Impact of chemically defined culture media formulations on extracellular vesicle production by amniotic epithelial cells

Proteomic profiling of human uterine extracellular vesicles reveal dynamic regulation of key players of embryo implantation and fertility during menstrual cycle

(2021) Alin Rai et al.   PROTEOMICS

Integrins mediate placental extracellular vesicle trafficking to lung and liver in vivo

(2021) Sean L. Nguyen et al.   Scientific Reports

Critical considerations for the development of potency tests for therapeutic applications of mesenchymal stromal cell-derived small extracellular vesicles

(2021) Mario Gimona et al.   CYTOTHERAPY

Proteome reprogramming of endometrial epithelial cells by human trophectodermal small extracellular vesicles reveals key insights into embryo implantation

(2021) Qi Hui Poh et al.   PROTEOMICS

Proteome characterisation of extracellular vesicles isolated from heart

(2021) Bethany Claridge et al.   PROTEOMICS

Secreted midbody remnants are a class of extracellular vesicles molecularly distinct from exosomes and microparticles

(2021) Alin Rai et al.   Communications Biology

The biology, function, and biomedical applications of exosomes

(2020) Raghu Kalluri et al.   SCIENCE

Fat Therapeutics: The Clinical Capacity of Adipose-Derived Stem Cells and Exosomes for Human Disease and Tissue Regeneration

(2020) Lipi Shukla et al.   Frontiers in Pharmacology

Sustained subcutaneous delivery of secretome of human cardiac stem cells promotes cardiac repair following myocardial infarction

(2020) Andrew R Kompa et al.   CARDIOVASCULAR RESEARCH

Nonclinical regulatory immunotoxicity testing of nanomedicinal products: Proposed strategy and possible pitfalls

(2020) Christina Giannakou et al.   Wiley Interdisciplinary Reviews-Nanomedicine and Nanobiotechnology

Boosting the Biogenesis and Secretion of Mesenchymal Stem Cell-Derived Exosomes

(2020) Jinli Wang et al.   Cells

A Comprehensive Proteomic SWATH-MS Workflow for Profiling Blood Extracellular Vesicles: A New Avenue for Glioma Tumour Surveillance

(2020) Susannah Hallal et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Extracellular vesicles as natural therapeutic agents and innate drug delivery systems for cancer treatment: Recent advances, current obstacles, and challenges for clinical translation

(2020) Marco Pirisinu et al.   SEMINARS IN CANCER BIOLOGY

Application of human amniotic epithelial cells in regenerative medicine: a systematic review

(2020) Qiuwan Zhang et al.   Stem Cell Research & Therapy

Engineering approaches for effective therapeutic applications based on extracellular vesicles

(2020) Seunglee Kwon et al.   JOURNAL OF CONTROLLED RELEASE

Human amnion cells for the prevention of bronchopulmonary dysplasia: a protocol for a phase I dose escalation study

(2019) Elizabeth Kate Baker et al.   BMJ Open

Reassessment of Exosome Composition

(2019) Dennis K. Jeppesen et al.   CELL

Optimization of cell culture conditions for exosome isolation using mini-size exclusion chromatography (mini-SEC)

(2019) Nils Ludwig et al.   EXPERIMENTAL CELL RESEARCH

Advances in therapeutic applications of extracellular vesicles

(2019) Oscar P. B. Wiklander et al.   Science Translational Medicine

Exosome manufacturing status

(2019) William Whitford et al.   Future Medicinal Chemistry

Human Amniotic Epithelial Cell-Derived Exosomes Restore Ovarian Function by Transferring MicroRNAs against Apoptosis

(2019) Qiuwan Zhang et al.   Molecular Therapy-Nucleic Acids

Defining mesenchymal stromal cell (MSC)-derived small extracellular vesicles for therapeutic applications

(2019) Kenneth W. Witwer et al.   Journal of Extracellular Vesicles

In Vitro Human Implantation Model Reveals a Role for Endometrial Extracellular Vesicles in Embryo Implantation: Reprogramming the Cellular and Secreted Proteome Landscapes for Bidirectional Fetal‐Maternal Communication

(2019) Jemma Evans et al.   PROTEOMICS

Human Amnion Epithelial Cell Therapy for Chronic Liver Disease

(2019) Neil Andrewartha et al.   Stem Cells International

Serum-free media supplements carry miRNAs that co-purify with extracellular vesicles

(2019) Martin Auber et al.   Journal of Extracellular Vesicles

Chronic methamphetamine interacts with BDNF Val66Met to remodel psychosis pathways in the mesocorticolimbic proteome

(2019) David W. Greening et al.   MOLECULAR PSYCHIATRY

Proteomic Insights into Endometrial Receptivity and Embryo‐Endometrial Epithelium Interaction for Implantation Reveal Critical Determinants of Fertility

(2019) Jemma Evans et al.   PROTEOMICS

Role of Mac-1 integrin in generation of extracellular vesicles with antibacterial capacity from neutrophilic granulocytes

(2019) Ákos M. Lőrincz et al.   Journal of Extracellular Vesicles

The influence of culture media upon observed cell secretome metabolite profiles: The balance between cell viability and data interpretability

