Amino Acid Depletion Therapies: Starving Cancer Cells to Death

The amino acid transporter SLC7A5 is required for efficient growth of KRAS-mutant colorectal cancer

(2021) Arafath K. Najumudeen et al.   NATURE GENETICS

Asparagine couples mitochondrial respiration to ATF4 activity and tumor growth

(2021) Abigail S. Krall et al.   Cell Metabolism

How I Treat: Selecting CD19 Targeted Immunotherapies in Adult Patients with Advanced Acute Lymphoblastic Leukemia

(2020) Ibrahim Aldoss et al.   BLOOD

Amino acids in cancer

(2020) Elizabeth L. Lieu et al.   EXPERIMENTAL AND MOLECULAR MEDICINE

Asparagine Synthetase in Cancer: Beyond Acute Lymphoblastic Leukemia

(2020) Martina Chiu et al.   Frontiers in Oncology

Supplementation of L‐arginine boosts the therapeutic efficacy of anticancer chemoimmunotherapy

(2020) Yusuke Satoh et al.   CANCER SCIENCE

ZBTB1 Regulates Asparagine Synthesis and Leukemia Cell Response to L-Asparaginase

(2020) Robert T. Williams et al.   Cell Metabolism

Impact of Asparaginase Discontinuation on Outcome in Childhood Acute Lymphoblastic Leukemia: A Report From the Children’s Oncology Group

(2020) Sumit Gupta et al.   JOURNAL OF CLINICAL ONCOLOGY

Cysteine depletion induces pancreatic tumor ferroptosis in mice

(2020) Michael A. Badgley et al.   SCIENCE

Dietary glutamine supplementation suppresses epigenetically-activated oncogenic pathways to inhibit melanoma tumour growth

(2020) Mari B. Ishak Gabra et al.   Nature Communications

Limited Environmental Serine and Glycine Confer Brain Metastasis Sensitivity to PHGDH Inhibition

(2020) Bryan Ngo et al.   Cancer Discovery

Immunotargeting of the xCT Cystine/Glutamate Antiporter Potentiates the Efficacy of HER2-Targeted Immunotherapies in Breast Cancer

(2020) Laura Conti et al.   Cancer Immunology Research

Amino Acids and Their Transporters in T Cell Immunity and Cancer Therapy

(2020) Weimin Wang et al.   MOLECULAR CELL

Cancer SLC43A2 alters T cell methionine metabolism and histone methylation

(2020) Yingjie Bian et al.   NATURE

In Vivo Evidence for Serine Biosynthesis-Defined Sensitivity of Lung Metastasis, but Not of Primary Breast Tumors, to mTORC1 Inhibition

(2020) Gianmarco Rinaldi et al.   MOLECULAR CELL

Glutamine Addiction and Therapeutic Strategies in Lung Cancer

(2019) Karolien Vanhove et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Targeting glutamine-addiction and overcoming CDK4/6 inhibitor resistance in human esophageal squamous cell carcinoma

(2019) Shuo Qie et al.   Nature Communications

Asparagine levels in the cerebrospinal fluid of children with acute lymphoblastic leukemia treated with PEG-Asparaginase in the induction phase of the AIEOP-BFM ALL 2009 study.

(2019) Carmelo Rizzari et al.   HAEMATOLOGICA

Cysteine depletion targets leukemia stem cells through inhibition of electron transport complex II

(2019) Courtney L. Jones et al.   BLOOD

Synthetic Lethality of Wnt Pathway Activation and Asparaginase in Drug-Resistant Acute Leukemias

(2019) Laura Hinze et al.   CANCER CELL

Targeting Glutamine Metabolism and Redox State for Leukemia Therapy

(2019) Mark A. Gregory et al.   CLINICAL CANCER RESEARCH

Methionine is a metabolic dependency of tumor-initiating cells

(2019) Zhenxun Wang et al.   NATURE MEDICINE

The Diverse Functions of Non-Essential Amino Acids in Cancer

(2019) Bo-Hyun Choi et al.   Cancers

Dietary methionine influences therapy in mouse cancer models and alters human metabolism

(2019) Xia Gao et al.   NATURE

Branched-Chain Amino Acid Metabolic Reprogramming Orchestrates Drug Resistance to EGFR Tyrosine Kinase Inhibitors

(2019) Yuetong Wang et al.   Cell Reports

Amino acid metabolism in hematologic malignancies and the era of targeted therapy

(2019) Yoko Tabe et al.   BLOOD

Mechanisms and Implications of Metabolic Heterogeneity in Cancer

(2019) Jiyeon Kim et al.   Cell Metabolism

Glutamine blockade induces divergent metabolic programs to overcome tumor immune evasion

