Immunotherapy: Building a bridge to a cure for type 1 diabetes

One in Ten CD8+ Cells in the Pancreas of Living Individuals With Recent Onset Type 1 Diabetes Recognizes the Preproinsulin Epitope PPI15-24

(2021) Teresa Rodriguez-Calvo et al.   DIABETES

Residual β cell function in long-term type 1 diabetes associates with reduced incidence of hypoglycemia

(2021) Rose A. Gubitosi-Klug et al.   JOURNAL OF CLINICAL INVESTIGATION

Teplizumab improves and stabilizes beta cell function in antibody-positive high-risk individuals

(2021) Emily K. Sims et al.   Science Translational Medicine

Revisiting the Hygiene Hypothesis in the Context of Autoimmunity

(2021) Jean-François Bach   Frontiers in Immunology

Preventing type 1 diabetes in childhood

(2021) Colin M. Dayan et al.   SCIENCE

Strategies for durable β cell replacement in type 1 diabetes

(2021) Todd M. Brusko et al.   SCIENCE

Circulating unmethylated insulin DNA as a biomarker of human beta cell death: a multi-laboratory assay comparison

(2020) Cate Speake et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

Preclinical evaluation of tyrosine kinase 2 inhibitors for human beta‐cell protection in type 1 diabetes

(2020) Alexandra Coomans de Brachène et al.   DIABETES OBESITY & METABOLISM

Low-dose IL-2 in children with recently diagnosed type 1 diabetes: a Phase I/II randomised, double-blind, placebo-controlled, dose-finding study

(2020) Michelle Rosenzwajg et al.   DIABETOLOGIA

Follicular helper T cell profiles predict response to costimulation blockade in type 1 diabetes

(2020) Natalie M. Edner et al.   NATURE IMMUNOLOGY

Gene editing to induce FOXP3 expression in human CD4+ T cells leads to a stable regulatory phenotype and function

(2020) Yuchi Honaker et al.   Science Translational Medicine

Endotypes in T1D: B lymphocytes and early onset

(2020) Mia J. Smith et al.   Current Opinion in Endocrinology Diabetes and Obesity

Safety and feasibility of intradermal injection with tolerogenic dendritic cells pulsed with proinsulin peptide—for type 1 diabetes

(2020) Tatjana Nikolic et al.   Lancet Diabetes & Endocrinology

Baseline Assessment of Circulating MicroRNAs Near Diagnosis of Type 1 Diabetes Predicts Future Stimulated Insulin Secretion

(2020) Isaac Snowhite et al.   DIABETES

Golimumab and Beta-Cell Function in Youth with New-Onset Type 1 Diabetes

(2020) Teresa Quattrin et al.   NEW ENGLAND JOURNAL OF MEDICINE

Emerging Roles of Exosomes in T1DM

(2020) Haipeng Pang et al.   Frontiers in Immunology

Engineering IL-2 to Give New Life to T Cell Immunotherapy

(2020) Willem W. Overwijk et al.   Annual Review of Medicine

Targeted Elimination of Senescent Beta Cells Prevents Type 1 Diabetes

(2019) Peter J. Thompson et al.   Cell Metabolism

An Anti-CD3 Antibody, Teplizumab, in Relatives at Risk for Type 1 Diabetes

(2019) Kevan C. Herold et al.   NEW ENGLAND JOURNAL OF MEDICINE

Next-generation regulatory T cell therapy

(2019) Leonardo M. R. Ferreira et al.   NATURE REVIEWS DRUG DISCOVERY

Dendritic cells license regulatory B cells to produce IL-10 and mediate suppression of antigen-specific CD8 T cells

(2019) Joanne Boldison et al.   Cellular & Molecular Immunology

Immunomodulation Followed By Antigen-Specific Treg Infusion Controls Islet Autoimmunity

(2019) Cecilia Cabello-Kindelan et al.   DIABETES

Autoreactive CD8+ T cell exhaustion distinguishes subjects with slow type 1 diabetes progression

(2019) Alice E. Wiedeman et al.   JOURNAL OF CLINICAL INVESTIGATION

Immune Recognition of β-Cells: Neoepitopes as Key Players in the Loss of Tolerance

(2018) Eddie A. James et al.   DIABETES

Low-Dose Anti-Thymocyte Globulin (ATG) Preserves β-Cell Function and Improves HbA1cin New-Onset Type 1 Diabetes

(2018) Michael J. Haller et al.   DIABETES CARE

Approaches and advances in the genetic causes of autoimmune disease and their implications