(2018) Evangelia Daskalaki et al.   ANALYTICA CHIMICA ACTA

Comparison of commercial exosome isolation kits for circulating exosomal microRNA profiling

(2018) Meng Ding et al.   ANALYTICAL AND BIOANALYTICAL CHEMISTRY

A Novel Strategy to Increase the Yield of Exosomes (Extracellular Vesicles) for an Expansion of Basic Research

(2018) Sherif E. Emam et al.   BIOLOGICAL & PHARMACEUTICAL BULLETIN

Regulatory context and validation of assays for clinical mass spectrometry proteomics (cMSP) methods

(2018) Christophe Hirtz et al.   CRITICAL REVIEWS IN CLINICAL LABORATORY SCIENCES

Comparison of membrane affinity-based method with size-exclusion chromatography for isolation of exosome-like vesicles from human plasma

(2018) Ruzena Stranska et al.   Journal of Translational Medicine

Extracellular vesicles in cancer — implications for future improvements in cancer care

(2018) Rong Xu et al.   Nature Reviews Clinical Oncology

Shedding light on the cell biology of extracellular vesicles

(2018) Guillaume van Niel et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Amnion Epithelial Cell-Derived Exosomes Restrict Lung Injury and Enhance Endogenous Lung Repair

(2018) Jean L. Tan et al.   Stem Cells Translational Medicine

Isolation of Extracellular Vesicles: General Methodologies and Latest Trends

(2018) Maria Yu. Konoshenko et al.   Biomed Research International

FGF2 Induces Migration of Human Bone Marrow Stromal Cells by Increasing Core Fucosylations on N-Glycans of Integrins

(2018) Baarkullah Awan et al.   Stem Cell Reports

Extracellular Vesicle Heterogeneity: Subpopulations, Isolation Techniques, and Diverse Functions in Cancer Progression

(2018) Eduard Willms et al.   Frontiers in Immunology

Phase 1 Trial of Amnion Cell Therapy for Ischemic Stroke

(2018) Thanh G. Phan et al.   Frontiers in Neurology

Amnion epithelial cells – a novel therapy for ischemic stroke?

(2018) ChristopherG Sobey et al.   Neural Regeneration Research

Efficient extracellular vesicle isolation by combining cell media modifications, ultrafiltration, and size-exclusion chromatography

(2018) Eduarda M. Guerreiro et al.   PLoS One

First-In-Human Administration of Allogeneic Amnion Cells in Premature Infants With Bronchopulmonary Dysplasia: A Safety Study

(2018) Rebecca Lim et al.   Stem Cells Translational Medicine

Understanding extracellular vesicle diversity – current status

(2018) David W. Greening et al.   Expert Review of Proteomics

A8321 Delayed post-stroke administration of human amnion epithelial cell-derived exosomes improve outcomes

(2018) Brad Broughton et al.   JOURNAL OF HYPERTENSION

Single-pot, solid-phase-enhanced sample preparation for proteomics experiments

(2018) Christopher S. Hughes et al.   Nature Protocols

Toward Standardization of Mesenchymal Stromal Cell-Derived Extracellular Vesicles for Therapeutic Use: A Call for Action

(2018) Santiago Roura et al.   PROTEOMICS

Exosomes Derived from Human Primary and Metastatic Colorectal Cancer Cells Contribute to Functional Heterogeneity of Activated Fibroblasts by Reprogramming Their Proteome

(2018) Alin Rai et al.   PROTEOMICS

Exosomes derived from human amniotic epithelial cells accelerate wound healing and inhibit scar formation

(2017) Bin Zhao et al.   JOURNAL OF MOLECULAR HISTOLOGY

Human amnion cells reverse acute and chronic pulmonary damage in experimental neonatal lung injury

(2017) Dandan Zhu et al.   Stem Cell Research & Therapy

Concise Review: Developing Best-Practice Models for the Therapeutic Use of Extracellular Vesicles

(2017) Agnes T. Reiner et al.   Stem Cells Translational Medicine

The Human Amnion Epithelial Cell Secretome Decreases Hepatic Fibrosis in Mice with Chronic Liver Fibrosis

(2017) Majid Alhomrani et al.   Frontiers in Pharmacology

Exosomes from metastatic cancer cells transfer amoeboid phenotype to non-metastatic cells and increase endothelial permeability: their emerging role in tumor heterogeneity

(2017) Odessa Schillaci et al.   Scientific Reports

Proteomic insights into extracellular vesicle biology – defining exosomes and shed microvesicles

(2016) David W. Greening et al.   Expert Review of Proteomics

The integrin adhesome network at a glance

(2016) Edward R. Horton et al.   JOURNAL OF CELL SCIENCE

Extracellular vesicle isolation and characterization: toward clinical application

(2016) Rong Xu et al.   JOURNAL OF CLINICAL INVESTIGATION

The MaxQuant computational platform for mass spectrometry-based shotgun proteomics

(2016) Stefka Tyanova et al.   Nature Protocols

Proteomic comparison defines novel markers to characterize heterogeneous populations of extracellular vesicle subtypes

(2016) Joanna Kowal et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Manufacturing of Human Umbilical Cord Mesenchymal Stromal Cells on Microcarriers in a Dynamic System for Clinical Use

(2016) Florian Petry et al.   Stem Cells International

Evaluating the Impact of Human Amnion Epithelial Cells on Angiogenesis

(2016) Dandan Zhu et al.   Stem Cells International

Matrix-bound nanovesicles within ECM bioscaffolds

(2016) L. Huleihel et al.   Science Advances

Low pH increases the yield of exosome isolation

(2015) Jae-Jun Ban et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Methods of isolating extracellular vesicles impact down-stream analyses of their cargoes

(2015) Douglas D. Taylor et al.   METHODS

Tumour exosome integrins determine organotropic metastasis

(2015) Ayuko Hoshino et al.   NATURE

Amnion cell-mediated immune modulation following bleomycin challenge: controlling the regulatory T cell response

(2015) Jean L Tan et al.   Stem Cell Research & Therapy

Expression of B-Cell Surface Antigens in Subpopulations of Exosomes Released From B-Cell Lymphoma Cells

(2014) Morten P. Oksvold et al.   CLINICAL THERAPEUTICS

Cell-based therapies for the preterm infant

(2014) Dandan Zhu et al.   CYTOTHERAPY

A novel “salting-out” procedure for the isolation of tumor-derived exosomes

(2014) Zachary Brownlee et al.   JOURNAL OF IMMUNOLOGICAL METHODS

Accurate Proteome-wide Label-free Quantification by Delayed Normalization and Maximal Peptide Ratio Extraction, Termed MaxLFQ

(2014) Jürgen Cox et al.   MOLECULAR & CELLULAR PROTEOMICS

Tetraspanins in Extracellular Vesicle Formation and Function

(2014) Zoraida Andreu et al.   Frontiers in Immunology

Human Amnion Epithelial Cells Mediate Lung Repair by Directly Modulating Macrophage Recruitment and Polarization

(2013) Jean L. Tan et al.   CELL TRANSPLANTATION

Comparison of serum exosome isolation methods for microRNA profiling

(2013) Kadri Rekker et al.   CLINICAL BIOCHEMISTRY

Tetraspanin protein CD9 interacts with metalloprotease CD10 and enhances its release via exosomes

(2013) Dmitriy Mazurov et al.   FEBS Journal

The Intracellular Interactome of Tetraspanin-enriched Microdomains Reveals Their Function as Sorting Machineries toward Exosomes

(2013) Daniel Perez-Hernandez et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Long-Term (Postnatal Day 70) Outcome and Safety of Intratracheal Transplantation of Human Umbilical Cord Blood-Derived Mesenchymal Stem Cells in Neonatal Hyperoxic Lung Injury

(2013) So Yoon Ahn et al.   YONSEI MEDICAL JOURNAL

Human lymphocytes cultured in 3-D bioreactors: Influence of configuration on metabolite transport and reactions

(2012) Efrem Curcio et al.   BIOMATERIALS

Hypoxic enhancement of exosome release by breast cancer cells

(2012) Hamish W King et al.   BMC CANCER

Toward tailored exosomes: The exosomal tetraspanin web contributes to target cell selection

(2012) Sanyukta Rana et al.   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY

Cell therapy medicinal product regulatory framework in Europe and its application for MSC-based therapy development

(2012) Janis Ancans   Frontiers in Immunology

Metabolomics Profiling of Cell Culture Media Leading to the Identification of Riboflavin Photosensitized Degradation of Tryptophan Causing Slow Growth in Cell Culture

(2011) Li Zang et al.   ANALYTICAL CHEMISTRY

The Tetraspanin CD63 Regulates ESCRT-Independent and -Dependent Endosomal Sorting during Melanogenesis

(2011) Guillaume van Niel et al.   DEVELOPMENTAL CELL

Andromeda: A Peptide Search Engine Integrated into the MaxQuant Environment

(2011) Jürgen Cox et al.   JOURNAL OF PROTEOME RESEARCH

System-wide Perturbation Analysis with Nearly Complete Coverage of the Yeast Proteome by Single-shot Ultra HPLC Runs on a Bench Top Orbitrap

(2011) Nagarjuna Nagaraj et al.   MOLECULAR & CELLULAR PROTEOMICS

High cell density cultivation and recombinant protein production with Escherichia coli in a rocking-motion-type bioreactor

(2010) Julia Glazyrina et al.   Microbial Cell Factories

Lateral organization of membrane proteins: tetraspanins spin their web

(2009) Stéphanie Charrin et al.   BIOCHEMICAL JOURNAL

Molecular mechanism and function of CD40/CD40L engagement in the immune system

(2009) Raul Elgueta et al.   IMMUNOLOGICAL REVIEWS

Tetraspanin-enriched microdomains: a functional unit in cell plasma membranes

(2009) María Yáñez-Mó et al.   TRENDS IN CELL BIOLOGY

Intercellular transfer of the oncogenic receptor EGFRvIII by microvesicles derived from tumour cells

(2008) Khalid Al-Nedawi et al.   NATURE CELL BIOLOGY