Transient receptor potential canonical 5 mediates inflammatory mechanical and spontaneous pain in mice

Structural basis for human TRPC5 channel inhibition by two distinct inhibitors

(2021) Kangcheng Song et al.   eLife

Quantitative differences in neuronal subpopulations between mouse and human dorsal root ganglia demonstrated with RNAscope in situ hybridization

(2020) Stephanie Shiers et al.   PAIN

NOD-like receptor protein 3 inflammasome drives postoperative mechanical pain in a sex-dependent manner

(2019) Ashley M. Cowie et al.   PAIN

[EXPRESS] Peripheral and central oxidative stress in chemotherapy-induced neuropathic pain

(2019) Hyun Soo Shim et al.   Molecular Pain

An Updated Review of Lysophosphatidylcholine Metabolism in Human Diseases

(2019) Shi-Hui Law et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Lysophosphatidic acids and their substrate lysophospholipids in cerebrospinal fluid as objective biomarkers for evaluating the severity of lumbar spinal stenosis

(2019) Kentaro Hayakawa et al.   Scientific Reports

Cryo-EM structure of TRPC5 at 2.8-Å resolution reveals unique and conserved structural elements essential for channel function

(2019) Jingjing Duan et al.   Science Advances

Comparison of modified Matyash method to conventional solvent systems for polar metabolite and lipid extractions

(2018) Jelena Sostare et al.   ANALYTICA CHIMICA ACTA

Non-invasive dural stimulation in mice: A novel preclinical model of migraine

(2018) Carolina Christina Burgos-Vega et al.   CEPHALALGIA

Optogenetic Inhibition of CGRPα Sensory Neurons Reveals Their Distinct Roles in Neuropathic and Incisional Pain

(2018) Ashley M. Cowie et al.   JOURNAL OF NEUROSCIENCE

Lipidomic analysis of serum samples from migraine patients

(2018) Caixia Ren et al.   Lipids in Health and Disease

Chemokine (c-c motif) receptor 2 mediates mechanical and cold hypersensitivity in sickle cell disease mice

(2018) Katelyn E. Sadler et al.   PAIN

Treatment with HC-070, a potent inhibitor of TRPC4 and TRPC5, leads to anxiolytic and antidepressant effects in mice

(2018) Stefan Just et al.   PLoS One

Parathyroid Hormone-Related Peptide Elicits Peripheral TRPV1-dependent Mechanical Hypersensitivity

(2018) Andrew J. Shepherd et al.   Frontiers in Cellular Neuroscience

Keratinocytes mediate innocuous and noxious touch via ATP-P2X4 signaling

(2018) Francie Moehring et al.   eLife

PIEZO2 mediates injury-induced tactile pain in mice and humans

(2018) Marcin Szczot et al.   Science Translational Medicine

The mechanosensitive ion channel Piezo2 mediates sensitivity to mechanical pain in mice

(2018) Swetha E. Murthy et al.   Science Translational Medicine

Human vs. Mouse Nociceptors – Similarities and Differences

(2017) Charlotte Rostock et al.   NEUROSCIENCE

A small-molecule inhibitor of TRPC5 ion channels suppresses progressive kidney disease in animal models

(2017) Yiming Zhou et al.   SCIENCE

Transient receptor potential canonical 5 (TRPC5) protects against pain and vascular inflammation in arthritis and joint inflammation

(2016) Khadija M Alawi et al.   ANNALS OF THE RHEUMATIC DISEASES

The Role of PIEZO2 in Human Mechanosensation

(2016) Alexander T. Chesler et al.   NEW ENGLAND JOURNAL OF MEDICINE

Lysophosphatidylcholines to phosphatidylcholines ratio predicts advanced knee osteoarthritis

(2016) Weidong Zhang et al.   RHEUMATOLOGY

Hypoxia-mediated impaired erythrocyte Lands’ Cycle is pathogenic for sickle cell disease

(2016) Hongyu Wu et al.   Scientific Reports

(−)-Englerin A is a Potent and Selective Activator of TRPC4 and TRPC5 Calcium Channels

(2015) Yasemin Akbulut et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Amplified Mechanically Gated Currents in Distinct Subsets of Myelinated Sensory Neurons following In Vivo Inflammation of Skin and Muscle

