Trans-synaptic degeneration in the visual pathway: Neural connectivity, pathophysiology, and clinical implications in neurodegenerative disorders

Efficacy of three neuroprotective drugs in secondary progressive multiple sclerosis (MS-SMART): a phase 2b, multiarm, double-blind, randomised placebo-controlled trial

(2020) Jeremy Chataway et al.   LANCET NEUROLOGY

MS optic neuritis-induced long-term structural changes within the visual pathway

(2020) Marc Pawlitzki et al.   Neurology-Neuroimmunology & Neuroinflammation

Dynamic Stimulation of Visual Cortex Produces Form Vision in Sighted and Blind Humans

(2020) Michael S. Beauchamp et al.   CELL

Neuroplasticity in adult human visual cortex

(2020) Elisa Castaldi et al.   NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS

Peripapillary retinal nerve fibre layer thinning rate as a biomarker discriminating stable and progressing relapsing remitting multiple sclerosis

(2019) Gabriel Bsteh et al.   EUROPEAN JOURNAL OF NEUROLOGY

Survival of retinal ganglion cells after damage to the occipital lobe in humans is activity dependent

(2019) Colleen L. Schneider et al.   PROCEEDINGS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES

Retrogeniculate Lesion of the Visual Pathways: Retinal Optical Coherence Tomography Angiography Shows Evidence of Transsynaptic Retrograde Degeneration

(2019) Francesco Pellegrini et al.   NEURO-OPHTHALMOLOGY

Bilateral Optic Atrophy from a Silent Occipital Lesion

(2019) Yuyi You et al.   OPHTHALMOLOGY

Retinal thickness as potential biomarker in posterior cortical atrophy and typical Alzheimer’s disease

(2019) Jurre den Haan et al.   Alzheimers Research & Therapy

Peripherally derived angiotensin converting enzyme-enhanced macrophages alleviate Alzheimer-related disease

(2019) Maya Koronyo-Hamaoui et al.   BRAIN

Evaluation of Retinal Nerve Fiber Layer Thickness, Electroretinogram and Visual Evoked Potential in Patients with Alzheimer’s Disease

(2019) Qi Zhe Ngoo et al.   Journal of Ophthalmology

Neurodegenerative Process Linking the Eye and the Brain

(2018) Mancino Raffaele et al.   CURRENT MEDICINAL CHEMISTRY

OCT is an alternative to MRI for monitoring MS – YES

(2018) Elias S Sotirchos et al.   Multiple Sclerosis Journal

Teaching NeuroImages: Evolving trans-synaptic degeneration of retinal ganglion cells after occipital lobe stroke

(2018) Jonathan A. Micieli et al.   NEUROLOGY

Locally coordinated synaptic plasticity of visual cortex neurons in vivo

(2018) Sami El-Boustani et al.   SCIENCE

Glaucoma and the brain: Trans-synaptic degeneration, structural change, and implications for neuroprotection

(2018) Mitchell Lawlor et al.   SURVEY OF OPHTHALMOLOGY

Inflammation, neurodegeneration and protein aggregation in the retina as ocular biomarkers for Alzheimer’s disease in the 3xTg-AD mouse model

(2018) Alfonso Grimaldi et al.   Cell Death & Disease

OCT is an alternative to MRI for monitoring MS – YES

(2018) Elias S Sotirchos et al.   Multiple Sclerosis Journal

Longitudinal study of retinal nerve fiber layer thickness changes in a multiple sclerosis patients cohort: A long term 5 year follow-up

(2018) JM. Abalo-Lojo et al.   Multiple Sclerosis and Related Disorders

Demyelination precedes axonal loss in the transneuronal spread of human neurodegenerative disease

(2018) Yuyi You et al.   BRAIN

Changes in the Synaptic Proteome in Tauopathy and Rescue of Tau-Induced Synapse Loss by C1q Antibodies

(2018) Borislav Dejanovic et al.   NEURON

Plasticity of intrinsic neuronal excitability

(2018) Dominique Debanne et al.   CURRENT OPINION IN NEUROBIOLOGY

Progression of retinal ganglion cell loss in multiple sclerosis is associated with new lesions in the optic radiations

(2017) A. Klistorner et al.   EUROPEAN JOURNAL OF NEUROLOGY

Retrograde trans-synaptic visual pathway degeneration in multiple sclerosis: A case series

