Trisomy 21 dysregulates T cell lineages toward an autoimmunity-prone state associated with interferon hyperactivity
出版年份 2019 全文链接
标题
Trisomy 21 dysregulates T cell lineages toward an autoimmunity-prone state associated with interferon hyperactivity
作者
关键词
-
出版物
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
Volume 116, Issue 48, Pages 24231-24241
出版商
Proceedings of the National Academy of Sciences
发表日期
2019-11-08
DOI
10.1073/pnas.1908129116
参考文献
相关参考文献
注意：仅列出部分参考文献，下载原文获取全部文献信息。- mTOR in Down syndrome: Role in Aß and tau neuropathology and transition to Alzheimer disease-like dementia
- (2018) Fabio Di Domenico et al. FREE RADICAL BIOLOGY AND MEDICINE
- Interleukin-10 Directly Inhibits CD8 + T Cell Function by Enhancing N-Glycan Branching to Decrease Antigen Sensitivity
- (2018) Logan K. Smith et al. IMMUNITY
- Effector T Cell Resistance to Suppression and STAT3 Signaling during the Development of Human Type 1 Diabetes
- (2018) Emmi-Leena Ihantola et al. JOURNAL OF IMMUNOLOGY
- Regulation of type I interferon signaling in immunity and inflammation: A comprehensive review
- (2017) Kun Chen et al. JOURNAL OF AUTOIMMUNITY
- Quantitative, Phenotypical, and Functional Characterization of Cellular Immunity in Children and Adolescents With Down Syndrome
- (2017) Justine Schoch et al. JOURNAL OF INFECTIOUS DISEASES
- JAK inhibition as a therapeutic strategy for immune and inflammatory diseases
- (2017) Daniella M. Schwartz et al. NATURE REVIEWS DRUG DISCOVERY
- Mechanisms and Dynamics of T Cell-Mediated Cytotoxicity In Vivo
- (2017) Stephan Halle et al. TRENDS IN IMMUNOLOGY
- IFN-γ is required for cytotoxic T cell-dependent cancer genome immunoediting
- (2017) Kazuyoshi Takeda et al. Nature Communications
- Aberrations in circulating inflammatory cytokine levels in patients with Down syndrome: a meta-analysis
- (2017) Yan Zhang et al. Oncotarget
- Trisomy 21 causes changes in the circulating proteome indicative of chronic autoinflammation
- (2017) Kelly D. Sullivan et al. Scientific Reports
- Low risk of solid tumors in persons with Down syndrome
- (2016) Henrik Hasle et al. GENETICS IN MEDICINE
- Estimation of the number of people with Down syndrome in the United States
- (2016) Gert de Graaf et al. GENETICS IN MEDICINE
- Trisomy 21 consistently activates the interferon response
- (2016) Kelly D Sullivan et al. eLife
- Breaking Free of Control: How Conventional T Cells Overcome Regulatory T Cell Suppression
- (2016) Emily R. Mercadante et al. Frontiers in Immunology
- Down syndrome and Alzheimer's disease: Common pathways, common goals
- (2015) Dean Hartley et al. Alzheimers & Dementia
- New insights into type I interferon and the immunopathogenesis of persistent viral infections
- (2015) Laura M Snell et al. CURRENT OPINION IN IMMUNOLOGY
- FlowSOM: Using self-organizing maps for visualization and interpretation of cytometry data
- (2015) Sofie Van Gassen et al. CYTOMETRY PART A
- Morbidity and medication in a large population of individuals with Down syndrome compared to the general population
- (2015) Myriam Alexander et al. DEVELOPMENTAL MEDICINE AND CHILD NEUROLOGY
- Interferon γ (IFNγ) Signaling via Mechanistic Target of Rapamycin Complex 2 (mTORC2) and Regulatory Effects in the Generation of Type II Interferon Biological Responses
- (2015) Barbara Kroczynska et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Pivotal Roles of GM-CSF in Autoimmunity and Inflammation
- (2015) Aoi Shiomi et al. MEDIATORS OF INFLAMMATION
- Decrease of interleukin (IL)17A gene expression in leucocytes and in the amount of IL-17A protein in CD4+ T cells in children with Down Syndrome
- (2015) Anna Jakubiuk-Tomaszuk et al. Pharmacological Reports
- Spatial Map of Human T Cell Compartmentalization and Maintenance over Decades of Life
- (2014) Joseph J.C. Thome et al. CELL
- Critical Roles for Rictor/Sin1 Complexes in Interferon-dependent Gene Transcription and Generation of Antiproliferative Responses
- (2014) Surinder Kaur et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- The Effector T Cells of Diabetic Subjects Are Resistant to Regulation via CD4+FOXP3+ Regulatory T Cells
- (2014) A. Schneider et al. JOURNAL OF IMMUNOLOGY
- IL-1 Promotes the Differentiation of Polyfunctional Human CCR6+CXCR3+ Th1/17 Cells That Are Specific for Pathogenic and Commensal Microbes
- (2014) T. Duhen et al. JOURNAL OF IMMUNOLOGY
- Alopecia areata is driven by cytotoxic T lymphocytes and is reversed by JAK inhibition
- (2014) Luzhou Xing et al. NATURE MEDICINE
- Causal analysis approaches in Ingenuity Pathway Analysis
- (2013) Andreas Krämer et al. BIOINFORMATICS
- The who's who of T-cell differentiation: Human memory T-cell subsets
- (2013) Yolanda D. Mahnke et al. EUROPEAN JOURNAL OF IMMUNOLOGY
- Differential Localization of T-bet and Eomes in CD8 T Cell Memory Populations
- (2013) L. M. McLane et al. JOURNAL OF IMMUNOLOGY
- IL-2 Produced by CD8+ Immune T Cells Can Augment Their IFN- Production Independently from Their Proliferation in the Secondary Response to an Intracellular Pathogen
- (2013) Q. Sa et al. JOURNAL OF IMMUNOLOGY
- Increased T-bet is associated with senescence of influenza virus-specific CD8 T cells in aged humans
- (2013) Douglas V. Dolfi et al. JOURNAL OF LEUKOCYTE BIOLOGY
- Down Syndrome Is Associated with Elevated Risk of Celiac Disease: A Nationwide Case-Control Study
- (2013) Karl Mårild et al. JOURNAL OF PEDIATRICS
- Down syndrome, autoimmunity and T regulatory cells
- (2012) F. P. Pellegrini et al. CLINICAL AND EXPERIMENTAL IMMUNOLOGY
- IL-17: A new actor in IFN-driven systemic autoimmune diseases
- (2012) Aurélie Ambrosi et al. EUROPEAN JOURNAL OF IMMUNOLOGY
- The interferons and their receptors-distribution and regulation
- (2012) Nicole A de Weerd et al. IMMUNOLOGY AND CELL BIOLOGY
- Global Activation of CD8+ Cytotoxic T Lymphocytes Correlates with an Impairment in Regulatory T Cells in Patients with Generalized Vitiligo
- (2012) Yang Lili et al. PLoS One
- Functional human regulatory T cells fail to control autoimmune inflammation due to PKB/c-akt hyperactivation in effector cells
- (2011) E. J. Wehrens et al. BLOOD
- Suppression assays with human T regulatory cells: A technical guide
- (2011) Alicia N. McMurchy et al. EUROPEAN JOURNAL OF IMMUNOLOGY
- Decreased Thymic Output Accounts for Decreased Naive T Cell Numbers in Children with Down Syndrome
- (2011) Beatrijs L. P. Bloemers et al. JOURNAL OF IMMUNOLOGY
- Immune evaluation and vaccine responses in Down syndrome: Evidence of immunodeficiency?
- (2011) Avni Y. Joshi et al. VACCINE
- Secretion of MIP-1β and MIP-1α by CD8+ T-lymphocytes correlates with HIV-1 inhibition independent of coreceptor usage
- (2010) Kevin O. Saunders et al. CELLULAR IMMUNOLOGY
- Distinct Abnormalities in the Innate Immune System of Children with Down Syndrome
- (2010) Beatrijs L.P. Bloemers et al. JOURNAL OF PEDIATRICS
- IL-10 production by CD4+ effector T cells: a mechanism for self-regulation
- (2010) D Jankovic et al. Mucosal Immunology
- Functional Delineation and Differentiation Dynamics of Human CD4+ T Cells Expressing the FoxP3 Transcription Factor
- (2009) Makoto Miyara et al. IMMUNITY
- Reduced CD4+,CD25− T cell sensitivity to the suppressive function of CD4+,CD25high,CD127−/lowregulatory T cells in patients with active systemic lupus erythematosus
- (2008) Ram Kumar Chowdary Venigalla et al. ARTHRITIS AND RHEUMATISM
- The defect in T-cell regulation in NOD mice is an effect on the T-cell effectors
- (2008) A. M. D'Alise et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Homeostatic Cytokines and Expansion of Regulatory T Cells Accompany Thymic Impairment in Children with Down Syndrome
- (2008) Erika Roat et al. REJUVENATION RESEARCH
Find Funding. Review Successful Grants.
Explore over 25,000 new funding opportunities and over 6,000,000 successful grants.
ExploreAdd your recorded webinar
Do you already have a recorded webinar? Grow your audience and get more views by easily listing your recording on Peeref.
Upload Now