Beta cells transfer vesicles containing insulin to phagocytes for presentation to T cells

The pancreas anatomy conditions the origin and properties of resident macrophages

(2015) Boris Calderon et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Insulin secretory granules control autophagy in pancreatic   cells

(2015) A. Goginashvili et al.   SCIENCE

Antigen Presentation in the Autoimmune Diabetes of the NOD Mouse

(2014) Emil R. Unanue   Annual Review of Immunology

ZnT8-Reactive T Cells Are Weakly Pathogenic in NOD Mice but Can Participate in Diabetes Under Inflammatory Conditions

(2014) D. K. Nayak et al.   DIABETES

Calcium Efflux From the Endoplasmic Reticulum Leads to β-Cell Death

(2014) Takashi Hara et al.   ENDOCRINOLOGY

A Minor Subset of Batf3-Dependent Antigen-Presenting Cells in Islets of Langerhans Is Essential for the Development of Autoimmune Diabetes

(2014) Stephen T. Ferris et al.   IMMUNITY

The central role of antigen presentation in islets of Langerhans in autoimmune diabetes

(2013) Boris Calderon et al.   CURRENT OPINION IN IMMUNOLOGY

Lost in translation: endoplasmic reticulum stress and the decline ofβ-cell health in diabetes mellitus

(2013) C. Evans-Molina et al.   DIABETES OBESITY & METABOLISM

Pathogenic CD4+T cells recognizing an unstable peptide of insulin are directly recruited into islets bypassing local lymph nodes

(2013) James F. Mohan et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Restoration of the Unfolded Protein Response in Pancreatic   Cells Protects Mice Against Type 1 Diabetes

(2013) F. Engin et al.   Science Translational Medicine

Islet  -Cell Endoplasmic Reticulum Stress Precedes the Onset of Type 1 Diabetes in the Nonobese Diabetic Mouse Model

(2012) S. A. Tersey et al.   DIABETES

Register shifting of an insulin peptide–MHC complex allows diabetogenic T cells to escape thymic deletion

(2011) James F. Mohan et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Cellular and molecular events in the localization of diabetogenic T cells to islets of Langerhans

(2011) B. Calderon et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The Unfolded Protein Response: From Stress Pathway to Homeostatic Regulation

(2011) P. Walter et al.   SCIENCE

Unique autoreactive T cells recognize insulin peptides generated within the islets of Langerhans in autoimmune diabetes

(2010) James F Mohan et al.   NATURE IMMUNOLOGY

Amplification of Autoimmune Response through Induction of Dendritic Cell Maturation in Inflamed Tissues

(2009) K. Melli et al.   JOURNAL OF IMMUNOLOGY

Insulin as an autoantigen in NOD/human diabetes

(2008) Li Zhang et al.   CURRENT OPINION IN IMMUNOLOGY

Dendritic cells in islets of Langerhans constitutively present   cell-derived peptides bound to their class II MHC molecules

(2008) B. Calderon et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA