Giant cells: Linking McClintock’s heredity to early embryogenesis and tumor origin throughout millennia of evolution on Earth

Telomeres: history, health, and hallmarks of aging

(2021) Deepavali Chakravarti et al.   CELL

Extrachromosomal DNA (ecDNA) in cancer pathogenesis

(2021) Sihan Wu et al.   CURRENT OPINION IN GENETICS & DEVELOPMENT

Inherent mosaicism and extensive mutation of human placentas

(2021) Tim H. H. Coorens et al.   NATURE

Characterizing genetic intra-tumor heterogeneity across 2,658 human cancer genomes

(2021) Stefan C. Dentro et al.   CELL

Human cell polyploidization: The good and the evil

(2021) Jing Zhang et al.   SEMINARS IN CANCER BIOLOGY

Poly‐aneuploid cancer cells promote evolvability, generating lethal cancer

(2020) Kenneth J. Pienta et al.   Evolutionary Applications

Blastulation of a zygote to a hatched blastocyst without any clear cell division: an observational finding in a time-lapse system after in vitro fertilization

(2020) N.L. Sandi-Monroy et al.   JOURNAL OF ASSISTED REPRODUCTION AND GENETICS

Pan-cancer analysis of whole genomes

(2020)   NATURE

The evolutionary history of 2,658 cancers

(2020) Moritz Gerstung et al.   NATURE

Pan-cancer analysis of whole genomes identifies driver rearrangements promoted by LINE-1 retrotransposition

(2020) Bernardo Rodriguez-Martin et al.   NATURE GENETICS

Comprehensive analysis of chromothripsis in 2,658 human cancers using whole-genome sequencing

(2020) Isidro Cortés-Ciriano et al.   NATURE GENETICS

Mechanisms generating cancer genome complexity from a single cell division error

(2020) Neil T. Umbreit et al.   SCIENCE

Reawakening the Developmental Origins of Cancer Through Transposable Elements

(2020) Chiemi F. Lynch-Sutherland et al.   Frontiers in Oncology

Human Embryogenesis: A Comparative Perspective

(2020) Claudia Gerri et al.   Annual Review of Cell and Developmental Biology

Single-Cell Multiomics Sequencing Reveals Prevalent Genomic Alterations in Tumor Stromal Cells of Human Colorectal Cancer

(2020) Yuan Zhou et al.   CANCER CELL

Extrachromosomal DNA is associated with oncogene amplification and poor outcome across multiple cancers

(2020) Hoon Kim et al.   NATURE GENETICS

Genome chaos: Creating new genomic information essential for cancer macroevolution

(2020) Julie Heng et al.   SEMINARS IN CANCER BIOLOGY

The art of oocyte meiotic arrest regulation

(2019) Bo Pan et al.   Reproductive Biology and Endocrinology

Transposable elements drive widespread expression of oncogenes in human cancers

(2019) Hyo Sik Jang et al.   NATURE GENETICS

Excessive Cell Growth Causes Cytoplasm Dilution And Contributes to Senescence

(2019) Gabriel E. Neurohr et al.   CELL

Coordination of Polyploid Chromosome Replication with Cell Size and Growth in a Cyanobacterium

(2019) Ryudo Ohbayashi et al.   mBio

Polyploidy in halophilic archaea: regulation, evolutionary advantages, and gene conversion

(2019) Katharina Ludt et al.   BIOCHEMICAL SOCIETY TRANSACTIONS

Spatiotemporal Patterning of Zygotic Genome Activation in a Model Vertebrate Embryo

(2019) Hui Chen et al.   DEVELOPMENTAL CELL

Advances in epigenetics link genetics to the environment and disease

(2019) Giacomo Cavalli et al.   NATURE

Stress: An evolutionary mutagen

(2019) Keith A. Maggert   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The “life code”: a theory that unifies the human life cycle and the origin of human tumors

(2019) Liu Jinsong   SEMINARS IN CANCER BIOLOGY

Filamentation initiated by Cas2 and its association with the acquisition process in cells

(2019) Lei Wang et al.   International Journal of Oral Science

Pan-cancer whole-genome analyses of metastatic solid tumours

(2019) Peter Priestley et al.   NATURE

Plants make galls to accommodate foreigners: some are friends, most are foes

(2019) Marion O. Harris et al.   NEW PHYTOLOGIST

Extrachromosomal circular DNA drives oncogenic genome remodeling in neuroblastoma

(2019) Richard P. Koche et al.   NATURE GENETICS

DiSUMO-LIKE Interacts with RNA-Binding Proteins and Affects Cell-Cycle Progression during Maize Embryogenesis