(2019) Robert D. Leone et al.   SCIENCE

Perturbation of Methionine/S-adenosylmethionine Metabolism as a Novel Vulnerability in MLL Rearranged Leukemia

(2019) Barve et al.   Cells

New aspects of amino acid metabolism in cancer

(2019) Lisa Vettore et al.   BRITISH JOURNAL OF CANCER

Exploiting methionine restriction for cancer treatment

(2018) Sushma Chaturvedi et al.   BIOCHEMICAL PHARMACOLOGY

Oncogenic KRAS Regulates Amino Acid Homeostasis and Asparagine Biosynthesis via ATF4 and Alters Sensitivity to L-Asparaginase

(2018) Dana M. Gwinn et al.   CANCER CELL

As Extracellular Glutamine Levels Decline, Asparagine Becomes an Essential Amino Acid

(2018) Natalya N. Pavlova et al.   Cell Metabolism

Cancer Metabolism: Current Understanding and Therapies

(2018) Jessica L. Counihan et al.   CHEMICAL REVIEWS

Glutaminase inhibition improves FLT3 inhibitor therapy for acute myeloid leukemia

(2018) Mark A. Gregory et al.   EXPERIMENTAL HEMATOLOGY

Asparagine bioavailability governs metastasis in a model of breast cancer

(2018) Simon R. V. Knott et al.   NATURE

Urea Cycle Dysregulation Generates Clinically Relevant Genomic and Biochemical Signatures

(2018) Joo Sang Lee et al.   CELL

Histidine catabolism is a major determinant of methotrexate sensitivity

(2018) Naama Kanarek et al.   NATURE

Inhibition of GCN2 sensitizes ASNS-low cancer cells to asparaginase by disrupting the amino acid response

(2018) Akito Nakamura et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Macrophage-derived IL-1β and TNF-α regulate arginine metabolism in neuroblastoma

(2018) Livingstone Fultang et al.   CANCER RESEARCH

Tumor-Stroma Mechanics Coordinate Amino Acid Availability to Sustain Tumor Growth and Malignancy

(2018) Thomas Bertero et al.   Cell Metabolism

Asparagine synthetase: Function, structure, and role in disease

(2017) Carrie L. Lomelino et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Drug-induced amino acid deprivation as strategy for cancer therapy

(2017) Marcus Kwong Lam Fung et al.   Journal of Hematology & Oncology

Modulating the therapeutic response of tumours to dietary serine and glycine starvation

(2017) Oliver D. K. Maddocks et al.   NATURE

Autophagy is required for cell survival under L-asparaginase-induced metabolic stress in acute lymphoblastic leukemia cells

(2017) H Takahashi et al.   ONCOGENE

The branched-chain amino acid transaminase 1 sustains growth of antiestrogen-resistant and ERα-negative breast cancer

(2017) V Thewes et al.   ONCOGENE

Surviving Stress: Modulation of ATF4-Mediated Stress Responses in Normal and Malignant Cells

(2017) Inge M.N. Wortel et al.   TRENDS IN ENDOCRINOLOGY AND METABOLISM

One-carbon metabolism and nucleotide biosynthesis as attractive targets for anticancer therapy

(2017) Oleg Shuvalov et al.   Oncotarget

Arginine Deprivation Inhibits the Warburg Effect and Upregulates Glutamine Anaplerosis and Serine Biosynthesis in ASS1-Deficient Cancers

(2017) Jeff Charles Kremer et al.   Cell Reports

Amino acid deprivation using enzymes as a targeted therapy for cancer and viral infections

(2016) H. S. Fernandes et al.   EXPERT OPINION ON THERAPEUTIC PATENTS

Arginine-Dual roles as an onconutrient and immunonutrient

(2016) Vance L. Albaugh et al.   JOURNAL OF SURGICAL ONCOLOGY

Systemic depletion of L-cyst(e)ine with cyst(e)inase increases reactive oxygen species and suppresses tumor growth

(2016) Shira L Cramer et al.   NATURE MEDICINE

Cornerstones of CRISPR–Cas in drug discovery and therapy

(2016) Christof Fellmann et al.   NATURE REVIEWS DRUG DISCOVERY

Combination therapy with BPTES nanoparticles and metformin targets the metabolic heterogeneity of pancreatic cancer

(2016) Amira Elgogary et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

A metabolic synthetic lethal strategy with arginine deprivation and chloroquine leads to cell death in ASS1-deficient sarcomas

(2016) Gregory R Bean et al.   Cell Death & Disease

Asparagine promotes cancer cell proliferation through use as an amino acid exchange factor

