Trisomy 21-associated increases in chromosomal instability are unmasked by comparing isogenic trisomic/disomic leukocytes from people with mosaic Down syndrome

Substrate-specific recognition of IKKs mediated by USP16 facilitates autoimmune inflammation

(2021) Jian-shuai Yu et al.   Science Advances

Health comorbidities and cognitive abilities across the lifespan in Down syndrome

(2020) Carla M. Startin et al.   Journal of Neurodevelopmental Disorders

Micronuclei and disease – Report of HUMN project workshop at Rennes 2019 EEMGS conference

(2020) Michael Fenech et al.   MUTATION RESEARCH-GENETIC TOXICOLOGY AND ENVIRONMENTAL MUTAGENESIS

Down syndrome

(2020) Stylianos E. Antonarakis et al.   Nature Reviews Disease Primers

Immune Dysregulation in Children With Down Syndrome

(2020) Dean Huggard et al.   Frontiers in Pediatrics

Regulation and Consequences of cGAS Activation by Self-DNA

(2020) Christian Zierhut et al.   TRENDS IN CELL BIOLOGY

Micronuclei, inflammation and auto-immune disease

(2020) Micheline Kirsch-Volders et al.   MUTATION RESEARCH-REVIEWS IN MUTATION RESEARCH

Cytokinesis-Block Micronucleus Cytome Assay Evolution into a More Comprehensive Method to Measure Chromosomal Instability

(2020) Michael Fenech   Genes

cGAS in action: Expanding roles in immunity and inflammation

(2019) Andrea Ablasser et al.   SCIENCE

Trisomy 21 dysregulates T cell lineages toward an autoimmunity-prone state associated with interferon hyperactivity

(2019) Paula Araya et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The cGAS–cGAMP–STING pathway connects DNA damage to inflammation, senescence, and cancer

(2018) Tuo Li et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Assessment of genomic instability and proliferation index in cultured lymphocytes of patients with Down syndrome, congenital anomalies and aplastic anaemia

(2018) Alex George et al.   MUTATION RESEARCH-GENETIC TOXICOLOGY AND ENVIRONMENTAL MUTAGENESIS

The molecular origins and pathophysiological consequences of micronuclei: New insights into an age-old problem

(2018) Xihan Guo et al.   MUTATION RESEARCH-REVIEWS IN MUTATION RESEARCH

cGAS surveillance of micronuclei links genome instability to innate immunity

(2017) Karen J. Mackenzie et al.   NATURE

Mitotic progression following DNA damage enables pattern recognition within micronuclei

(2017) Shane M. Harding et al.   NATURE

cGAS Conducts Micronuclei DNA Surveillance

(2017) Carina C. de Oliveira Mann et al.   TRENDS IN CELL BIOLOGY

p53 Prohibits Propagation of Chromosome Segregation Errors that Produce Structural Aneuploidies

(2017) Mar Soto et al.   Cell Reports

Low risk of solid tumors in persons with Down syndrome

(2016) Henrik Hasle et al.   GENETICS IN MEDICINE

Regulation and function of the cGAS–STING pathway of cytosolic DNA sensing

(2016) Qi Chen et al.   NATURE IMMUNOLOGY

The presence of extra chromosomes leads to genomic instability

(2016) Verena Passerini et al.   Nature Communications

Trisomy 21 consistently activates the interferon response

(2016) Kelly D Sullivan et al.   eLife

Whole Chromosome Instability induces senescence and promotes SASP

(2016) Grasiella Angelina Andriani et al.   Scientific Reports

Aneuploid proliferation defects in yeast are not driven by copy number changes of a few dosage-sensitive genes

(2015) Megan E. Bonney et al.   GENES & DEVELOPMENT

Short- and long-term effects of chromosome mis-segregation and aneuploidy

(2015) Stefano Santaguida et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Chromosome mis-segregation and cytokinesis failure in trisomic human cells

(2015) Joshua M Nicholson et al.   eLife

Mosaicism for trisomy 21: A review

(2014) Paulie Papavassiliou et al.   AMERICAN JOURNAL OF MEDICAL GENETICS PART A

Reactive oxygen species mediate IL-8 expression in Down syndrome candidate region-1-overexpressed cells

(2014) Je Won Ko et al.   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY

The epigenetic landscape of aneuploidy: constitutional mosaicism leading the way?

(2014) Josef Davidsson   Epigenomics

DNA-Damage Response during Mitosis Induces Whole-Chromosome Missegregation

(2014) S. F. Bakhoum et al.   Cancer Discovery

Atypical aging in down syndrome

(2013) Warren B. Zigman   Developmental Disabilities Research Reviews

Down's syndrome link to ageing

(2013) George P. Souroullas et al.   NATURE

Usp16 contributes to somatic stem-cell defects in Down’s syndrome

(2013) Maddalena Adorno et al.   NATURE

Translating dosage compensation to trisomy 21

(2013) Jun Jiang et al.   NATURE

Cancer cells preferentially lose small chromosomes

(2012) Pascal H.G. Duijf et al.   INTERNATIONAL JOURNAL OF CANCER

Mechanisms leading to the formation of micronuclei containing sex chromosomes differ with age

(2012) Kimberly H. Jones et al.   MUTATION RESEARCH-GENETIC TOXICOLOGY AND ENVIRONMENTAL MUTAGENESIS

Genetic and environmental influences on spontaneous micronuclei frequencies in children and adults: a twin study

(2011) K. H. Jones et al.   MUTAGENESIS

Decreasing mosaicism in Down's syndrome

(2010) Miriam G. Wilson et al.   CLINICAL GENETICS

Micronuclei in neonates and children: effects of environmental, genetic, demographic and disease variables

(2010) N. Holland et al.   MUTAGENESIS

Study design and statistical analysis of data in human population studies with the micronucleus assay

(2010) M. Ceppi et al.   MUTAGENESIS

The HUMN and HUMNxL international collaboration projects on human micronucleus assays in lymphocytes and buccal cells--past, present and future

(2010) M. Fenech et al.   MUTAGENESIS

The effect of age, gender, diet and lifestyle on DNA damage measured using micronucleus frequency in human peripheral blood lymphocytes

(2010) M. Fenech et al.   MUTAGENESIS

The phenotype of persons having mosaicism for trisomy 21/Down syndrome reflects the percentage of trisomic cells present in different tissues

(2009) Paulie Papavassiliou et al.   AMERICAN JOURNAL OF MEDICAL GENETICS PART A

Buccal micronucleus frequency is associated with age in Down syndrome

(2009) F.L.S. Ferreira et al.   GENETICS AND MOLECULAR RESEARCH

Examining the link between chromosomal instability and aneuploidy in human cells

(2008) Sarah L. Thompson et al.   JOURNAL OF CELL BIOLOGY

The buccal cytome and micronucleus frequency is substantially altered in Down's syndrome and normal ageing compared to young healthy controls

(2007) Philip Thomas et al.   MUTATION RESEARCH-FUNDAMENTAL AND MOLECULAR MECHANISMS OF MUTAGENESIS