(2017) Omar Al-Louzi et al.   Multiple Sclerosis Journal

Trans-synaptic Retrograde Degeneration Following Hemispherectomy in Childhood

(2017) Sian E. Handley et al.   NEURO-OPHTHALMOLOGY

Prion-like mechanisms and potential therapeutic targets in neurodegenerative disorders

(2017) Masato Hasegawa et al.   PHARMACOLOGY & THERAPEUTICS

Retrograde trans-synaptic visual pathway degeneration in multiple sclerosis: A case series

(2017) Omar Al-Louzi et al.   Multiple Sclerosis Journal

Retinal Ganglion Cells and Circadian Rhythms in Alzheimer’s Disease, Parkinson’s Disease, and Beyond

(2017) Chiara La Morgia et al.   Frontiers in Neurology

Trans-synaptic degeneration in the optic pathway. A study in clinically isolated syndrome and early relapsing-remitting multiple sclerosis with or without optic neuritis

(2017) Marco Puthenparampil et al.   PLoS One

Longitudinal evidence for anterograde trans-synaptic degeneration after optic neuritis

(2016) Carmen Tur et al.   BRAIN

Afferent visual pathways in multiple sclerosis: a review

(2016) Stuart L Graham et al.   CLINICAL AND EXPERIMENTAL OPHTHALMOLOGY

Potential Role of (-)-Epigallocatechin-3-Gallate (EGCG) in the Secondary Prevention of Alzheimer Disease

(2016) Laura Xicota et al.   CURRENT DRUG TARGETS

Early changes of brain connectivity in primary open angle glaucoma

(2016) Paolo Frezzotti et al.   HUMAN BRAIN MAPPING

Reconnecting Eye to Brain

(2016) Michael C. Crair et al.   JOURNAL OF NEUROSCIENCE

Lateral geniculate atrophy in Parkinson's with visual hallucination: A trans-synaptic degeneration?

(2016) Jee-Young Lee et al.   MOVEMENT DISORDERS

Retinal degeneration in primary-progressive multiple sclerosis: A role for cortical lesions?

(2016) Maria Petracca et al.   Multiple Sclerosis Journal

Neural activity promotes long-distance, target-specific regeneration of adult retinal axons

(2016) Jung-Hwan A Lim et al.   NATURE NEUROSCIENCE

Early diffusion evidence of retrograde transsynaptic degeneration in the human visual system

(2016) Kevin R. Patel et al.   NEUROLOGY

Transplanted neurons integrate into adult retinas and respond to light

(2016) Praseeda Venugopalan et al.   Nature Communications

Double-blind, placebo-controlled, proof-of-concept trial of bexarotene in moderate Alzheimer’s disease

(2016) Jeffrey L. Cummings et al.   Alzheimers Research & Therapy

Retinal Ganglion Cell Atrophy in Homonymous Hemianopia due to Acquired Occipital Lesions Observed Using Cirrus High-Definition-OCT

(2016) Tsutomu Yamashita et al.   Journal of Ophthalmology

Retinal degeneration in primary-progressive multiple sclerosis: A role for cortical lesions?

(2016) Maria Petracca et al.   Multiple Sclerosis Journal

Genetic associations with brain cortical thickness in multiple sclerosis

(2015) T. Matsushita et al.   GENES BRAIN AND BEHAVIOR

The connectomics of brain disorders

(2015) Alex Fornito et al.   NATURE REVIEWS NEUROSCIENCE

The cellular and molecular landscape of neuroligins

(2015) Michael A. Bemben et al.   TRENDS IN NEUROSCIENCES

Effect of Brimonidine on Retinal Vascular Autoregulation and Short-term Visual Function in Normal Tension Glaucoma

(2014) Gilbert T. Feke et al.   AMERICAN JOURNAL OF OPHTHALMOLOGY

Glaucoma severity affects diffusion tensor imaging (DTI) parameters of the optic nerve and optic radiation

(2014) S. Sidek et al.   EUROPEAN JOURNAL OF RADIOLOGY

Optic radiation damage in multiple sclerosis is associated with visual dysfunction and retinal thinning – an ultrahigh-field MR pilot study

(2014) Tim Sinnecker et al.   EUROPEAN RADIOLOGY

Homonymous Ganglion Cell Layer Thinning After Isolated Occipital Lesion

(2014) Paolo G. Meier et al.   JOURNAL OF NEURO-OPHTHALMOLOGY

Bidirectional trans-synaptic axonal degeneration in the visual pathway in multiple sclerosis

(2014) L J Balk et al.   JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY

A dam for retrograde axonal degeneration in multiple sclerosis?