(2018) Junyi Chen et al.   CURRENT BIOLOGY

A Phenotyping Method of Giant Cells from Root-Knot Nematode Feeding Sites by Confocal Microscopy Highlights a Role for CHITINASE-LIKE 1 in Arabidopsis

(2018) Javier Cabrera et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Extrachromosomal circular DNA-based amplification and transmission of herbicide resistance in crop weedAmaranthus palmeri

(2018) Dal-Hoe Koo et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The Dualistic Origin of Human Tumors

(2018) Jinsong Liu   SEMINARS IN CANCER BIOLOGY

Nimble and Ready to Mingle: Transposon Outbursts of Early Development

(2018) Diego Rodriguez-Terrones et al.   TRENDS IN GENETICS

Speciation Theory of Carcinogenesis Explains Karyotypic Individuality and Long Latencies of Cancers

(2018) Ankit Hirpara et al.   Genes

Somatic mutant clones colonize the human esophagus with age

(2018) Iñigo Martincorena et al.   SCIENCE

Germ cell tumour growth patterns originating from clear cell carcinomas of the ovary and endometrium: a comparative immunohistochemical study favouring their origin from somatic stem cells

(2017) Francisco F Nogales et al.   HISTOPATHOLOGY

Epigenetic restriction of extraembryonic lineages mirrors the somatic transition to cancer

(2017) Zachary D. Smith et al.   NATURE

Dedifferentiation into blastomere-like cancer stem cells via formation of polyploid giant cancer cells

(2017) N Niu et al.   ONCOGENE

Rebuilding Chromosomes After Catastrophe: Emerging Mechanisms of Chromothripsis

(2017) Peter Ly et al.   TRENDS IN CELL BIOLOGY

Application of Nuclear Volume Measurements to Comprehend the Cell Cycle in Root-Knot Nematode-Induced Giant Cells

(2017) José Dijair Antonino de Souza Junior et al.   Frontiers in Plant Science

Endogenous Retroviruses: With Us and against Us

(2017) Thomas J. Meyer et al.   Frontiers in Chemistry

Evolutionary consequences of polyploidy in prokaryotes and the origin of mitosis and meiosis

(2016) Alexander V. Markov et al.   Biology Direct

Beyond the simplicity of Mendelian inheritance

(2016) Joseph Schacherer   COMPTES RENDUS BIOLOGIES

The impact of transposable elements on mammalian development

(2016) Jose L. Garcia-Perez et al.   DEVELOPMENT

Specification and epigenetic programming of the human germ line

(2016) Walfred W. C. Tang et al.   NATURE REVIEWS GENETICS

Linking genomic reorganization to tumor initiation via the giant cell cycle

(2016) N Niu et al.   Oncogenesis

Somatic embryogenesis — Stress-induced remodeling of plant cell fate

(2015) Attila Fehér   Biochimica et Biophysica Acta-Gene Regulatory Mechanisms

Stress induces cell dedifferentiation in plants

(2015) Gideon Grafi et al.   Biochimica et Biophysica Acta-Gene Regulatory Mechanisms

Chromothripsis and Kataegis Induced by Telomere Crisis

(2015) John Maciejowski et al.   CELL

Chromosomal instability in mammalian pre-implantation embryos: potential causes, detection methods, and clinical consequences

(2015) Brittany L. Daughtry et al.   CELL AND TISSUE RESEARCH

Transposable Elements in Cancer and Other Human Diseases

(2015) Benoit Chenais   CURRENT CANCER DRUG TARGETS

Genetic and Genomic Toolbox of Zea mays

(2015) N. J. Nannas et al.   GENETICS

The expanding implications of polyploidy

(2015) Kevin P. Schoenfelder et al.   JOURNAL OF CELL BIOLOGY

Intrinsic retroviral reactivation in human preimplantation embryos and pluripotent cells

(2015) Edward J. Grow et al.   NATURE

Polyploidy can drive rapid adaptation in yeast

(2015) Anna M. Selmecki et al.   NATURE

Chromothripsis from DNA damage in micronuclei

(2015) Cheng-Zhong Zhang et al.   NATURE

Short- and long-term effects of chromosome mis-segregation and aneuploidy

(2015) Stefano Santaguida et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Plasticity in ploidy: a generalized response to stress

(2015) Daniel R. Scholes et al.   TRENDS IN PLANT SCIENCE

Imprinting in plants as a mechanism to generate seed phenotypic diversity

(2015) Fang Bai et al.   Frontiers in Plant Science

Remembering Johann Gregor Mendel: a human, a Catholic priest, an Augustinian monk, and abbot

(2015) Father Clemens Richter   Molecular Genetics & Genomic Medicine

Polyploidy in Archaea and Bacteria: About Desiccation Resistance, Giant Cell Size, Long-Term Survival, Enforcement by a Eukaryotic Host and Additional Aspects