(2018) Jamie R. J. Inshaw et al.   NATURE IMMUNOLOGY

Peptide Immunotherapy for Type 1 Diabetes—Clinical Advances

(2018) Emma L. Smith et al.   Frontiers in Immunology

Proinsulin Secretion Is a Persistent Feature of Type 1 Diabetes

(2018) Emily K. Sims et al.   DIABETES CARE

Autoreactive T cells in type 1 diabetes

(2017) Alberto Pugliese   JOURNAL OF CLINICAL INVESTIGATION

Discovery of stimulation-responsive immune enhancers with CRISPR activation

(2017) Dimitre R. Simeonov et al.   NATURE

Resident macrophages of pancreatic islets have a seminal role in the initiation of autoimmune diabetes of NOD mice

(2017) Javier A. Carrero et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Control of GVHD by regulatory T cells depends on TNF produced by T cells and TNFR2 expressed by regulatory T cells

(2016) M. Leclerc et al.   BLOOD

The Expanding Role of Natural Killer Cells in Type 1 Diabetes and Immunotherapy

(2016) Chris Fraker et al.   Current Diabetes Reports

Expression of Interferon-Stimulated Genes in Insulitic Pancreatic Islets of Patients Recently Diagnosed With Type 1 Diabetes

(2016) Marcus Lundberg et al.   DIABETES

Antithymocyte globulin therapy for patients with recent-onset type 1 diabetes: 2 year results of a randomised trial

(2016) Stephen E. Gitelman et al.   DIABETOLOGIA

Interleukin-1 antagonism moderates the inflammatory state associated with Type 1 diabetes during clinical trials conducted at disease onset

(2016) Susanne M. Cabrera et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Enhanced T cell responses to IL-6 in type 1 diabetes are associated with early clinical disease and increased IL-6 receptor expression

(2016) Christian Hundhausen et al.   Science Translational Medicine

TYK2, a Candidate Gene for Type 1 Diabetes, Modulates Apoptosis and the Innate Immune Response in Human Pancreatic β-Cells

(2015) Laura Marroqui et al.   DIABETES

Staging Presymptomatic Type 1 Diabetes: A Scientific Statement of JDRF, the Endocrine Society, and the American Diabetes Association

(2015) Richard A. Insel et al.   DIABETES CARE

Alefacept provides sustained clinical and immunological effects in new-onset type 1 diabetes patients

(2015) Mark R. Rigby et al.   JOURNAL OF CLINICAL INVESTIGATION

Beta cells transfer vesicles containing insulin to phagocytes for presentation to T cells

(2015) Anthony N. Vomund et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Type 1 diabetes immunotherapy using polyclonal regulatory T cells

(2015) Jeffrey A. Bluestone et al.   Science Translational Medicine

Increased Immune Cell Infiltration of the Exocrine Pancreas: A Possible Contribution to the Pathogenesis of Type 1 Diabetes

(2014) Teresa Rodriguez-Calvo et al.   DIABETES

Citrullinated Glucose-Regulated Protein 78 Is an Autoantigen in Type 1 Diabetes

(2014) Dieter Rondas et al.   DIABETES

A Type I Interferon Transcriptional Signature Precedes Autoimmunity in Children Genetically at Risk for Type 1 Diabetes

(2014) R. C. Ferreira et al.   DIABETES

The Effector T Cells of Diabetic Subjects Are Resistant to Regulation via CD4+FOXP3+ Regulatory T Cells

(2014) A. Schneider et al.   JOURNAL OF IMMUNOLOGY

Teplizumab Preserves C-Peptide in Recent-Onset Type 1 Diabetes: Two-Year Results From the Randomized, Placebo-Controlled Protege Trial

(2013) W. Hagopian et al.   DIABETES

Costimulation Modulation With Abatacept in Patients With Recent-Onset Type 1 Diabetes: Follow-up 1 Year After Cessation of Treatment

(2013) Tihamer Orban et al.   DIABETES CARE

Administration of CD4+CD25highCD127- Regulatory T Cells Preserves  -Cell Function in Type 1 Diabetes in Children

(2012) N. Marek-Trzonkowska et al.   DIABETES CARE

Insulin-Dependent Diabetes: Strategy for Immune Intervention

(2009) Monique Debbay-Sachs et al.   EXPERIMENTAL AND CLINICAL ENDOCRINOLOGY & DIABETES

Rituximab, B-Lymphocyte Depletion, and Preservation of Beta-Cell Function

(2009) Mark D. Pescovitz et al.   NEW ENGLAND JOURNAL OF MEDICINE