(2014) L. J. Balk et al.   JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY

Axonal loss of retinal neurons in multiple sclerosis associated with optic radiation lesions

(2014) A. Klistorner et al.   NEUROLOGY

CaMKII: Claiming Center Stage in Postsynaptic Function and Organization

(2014) Johannes W. Hell   NEURON

Glial Development: The Crossroads of Regeneration and Repair in the CNS

(2014) Vittorio Gallo et al.   NEURON

Mapping Cortical Thickness of the Patients with Unilateral End-Stage Open Angle Glaucoma on Planar Cerebral Cortex Maps

(2014) Piotr Bogorodzki et al.   PLoS One

Lesions in the Posterior Visual Pathway Promote Trans-Synaptic Degeneration of Retinal Ganglion Cells

(2014) Johannes Keller et al.   PLoS One

Relationship between Optical Coherence Tomography and Electrophysiology of the Visual Pathway in Non-Optic Neuritis Eyes of Multiple Sclerosis Patients

(2014) Prema Sriram et al.   PLoS One

Birthdate and Outgrowth Timing Predict Cellular Mechanisms of Axon Target Matching in the Developing Visual Pathway

(2014) Jessica A. Osterhout et al.   Cell Reports

Distribution of Retinal Layer Atrophy in Patients With Parkinson Disease and Association With Disease Severity and Duration

(2013) Elena Garcia-Martin et al.   AMERICAN JOURNAL OF OPHTHALMOLOGY

Trans-synaptic axonal degeneration in the visual pathway in multiple sclerosis

(2013) Iñigo Gabilondo et al.   ANNALS OF NEUROLOGY

Retrograde retinal damage after acute optic tract lesion in MS

(2013) I. Gabilondo et al.   JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY

Correlation between lateral geniculate nucleus atrophy and damage to the optic disc in glaucoma

(2013) Zhiqi Chen et al.   JOURNAL OF NEURORADIOLOGY

Retinal nerve fiber layer thickness and visual hallucinations in Parkinson's Disease

(2013) Jee-Young Lee et al.   MOVEMENT DISORDERS

Wallerian and trans-synaptic degeneration contribute to optic radiation damage in multiple sclerosis: a diffusion tensor MRI study

(2013) Maria A Rocca et al.   Multiple Sclerosis Journal

Transneuronal Retrograde Degeneration of the Retinal Ganglion Cells in Patients with Cerebral Infarction

(2013) Hae-Young Lopilly Park et al.   OPHTHALMOLOGY

Long-Term In Vivo Imaging of Fibrillar Tau in the Retina of P301S Transgenic Mice

(2013) Christian Schön et al.   PLoS One

Reduced Cortical Thickness in Primary Open-Angle Glaucoma and Its Relationship to the Retinal Nerve Fiber Layer Thickness

(2013) Longhua Yu et al.   PLoS One

Microglia: An Active Player in the Regulation of Synaptic Activity

(2013) Kyungmin Ji et al.   NEURAL PLASTICITY

A combined post-mortem magnetic resonance imaging and quantitative histological study of multiple sclerosis pathology

(2012) James Kolasinski et al.   BRAIN

The time course of retrograde trans-synaptic degeneration following occipital lobe damage in humans

(2012) Panitha Jindahra et al.   BRAIN

Diffusion tensor magnetic resonance imaging reveals visual pathway damage that correlates with clinical severity in glaucoma

(2012) Zhiqi Chen et al.   CLINICAL AND EXPERIMENTAL OPHTHALMOLOGY

Retinal Nerve Fiber Layer Thickness in Patients With Alzheimer Disease

(2012) Serkan Kirbas et al.   JOURNAL OF NEURO-OPHTHALMOLOGY

Reduced white matter integrity in primary open-angle glaucoma: A DTI study using tract-based spatial statistics

(2012) Peigang Lu et al.   JOURNAL OF NEURORADIOLOGY

Axonal loss in non-optic neuritis eyes of patients with multiple sclerosis linked to delayed visual evoked potential

(2012) A. Klistorner et al.   NEUROLOGY

Development and Plasticity of the Primary Visual Cortex

(2012) J. Sebastian Espinosa et al.   NEURON

The Spread of Neurodegenerative Disease

(2012) John Hardy et al.   NEW ENGLAND JOURNAL OF MEDICINE

Secondary Post-Geniculate Involvement in Leber’s Hereditary Optic Neuropathy

(2012) Giovanni Rizzo et al.   PLoS One

Visual Cortex Plasticity: A Complex Interplay of Genetic and Environmental Influences

(2012) José Fernando Maya-Vetencourt et al.   NEURAL PLASTICITY

Assessment of Lateral Geniculate Nucleus Atrophy with 3T MR Imaging and Correlation with Clinical Stage of Glaucoma

(2011) H. Dai et al.   AMERICAN JOURNAL OF NEURORADIOLOGY

Voxel-Based Morphometry and Diffusion Tensor Imaging of the Optic Pathway in Primary Open-Angle Glaucoma: A Preliminary Study

(2011) A.K. Zikou et al.   AMERICAN JOURNAL OF NEURORADIOLOGY

Demyelination affects temporal aspects of perception: An optic neuritis study

(2011) Noa Raz et al.   ANNALS OF NEUROLOGY

Primary retinal pathology in multiple sclerosis as detected by optical coherence tomography

(2011) Shiv Saidha et al.   BRAIN

Synapse adhesion: a dynamic equilibrium conferring stability and flexibility

(2011) Deanna L Benson et al.   CURRENT OPINION IN NEUROBIOLOGY

Diffusion tensor imaging of the optic radiations after optic neuritis

(2011) Scott Kolbe et al.   HUMAN BRAIN MAPPING

Early pericalcarine atrophy in acute optic neuritis is associated with conversion to multiple sclerosis

(2011) T. M. Jenkins et al.   JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY

Regional brain atrophy in children with multiple sclerosis

(2011) B. Aubert-Broche et al.   NEUROIMAGE

Cadherin-6 Mediates Axon-Target Matching in a Non-Image-Forming Visual Circuit

(2011) Jessica A. Osterhout et al.   NEURON

Latrophilin 1 and its endogenous ligand Lasso/teneurin-2 form a high-affinity transsynaptic receptor pair with signaling capabilities

(2011) J.-P. Silva et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Cortical Plasticity during Motor Learning and Recovery after Ischemic Stroke

(2011) Jonas A. Hosp et al.   NEURAL PLASTICITY

Synaptic organizing complexes

(2010) Tabrez J Siddiqui et al.   CURRENT OPINION IN NEUROBIOLOGY

Morphologic Changes and Functional Retinal Impairment in Patients with Parkinson Disease without Visual Loss

(2010) Marilita M. Moschos et al.   EUROPEAN JOURNAL OF OPHTHALMOLOGY

Evidence for retrochiasmatic tissue loss in Leber's hereditary optic neuropathy

(2010) Valeria Barcella et al.   HUMAN BRAIN MAPPING

Gene delivery of AAV2-neurturin for Parkinson's disease: a double-blind, randomised, controlled trial

(2010) William J Marks et al.   LANCET NEUROLOGY

Regulation of synaptic connectivity by glia

(2010) Cagla Eroglu et al.   NATURE

Heterogeneous Pattern of Retinal Nerve Fiber Layer in Multiple Sclerosis. High Resolution Optical Coherence Tomography: Potential and Limitations

(2010) Nermin Serbecic et al.   PLoS One

Damage to the Optic Radiation in Multiple Sclerosis Is Associated With Retinal Injury and Visual Disability

(2009) Daniel S. Reich et al.   ARCHIVES OF NEUROLOGY

Inner Retinal Layer Thinning in Parkinson Disease

(2009) Mohammedyusuf E. Hajee   ARCHIVES OF OPHTHALMOLOGY

Retrograde trans-synaptic retinal ganglion cell loss identified by optical coherence tomography

(2009) P. Jindahra et al.   BRAIN

The retina in Parkinson's disease

(2009) N. K. Archibald et al.   BRAIN

Propagation of Tau Misfolding from the Outside to the Inside of a Cell

(2009) Bess Frost et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Kinase-Dead Knock-In Mouse Reveals an Essential Role of Kinase Activity of Ca2+/Calmodulin-Dependent Protein Kinase II  in Dendritic Spine Enlargement, Long-Term Potentiation, and Learning

(2009) Y. Yamagata et al.   JOURNAL OF NEUROSCIENCE

PYM50028, a novel, orally active, nonpeptide neurotrophic factor inducer, prevents and reverses neuronal damage induced by MPP+ in mesencephalic neurons and by MPTP in a mouse model of Parkinson’s disease

(2008) Naomi P. Visanji et al.   FASEB JOURNAL

Axonal loss in the retinal nerve fiber layer in patients with multiple sclerosis

(2008) V Pueyo et al.   Multiple Sclerosis Journal