RNA 5-methylcytosine modification and its emerging role as an epitranscriptomic mark

Nanopore direct RNA sequencing maps the complexity of Arabidopsis mRNA processing and m6A modification

(2020) Matthew T Parker et al.   eLife

OsNSUN2-Mediated 5-Methylcytosine mRNA Modification Enhances Rice Adaptation to High Temperature

(2020) Yongyan Tang et al.   DEVELOPMENTAL CELL

TeamTat: a collaborative text annotation tool

(2020) Rezarta Islamaj et al.   NUCLEIC ACIDS RESEARCH

Advances in the profiling of N6-methyladenosine (m6A) modifications

(2020) Hong-xiang Zheng et al.   BIOTECHNOLOGY ADVANCES

Translational adaptation to heat stress is mediated by RNA 5‐methylcytosine in Caenorhabditis elegans

(2020) Isabela Cunha Navarro et al.   EMBO JOURNAL

Division of labour: tRNA methylation by the NSun2 tRNA methyltransferases Trm4a and Trm4b in fission yeast

(2019) Martin Müller et al.   RNA Biology

Transcriptome-wide profiling of multiple RNA modifications simultaneously at single-base resolution

(2019) Vahid Khoddami et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Genome-wide identification of mRNA 5-methylcytosine in mammals

(2019) Tao Huang et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

5-methylcytosine promotes pathogenesis of bladder cancer through stabilizing mRNAs

(2019) Xin Chen et al.   NATURE CELL BIOLOGY

NSUN2 introduces 5-methylcytosines in mammalian mitochondrial tRNAs

(2019) Lindsey Van Haute et al.   NUCLEIC ACIDS RESEARCH

Mammalian NSUN2 introduces 5-methylcytidines into mitochondrial tRNAs

(2019) Saori Shinoda et al.   NUCLEIC ACIDS RESEARCH

Epigenetics in Neurodevelopment: Emerging Role of Circular RNA

(2019) Shujuan Meng et al.   Frontiers in Cellular Neuroscience

Loss of 5-methylcytosine alters the biogenesis of vault-derived small RNAs to coordinate epidermal differentiation

(2019) Abdulrahim A. Sajini et al.   Nature Communications

Cytosine-5 RNA methylation links protein synthesis to cell metabolism

(2019) Nikoletta A. Gkatza et al.   PLOS BIOLOGY

Agenesis and Hypomyelination of Corpus Callosum in Mice Lacking Nsun5, an RNA Methyltransferase

(2019) Zihao Yuan et al.   Cells

Epigenetic loss of RNA-methyltransferase NSUN5 in glioma targets ribosomes to drive a stress adaptive translational program

(2019) Maxime Janin et al.   ACTA NEUROPATHOLOGICA

NOP 2/Sun RNA methyltransferase 2 promotes tumor progression via its interacting partner RPL 6 in gallbladder carcinoma

(2019) Yuan Gao et al.   CANCER SCIENCE

m5C Methylation Guides Systemic Transport of Messenger RNA over Graft Junctions in Plants

(2019) Lei Yang et al.   CURRENT BIOLOGY

RNA 5-Methylcytosine Facilitates the Maternal-to-Zygotic Transition by Preventing Maternal mRNA Decay

(2019) Ying Yang et al.   MOLECULAR CELL

Loss of the ribosomal RNA methyltransferase NSUN5 impairs global protein synthesis and normal growth

(2019) Clemens Heissenberger et al.   NUCLEIC ACIDS RESEARCH

Transfer RNA methyltransferase gene NSUN2 mRNA expression modifies the effect of T cell activation score on patient survival in head and neck squamous carcinoma

(2019) Lingeng Lu et al.   ORAL ONCOLOGY

High tRNA Transferase NSUN2 Gene Expression is Associated with Poor Prognosis in Head and Neck Squamous Carcinoma

(2018) Lingeng Lu et al.   CANCER INVESTIGATION

Tet2 promotes pathogen infection-induced myelopoiesis through mRNA oxidation

(2018) Qicong Shen et al.   NATURE

Dnmt2 mediates intergenerational transmission of paternally acquired metabolic disorders through sperm small non-coding RNAs

(2018) Yunfang Zhang et al.   NATURE CELL BIOLOGY

Highly parallel direct RNA sequencing on an array of nanopores

(2018) Daniel R Garalde et al.   NATURE METHODS

RNA cytosine methylation and methyltransferases mediate chromatin organization and 5-azacytidine response and resistance in leukaemia

