggang Huang, Ming Chen
Summary: A type of organic coordination polymer photocatalyst (PhC2Ag) that can respond to visible light was successfully synthesized. The PhC2Ag with a nanorods structure exhibits good hydrophobicity and shows promising potential in the elimination of organic pollutants. The characterization results confirm the photoexcited carrier separation ability of PhC2Ag, which has a band gap of 2.63 eV. Experimental findings suggest that the superoxide and hydroxyl radicals are the dominant active species in the PhC2Ag photocatalytic system. Theoretical calculations reveal the superior migration ability of photogenerated electrons due to their smaller effective mass. This research provides support for the practical application of PhC2Ag and its derivatives in fields such as photocatalytic degradation, hydrogen evolution, and hydrogen peroxide production.
CANADIAN JOURNAL OF CHEMICAL ENGINEERING
(2023)
Article
Chemistry, Multidisciplinary
Ling Xu, Yuan Chen, Chun Xu, Hua-Dong Huang, Hao Lin, Gan-Ji Zhong, Zhong-Ming Li
Summary: Sustainable PLA films with superhydrophobicity and superior mechanical properties were prepared by combining annealing stretching and NIPS-based surface structuring. The films demonstrated low surface adhesion, excellent self-cleaning function, and resistance to chemical and mechanical damages. The stiffness-toughness balance of the PLA films was dramatically improved compared to the unstructured casting PLA film, making them potential candidates for self-cleaning and moisture-proof applications.
ACS SUSTAINABLE CHEMISTRY & ENGINEERING
(2023)
Article
Chemistry, Multidisciplinary
Sepanta Hosseinpour, Huan Dai, Laurence J. Walsh, Chun Xu
Summary: Nanoparticles can be used to deliver miRNA-26a to macrophages, leading to the suppression of pro-inflammatory cytokines and the promotion of osteogenic differentiation. The biocompatible MSN-CC nanoparticles showed low toxicity and efficient internalization in macrophages. The conditioned macrophages created a favorable osteoimmune environment for preosteoblasts, enhancing bone production.
Review
Pharmacology & Pharmacy
Yiwei Li, Chun Xu, Chang Lei
Summary: Bone regeneration is a complex process involving different stages, and growth factors (GFs) are essential for this process. Nanomaterials have emerged as promising vehicles for delivering GFs, as they can protect and control the release of GFs, as well as activate endogenous GFs to modulate the regeneration process.
Article
Engineering, Biomedical
Juan Wen, Huimin Li, Huan Dai, Shu Hua, Xing Long, Huang Li, Saso Ivanovski, Chun Xu
Summary: This review systematically summarizes nanoparticle-based therapies for the management of osteoarthritis (OA) and rheumatoid arthritis (RA). The interaction between nanoparticles and joint tissues, including articular fluids and cells, is explored. Current nanoparticles designed for OA/RA treatment are analyzed, and challenges and future clinical translation of nanoparticle-based therapies are discussed.
MATERIALS TODAY BIO
(2023)
Article
Chemistry, Multidisciplinary
Feixiang Ding, Junyan Liu, Kelong Ai, Chun Xu, Xiaoyuan Mao, Zhaoqian Liu, Haihua Xiao
Summary: This study presents a tumor-specific nanotheranostic platform that combines photodynamic therapy (PDT) with epigenetic therapy to simultaneously activate pyroptosis and the cGAS-STING pathway in a light-controlled manner. The approach involves the use of oxidation-sensitive nanoparticles loaded with a photosensitizer and decitabine nanomicelles to restore the expression of gasdermin and STING. The study demonstrates the potential of this strategy for targeted photoimmunotherapy in immunotolerant tumors.
ADVANCED MATERIALS
(2023)
Article
Materials Science, Multidisciplinary
Ashkan Ahangari, Ali Mokhtarzade, Mahboobeh Mahmoodi
Summary: This study aimed to improve the surface mechanical, topographical features, and biocompatibility of tantalum implants by applying a coating of ZrO2, SiO2, and TiO2 nanoparticles using the plasma electrolytic oxidation (PEO) technique. The coated Ta samples showed significant improvements in hardness, stiffness, surface roughness, and wettability compared to uncoated Ta. Corrosion resistance was also enhanced, and the coated Ta exhibited enhanced cell adhesion and viability. The SiO2/TiO2/ZrO2 ceramic coatings have the potential to extend the lifetime of Ta implants in dental and orthopedic applications.
MATERIALS CHEMISTRY AND PHYSICS
(2023)
Article
Chemistry, Multidisciplinary
Huiyun Li, Yusong Yuan, Lingpu Zhang, Chun Xu, Hailin Xu, Zhiwei Chen
Summary: This study demonstrates a novel strategy to modulate macrophage polarization for the treatment of osteoarthritis. By reducing intracellular ROS levels and regulating mitochondrial function, a ROS-responsive nanoparticle successfully repolarized M1 macrophages into M2 phenotypes, promoting chondrocyte proliferation and viability while inhibiting apoptosis. In vivo experiments confirmed the anti-inflammatory and cartilage-protective effects of this nanoparticle.
Review
Engineering, Biomedical
Farzaneh Afkhami, Golriz Rostami, Chun Xu, Laurence J. Walsh, Ove A. Peters
Summary: This study reviewed the histological results of various dental lasers used for vital pulp therapy. The findings suggest that lasers can effectively reduce inflammation, accelerate healing, and increase dentinal bridge thickness. Combining lasers with pulp capping agents enhances the success rate of vital pulp therapy.
LASERS IN MEDICAL SCIENCE
(2023)