(2015) A. D. Weyer et al.   JOURNAL OF NEUROSCIENCE

Gabapentin alleviates affective pain after traumatic nerve injury

(2015) Ryan B. Griggs et al.   NEUROREPORT

Keratinocytes can modulate and directly initiate nociceptive responses

(2015) Kyle M Baumbauer et al.   eLife

Secreted phospholipase A 2 and mast cells

(2015) Makoto Murakami et al.   ALLERGOLOGY INTERNATIONAL

Plasma Membrane Mechanical Stress Activates TRPC5 Channels

(2015) Bing Shen et al.   PLoS One

Olfactory exposure to males, including men, causes stress and related analgesia in rodents

(2014) Robert E Sorge et al.   NATURE METHODS

Unbiased classification of sensory neuron types by large-scale single-cell RNA sequencing

(2014) Dmitry Usoskin et al.   NATURE NEUROSCIENCE

Mechanical allodynia

(2014) Stéphane Lolignier et al.   PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY

Metabolomics Analysis and Modeling Suggest a Lysophosphocholines-PAF Receptor Interaction in Fibromyalgia

(2014) Pierluigi Caboni et al.   PLoS One

Mechanical Sensitization of Cutaneous Sensory Fibers in the Spared Nerve Injury Mouse Model

(2013) Amanda K Smith et al.   Molecular Pain

CGRP and migraine: Could PACAP play a role too?

(2013) Eric A. Kaiser et al.   NEUROPEPTIDES

Lysoglycerophospholipids in chronic inflammatory disorders: The PLA2/LPC and ATX/LPA axes

(2012) Ioanna Sevastou et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS

Central Amygdala Metabotropic Glutamate Receptor 5 in the Modulation of Visceral Pain

(2012) L. W. Crock et al.   JOURNAL OF NEUROSCIENCE

Biomarkers of primary dysmenorrhea and herbal formula intervention: an exploratory metabonomics study of blood plasma and urine

(2012) Pei Liu et al.   Molecular BioSystems

TRPA1 Mediates Mechanical Sensitization in Nociceptors during Inflammation

(2012) Richard C. Lennertz et al.   PLoS One

Identification of ML204, a Novel Potent Antagonist That Selectively Modulates Native TRPC4/C5 Ion Channels

(2011) Melissa Miller et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Transient receptor potential cation channel, subfamily C, member 5 (TRPC5) is a cold-transducer in the peripheral nervous system

(2011) K. Zimmermann et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Activation of Metabotropic Glutamate Receptor 5 in the Amygdala Modulates Pain-Like Behavior

(2010) B. J. Kolber et al.   JOURNAL OF NEUROSCIENCE

Central sensitization: Implications for the diagnosis and treatment of pain

(2010) Clifford J. Woolf   PAIN

Piezo1 and Piezo2 Are Essential Components of Distinct Mechanically Activated Cation Channels

(2010) B. Coste et al.   SCIENCE

Essential Role for TRPC5 in Amygdala Function and Fear-Related Behavior

(2009) Antonio Riccio et al.   CELL

TRPC channel lipid specificity and mechanisms of lipid regulation

(2009) David J. Beech et al.   CELL CALCIUM

TRPA1 Modulates Mechanotransduction in Cutaneous Sensory Neurons

(2009) K. Y. Kwan et al.   JOURNAL OF NEUROSCIENCE

Pharmacological Blockade of TRPA1 Inhibits Mechanical Firing in Nociceptors

(2009) Patrick C Kerstein et al.   Molecular Pain

Unmasking the tonic-aversive state in neuropathic pain

(2009) Tamara King et al.   NATURE NEUROSCIENCE

Animal models of pain: progress and challenges

(2009) Jeffrey S. Mogil   NATURE REVIEWS NEUROSCIENCE

Inflammation reduces mechanical thresholds in a population of transient receptor potential channel A1-expressing nociceptors in the rat

(2008) James P. Dunham et al.   EUROPEAN JOURNAL OF NEUROSCIENCE

Hypoosmotic- and pressure-induced membrane stretch activate TRPC5 channels

(2008) Ana Gomis et al.   JOURNAL OF PHYSIOLOGY-LONDON

Elucidation of a TRPC6-TRPC5 Channel Cascade That Restricts Endothelial Cell Movement

(2008) Pinaki Chaudhuri et al.   MOLECULAR BIOLOGY OF THE CELL

HC-030031, a TRPA1 Selective Antagonist, Attenuates Inflammatory- and Neuropathy-Induced Mechanical Hypersensitivity

(2008) Samer R Eid et al.   Molecular Pain

Pharmacological blockade of the vanilloid receptor TRPV1 elicits marked hyperthermia in humans

(2008) Narender R. Gavva et al.   PAIN