(2018) Jason X. Cheng et al.   Nature Communications

Mutations in Cytosine-5 tRNA Methyltransferases Impact Mobile Element Expression and Genome Stability at Specific DNA Repeats

(2018) Bianca Genenncher et al.   Cell Reports

Transcriptome-Wide Annotation of m5C RNA Modifications Using Machine Learning

(2018) Jie Song et al.   Frontiers in Plant Science

Archaeal NSUN6 catalyzes m5C72 modification on a wide-range of specific tRNAs

(2018) Jing Li et al.   NUCLEIC ACIDS RESEARCH

IFIT1 Exerts Opposing Regulatory Effects on the Inflammatory and Interferon Gene Programs in LPS-Activated Human Macrophages

(2018) Sinu P. John et al.   Cell Reports

Nucleotide Modifications Decrease Innate Immune Response Induced by Synthetic Analogs of snRNAs and snoRNAs

(2018) Grigory Stepanov et al.   Genes

Statistically robust methylation calling for whole-transcriptome bisulfite sequencing reveals distinct methylation patterns for mouse RNAs

(2017) Carine Legrand et al.   GENOME RESEARCH

NSUN2-Mediated m5C Methylation and METTL3/METTL14-Mediated m6A Methylation Cooperatively Enhance p21 Translation

(2017) Qiu Li et al.   JOURNAL OF CELLULAR BIOCHEMISTRY

Visualization of chemical modifications in the human 80S ribosome structure

(2017) S. Kundhavai Natchiar et al.   NATURE

The DNA methyltransferase family: a versatile toolkit for epigenetic regulation

(2017) Frank Lyko   NATURE REVIEWS GENETICS

Detecting RNA modifications in the epitranscriptome: predict and validate

(2017) Mark Helm et al.   NATURE REVIEWS GENETICS

Structural basis for substrate binding and catalytic mechanism of a human RNA:m5C methyltransferase NSun6

(2017) Ru-Juan Liu et al.   NUCLEIC ACIDS RESEARCH

Synthetic mRNA devices that detect endogenous proteins and distinguish mammalian cells

(2017) Shunsuke Kawasaki et al.   NUCLEIC ACIDS RESEARCH

Transcriptome-Wide Mapping of RNA 5-Methylcytosine in Arabidopsis mRNAs and Noncoding RNAs

(2017) Rakesh David et al.   PLANT CELL

Cytosine-5 RNA Methylation Regulates Neural Stem Cell Differentiation and Motility

(2017) Joana V. Flores et al.   Stem Cell Reports

TET1-Mediated Oxidation of 5-Formylcytosine (5fC) to 5-Carboxycytosine (5caC) in RNA

(2016) Maria Basanta-Sanchez et al.   CHEMBIOCHEM

The existence of 5-hydroxymethylcytosine and 5-formylcytosine in both DNA and RNA in mammals

(2016) Hao-Ying Zhang et al.   CHEMICAL COMMUNICATIONS

Posttranscriptional methylation of transfer and ribosomal RNA in stress response pathways, cell differentiation, and cancer

(2016) Martyna C. Popis et al.   CURRENT OPINION IN ONCOLOGY

NSUN3 and ABH1 modify the wobble position of mt‐tRNAMetto expand codon recognition in mitochondrial translation

(2016) Sara Haag et al.   EMBO JOURNAL

Sequence-specific and Shape-selective RNA Recognition by the Human RNA 5-Methylcytosine Methyltransferase NSun6

(2016) Tao Long et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Analysis of RNA modifications by liquid chromatography–tandem mass spectrometry

(2016) Kathrin Thüring et al.   METHODS

Sequence mapping of transfer RNA chemical modifications by liquid chromatography tandem mass spectrometry

(2016) Robert Ross et al.   METHODS

Stem cell function and stress response are controlled by protein synthesis

(2016) Sandra Blanco et al.   NATURE

Transcriptome-wide distribution and function of RNA hydroxymethylcytosine

(2016) B. Delatte et al.   SCIENCE

Formation and determination of the oxidation products of 5-methylcytosine in RNA

(2016) Wei Huang et al.   Chemical Science

Deficient methylation and formylation of mt-tRNAMet wobble cytosine in a patient carrying mutations in NSUN3

(2016) Lindsey Van Haute et al.   Nature Communications

RNA methyltransferase NSUN2 promotes stress-induced HUVEC senescence

(2016) Xiaoyu Cai et al.   Oncotarget

Overexpression of NSUN2 by DNA hypomethylation is associated with metastatic progression in human breast cancer

(2016) Jie Yi et al.   Oncotarget

Deposition of 5-Methylcytosine on Enhancer RNAs Enables the Coactivator Function of PGC-1α

(2016) Francesca Aguilo et al.   Cell Reports

Structural Chemistry of Human RNA Methyltransferases

(2015) Matthieu Schapira   ACS Chemical Biology

NSun2 delays replicative senescence by repressing p27 (KIP1) translation and elevating CDK1 translation

(2015) Hao Tang et al.   Aging-US

Formation and Abundance of 5-Hydroxymethylcytosine in RNA

(2015) Sabrina M. Huber et al.   CHEMBIOCHEM

The tRNA methyltransferase Dnmt2 is required for accurate polypeptide synthesis during haematopoiesis

(2015) F. Tuorto et al.   EMBO JOURNAL

NSun2 Promotes Cell Growth via Elevating Cyclin-Dependent Kinase 1 Translation

(2015) Junyue Xing et al.   MOLECULAR AND CELLULAR BIOLOGY

NSUN6 is a human RNA methyltransferase that catalyzes formation of m5C72 in specific tRNAs

(2015) Sara Haag et al.   RNA

Methylation of ribosomal RNA by NSUN5 is a conserved mechanism modulating organismal lifespan

(2015) Markus Schosserer et al.   Nature Communications

Cytosine methylation of tRNA-Asp by DNMT2 has a role in translation of proteins containing poly-Asp sequences

(2015) Raghuvaran Shanmugam et al.   Cell Discovery

Eukaryotic rRNA Modification by Yeast 5-Methylcytosine-Methyltransferases and Human Proliferation-Associated Antigen p120

(2015) Gabrielle Bourgeois et al.   PLoS One

The identification and characterization of non-coding and coding RNAs and their modified nucleosides by mass spectrometry

(2015) Kirk W Gaston et al.   RNA Biology

The Pivotal Regulatory Landscape of RNA Modifications

(2014) Sheng Li et al.   Annual Review of Genomics and Human Genetics

Trm4 and Nsun2 RNA:m5C Methyltransferases Form Metabolite-Dependent, Covalent Adducts with Previously Methylated RNA

(2014) Haley J. Moon et al.   BIOCHEMISTRY

Aberrant methylation of tRNAs links cellular stress to neuro-developmental disorders

(2014) S. Blanco et al.   EMBO JOURNAL

New themes in the biological functions of 5-methylcytosine and 5-hydroxymethylcytosine

(2014) Erika L. Moen et al.   IMMUNOLOGICAL REVIEWS

Tet-Mediated Formation of 5-Hydroxymethylcytosine in RNA

(2014) Lijuan Fu et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Methylation by NSun2 Represses the Levels and Function of MicroRNA 125b

(2014) S. Yuan et al.   MOLECULAR AND CELLULAR BIOLOGY

tRNA Modifying Enzymes, NSUN2 and METTL1, Determine Sensitivity to 5-Fluorouracil in HeLa Cells

(2014) Mayumi Okamoto et al.   PLoS Genetics

NSUN4 Is a Dual Function Mitochondrial Protein Required for Both Methylation of 12S rRNA and Coordination of Mitoribosomal Assembly

(2014) Metodi Dimitrov Metodiev et al.   PLoS Genetics

Mass spectrometry sequencing of transfer ribonucleic acids by the comparative analysis of RNA digests (CARD) approach

(2013) Siwei Li et al.   ANALYST

Expression of NOL1/NOP2/sun domain (Nsun) RNA methyltransferase family genes in early mouse embryogenesis

(2013) Lijun Chi et al.   GENE EXPRESSION PATTERNS

The Mouse Cytosine-5 RNA Methyltransferase NSun2 Is a Component of the Chromatoid Body and Required for Testis Differentiation

(2013) S. Hussain et al.   MOLECULAR AND CELLULAR BIOLOGY

Identification of direct targets and modified bases of RNA cytosine methyltransferases

(2013) Vahid Khoddami et al.   NATURE BIOTECHNOLOGY

Target recognition, RNA methylation activity and transcriptional regulation of the Dictyostelium discoideum Dnmt2-homologue (DnmA)

(2013) S. Muller et al.   NUCLEIC ACIDS RESEARCH

Yeast Nop2 and Rcm1 methylate C2870 and C2278 of the 25S rRNA, respectively

(2013) Sunny Sharma et al.   NUCLEIC ACIDS RESEARCH

Long non-coding RNAs as targets for cytosine methylation

(2013) Thomas Amort et al.   RNA Biology

The RNA Methyltransferase Dnmt2 Is Required for Efficient Dicer-2-Dependent siRNA Pathway Activity in Drosophila

(2013) Zeljko Durdevic et al.   Cell Reports

NSun2-Mediated Cytosine-5 Methylation of Vault Noncoding RNA Determines Its Processing into Regulatory Small RNAs

(2013) Shobbir Hussain et al.   Cell Reports

Transcriptome-Wide Mapping of 5-methylcytidine RNA Modifications in Bacteria, Archaea, and Yeast Reveals m5C within Archaeal mRNAs

(2013) Sarit Edelheit et al.   PLoS Genetics

Mutation in NSUN2, which Encodes an RNA Methyltransferase, Causes Autosomal-Recessive Intellectual Disability

(2012) Muzammil Ahmad Khan et al.   AMERICAN JOURNAL OF HUMAN GENETICS

Mapping the tRNA Binding Site on the Surface of Human DNMT2 Methyltransferase

(2012) Tomasz P. Jurkowski et al.   BIOCHEMISTRY

Whole exome sequencing identifies a splicing mutation inNSUN2as a cause of a Dubowitz-like syndrome

(2012) Fernando Jose Martinez et al.   JOURNAL OF MEDICAL GENETICS

RNA cytosine methylation by Dnmt2 and NSun2 promotes tRNA stability and protein synthesis

(2012) Francesca Tuorto et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Pmt1, a Dnmt2 homolog in Schizosaccharomyces pombe, mediates tRNA methylation in response to nutrient signaling

(2012) Maria Becker et al.   NUCLEIC ACIDS RESEARCH

Widespread occurrence of 5-methylcytosine in human coding and non-coding RNA

(2012) Jeffrey E. Squires et al.   NUCLEIC ACIDS RESEARCH

Structure Analysis of Entamoeba histolytica DNMT2 (EhMeth)

(2012) Eike C. Schulz et al.   PLoS One

The human tRNA m5C methyltransferase Misu is multisite-specific

(2012) Sylvie Auxilien et al.   RNA Biology

The tRNA methyltransferase NSun2 stabilizes p16INK4 mRNA by methylating the 3′-untranslated region of p16

(2012) Xiaotian Zhang et al.   Nature Communications

Frequent Increased Gene Copy Number and High Protein Expression of tRNA (Cytosine-5-)-Methyltransferase (NSUN2) in Human Cancers

(2011) Mayumi Okamoto et al.   DNA AND CELL BIOLOGY

Angiogenin-Induced tRNA Fragments Inhibit Translation Initiation

(2011) Pavel Ivanov et al.   MOLECULAR CELL

The RNA–Methyltransferase Misu (NSun2) Poises Epidermal Stem Cells to Differentiate

(2011) Sandra Blanco et al.   PLoS Genetics

RNA methylation by Dnmt2 protects transfer RNAs against stress-induced cleavage

(2010) M. Schaefer et al.   GENES & DEVELOPMENT

Azacytidine Inhibits RNA Methylation at DNMT2 Target Sites in Human Cancer Cell Lines

(2009) M. Schaefer et al.   CANCER RESEARCH

The nucleolar RNA methyltransferase Misu (NSun2) is required for mitotic spindle stability

(2009) Shobbir Hussain et al.   JOURNAL OF CELL BIOLOGY

tRNA over-expression in breast cancer and functional consequences

(2009) Mariana Pavon-Eternod et al.   NUCLEIC ACIDS RESEARCH

RNA cytosine methylation analysis by bisulfite sequencing

(2008) M. Schaefer et al.   NUCLEIC ACIDS RESEARCH

Human DNMT2 methylates tRNAAsp molecules using a DNA methyltransferase-like catalytic mechanism

(2008) T. P. Jurkowski et al.   RNA