(2015) Jörg Soppa   JOURNAL OF MOLECULAR MICROBIOLOGY AND BIOTECHNOLOGY

Coming Full Circle—From Endless Complexity to Simplicity and Back Again

(2014) Robert A. Weinberg   CELL

Chromothripsis: potential origin in gametogenesis and preimplantation cell divisions. A review

(2014) Franck Pellestor et al.   FERTILITY AND STERILITY

DNA methylation dynamics during epigenetic reprogramming in the germline and preimplantation embryos

(2014) D. M. Messerschmidt et al.   GENES & DEVELOPMENT

Chromothripsis: how does such a catastrophic event impact human reproduction?

(2014) F. Pellestor   HUMAN REPRODUCTION

From gene action to reactive genomes

(2014) Evelyn Fox Keller   JOURNAL OF PHYSIOLOGY-LONDON

Extensive transduction of nonrepetitive DNA mediated by L1 retrotransposition in cancer genomes

(2014) J. M. C. Tubio et al.   SCIENCE

Processed pseudogenes acquired somatically during cancer development

(2014) Susanna L. Cooke et al.   Nature Communications

Generation of erythroid cells from fibroblasts and cancer cells in vitro and in vivo

(2013) Shiwu Zhang et al.   CANCER LETTERS

Punctuated Evolution of Prostate Cancer Genomes

(2013) Sylvan C. Baca et al.   CELL

Lamarck, Evolution, and the Inheritance of Acquired Characters

(2013) Richard W. Burkhardt   GENETICS

Tumor stroma and differentiated cancer cells can be originated directly from polyploid giant cancer cells induced by paclitaxel

(2013) Shiwu Zhang et al.   INTERNATIONAL JOURNAL OF CANCER

The Role of Transposable Elements in Health and Diseases of the Central Nervous System

(2013) M. T. Reilly et al.   JOURNAL OF NEUROSCIENCE

Pan-cancer patterns of somatic copy number alteration

(2013) Travis I Zack et al.   NATURE GENETICS

Generation of cancer stem-like cells through the formation of polyploid giant cancer cells

(2013) S Zhang et al.   ONCOGENE

Human pre-implantation embryo development

(2012) K. K. Niakan et al.   DEVELOPMENT

The impact of transposable elements on eukaryotic genomes: From genome size increase to genetic adaptation to stressful environments

(2012) Benoît Chénais et al.   GENE

Microarray analysis reveals abnormal chromosomal complements in over 70% of 14 normally developing human embryos

(2012) A. Mertzanidou et al.   HUMAN REPRODUCTION

The cleavage stage embryo

(2012) F. J. Prados et al.   HUMAN REPRODUCTION

Turing centenary: Life's code script

(2012) Sydney Brenner   NATURE

McClintock's challenge in the 21st century

(2012) N. V. Fedoroff   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Transposable Elements, Epigenetics, and Genome Evolution

(2012) N. V. Fedoroff   SCIENCE

Landscape of Somatic Retrotransposition in Human Cancers

(2012) E. Lee et al.   SCIENCE

Dynamic blastomere behaviour reflects human embryo ploidy by the four-cell stage

(2012) Shawn L. Chavez et al.   Nature Communications

Formation of solid tumors by a single multinucleated cancer cell

(2011) Zhang Weihua et al.   CANCER

Massive Genomic Rearrangement Acquired in a Single Catastrophic Event during Cancer Development

(2011) Philip J. Stephens et al.   CELL

Is carcinogenesis a form of speciation?

(2011) Peter Duesberg et al.   CELL CYCLE

The Human Cleavage Stage Embryo Is a Cradle of Chromosomal Rearrangements

(2011) T. Voet et al.   CYTOGENETIC AND GENOME RESEARCH

Repetitive Elements May Comprise Over Two-Thirds of the Human Genome

(2011) A. P. Jason de Koning et al.   PLoS Genetics

Transposable elements have rewired the core regulatory network of human embryonic stem cells

(2010) Galih Kunarso et al.   NATURE GENETICS

The maternal-to-zygotic transition: a play in two acts

(2009) W. Tadros et al.   DEVELOPMENT

Chaos in the embryo

(2009) David H Ledbetter   NATURE MEDICINE

Chromosome instability is common in human cleavage-stage embryos

(2009) Evelyne Vanneste et al.   NATURE MEDICINE

The B73 Maize Genome: Complexity, Diversity, and Dynamics

(2009) P. S. Schnable et al.   SCIENCE

Extreme polyploidy in a large bacterium

(2008) J. E. Mendell et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA