Article
Pharmacology & Pharmacy
Hichem Bouchenaki, Aurore Danigo, Amandine Bernard, Flavien Bessaguet, Laurence Richard, Franck Sturtz, David Balayssac, Laurent Magy, Claire Demiot
Summary: The study evaluated the effect of the ACE inhibitor ramipril in a mouse model of oxaliplatin-induced acute pain syndrome, showing that ramipril can prevent cold sensitivity and improve tactile sensitivity in treated mice.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Chemistry, Physical
Jung-uk Lee, Wookjin Shin, Yongjun Lim, Jungsil Kim, Woon Ryoung Kim, Heehun Kim, Jae-Hyun Lee, Jinwoo Cheon
Summary: m-Torquer is a magnetic toolkit that mimics magnetoreception in nature, providing precise stimulation to cells and reliable neuromodulation in animals like mice. Its versatility allows for a wide range of applications, potentially even in large animals such as primates.
Article
Biochemistry & Molecular Biology
Zhaoke Luo, Xinyue Liao, Lili Luo, Qitong Fan, Xiaofen Zhang, Yuefeng Guo, Feng Wang, Zucheng Ye, Daoshu Luo
Summary: The study reveals that Piezo2-mediated mechanotransduction plays a crucial role in peripheral mechanical allodynia in the rat CCT model of trigeminal neuralgia. Additionally, extracellular ATP, Ca2+ influx, and the cAMP-to-Epac1 signaling pathway synergistically contribute to the pathogenesis and persistence of mechanical allodynia.
JOURNAL OF NEUROCHEMISTRY
(2022)
Article
Pharmacology & Pharmacy
Neha Munawar, Joelle Nader, Najat H. Khadadah, Ashraf Al Madhoun, Waleed Al-Ali, Linu A. Varghese, Willias Masocha, Fahd Al-Mulla, Milad S. Bitar
Summary: This study found that alpha-2A adrenoceptors (alpha 2-AR) in the nervous system of streptozotocin diabetic rats are upregulated, and the upregulation is associated with increased pain sensitivity. Chronic administration of the selective alpha 2-AR agonist guanfacine can downregulate the upregulation of alpha 2-AR and relieve hyperalgesia and allodynia in diabetic animals. These findings suggest that guanfacine may have potential as a potent analgesic for diabetic neuropathic pain.
Article
Neurosciences
Sang-Min Jeon, Dennis Chang, Aleksander Geske, David D. Ginty, Michael J. Caterina
Summary: The study identified that Merkel cell-A beta afferent complexes partially contribute to mechanical allodynia produced by peripheral nerve injury, with this effect being sex-dependent in mice. This finding will help in understanding the mechanisms underlying neuropathic pain.
JOURNAL OF NEUROSCIENCE
(2021)
Article
Pharmacology & Pharmacy
Gabriela Becker, Maria Fernanda Pessano Fialho, Indiara Brusco, Sara Marchesan Oliveira
Summary: Cisplatin is a commonly used chemotherapy drug for solid tumors, but its effectiveness is limited by neurotoxic side effects such as peripheral neuropathy. This study investigates the role of kinin B-1 and B-2 receptors in cisplatin-induced peripheral neuropathy in mice. The results suggest that targeting these receptors may be a potential strategy for treating the painful symptoms caused by cisplatin treatment.
Article
Plant Sciences
Nari Kim, Geehoon Chung, So-Ri Son, Jae Hyun Park, Young Hyun Lee, Keon-Tae Park, Ik-Hyun Cho, Dae Sik Jang, Sun Kwang Kim
Summary: This study aimed to investigate the suppressive effects of magnolin, an ERK inhibitor substance derived from Magnolia denudata seeds, on the symptoms of chemotherapy-induced peripheral neuropathy (CIPN). The results showed that magnolin administration exerted an analgesic effect on CIPN-induced cold allodynia and inhibited ERK phosphorylation in the dorsal root ganglion (DRG). These results suggest that magnolin could be developed as an alternative treatment to suppress paclitaxel-induced neuropathic pain symptoms.
Article
Cell Biology
Huixing Wang, Xiaodong Huo, Chenyang Han, Jiang Ning, Hongguang Chen, Bo Li, Jingzhi Liu, Wenting Ma, Quanbo Li, Yonghao Yu, Kemei Shi
Summary: The study in rats indicated that ferroptosis is involved in the development of neuropathic pain by blocking neuron and astrocyte activation in the spinal dorsal horn.
MOLECULAR AND CELLULAR BIOCHEMISTRY
(2021)
Article
Biochemistry & Molecular Biology
Neha Munawar, Milad S. Bitar, Willias Masocha
Summary: This study investigates the role of serotoninergic nervous system in diabetic neuropathic pain (DNP) and suggests that treatment with 8-OH-DPAT, a selective 5-HT1AR agonist, could be effective in alleviating DNP symptoms.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Clinical Neurology
Zhen-Rong Zhang, Yao Wu, Wen-Jing Wang, Fang-Yong Wang
Summary: The role of GABAergic cell transplantation in improving neuropathic pain is significant, showing statistically significant improvements in allodynia and hyperalgesia. Differentiated GABAergic cells and avoiding the use of antibiotics may have a better effect in improving neuropathic pain.
FRONTIERS IN NEUROLOGY
(2022)
Article
Neurosciences
Shenglan Wang, Simin Qi, Yoko Kogure, Hirosato Kanda, Lin Tian, Satoshi Yamamoto, Koichi Noguchi, Yi Dai
Summary: Nedd4-2 modulates pain transmission in neurons by downregulating TRPA1 levels, relieving mechanical allodynia in diabetic mice. Abnormal expression of Nedd4-2 contributes to neuropathic pain.
EUROPEAN JOURNAL OF NEUROSCIENCE
(2021)
Article
Cell Biology
MingXing Liu, Yan Li, Jun Zhong, Lei Xia, NingNing Dou
Summary: The upregulation of Piezo2 and IL-6 in the trigeminal nerve injury model suggests that Piezo2 may play a key role in the development of neuralgia, and its expression may be modulated by inflammatory cytokines like IL-6.
Article
Clinical Neurology
Donald Iain MacDonald, Ana P. Luiz, Federico Iseppon, Queensta Millet, Edward C. Emery, John N. Wood
Summary: Neuropathic pain leads to innocuous cooling being perceived as excruciating pain, yet the cell and molecular basis of this cold allodynia remains poorly understood. Research has found that in neuropathic pain states, normally silent large diameter cold-sensing neurons become sensitive to cooling, with many of them responding to noxious mechanical stimuli.
Article
Pharmacology & Pharmacy
Myrna Deciga-Campos, Rodrigo Villafan-Gutierrez, Josue Vidal Espinosa-Juarez, Osmar Antonio Jaramillo-Morales, Francisco Javier Lopez-Munoz
Summary: The study found that specific combinations of gabapentin and haloperidol can synergistically reduce nerve injury-induced allodynia and hyperalgesia, demonstrating an antiallodynic and antihyperalgesic effect.
EUROPEAN JOURNAL OF PHARMACOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Gulay Sezer, Arzu H. Yay, Zeynep S. Sarica, Zeynep B. Gonen, Gozde O. Onder, Aydin Alan, Secil Yilmaz, Berkay Saraymen, Dilek Bahar
Summary: This study aimed to investigate the efficacy of two different doses of BM-MSCs on PTX-induced mechanical allodynia. The results showed that high-dose BM-MSCs can alleviate symptoms earlier and reduce spinal inflammatory cytokine levels induced by PTX. Moreover, high-dose BM-MSCs were more frequently localized to damaged tissues. These findings suggest that BM-MSCs may be a novel approach in the treatment of PTX-induced mechanical allodynia.
JOURNAL OF BIOCHEMICAL AND MOLECULAR TOXICOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Dimitra Gkika, Stephane Lolignier, Guillaume P. Grolez, Alexis Bavencoffe, Georges Shapovalov, Dmitri Gordienko, Artem Kondratskyi, Mathieu Meleine, Laetitia Prival, Eric Chapuy, Monique Etienne, Alain Eschalier, Yaroslav Shuba, Roman Skryma, Jerome Busserolles, Natalia Prevarskaya
Review
Pharmacology & Pharmacy
Jerome Busserolles, Stephane Lolignier, Nicolas Kerckhove, Celian Bertin, Nicolas Authier, Alain Eschalier
PHARMACOLOGY & THERAPEUTICS
(2020)
Article
Pharmacology & Pharmacy
Jerome Busserolles, Ismail Ben Soussia, Laetitia Pouchol, Nicolas Marie, Mathieu Meleine, Maily Devilliers, Celine Judon, Julien Schopp, Loic Clemenceau, Laura Poupon, Eric Chapuy, Serge Richard, Florence Noble, Florian Lesage, Sylvie Ducki, Alain Eschalier, Stephane Lolignier
BRITISH JOURNAL OF PHARMACOLOGY
(2020)
Correction
Multidisciplinary Sciences
Michael S. Minett, Niels Eijkelkamp, John N. Wood
Review
Oncology
Cornelia J. C. Vermeer, Anouk E. Hiensch, Laurence Cleenewerk, Anne M. May, Niels Eijkelkamp
Summary: Paclitaxel-induced peripheral neuropathy (PIPN) is mainly caused by mechanisms such as affecting ion channels expression and function, promoting spinal transmission, and inducing inflammatory responses. Human studies are needed to validate these mechanistic data and facilitate the development of therapeutic strategies.
Article
Orthopedics
E. M. van Helvoort, H. M. de Visser, F. P. J. G. Lafeber, K. Coeleveld, S. Versteeg, H. H. Weinans, J. Popov-Celeketic, N. Eijkelkamp, S. C. Mastbergen
Summary: rIL4-10 FP demonstrated chondroprotective and analgesic activity in a rat model of OA, reducing cartilage degeneration and mechanical allodynia.
Article
Neurosciences
Michiel van der Vlist, Ramin Raoof, Hanneke L. D. M. Willemen, Judith Prado, Sabine Versteeg, Christian Martin Gil, Martijn Vos, Roeland E. Lokhorst, R. Jeroen Pasterkamp, Toshiyuki Kojima, Hajime Karasuyama, William Khoury-Hanold, Linde Meyaard, Niels Eijkelkamp
Summary: The resolution of inflammatory pain is actively controlled by macrophages through the transfer of mitochondria to sensory neurons. This process requires the expression of CD200R on macrophages and the non-canonical CD200R ligand iSec1 on sensory neurons.
Article
Rheumatology
Eefje Martine van Helvoort, Paco M. J. Welsing, Mylene P. Jansen, Willem Paul Gielis, Marieke Loef, Margreet Kloppenburg, Francisco Blanco, Ida K. Haugen, Francis Berenbaum, Anne-C Bay-Jensen, Christoph Ladel, Agnes Lalande, Jonathan Larkin, John Loughlin, Ali Mobasheri, Harrie Weinans, Floris Lafeber, Niels Eijkelkamp, Simon Mastbergen
Summary: Patients with osteoarthritis and a likely neuropathic pain component may represent a specific phenotype where joint damage is not the main cause of pain and disability. Those with a higher painDETECT score had less radiographic joint damage but impaired physical function compared to those with a lower painDETECT score. Severe pain was also found in joints other than the index knee, indicating the need for targeted treatment approaches.
Article
Medicine, Research & Experimental
Anouk Vroegindeweij, Joost F. Swart, Jan Houtveen, Niels Eijkelkamp, Elise M. van de Putte, Nico M. Wulffraat, Sanne L. Nijhof
Summary: This study aims to explore the impact of chronic fatigue caused by different diseases and the influence of biological factors and personalized lifestyle advices on adolescents and young adults. Through a randomized controlled trial and experience sampling methodology, the study will compare the effectiveness of personalized lifestyle advices and generic dietary advices in reducing fatigue severity. The study aims to contribute to biological research and personalized treatment for these diseases.
Article
Medicine, Research & Experimental
Mohammed M. H. Albariqi, Sabine Versteeg, Elisabeth M. Brakkee, J. Henk Coert, Barend O. W. Elenbaas, Judith Prado, C. Erik Hack, Jo W. M. Hoppener, Niels Eijkelkamp
Summary: This study found that human islet amyloid polypeptide (hIAPP) may be involved in peripheral neuropathy associated with type 2 diabetes mellitus (T2DM). In vitro experiments and mouse models showed that hIAPP aggregates can reduce neurite outgrowth and increase reactive oxygen species in sensory neurons, leading to neuropathy. The presence of more hIAPP aggregates in the skin of T2DM patients further supports the role of hIAPP in T2DM neuropathy.
JOURNAL OF CLINICAL INVESTIGATION
(2023)
Article
Immunology
Patricia Silva Santos Ribeiro, Hanneke L. D. M. Willemen, Sabine Versteeg, Christian Martin Gil, Niels Eijkelkamp
Summary: Pain is a debilitating symptom in rheumatic diseases, and can persist even after total knee replacement or in the absence of inflammation. Mitochondrial dysfunction and NLRP3 inflammasome activation have been found to promote chronic pain. This study investigated the role of mitochondrial dysfunction and NLRP3 inflammasome activation in the transition from acute to persistent inflammation-induced nociplastic pain and in persistent monoiodoacetate-induced osteoarthritis pain. The results suggest that targeting the NLRP3 inflammasome pathway may be a promising approach to treat chronic pain.
IMMUNOTHERAPY ADVANCES
(2023)
Meeting Abstract
Cell & Tissue Engineering
Anna Tellegen, Imke Rudnik Jansen, Lizette Utomo, Martijn Beukers, Erik Teske, Rene Van Weeren, Nina Karssemakers Degen, George Mihov, Jens Thies, Niels Eijkelkamp, Laura Creemers, Bjorn Meiji, Marianna Tryfonidou
TISSUE ENGINEERING PART A
(2023)
Meeting Abstract
Cell & Tissue Engineering
J. L. Rios, H. M. de Visser, G. Geusebroek, G. Storm, N. Dupuis, S. G. Plomp, K. Warmink, N. Eijkelkamp, M. Tryfonidou, P. R. van Weeren, H. Weinans, N. M. Korthagen
TISSUE ENGINEERING PART A
(2022)
Meeting Abstract
Cell & Tissue Engineering
Kelly Warmink, Devin van Valkengoed, Sabine Versteeg, Niels Eijkelkamp, Harrie Weinans, Nicoline Korthagen, Magdalena Lorenowicz
TISSUE ENGINEERING PART A
(2022)
Meeting Abstract
Orthopedics
K. Warmink, J. L. Rios, S. Varderidou-Minasian, M. Torres-Torrillas, D. R. van Valkengoed, S. Versteeg, N. Eijkelkamp, H. Weinans, N. M. Korthagen, M. J. Lorenowicz
OSTEOARTHRITIS AND CARTILAGE
(2022)