Article
Clinical Neurology
Yu Qi, Rui-Li Li, Yuan-Yuan Wang, Wei Wang, Xu-Ze Liu, Jing Liu, Xing Li, Xiao-Dong Zhang, Wen Yu, Jiao-Jiao Liu, Yi-Fan Guo, Bo Rao, Hong-Jun Li
Summary: The co-infection of syphilis can have an additive or synergistic effect on the microstructure of white matter in HIV-infected male patients. HIV-infected patients without syphilis should actively seek treatment to avoid syphilis infection.
FRONTIERS IN NEUROLOGY
(2022)
Article
Neurosciences
Harri Merisaari, Linnea Karlsson, Noora M. Scheinin, Satu J. Shulist, John D. Lewis, Hasse Karlsson, Jetro J. Tuulari
Summary: This study analyzed DTI images of 133 neonates, finding significant bias in ROI values when only 6 directions were used, while the difference to scalar values calculated from 54 direction DTI was negligible when using 24 directions and above. Therefore, DTI measurements from data with at least 24 directions may be used in comparisons with DTI measurements from data with higher numbers of directions.
EUROPEAN JOURNAL OF NEUROSCIENCE
(2023)
Article
Geriatrics & Gerontology
Hikaru Sugimoto, Mihoko Otake-Matsuura
Summary: Diffusion tensor imaging (DTI) is used to investigate white matter properties in the brain. This study aims to examine the effects of a cognitive intervention program (PICMOR) on older adults' cognitive function and white matter fiber health. Results showed improved verbal fluency task scores in the intervention group compared to the control group. Tract-based spatial statistics analyses revealed higher FA values and lower MD, AD, or RD values in the intervention group across various fiber tracts. The findings suggest left frontal white matter structures may be responsible for the enhancement of verbal fluency.
FRONTIERS IN AGING NEUROSCIENCE
(2022)
Article
Ophthalmology
Jing Na He, Tsz Kin Ng, Shi Yao Lu, Pancy Oi Sin Tam, Poemen P. Chan, Clement C. Tham, Chi Pui Pang, Li Jia Chen, Wai Kit Chu
Summary: This study investigated the association between the ANGPT2 gene and primary open-angle glaucoma (POAG) in the Chinese population. The results showed that the SNP rs11775442 was associated with normal tension glaucoma (NTG) in the Hong Kong cohort, while rs13269021 was associated with NTG in males in the Shantou cohort. Further studies are needed to confirm the association between the ANGPT2 locus and NTG in Chinese males.
Article
Medicine, General & Internal
Antonio Maria Fea, Martina Menchini, Alessandro Rossi, Chiara Posarelli, Lorenza Malinverni, Michele Figus
Summary: The study investigated the efficacy and safety of the XEN63 implant in open-angle glaucoma patients, showing significant reduction in intraocular pressure and the need for hypotensive medications, with good short-term safety profile.
JOURNAL OF CLINICAL MEDICINE
(2021)
Article
Medicine, General & Internal
Ya-Hui Wei, Yu Cai, Bonnie N. K. Choy, Bai-Bing Li, Ruo-Shi Li, Chen Xing, Xia Wang, Tian Tian, Yuan Fang, Mei Li, Ying-Zi Pan
Summary: NTG patients showed higher DCR values compared to controls, with some DCRs being negatively correlated with CCT and IOP, while others were positively correlated with these factors. The cornea was more deformable in NTG compared to HTG or controls, indicating a potential biomechanical mechanism underlying glaucomatous optic neuropathy in NTG patients.
CHINESE MEDICAL JOURNAL
(2021)
Article
Medicine, General & Internal
Santiago Diaz-Torres, Weixiong He, Jackson Thorp, Sahba Seddighi, Sean Mullany, Pirro G. IGGC Int Glaucoma Genetics Consortium, Christopher J. Hammond, Pirro G. Hysi, Louis R. Pasquale, Anthony P. Khawaja, Alex W. Hewitt, Jamie E. Craig, David A. Mackey, Janey L. Wiggs, Cornelia van Duijn, Michelle K. Lupton, Jue-Sheng Ong, Stuart MacGregor, Puya Gharahkhani
Summary: This study reveals a genetic overlap and causal relationship between primary open-angle glaucoma (POAG) and neurodegenerative disorders, but does not find strong evidence of a causal association between these traits. It also identifies some genetic overlaps and shared risk loci, suggesting a potential shared genetic risk between glaucoma and neurodegenerative disorders. Despite some similarities at the genetic level, the neurodegenerative process of glaucoma appears to be distinct from that of neurodegenerative diseases.
Article
Medicine, General & Internal
Michele Lanza, Angelo Leone, Gabriele Scognamiglio, Luigi Serra, Clemente Maria Iodice, Paolo Melillo, Francesca Simonelli
Summary: This study found no significant differences in the efficacy of first-choice medications for primary open-angle glaucoma, but the efficacy may be influenced by various ocular and systemic features in different groups.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Medicine, General & Internal
Faisal A. Almobarak, Ahmed Alrubean, Waleed Alsarhani, Abdullah Aljenaidel, Essam A. Osman
Summary: Ultrasound cyclo plasty (UCP) is effective in controlling intraocular pressure (IOP) and reducing the need for antiglaucoma medications in primary open-angle glaucoma (POAG) eyes. However, the success rate is modest, with higher baseline IOP and number of medications associated with a higher risk of failure.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Clinical Neurology
Shirui Cheng, Xiaohui Dong, Jun Zhou, Chenjian Tang, Wenhua He, Yang Chen, Xinyue Zhang, Peihong Ma, Tao Yin, Yimei Hu, Fang Zeng, Zhengjie Li, Fanrong Liang
Summary: Patients with knee osteoarthritis (KOA) exhibit structural and functional alterations in white matter, as revealed by magnetic resonance imaging (MRI) and diffusion tensor imaging (DTI). Extensive white matter changes are observed in sensorimotor and pain-related regions in KOA patients. Additionally, a negative correlation is found between disease severity and white matter abnormalities in KOA.
FRONTIERS IN NEUROLOGY
(2022)
Article
Clinical Neurology
Lin Mei, Xiaodan Li, Guifei Zhou, Tingting Ji, Jun Chen, Zhifei Xu, Yun Peng, Yue Liu, Hongbin Li, Jie Zhang, Shengcai Wang, Yamei Zhang, Wentong Ge, Yongli Guo, Yue Qiu, Xinbei Jia, Jinghong Tian, Li Zheng, Jiangang Liu, Jun Tai, Xin Ni
Summary: The study found that male children with severe OSA demonstrated more severe issues in neurocognition, attention, sleep quality, and brain white matter integrity compared to those with mild OSA, while no significant differences were observed in female children.
Article
Ophthalmology
Brian S. Cole, Harini V. Gudiseva, Maxwell Pistilli, Rebecca Salowe, Caitlin P. McHugh, Michael C. Zody, Venkata R. M. Chavali, Gui Shuang Ying, Jason H. Moore, Joan M. O'Brien
Summary: This study examines the association of autosomal ancestry with POAG risk in a large cohort of self-identified African Americans. The results show that a higher degree of African ancestry is associated with an increased risk of POAG. Additionally, it is found that both known POAG single nucleotide polymorphisms and an omnigenic ancestry effect influence POAG risk.
INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE
(2021)
Article
Ophthalmology
Yanin Suwan, Masoud Aghsaei Fard, Nantinee Vilainerun, Purit Petpiroon, Apichat Tantraworasin, Chaiwat Teekhasaenee, Robert Ritch, Rahele Kafieh, Sahar Hojati, Wasu Supakontanasan
Summary: This study compared the parapapillary choroidal microvasculature (PPCMv) density between acute primary angle-closure (APAC), primary open-angle glaucoma (POAG) and controls. The results showed that while superficial peripapillary vessels were affected to a similar degree in APAC and POAG, PPCMv drop-out was greater with POAG, suggesting a lesser extent of choroidal vessel density following an acute increase in intraocular pressure before glaucoma develops.
BRITISH JOURNAL OF OPHTHALMOLOGY
(2023)
Article
Medicine, General & Internal
Kinga Golaszewska, Iwona Obuchowska, Joanna Konopinska
Summary: This study evaluated the efficacy and safety profile of iStent bypass implantation and ab externo canaloplasty in POAG patients, and found that both procedures effectively reduced intraocular pressure and the need for anti-glaucoma medications.
JOURNAL OF CLINICAL MEDICINE
(2023)
Review
Medicine, General & Internal
Aditya Belamkar, Alon Harris, Francesco Oddone, Alice Verticchio Vercellin, Anna Fabczak-Kubicka, Brent Siesky
Summary: Primary open-angle glaucoma (POAG) is prevalent in aging Asian populations, with distinctive characteristics and genetic differences compared to other ethnicities. Further research is needed to improve treatment plans for this high prevalence of glaucoma in Asian populations.
JOURNAL OF CLINICAL MEDICINE
(2022)
Letter
Clinical Neurology
Yin Xia Chao, Bernett Lee, Ebonne Yulin Ng, Michelle Mulan Lian, Elaine Guo Yan Chew, Moses Tandiono, Zheng Li, Chiea Chuen Khor, Prakash Kumar, Louis C. S. Tan, Jia Nee Foo, Eng-King Tan
Article
Oncology
Shuilian Chen, Xi Chen, Jin Qiu, Pei Chen, Xiaokun Han, Yihui Wu, Jiejie Zhuang, Meng Yang, Chuangran Wu, Nandan Wu, Ying Yang, Jian Ge, Keming Yu, Jing Zhuang
Summary: The study revealed that exosomes (EXOs) from retinoblastoma cells inhibited the antitumour activity of macrophages and promoted tumor growth, leading to tumor progression. This was mediated by an increase in monocyte chemotactic protein 1 and infiltration of the microenvironment by EXOs, along with the presence of microRNAs and certain proteins in the EXOs.
Article
Medicine, General & Internal
Zheng Li, Zhenxun Wang, Mei Chin Lee, Matthias Zenkel, Esther Peh, Mineo Ozaki, Fotis Topouzis, Satoko Nakano, Anita Chan, Shuwen Chen, Susan E. I. Williams, Andrew Orr, Masakazu Nakano, Nino Kobakhidze, Tomasz Zarnowski, Alina Popa-Cherecheanu, Takanori Mizoguchi, Shin-ichi Manabe, Ken Hayashi, Shigeyasu Kazama, Kenji Inoue, Yosai Mori, Kazunori Miyata, Kazuhisa Sugiyama, Tomomi Higashide, Etsuo Chihara, Ryuichi Ideta, Satoshi Ishiko, Akitoshi Yoshida, Kana Tokumo, Yoshiaki Kiuchi, Tsutomu Ohashi, Toshiya Sakurai, Takako Sugimoto, Hideki Chuman, Makoto Aihara, Masaru Inatani, Kazuhiko Mori, Yoko Ikeda, Morio Ueno, Daniel Gaston, Paul Rafuse, Lesya Shuba, Joseph Saunders, Marcelo Nicolela, George Chichua, Sergo Tabagari, Panayiota Founti, Kar Seng Sim, Wee Yang Meah, Hui Meng Soo, Xiao Yin Chen, Anthi Chatzikyriakidou, Christina Keskini, Theofanis Pappas, Eleftherios Anastasopoulos, Alexandros Lambropoulos, Evangelia S. Panagiotou, Dimitrios G. Mikropoulos, Ewa Kosior-Jarecka, Augustine Cheong, Yuanhan Li, Urszula Lukasik, Monisha E. Nongpiur, Rahat Husain, Shamira A. Perera, Lydia Alvarez, Montserrat Garcia, Hector Gonzalez-Iglesias, Andres F. V. Cueto, Luis F. V. Cueto, Federico Martinon-Torres, Antonio Salas, Cilingir Oguz, Nevbahar Tamcelik, Eray Atalay, Bilge Batu, Murat Irkec, Dilek Aktas, Burcu Kasim, Yury S. Astakhov, Sergei Y. Astakhov, Eugeny L. Akopov, Andreas Giessl, Christian Mardin, Claus Hellerbrand, Jessica N. Cooke Bailey, Robert P. Igo, Jonathan L. Haines, Deepak P. Edward, Steffen Heegaard, Sonia Davila, Patrick Tan, Jae H. Kang, Louis R. Pasquale, Friedrich E. Kruse, Andre Reis, Trevor R. Carmichael, Michael Hauser, Michele Ramsay, Georg Mossbock, Nilgun Yildirim, Kei Tashiro, Anastasios G. P. Konstas, Miguel Coca-Prados, Jia Nee Foo, Shigeru Kinoshita, Chie Sotozono, Toshiaki Kubota, Michael Dubina, Robert Ritch, Janey L. Wiggs, Francesca Pasutto, Ursula Schloetzer-Schrehardt, Ying Swan Ho, Tin Aung, Wai Leong Tam, Chiea Chuen Khor
Summary: Exfoliation syndrome is significantly associated with functionally deficient variants in the CYP39A1 gene, indicating the need for further research on the clinical implications of these findings.
JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION
(2021)
Article
Ophthalmology
Katharina Bell, Mineo Ozaki, Kazuhiko Mori, Takanori Mizoguchi, Satoko Nakano, Natalia Porporato, Yoko Ikeda, Etsuo Chihara, Kenji Inoue, Shinichi Manabe, Ken Hayashi, Tomomi Higashide, Ryuichi Ideta, Kana Tokumo, Yoshiaki Kiuchi, Masakazu Nakano, Morio Ueno, Shigeru Kinoshita, Kei Tashiro, Chie Sotozono, Masaru Inatani, Kazuhisa Sugiyama, Toshiaki Kubota, Zheng Li, Zhenxun Wang, Chiea Chuen Khor, Tin Aung
Summary: This study found that patients with XFS carrying the CYP39A1 G204E variant had a significantly increased risk of blindness, higher occurrence of XFG, and more severe glaucoma compared with patients with XFS without any CYP39A1 mutation.
Article
Neurosciences
Rong Ning, Dandan Zheng, Bingbing Xie, Guanjie Gao, Jinhai Xu, Ping Xu, Yuan Wang, Fuhua Peng, Bin Jiang, Jian Ge, Xiufeng Zhong
Summary: This study explored the development of human Muller glial cells (MGCs) in hiPSC-derived retinal organoids (ROs) and developed a method to select and expand induced MGCs (iMGCs). The study revealed the timecourse of MGC development in the RO model and demonstrated that iMGCs can be enriched and expanded from ROs aged older than 120 days. The iMGCs exhibited typical features of human MGCs and could be passaged serially, yielding a large number of cells in a short period.
FRONTIERS IN CELLULAR NEUROSCIENCE
(2022)
Article
Psychiatry
Zhi Wen, Xu Han, Yao Wang, Weina Ding, Yawen Sun, Yan Kang, Yan Zhou, Hao Lei, Fuchun Lin
Summary: Biological sex plays a significant role in cigarette use and cessation outcomes, as well as the brain structure and function of smokers. This study found sex-specific alterations in spontaneous brain activity among smokers and non-smokers, suggesting the potential influence of sex on nicotine addiction and the effectiveness of quitting smoking.
FRONTIERS IN PSYCHIATRY
(2022)
Article
Cell Biology
Na Yu, Jin Qiu, Kaijing Li, Qian Luo, Xuan Liu, Ying Yang, Zihua Jiang, Shengyu He, Anqi He, Shuilian Chen, Xi Chen, Yan Li, Jian Ge, Jing Zhuang, Keming Yu
Summary: This study compares the DNA stability between primary neurons and differentiated neurons. The researchers found that iPSCs-derived neurons have a higher basal level of gamma-H2AX phosphorylation compared to primary retinal neurons. However, iPSCs-derived neurons are more sensitive to UV treatment. The expression of Ku80 and Ku70 in stem cell-derived neurons promotes DNA stability and cell viability.
CELL BIOLOGY INTERNATIONAL
(2022)
Article
Biochemistry & Molecular Biology
Yihui Wu, Jin Qiu, Shuilian Chen, Xi Chen, Jing Zhang, Jiejie Zhuang, Sian Liu, Meng Yang, Pan Zhou, Haoting Chen, Keming Yu, Jian Ge, Jing Zhuang
Summary: This study analyzed the development of retinal organoids and zebrafish retina after inhibiting CXCR4 with the antagonist AMD3100. The results showed that AMD3100 treatment affected the generation, differentiation, morphology, and neuronal outgrowth of retinal organoids. Similar effects were observed in zebrafish retina, but abnormal photoreceptor ensembles were not found as in the organoids.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Oncology
Ning-Yuan Lee, Melissa Hum, Pei-Yi Ong, Matthew Khine Myint, Enya H. W. Ong, Kar-Perng Low, Zheng Li, Boon-Cher Goh, Joshua K. Tay, Kwok-Seng Loh, Melvin L. K. Chua, Soo-Chin Lee, Chiea-Chuen Khor, Ann S. G. Lee
Summary: This study aimed to identify germline genetic variants associated with an increased risk of developing nasopharyngeal carcinoma (NPC). Through sequencing DNA samples from Singaporean NPC patients, the study found 17 pathogenic variants enriched in NPC patients as compared to unaffected controls. Five of these variants were supported by repeated testing on an independent set of Singaporean NPC patients and controls. The study also identified the association between specific genes (JAK2, PRDM16, LRP1B, NIN, and NKX2-1) and NPC risk. Pathway analysis revealed a higher frequency of germline mutations in endocytosis and immune-modulating pathways. Overall, this research provides important insights into the genetic predisposition of NPC.
Article
Neuroimaging
Xianxin Qiu, Xu Han, Yao Wang, Weina Ding, Yawen Sun, Hao Lei, Yan Zhou, Fuchun Lin
Summary: This study investigated the interaction between smoking and internet gaming disorder (IGD) and its effects on brain functional network organization. The findings showed that the interaction between smoking and IGD led to significant changes in the functional network characteristics in specific brain regions. This provides valuable insights into the neurophysiological mechanisms of smoking and IGD, and suggests a potential target for future clinical treatment.
BRAIN IMAGING AND BEHAVIOR
(2022)
Article
Pharmacology & Pharmacy
Chiea Chuen Khor, Stefan Winter, Natalia Sutiman, Thomas E. Muerdter, Sylvia Chen, Joanne Siok Liu Lim, Zheng Li, Jingmei Li, Kar Seng Sim, Boian Ganchev, Diana Eccles, Bryony Eccles, William Tapper, Nathalie K. K. Zgheib, Arafat Tfayli, Raymond Chee Hui Ng, Yoon Sim Yap, Elaine Lim, Mabel Wong, Nan Soon Wong, Peter Cher Siang Ang, Rebecca Dent, Roman Tremmel, Kathrin Klein, Elke Schaeffeler, Yitian Zhou, Volker M. M. Lauschke, Michel Eichelbaum, Matthias Schwab, Hiltrud B. B. Brauch, Balram Chowbay, Werner Schroth
Summary: The extended CYP2D6 locus at 22q13 is the principal genetic determinant of endoxifen plasma concentration, as revealed by the first cross-ancestry genome-wide association study. Functional analysis showed that 66% of the associated variants in this region were significantly correlated with hepatic CYP2D6 activity or expression. Machine learning models demonstrated that hotspot variants in this region, combined with CYP2D6 activity score, could explain a significant portion of the variability in tamoxifen metabolites.
CLINICAL PHARMACOLOGY & THERAPEUTICS
(2023)
Article
Cell Biology
Tian Zhou, Ziqi Yang, Biyan Ni, Hong Zhou, Huiyi Xu, Xiaojing Lin, Yingmin Li, Chunqiao Liu, Rong Ju, Jian Ge, Chang He, Xialin Liu
Summary: IL-4 exerts neuroprotective effects in retinal degeneration by upregulating IL-4Rα and activating Nrf2, thereby reducing oxidative stress and inflammation.
CELL DEATH & DISEASE
(2022)
Article
Neurosciences
Shengjuan Wu, Zhi Wen, Wenzhong Yang, Chengcheng Jiang, Yurong Zhou, Zhiwei Zhao, Aiqin Zhou, Xinglian Liu, Xiaoyan Wang, Yue Wang, Hong Wang, Fuchun Lin
Summary: This study aimed to investigate the differences in dynamic brain activity between children with autism spectrum disorder (ASD) and language development delay (LDD), and whether these differences can be used as imaging biomarkers for the early differential diagnosis of ASD and LDD. The findings showed that the pattern of brain activity was different between children with ASD and those with LDD, suggesting that dynamic regional indices might be novel neuroimaging biomarkers to distinguish ASD from LDD in toddlers.
FRONTIERS IN NEUROSCIENCE
(2023)
Article
Neurosciences
Yajuan Wang, Yingshuang Wang, Lihong Bu, Shaoyang Wang, Xinhui Xie, Fuchun Lin, Zheman Xiao
Summary: This study examines the differences in resting-state functional connectivity (rsFC) between migraine and tension-type headache patients, focusing on brain regions associated with cognition and emotion. The results demonstrate that rsFC alterations in the amygdala and hippocampus with the occipital lobe can be effective in distinguishing patients with migraine from patients with tension-type headaches.
FRONTIERS IN NEUROSCIENCE
(2022)
Article
Biochemistry & Molecular Biology
Xiaowei Yu, Nannan Sun, Congcong Guo, Zhenni Zhao, Meifang Ye, Jiamin Zhang, Jian Ge, Zhigang Fan
Summary: This study investigated novel candidate genes for PACG by studying the variants of nanophthalmos-associated genes. Four novel MYRF gene missense variants were identified in four out of 45 PACG patients, suggesting that MYRF might be a potential novel candidate gene for PACG.