(2016) Abigail S. Krall et al.   Nature Communications

Methionine deprivation suppresses triple-negative breast cancer metastasis in vitro and in vivo

(2016) Hyein Jeon et al.   Oncotarget

Arginine dependence of acute myeloid leukemia blast proliferation: a novel therapeutic target

(2015) F. Mussai et al.   BLOOD

Targeting glutaminolysis has antileukemic activity in acute myeloid leukemia and synergizes with BCL-2 inhibition

(2015) N. Jacque et al.   BLOOD

Arginine deprivation by arginine deiminase ofStreptococcus pyogenescontrols primary glioblastoma growthin vitroandin vivo

(2015) Tomas Fiedler et al.   CANCER BIOLOGY & THERAPY

Multiple amino acid sensing inputs to mTORC1

(2015) Mitsugu Shimobayashi et al.   CELL RESEARCH

cMyc-mediated activation of serine biosynthesis pathway is critical for cancer progression under nutrient deprivation conditions

(2015) Linchong Sun et al.   CELL RESEARCH

Methionine Deprivation Induces a Targetable Vulnerability in Triple-Negative Breast Cancer Cells by Enhancing TRAIL Receptor-2 Expression

(2015) E. Strekalova et al.   CLINICAL CANCER RESEARCH

Inhibition of glutamine utilization sensitizes lung cancer cells to apigenin-induced apoptosis resulting from metabolic and oxidative stress

(2015) YOON-MI LEE et al.   INTERNATIONAL JOURNAL OF ONCOLOGY

Compensatory glutamine metabolism promotes glioblastoma resistance to mTOR inhibitor treatment

(2015) Kazuhiro Tanaka et al.   JOURNAL OF CLINICAL INVESTIGATION

Targeted inhibition of tumor-specific glutaminase diminishes cell-autonomous tumorigenesis

(2015) Yan Xiang et al.   JOURNAL OF CLINICAL INVESTIGATION

Classification of treatment-related mortality in children with cancer: a systematic assessment

(2015) Sarah Alexander et al.   LANCET ONCOLOGY

Metabolic reprogramming induces resistance to anti-NOTCH1 therapies in T cell acute lymphoblastic leukemia

(2015) Daniel Herranz et al.   NATURE MEDICINE

Glutamine-based PET imaging facilitates enhanced metabolic evaluation of gliomas in vivo

(2015) Sriram Venneti et al.   Science Translational Medicine

Differential mechanisms of asparaginase resistance in B-type acute lymphoblastic leukemia and malignant natural killer cell lines

(2015) Wei-Wen Chien et al.   Scientific Reports

Adipocytes Cause Leukemia Cell Resistance to L-Asparaginase via Release of Glutamine

(2013) E. A. Ehsanipour et al.   CANCER RESEARCH

The eEF2 Kinase Confers Resistance to Nutrient Deprivation by Blocking Translation Elongation

(2013) Gabriel Leprivier et al.   CELL

The eIF2α kinases: their structures and functions

(2013) Neysan Donnelly et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Arginine Deiminase Resistance in Melanoma Cells Is Associated with Metabolic Reprogramming, Glucose Dependence, and Glutamine Addiction

(2013) Yan Long et al.   MOLECULAR CANCER THERAPEUTICS

NNMT promotes epigenetic remodeling in cancer by creating a metabolic methylation sink

(2013) Olesya A Ulanovskaya et al.   Nature Chemical Biology

ATF4 Regulates MYC-Mediated Neuroblastoma Cell Death upon Glutamine Deprivation

(2012) Guoliang Qing et al.   CANCER CELL

Activation of Ras/PI3K/ERK Pathway Induces c-Myc Stabilization to Upregulate Argininosuccinate Synthetase, Leading to Arginine Deiminase Resistance in Melanoma Cells

(2012) W.-B. Tsai et al.   CANCER RESEARCH

Improvements in the survival of children and adolescents with acute lymphoblastic leukemia

(2012) J. Cools   HAEMATOLOGICA

Serine starvation induces stress and p53-dependent metabolic remodelling in cancer cells

(2012) Oliver D. K. Maddocks et al.   NATURE

Stromal control of cystine metabolism promotes cancer cell survival in chronic lymphocytic leukaemia

(2012) Wan Zhang et al.   NATURE CELL BIOLOGY

Phosphoglycerate dehydrogenase diverts glycolytic flux and contributes to oncogenesis

(2011) Jason W Locasale et al.   NATURE GENETICS

L-asparaginase treatment in acute lymphoblastic leukemia

(2010) Rob Pieters et al.   CANCER